Clinical trials: Hydrocephaly
Hydrocephalus
Value of MRI CSF Flowmetry in Assessment of Grey Zone Hydrocephalic Patients
To evaluate accuracy of (MRI) cerebrospinal fluid flowmetry after shunt operation in patients with borderline (grey zone) hydrocephalus.
- Trial name
- NCT04060810
- Testing
- MR CSF flowmetry
- Volunteers
- 10 people
- Sponsor
- Assiut University
Hydrocephalus
EVD Drainage Data and Intracranial Pressure (ICP) Measurements
Rhaeos, Inc. is initially targeting hydrocephalus, a life threatening condition caused by an abnormal accumulation of cerebrospinal fluid (CSF).
- Trial name
- RHAEOS (NCT05546996)
- Testing
- FlowSense
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Baylor College of Medicine
Probable Alzheimer Disease, Parkinson Disease
In Vivo Alzheimer Proteomics
In France, an estimated 860 000 patients are affected by Alzheimer Disease (AD) which represents, as in other developed countries, a major public health issue.
- Conditions
- Probable Alzheimer Disease, Parkinson Disease, Neurological Disease Without Cognitive Degradation, Brain Trauma
- Trial name
- PROMARA (NCT02263235)
- Testing
- administration of stable isotope-labelled leucine-, collection of CSF, blood, urine, saliva
- Where
- France
- Volunteers
- 89 people
- Sponsor
- University Hospital, Montpellier
Hydrocephalus
Guided Application of Ventricular Catheters
Failure of ventricular catheters remains a significant problem in patients with hydrocephalus. The purpose of this study is to determine whether the use of a simple instrument assisted by a smart phone application software can…
- Trial name
- GAVCA (NCT01811589)
- Testing
- Thomale-Guide, Free-hand
- Where
- 9 sites in Germany
- Volunteers
- 144 people
- Sponsor
- Aesculap AG
Anemia of Prematurity
Premature Infants in Need of Transfusion (PINT)
Hypothesis: That a high hemoglobin threshold for transfusion in extremely low birth weight (ELBW) infants is associated with a lower rate of survival without severe morbidity (defined as one or more of retinopathy of prematurity…
- Trial name
- NCT00182390
- Testing
- Red blood cell transfusion
- Where
- 10 sites in United States, Australia and 1 more
- Volunteers
- 424 people
- Sponsor
- McMaster University
Hydrocephalus
Ventricular Size Involvement in Neuropsychological Outcomes in Pediatric Hydrocephalus
This multicenter, prospective study of children with hydrocephalus will examine whether or not ventricle size is associated with poor cognitive outcomes.
- Trial name
- VINOH (NCT01797627)
- Where
- 8 sites in United States, Canada
- Volunteers
- 78 people
- Sponsor
- University of Utah
Hydrocephalus, Intracranial Hypertension
Intraventricular Drain Insertion: Comparison of Ultrasound-guided and Landmark-based Puncture of the Ventricular System
Puncture of the ventricular system is one of the most frequently performed neurosurgical interventions. This procedure is commonly performed in order to treat and/or measure pathologically elevated intracranial pressure.Therefore…
- Trial name
- In-Vent (NCT01973764)
- Testing
- Ultrasound guided ventricular drain insertion, landmark-based ventricular drain insertion
- Where
- Switzerland
- Volunteers
- 17 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Hydrocephalus, Idiopathic Normal Pressure Hydrocephalus
Clinical Outcome in Patients With INPH
The aim of this study is to determine the clinical spectrum and natural progression of idiopathic normal pressure hydrocephalus （iNPH ) and related disorders in a prospective single center study, identify digital, imaging and…
- Conditions
- Hydrocephalus, Idiopathic Normal Pressure Hydrocephalus, CSF, Glympathic System
- Trial name
- NCT06428734
- Testing
- hydrocephalus group, normal group
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Idiopathic Normal Pressure Hydrocephalus
Improved Analysis Methods for Infusion Tests
Objective: Patients with Idiopathic Normal Pressure Hydrocephalus are improved with shunt surgery. To increase the accuracy of the diagnosis, supplementary tests that characterize the cerebrospinal fluid (CSF) dynamics are used.
- Trial name
- NCT01319136
- Where
- 2 sites in Sweden
- Volunteers
- 48 people
- Sponsor
- Umeå University
Hypnosis, Hydrocephalus
Impact of Hypnosis for Performing Lumbar Infusion Tests
Infusion tests are now the gold standard for the diagnosis of chronic adult hydrocephalus (CAH), also known as normal pressure hydrocephalus. It is an invasive procedure using the same approach as a lumbar puncture.
- Conditions
- Hypnosis, Hydrocephalus, Anxiety, Pain
- Trial name
- HYPNINF (NCT06419842)
- Testing
- hypnosis, comfort
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Hydrocephalus
UVC in Prevention of Surgical Wound Infection
The LF-PODD study investigates the use of UVC (270nm) light in the prevention of surgical wound infections. Three devices are used in the study, two of which are actively producing UVC light (265 and 275 nm) and one device does…
- Trial name
- UVCJAS (NCT07600463)
- Testing
- UVC Irradiation
- Where
- Finland
- Volunteers
- 75 people
- Sponsor
- Ville Leinonen
Post-Hemorrhagic Hydrocephalus
Cerebral Perfusion, Oxygenation, Electrical Activity
The specific aim of the research proposal in preterm infants with IVH and PHH who require placement of an Omaya reservoir or a shunt is to determine if decreasing ventricular volume improves, middle cerebral artery flow, cerebral…
- Trial name
- NCT00747682
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Utah
Educational, Simulation
Simulation Efficacy in Neurosurgical Education
This study aims to investigate the efficacy of simulation in neurosurgical training.
- Conditions
- Educational, Simulation, Hydrocephalus, Intraventricular Hemorrhage
- Trial name
- SENSE (NCT02988154)
- Testing
- Simulation training, ''See one, do one'' approach
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Johannes Gutenberg University Mainz
NPH (Normal Pressure Hydrocephalus)
Examining the Feasibility of Using Pressure Gradient Regulated Automated Cerebral Spinal Fluid Drainage During External Lumbar Drain Trials
The intellidrop device is an FDA-approved system that automates safe, small volume of cerebral spinal fluid drainage with continuous pressure monitoring, reducing nursing workload and human error while improving patient mobility…
- Trial name
- UPGRADE (NCT07494812)
- Testing
- Intellidrop Automated CSF Drainage System
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Texas Southwestern Medical Center
Idiopathic Normal Pressure Hydrocephalus (INPH)
Change in Cognition and Frailty After Shunt Surgery in Idiopathic Normal Pressure Hydrocephalus (iNPH)
The goal of this observational study is to describe changes in cognitive profile and frailty from pre shunt to one year after the shunt surgery and to identify clinical predictors of an improvement in terms of cognition and…
- Trial name
- NCT07642726
- Testing
- Ventriculoperitoneal shunt
- Where
- Norway
- Volunteers
- 276 people
- Sponsor
- Oslo University Hospital
Normal Pressure Hydrocephalus, Sleep Apnea
Normal Pressure Hydrocephalus and Sleep Apnea
Normal-pressure hydrocephalus is associated with increases in the intracranial pressure during the night sleep. Sleep apnea also increases the intracranial pressure during the apneic spells.
- Conditions
- Normal Pressure Hydrocephalus, Sleep Apnea, Cerebrospinal Fluid Shunt Occlusion
- Trial name
- NPH/OSA (NCT04471740)
- Testing
- CSF shunt diversion
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- University of Valencia
Normal Pressure Hydrocephalus Patients, Normal Pressure Hydrocephalus
Non-invasive Diagnostics of Shunt Obstruction in Adult Hydrocephalus
The goal of this RCT is to test whether volumetric assessment of magnetic resonance imaging (MRI) could diagnose shunt obstruction in Adult Hydrocephalus patients, and in addition to explore correlations of blood biomarkers…
- Trial name
- NCT07172841
- Testing
- Intervention group "Virtual OFF", Control group (no change in shunt setting)
- Volunteers
- 60 people
- Sponsor
- Göteborg University
Hydrocephalus
First-in-human Trial of Home Brain Pressure Measured Using Kitea ICP Sensor, Placed During Hydrocephalus Shunt Surgery.
Patients with hydrocephalus have an abnormal build-up of fluid around the brain and need a tube surgically implanted to drain that fluid. Patients and their caregivers live with the constant fear that the tube will block.
- Trial name
- HomeICP (NCT06402786)
- Testing
- Kitea ICP Sensor
- Where
- New Zealand
- Volunteers
- 21 people
- Sponsor
- University of Auckland, New Zealand
Pediatric Hydrocephalus
HCRN Core Data Project: Characterizing Patient Populations in the Hydrocephalus Clinical Research Network (HCRN)
The Hydrocephalus Clinical Research Network (HCRN) has been established by philanthropic funding to conduct multi-institutional research (clinical trials and observational studies) on pediatric hydrocephalus.
- Trial name
- NCT00670735
- Where
- 14 sites in United States, Canada
- Volunteers
- 1,400 people
- Sponsor
- University of Utah
Myelomeningocele Without Hydrocephalus, Sensory Defect
Effects of Photobiomodulation on Superficial Sensitivity and Muscle Activity of Individuals With Myelomeningocele
Myelomeningocele is a neural tube defect that occurs between the third and fourth week of gestation. Functional impairment occurs due to dysplasia of the nerve roots, which can lead to flaccid paralysis and sensory-motor…
- Conditions
- Myelomeningocele Without Hydrocephalus, Sensory Defect, Motor Activity
- Trial name
- NCT04035863
- Testing
- Low level laser therapy
- Volunteers
- 30 people
- Sponsor
- University of Nove de Julho