Clinical trials: Hydrocephalus., active
Hydrocephalus
EVD Drainage Data and Intracranial Pressure (ICP) Measurements
Rhaeos, Inc. is initially targeting hydrocephalus, a life threatening condition caused by an abnormal accumulation of cerebrospinal fluid (CSF).
- Trial name
- RHAEOS (NCT05546996)
- Testing
- FlowSense
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Baylor College of Medicine
Hydrocephalus
Magnetic Resonance Elastography in Hydrocephalus
The purpose of this project is to assess the utility of a new magnetic resonance technique called magnetic resonance elastography (MRE) in the non-invasive diagnosis of normal pressure hydrocephalus.
- Trial name
- NCT02230124
- Testing
- MRE
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Hydrocephalus
First-in-human Trial of Home Brain Pressure Measured Using Kitea ICP Sensor, Placed During Hydrocephalus Shunt Surgery.
Patients with hydrocephalus have an abnormal build-up of fluid around the brain and need a tube surgically implanted to drain that fluid. Patients and their caregivers live with the constant fear that the tube will block.
- Trial name
- HomeICP (NCT06402786)
- Testing
- Kitea ICP Sensor
- Where
- New Zealand
- Volunteers
- 21 people
- Sponsor
- University of Auckland, New Zealand
Normal Pressure Hydrocephalus, Hydrocephalus
European Study of Prodromal iNPH
To investigate if progression from prodromal into symptomatic NPH can be predicted from advanced neuroimaging, biomarkers in cerebrospinal fluid (CSF) and plasma and investigate the unknown mechanisms causing deterioration by…
- Trial name
- STOP iNPH (NCT05910944)
- Testing
- Shunt surgery
- Where
- 7 sites in Finland, Italy and 1 more
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Johan Virhammar
Brain Pulsatility, Idiopathic Normal Pressure Hydrocephalus (INPH)
Transcranial Ultrasound Assessment of Cerebral Pulsatility in Shunt Decision-making for Suspected Idiopathic Normal Pressure Hydrocephalus: a Prospective Cohort Study
This will be a single-center, prospective, analytical cohort study. All included patients will undergo transcranial ultrasound (TPI) with measurement of cerebral pulsatility parameters prior to subtractive lumbar puncture during…
- Trial name
- HYDROPULSE (NCT07285928)
- Where
- France
- Volunteers
- 110 people
- Sponsor
- University Hospital, Tours
Intraventricular Hemorrhage Neonatal, Post-hemorrhagic Hydrocephalus
Advanced MRI in IVH
55,000 babies are born prematurely in the UK annually. Bleeding in the fluid spaces of the brain (ventricles) is common after prematurity; in England around 450 babies suffer from severe bleeds every year.
- Trial name
- NCT07412886
- Testing
- Advanced MRI
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Pediatric Hydrocephalus
HCRN Core Data Project: Characterizing Patient Populations in the Hydrocephalus Clinical Research Network (HCRN)
The Hydrocephalus Clinical Research Network (HCRN) has been established by philanthropic funding to conduct multi-institutional research (clinical trials and observational studies) on pediatric hydrocephalus.
- Trial name
- NCT00670735
- Where
- 14 sites in United States, Canada
- Volunteers
- 1,400 people
- Sponsor
- University of Utah
Post-hemorrhagic Hydrocephalus (PHH)
Ventricular mTOR Inhibition to Prevent Hydrocephalus After Brain Hemorrhage
Hydrocephalus is a serious condition in which fluid builds up inside the brain, often requiring lifelong surgical placement of a shunt to drain excess cerebrospinal fluid (CSF).
- Trial name
- VENTURE-PHH (NCT07662174)
- Testing
- Sirolimus (Rapamune®)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Massachusetts General Hospital
Subarachnoid Hemorrhage, Intracerebral Hemorrhage
Prophylactic Antibiotics Useful With Antibiotic Impregnated External Ventricular Drains (EVDs)?
The principal objective of this study is to compare the incidence of ventriculostomy related infections (VRIs) in patients who receive twenty-four hours of antibiotics, beginning no more than sixty minutes prior to EVD placement…
- Conditions
- Subarachnoid Hemorrhage, Intracerebral Hemorrhage, Ventriculitis, Cerebral, Hydrocephalus
- Trial name
- NCT05001750
- Testing
- Long term (continuous) prophylactic antibiotics, 24 hours antibiotics
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Montefiore Medical Center
Hydrocephalus
Assessment of Flow in Cerebrospinal Fluid Shunts With a Wireless Thermal Anisotropy Measurement Device in Asymptomatic Patients
This study evaluates the performance of the study device, FlowSense®, a sensor for non-invasively assessing cerebrospinal fluid (CSF) shunt flow.
- Trial name
- NCT06410885
- Testing
- Thermal Anisotropy Measurement Device
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Rhaeos, Inc.
Hydrocephalus
HCRN Endoscopic Versus Shunt Treatment of Hydrocephalus in Infants
Hydrocephalus is a potentially debilitating neurological condition that primarily affects babies under a year of age and has traditionally been treated by inserting a shunt between the brain and the abdomen.
- Trial name
- ESTHI (NCT04177914)
- Testing
- Endoscopic Third Ventriculostomy with Choroid Plexus Cauterization (ETV+CPC), Ventriculoperitoneal Shunt
- Where
- 21 sites in United States, Canada
- Volunteers
- 165 people
- Sponsor
- University of Utah
Subarachnoid Hemorrhage, Hydrocephalus
Strategies for Weaning From External Ventricular Drainage
External ventricular drainage is frequently used in neurocritical care, particularly in patients admitted for non-traumatic subarachnoid hemorrhage who develop hydrocephalus and/or intracranial hypertension.
- Conditions
- Subarachnoid Hemorrhage, Hydrocephalus, Intracranial Hypertension, External Ventricular Drainage
- Trial name
- SEVDVE2 (NCT07630051)
- Testing
- Direct clamping of external ventricular drain, Progressive (gradual) weaning of external ventricular drain
- Where
- 5 sites in France
- Volunteers
- 170 people
- Sponsor
- University Hospital, Angers
Paediatric Hydrocephalus
Efficacy of Combined Endoscopic Third Ventriculostomy and Choroid Plexus Cauterization in Treatment of Hydrocephalus
Hydrocephalus remains one of the most common conditions encountered in neurosurgery, traditionally managed by ventriculoperitoneal (VP) shunting.
- Trial name
- NCT07735936
- Testing
- Combined endoscopic third ventriculostomy & coroid plexus cauterization
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Assiut University
Hemorrhage, Premature Infants
NIRS Monitoring in Premature Infants
This study uses frequency domain near-infrared spectroscopy coupled with diffuse correlation spectroscopy (FDNIRS-DCS) technology for monitoring cerebral blood flow (CBF) and cerebral oxygen metabolism (CMRO2) at the bedside for…
- Conditions
- Hemorrhage, Premature Infants, Newborn, Hydrocephalus
- Trial name
- NCT02601339
- Testing
- ETV/CPC
- Where
- 3 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Acute Brain Injury, Traumatic Brain Injury
Bedside Cranial Ultrasound for Risk-Stratified Imaging in Pediatric Acute Brain Injury
Acute brain injury (ABI) is a leading cause of death and long-term disability in children. Diagnosis depends on fast neuroimaging, and head computed tomography (CT) is the bedside reference standard despite exposing the…
- Conditions
- Acute Brain Injury, Traumatic Brain Injury, Intracranial Hemorrhage, Hydrocephalus
- Trial name
- CUPID-Peds (NCT07772323)
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Virginia Commonwealth University
Hydrocephalus
Role of Endoscopic Third Ventriculostomy Imanagement of Hydrocephalus in Pediatric Age Group; Clinical and Surgical Outcome
Endoscopic third ventriculostomy in cases of hydrocephalus provide less invasive and safe technique than ventriculoperitoneal Shunt also decrease complications of ventriculoperitoneal Shunt
- Trial name
- NCT07694518
- Testing
- Fenestration of the floor of the third ventricle, Endoscopic third ventriculostomy of the brain third ventricle, Endoscopic third ventriculostomy
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Sohag University
Normal Pressure Hydrocephalus
Evaluation of the Safety and Effectiveness of the CereVasc® eShunt® System in Normal Pressure Hydrocephalus
Prospective, multi-center, randomized, controlled trial of the eShunt System in the treatment of patients with normal pressure hydrocephalus.
- Trial name
- STRIDE (NCT06498960)
- Testing
- CereVasc eShunt System, VP Shunt
- Where
- 32 sites in United States, Argentina and 1 more
- Volunteers
- 230 people
- Sponsor
- CereVasc Inc
Hydrocephalus in Infants
Non-Invasive Pressure Monitor for Neonates & Infants at Risk of Developing Hydrocephalus
The goal of this clinical trial is to test a modified smart soft contact lens in neonates and infants at risk of developing hydrocephalus.
- Trial name
- NCT06310213
- Testing
- Non-Invasive Pressure Monitor
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Indiana University
Normal Pressure Hydrocephalus Patients, Normal Pressure Hydrocephalus
Non-invasive Diagnostics of Shunt Obstruction in Adult Hydrocephalus
The goal of this RCT is to test whether volumetric assessment of magnetic resonance imaging (MRI) could diagnose shunt obstruction in Adult Hydrocephalus patients, and in addition to explore correlations of blood biomarkers…
- Trial name
- NCT07172841
- Testing
- Intervention group "Virtual OFF", Control group (no change in shunt setting)
- Volunteers
- 60 people
- Sponsor
- Göteborg University
Normal Pressure Hydrocephalus
White Matter Distortion and Dementia Biomarkers in Normal Pressure Hydrocephalus (NPH)
Idiopathic Normal Pressure Hydrocephalus (iNPH) is a progressive condition of the elderly that results in severe disability. iNPH can dramatically respond to Cerebral spinal fluid(CSF)-shunting where excess ventricular fluid is…
- Trial name
- OWN-NPH (NCT07103681)
- Testing
- Ventriculoperitoneal Shunt (VP), Brain and Skin Biopsy, MRI Brain
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Imperial College London