Clinical trials: Hyperaldosteronism; Primary
Adrenal Disease
Comparison Between Posterior Retroperitoneoscopic Adrenalectomy and Laparoscopic Adrenalectomy
The purpose of this study is to compare two surgical methods of adrenalectomy. One is called PRA(posterior retroperitoneal adrenalectomy), which is performed through 3 or 4 holes at patient's back.
- Trial name
- PRA (NCT01676025)
- Testing
- PRA, LA
- Where
- South Korea
- Volunteers
- 83 people
- Sponsor
- Seoul National University Hospital
Primary Aldosteronism
Study on Cutoff Revision Effects and Evaluation of NNT in Primary Aldosteronism
The goal of this observational study is to evaluate the real-world impact of applying the revised aldosterone-to-renin ratio (ARR) cutoff recommended in the 2025 primary aldosteronism guideline in adults with hypertension and…
- Trial name
- SCREEN-PA (NCT07621458)
- Testing
- Saline Infusion Test
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Seoul National University Hospital
Primary Aldosteronism
Untargeted Metabolomics for Primary Aldosteronism
Primary aldosteronism (PA) is a common and likely under-diagnosed cause of secondary hypertension with associated cardiovascular morbidity and mortality.
- Trial name
- PUMPAP (NCT06076473)
- Testing
- Untargeted metabolomics
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Primary Aldosteronism
Study on the Diagnostic Cut-off Point of 24-hour Urinary Aldosterone Measured by Liquid Chromatography-Tandem Mass Spectrometry in the Diagnosis of Primary Aldosteronism in the Oral Sodium Loading Test
Primary aldosteronism (PA) is the most common cause of secondary hypertension. Liquid chromatography - tandem mass spectrometry (LC-MS/MS) is more accurate than the traditional radioimmunoassay in measuring aldosterone.
- Trial name
- NCT07635134
- Testing
- The oral sodium loading test
- Where
- China
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Hypertension, Primary Aldosteronism
Genetic Predisposition to High Blood Pressure
Primary aldosteronism (PA) is a known but underdiagnosed cause of high blood pressure. It is estimated that more than 10% of all people with high blood pressure (HT) suffer from PA, which is often caused by aldosterone-producing…
- Conditions
- Hypertension, Primary Aldosteronism, Genetic Predisposition to Disease
- Trial name
- NCT07181213
- Testing
- Adrenalectomy
- Where
- Sweden
- Volunteers
- 76 people
- Sponsor
- Linkoeping University
Primary Hyperaldosteronism, Hypertensive Disorder of Pregnancy
HyperAldosteronism in Pregnancy Predicted Impacts (H.A.P.P.I. Trial)
Primary hyperaldosteronism confers a higher risk of cardiovascular complications compared to essential hypertension. Preliminary data is controversial in regards of excessive maternal fetal and neonatal excessive risks in…
- Trial name
- NCT05636995
- Testing
- Aldosterone/Renin Ratio
- Where
- 2 sites in Canada
- Volunteers
- 200 people
- Sponsor
- Université de Sherbrooke
Primary Aldosteronism Concurrent With Autonomous Cortisol Secretion
Diagnostic Value of 68Ga-Pentixafor PET/CT in Adrenal Tumors With Aldosterone and Cortisol Cosecretion
The goal of this observational study is to evaluate the diagnostic accuracy of 68 68 Ga-Pentixafor-CXCR4 PET/CT in identifying the dominant side of hormone excess in adult patients (aged 18-80 years) with primary aldosteronism…
- Trial name
- NCT07605156
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Peking University First Hospital
Primary Aldosteronism Due to Aldosterone Producing Adenoma
MRA and ARB Treatment in Screening of Primary Aldosteronism
Current guidelines recommend withdrawal of treatments that affect the aldosterone/renin ratio (ARR) when screening for primary aldosteronism (PA).
- Trial name
- EMIRA (NCT04185857)
- Testing
- canrenone 50-100 mg orally once a day, olmesartan 10-20 mg orally once a day
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University Hospital Padova
Positron-Emission Tomography
Application of 68Ga-Pentixafor PET/CT in Primary Aldosteronism and Pre-postoperative of SAAE
Primary aldosteronism is the most common cause of secondary hypertension. The two main types of primary aldosteronism are aldosteronoma(30%) and adrenal hyperplasia(60%).
- Trial name
- NCT05188872
- Testing
- 68Ga-Pentixafor
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Primary Aldosteronism, Suprarenalectomy
Primary Aldosteronism: Superselective Embolization vs. Laparoscopic Endocrine Curative Therapy
The aim of this study was to compare the efficacy and safety of adrenalectomy and superselective adrenal artery embolization in a prospective, multicenter, randomized controlled study.
- Conditions
- Primary Aldosteronism, Suprarenalectomy, Super Selective Adrenal Artery Embolization
- Trial name
- PA-SELECT (NCT06513585)
- Testing
- Superselective adrenal artery embolization or adrenalectomy
- Where
- China
- Volunteers
- 570 people
- Sponsor
- Xinjiang Medical University
Primary Aldosteronism
Baxdrostat and Molecular Imaging of Adrenal Cytoreduction in Primary Aldosteronism
The goal of this clinical trial is to find out whether treatment with baxdrostat changes aldosterone-producing activity in the adrenal glands of people with primary aldosteronism.
- Trial name
- EliXir (NCT07800858)
- Testing
- baxdrostat
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Queen Mary University of London
Evaluation of Cerebral Small Vessel Disease in Patient With Primary Aldosteronism
Evaluation of Cerebral Small Vessel Disease in Patient With Primary Aldosteronism
Hypertension is known to be the major risk factor for stroke. The most common cause of secondary hypertension, primary aldosteronism (PA), is characterized by the excessive secretion of aldosterone and is related to hypertension…
- Trial name
- NCT03821571
- Testing
- Brain MRI
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Primary Aldosteronism
68Ga-Pentixafor PET/CT Versus Adrenal Vein Sampling in Primary Aldosteronism: The GAPA Randomized Clinical Trial
To compare the 68Ga-Pentixafor PET/CT and adrenal vein sampling on the long-term outcomes of primary aldosteronism (PA) patients with adrenal nodule (≥1cm)
- Trial name
- GAPA (NCT06238232)
- Testing
- 68Ga-Pentixafor PET/CT
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Chongqing Medical University
Primary Hyperaldosteronism, Electrolyte Disturbance
Tissue K+ in Primary Hyperaldosteronism
Recent human studies found tissue sodium storage in patients with hyperaldosteronism that could be detected non-invasively by 23Na-MRI. Tissue sodium accumulation could be mobilized upon treatment of hyperaldosteronism.
- Trial name
- NCT04251780
- Testing
- Surgical Treatment of Primary Aldosteronism, Drug treatment of Primary Aldosteronism
- Where
- 2 sites in Germany
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Primary Aldosteronism
Glucose Metabolism in Subjects With Aldosterone-Producing Adenomas
This observational study tests the hypothesis that endogenous aldosterone impairs insulin secretion and insulin sensitivity in subjects with primary aldosteronism.
- Trial name
- NCT02362308
- Testing
- Adrenalectomy, mineralocorticoid receptor antagonist
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Vanderbilt University
Primary Aldosteronism, Autonomous Cortisol Secretion
Study on the Incidence of Adrenal Insufficiency After Surgery in Primary Aldosteronism Patients Concurrent With or Without Autonomous Cortisol Secretion
To evaluate the incidence of adrenal insufficiency after surgery in Primary aldosteronism (PA) patients concurrent with or without autonomous cortisol secretion (ACS).
- Conditions
- Primary Aldosteronism, Autonomous Cortisol Secretion, Adrenal Insufficiency
- Trial name
- NCT06955286
- Testing
- complete ACTH stimulation test the day after surgery and complete ACTH stimulation test 1 or 4 week for patients with Adrenal Insufficiency
- Where
- China
- Volunteers
- 521 people
- Sponsor
- Qifu Li
Primary Aldosteronism
CETO First in Human Trial
The study is a Phase 1, single-centre, open label, micro-dosing study. The aim is to investigate an innovative new tracer, [18F]CETO, as a potential alternative to adrenal vein sampling for the lateralisation of primary…
- Trial name
- CETO (NCT04529018)
- Testing
- [18F]CETO
- Where
- United Kingdom
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Cambridge
Primary Aldosteronism
Study of CS-3150 in Patients With Primary Aldosteronism
To examine antihypertensive effect and safety of CS-3150 in patients with primary aldosteronism.
- Trial name
- NCT02885662
- Testing
- CS-3150
- Where
- Japan
- Volunteers
- 44 people
- Sponsor
- Daiichi Sankyo Co., Ltd.
Primary Aldosteronism, Hypertension
Regular Sauna Use to Lower Blood Pressure in Primary Aldosteronism
1. Background and Rationale: Primary aldosteronism is a hypertension-related disorder where salt restriction/salt loss is a central part of therapy.
- Trial name
- SAUNA-PA (NCT07796048)
- Testing
- sauna session
- Volunteers
- 10 people
- Sponsor
- University of Calgary
Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism
Predicting Reduction of Hypertension After Adrenalectomy for Primary Aldosteronism: a Multicenter Analysis
Primary aldosteronism (PA) is the excessive endogenous production of the mineralocorticoid aldosterone. Although various rare forms of PA exist, the vast majority of cases are accounted by either an aldosterone-producing adenoma…
- Conditions
- Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism, Primary Aldosteronism Due to Conn Adenoma
- Trial name
- NCT04761354
- Testing
- Unilateral adrenalectomy
- Where
- 14 sites in United States, Australia and 3 more
- Volunteers
- 514 people
- Sponsor
- UMC Utrecht