Clinical trials: Hydrocephalus.
Hydrocephalus, NPH (Normal Pressure Hydrocephalus)
CERTAS Programmable Valve Registry
Post-Market Clinical Follow-up Registry of Patients with CODMAN CERTAS Plus Programmable Valves.
- Conditions
- Hydrocephalus, NPH (Normal Pressure Hydrocephalus), IIH - Idiopathic Intracranial Hypertension
- Trial name
- CERTAS (NCT04207229)
- Testing
- CODMAN CERTAS Programmable Valves
- Where
- 8 sites in Germany, Netherlands
- Volunteers
- 35 people
- Sponsor
- Integra LifeSciences Corporation
Normal Pressure Hydrocephalus
Endoscopic Third Ventriculostomy Versus Ventriculo-peritoneal Shunting in Idiopathic Normal Pressure Hydrocephalus
An endoscopic third ventriculostomy is considered to be successful in idiopathic normal pressure hydrocephalus (iNPH) in some literature reports, but there is a lack of high quality data.
- Trial name
- NCT03245138
- Testing
- Endoscopic Third Ventriculostomy, Ventriculo-Peritoneal Shunting
- Where
- 3 sites in Germany
- Volunteers
- 100 people
- Sponsor
- University Medicine Greifswald
Hydrocephalus
The CSF Shunt Entry Site Trial
The purpose of the study is to compare the survival time (time to first shunt failure) of ventriculoperitoneal (VP) shunts inserted through an anterior entry site with those inserted through a posterior entry site in children.
- Trial name
- NCT02425761
- Testing
- Ventriculoperitoneal shunt insertion surgery
- Where
- 14 sites in United States, Canada
- Volunteers
- 448 people
- Sponsor
- Baylor College of Medicine
Subarachnoid Hemorrhage, Hydrocephalus
Strategies for Weaning From External Ventricular Drainage
External ventricular drainage is frequently used in neurocritical care, particularly in patients admitted for non-traumatic subarachnoid hemorrhage who develop hydrocephalus and/or intracranial hypertension.
- Conditions
- Subarachnoid Hemorrhage, Hydrocephalus, Intracranial Hypertension, External Ventricular Drainage
- Trial name
- SEVDVE2 (NCT07630051)
- Testing
- Direct clamping of external ventricular drain, Progressive (gradual) weaning of external ventricular drain
- Where
- 5 sites in France
- Volunteers
- 170 people
- Sponsor
- University Hospital, Angers
Normal Pressure Hydrocephalus, Cognitive Impairment
Normal Pressure Hydrocephalus Biomarkers Investigation
Normal Pressure Hydrocephalus (NPH) is a clinical condition that induces cognitive deterioration that can be reverted, at least in part, by introducing ventricular-peritoneal diversion controlled by a miniaturized valve system.
- Trial name
- NORPHY (NCT05562596)
- Testing
- Measurement of oxysterol profile, including 20 molecules, in liquor before and after surgery
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Roma La Sapienza
Hydrocephalus, Normal Pressure Hydrocephalus
A Precision and Accuracy Study of the Codman Valve Position Verification (VPV) System.
The purpose of this study is to determine the agreement rate between the CODMAN Valve Position Verification (VPV) adjustment outcome (reprogramming) and X-ray verification in order to support an alternative to X-ray confirmation…
- Trial name
- NCT00196196
- Testing
- Codman VPV System
- Where
- 8 sites in United States
- Volunteers
- 274 people
- Sponsor
- Codman & Shurtleff
Idiopathic Normal Pressure Hydrocephalus (iNPH)
The Pilot Study of Medical Device-Neuclare for Patients With Idiopathic Normal Pressure Hydrocephalus (iNPH)
This clinical trial aims to explore the effectiveness and safety of gait improvemen of Neuclare, a science medical device, for patients with Idiopathic Normal Pressure Hydrocephalus (iNPH) Through methods such as Timed Up \& Go…
- Trial name
- NCT06478979
- Testing
- Neuclare
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Deepsonbio
Hydrocephalus
Relationship Between Hydrocephalus and Endolymphatic Hydrops
The goal of this observational study is to assess the prevalence of endolymphatic hydrops in patients with hydrocephalus and assess the auditory functions in patients with hydrocephalus including male and female with 20-60 year…
- Trial name
- NCT07003152
- Testing
- diagnosis of endolymphatic hydrops in hydrocephalus patients
- Volunteers
- 20 people
- Sponsor
- Sohag University
Hydrocephalus
Comparison of Optic Nerve Sheath Diameter Measured by Ultrasonography Before and After Ventriculoperitoneal Shunt Surgery in Adult Patients With Hydrocephalus
Hydrocephalus is a disturbance of cerebrospinal fluid production, flow and absorption leading to intracranial hypertension. Assessment of the change in intracranial pressure after ventriculoperitoneal shunt surgery is important…
- Trial name
- NCT02663947
- Testing
- ultrasonographic measurement of optic nerve sheath diameter
- Where
- South Korea
- Sponsor
- Yonsei University
Arnold Chiari Deformity, Hydrocephalus
Establishing the Physiology of Syringomyelia
The brain and spinal cord are surrounded by fluid called cerebrospinal fluid (CSF). The CSF flows through channels in the brain and around the spinal cord. Occasionally, people are born with malformations of these channels.
- Conditions
- Arnold Chiari Deformity, Hydrocephalus, Syringomyelia
- Trial name
- NCT00001327
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Hydrocephalus, Ventriculomegally
Late Post Traumatic Ventriculomegally Does it Requires CSF Diversion ?
Aim of the study is : 1. prevelance of ventriculomegally in post traumatic patients after head trauma 2. To determine the incidence of surgically treated ventriculomegally within 6 months from head injury in a series of…
- Trial name
- NCT06703164
- Volunteers
- 34 people
- Sponsor
- Assiut University
Hydrocephalus
Crystallization of LA and Adjuvant Mixtures in Cerebrospinal Fluid
Different mixtures of local anesthetics or local anesthetics with adjuvants that are known to precipitate in vitro are tested in human cerebrospinal fluid (CSF).
- Trial name
- NCT07442929
- Where
- Austria
- Volunteers
- 2 people
- Sponsor
- Medical University Innsbruck
Educational, Simulation
Simulation Efficacy in Neurosurgical Education
This study aims to investigate the efficacy of simulation in neurosurgical training.
- Conditions
- Educational, Simulation, Hydrocephalus, Intraventricular Hemorrhage
- Trial name
- SENSE (NCT02988154)
- Testing
- Simulation training, ''See one, do one'' approach
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Johannes Gutenberg University Mainz
Hydrocephalus
Endoscopic Third Ventriculostomy for Adults: A Prognostic Model for Success
Endoscopic Third Ventriculostomy for Adults with Hydrocephalus: Creating a Prognostic Model for Success - A Retrospective Multicenter Study Background: Endoscopic third ventriculostomy (ETV) is becoming an increasingly widespread…
- Trial name
- NordicETV (NCT04773938)
- Where
- 19 sites in Denmark, Finland and 2 more
- Volunteers
- 1,000 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Primary Dystonia, Epilepsy
Assess Specific Kinds of Children Challenges for Neurologic Devices Study
The ASK CHILDREN study is intended to aid in future development of various neurologic devices (i.e. neuroprostheses). The ASK CHILDREN study seeks to use study information obtained to identify more efficient strategies in the…
- Conditions
- Primary Dystonia, Epilepsy, Hydrocephalus, Bladder Control
- Trial name
- NCT01191307
- Volunteers
- 16 people
- Sponsor
- Carlos Pena, PhD, MS
Normal Pressure Hydrocephalus, Hydrocephalus
European Study of Prodromal iNPH
To investigate if progression from prodromal into symptomatic NPH can be predicted from advanced neuroimaging, biomarkers in cerebrospinal fluid (CSF) and plasma and investigate the unknown mechanisms causing deterioration by…
- Trial name
- STOP iNPH (NCT05910944)
- Testing
- Shunt surgery
- Where
- 7 sites in Finland, Italy and 1 more
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Johan Virhammar
Normal Pressure Hydrocephalus, Hakim Syndrome
Addressing Health Disparities in Normal Pressure Hydrocephalus (NPH) in Maryland
The study aims to estimate Normal Pressure Hydrocephalus (NPH) prevalence and evaluate health equity gaps in Baltimore and Maryland based on zip codes and race, with a focus on the Black community.
- Trial name
- NPH (NCT06426004)
- Testing
- patients will receive NPH education, primary care physicians (PCPs) will receive professional NPH education, A community health worker will assist PCP
- Where
- 2 sites in United States
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Hydrocephalus, Critical Care
Quantitative Pupillometry
The aim of this study is to assess the diagnostic ability of quantitative pupillometry for the early detection of hydrocephalus during the weaning process of the external ventricular drain.
- Trial name
- HYDRO-NiP (NCT05386303)
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- Nantes University Hospital
Normal Pressure Hydrocephalus
Conservative Versus Surgical Management of Idiopathic Normal Pressure Hydrocephalus (INPH)
This study aims to provide class 1 evidence supporting or refuting the existence of normal pressure hydrocephalus.
- Trial name
- NCT00727142
- Testing
- Surgical treatment
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- University College London Hospitals
Low Pressure Hydrocephalus
The Use of Q-Collar to Increase CSF Drainage in Low-pressure Hydrocephalus Patients
The investigators hypothesize that the Q-collar compression on bilateral internal jugular veins of patients with low pressure hydrocephalus will decrease venous drainage from the intracranial space, therefore increasing…
- Trial name
- NCT06129565
- Testing
- Q-collar
- Sponsor
- University of Kansas Medical Center