Clinical trials: Hyperaldosteronism
Primary Aldosteronism Due to Aldosterone Producing Adenoma
Renal Sympathetic Denervation From The Adventitia on Hypertension
Renal sympathetic denervation from the intima of renal arteries has become an important method for the treatment of resistant hypertension, but renal sympathetic nerve are mainly located in the adventitia, and there is no report…
- Trial name
- RSDAH (NCT02642445)
- Testing
- Renal Sympathetic Denervation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
Apparent Mineralocorticoid Excess
An Investigation Into the Effect of Liquorice Ingestion on the Salivary Cortisol to Cortisone Molar Ratio
Aldosterone, the major mineralocorticoid hormone and cortisol, the major glucocorticoid hormone are produced in the adrenal gland.
- Trial name
- NCT02939144
- Testing
- Liquorice
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
Apparent Mineralocorticoid Excess Syndrome
Natural History of Apparent Mineralocorticoid Excess Syndrome
Apparent mineralocorticoid excess (AME) is a rare inherited disease that can cause severe high blood pressure and low blood potassium in children and adults. It is caused by abnormal hormone metabolism and can be fatal.
- Trial name
- NCT00474942
- Where
- 4 sites in United States, Brazil and 1 more
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Hypertension, Primary Aldosteronism
Genetic Predisposition to High Blood Pressure
Primary aldosteronism (PA) is a known but underdiagnosed cause of high blood pressure. It is estimated that more than 10% of all people with high blood pressure (HT) suffer from PA, which is often caused by aldosterone-producing…
- Conditions
- Hypertension, Primary Aldosteronism, Genetic Predisposition to Disease
- Trial name
- NCT07181213
- Testing
- Adrenalectomy
- Where
- Sweden
- Volunteers
- 76 people
- Sponsor
- Linkoeping University
Hypertension, Mineralocorticoid Excess
MR Antagonist and LSD1
Lysine specific demethylase-1 (LSD1) is an epigenetic regulator of gene transcription involved in the pathophysiology of elevated blood pressure and likely renal damage in Blacks.
- Trial name
- NCT04840342
- Testing
- Eplerenone, Amlodipine
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Brigham and Women's Hospital
Primary Aldosteronism
Study on Cutoff Revision Effects and Evaluation of NNT in Primary Aldosteronism
The goal of this observational study is to evaluate the real-world impact of applying the revised aldosterone-to-renin ratio (ARR) cutoff recommended in the 2025 primary aldosteronism guideline in adults with hypertension and…
- Trial name
- SCREEN-PA (NCT07621458)
- Testing
- Saline Infusion Test
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Seoul National University Hospital
Bartter Syndrome
Acetazolamide (AZ) for Management of Alkalosis in Bartter Syndrome
In this prospective controlled cross over clinical trial, the investigators aim to evaluate the efficacy and safety of acetazolamide for the management of metabolic alkalosis in children with Bartter syndrome.
- Trial name
- AZ (NCT03847571)
- Testing
- Acetazolamide
- Where
- 4 sites in Iran
- Volunteers
- 20 people
- Sponsor
- Tehran University of Medical Sciences
Primary Aldosteronism
The Effect of Disease-specific Treatment on Bone Turnover Markers in Patients With Primary Aldosteronism
Primary aldosteronism (PA) is a disorder of the adrenal gland causing an autonomous overproduction of mineralocorticoids, leading to arterial hypertension. Although rare, it is the most frequent cause of secondary hypertension.
- Trial name
- NCT02216721
- Where
- Malaysia
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University Malaysia Sarawak
Primary Aldosteronism Due to Aldosterone Producing Adenoma
MRA and ARB Treatment in Screening of Primary Aldosteronism
Current guidelines recommend withdrawal of treatments that affect the aldosterone/renin ratio (ARR) when screening for primary aldosteronism (PA).
- Trial name
- EMIRA (NCT04185857)
- Testing
- canrenone 50-100 mg orally once a day, olmesartan 10-20 mg orally once a day
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University Hospital Padova
Hypertension, Primary Aldosteronism
Screening for Primary Aldosteronism in Hypertension With 24-hour URinary aLdosterone
This is an observational study compares the positivity rates of two tests for screening for primary aldosteronism: plasma aldosterone renin ratio and 24-hour urine aldosterone in patients with young-onset hypertension with or…
- Conditions
- Hypertension, Primary Aldosteronism, Urine Aldosterone
- Trial name
- PURL (NCT06047912)
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Dr Ian B Wilkinson
Primary Aldosteronism, Endocrine Hypertension
Efficacy and Safety of Finerenone Compared to Spironolactone in Treatment of Primary Aldosteronism
The goal of this study is to compare the efficacy and safety of finerenone versus spironolactone in the treatment of hypertension due to primary aldosteronism.
- Trial name
- NCT07688928
- Testing
- Finerenone
- Where
- Bangladesh
- Volunteers
- 104 people
- Sponsor
- Bangladesh Medical University
Primary Aldosteronism, Stroke
Prevalence of Primary Aldosteronism in Patients With Stroke
Strokes leads to significant morbidity and mortality, and hypertension is the most important risk factor for strokes. It is estimated that up to 10% of patients with hypertension have the underlying, treatable condition of…
- Trial name
- NCT03789357
- Testing
- Aldosterone renin ratio
- Where
- Singapore
- Volunteers
- 300 people
- Sponsor
- Changi General Hospital
Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma
Ipsilateral and Contralateral Index for the Interpretation of Adrenal Vein Sampling (AVS) in Primary Aldosteronism
Adrenal vein sampling (AVS) is currently considered the gold standard for subtype diagnosis of primary aldosteronism (PA). However, the percentage of unsuitable procedures due to the unsuccessful cannulation of one of the two…
- Conditions
- Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism Due to Adrenal Hyperplasia (Bilateral)
- Trial name
- NCT04378387
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Turin, Italy
Aldosterone-Producing Adenoma
CXCR4 Targeted PET Imaging in APA Preoperative Localization Diagnosis
The goal of this clinical trial is to evaluate the effectiveness of CXCR4 targeted PET imaging in preoperative localization diagnosis of primary aldosteronism (PA).
- Trial name
- NCT05839483
- Testing
- CXCR4
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zhongnan Hospital
Primary Aldosteronism, Hypertension
Effects of Adrenal Artery Ablation and Spironolactone in Patients With Primary Aldosteronism
Primary aldosteronism (PA) is one of the most common cause of endocrine and resistant hypertension. Current studies have shown that the activation of the renin-angiotensin-aldosterone system (RAAS) and the increased sympathetic…
- Trial name
- NCT04409431
- Testing
- Endovascular chemical Ablation of Adrenal Gland
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Third Military Medical University
Primary Aldosteronism
Simplification of Oral Sodium Loading Test in the Diagnosis of Primary Aldosteronism: 2-day Replacing 3-day Method
To compare the consistency of 24-hour urinary aldosterone in the diagnosis of primary aldosteronism by oral sodium loading test between the second day method and the third day method
- Trial name
- NCT06750172
- Testing
- The oral sodium loading test
- Where
- China
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Primary Aldosteronism
Evaluation of [68Ga]Ga-PentixaFor PET Imaging for the Identification of Unilateral Adrenal Secretion of ALdosterON in Patients With Primary Aldosteronism
PentixaFor radiolabeled with 68Gallium (68Ga) is a radiopharmaceutical targeting the CXC chemokine receptor 4 (CXCR4) receptor. The CXCR4 receptor is expressed in zona glomerulosa of the adrenal cortex and in aldosterone…
- Trial name
- PENTALON (NCT06478875)
- Testing
- [68Ga]Ga-PentixaFor PET imaging
- Where
- 2 sites in France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Primary Aldosteronism, Hypertension
Screening for Primary Aldosteronism in a Population of Patients With Hypertension
Primary aldosteronism (PA) is an under-diagnosed cause of arterial hypertension. Cardiovascular morbidity and mortality in hypertension rises significantly for patients who have aldosterone overproduction when compared with those…
- Conditions
- Primary Aldosteronism, Hypertension, Hypertension Secondary
- Trial name
- PRIMAL (NCT03105531)
- Where
- Sweden
- Volunteers
- 1,183 people
- Sponsor
- Uppsala University
Primary Aldosteronism, Essential Hypertension
The Plasma Metabolomics Profiling of Primary Aldosteronism
Primary aldosteronism (PA), characterized by overt renin-independent aldosterone production, is the most common form endocrine hypertension.
- Conditions
- Primary Aldosteronism, Essential Hypertension, Idiopathic Aldosteronism, Aldosterone-producing Adenoma
- Trial name
- NCT06500000
- Testing
- liquid chromatography-mass spectrometry (LC/MS)
- Where
- China
- Volunteers
- 95 people
- Sponsor
- Third Military Medical University
Primary Aldosteronism, Hypertension
Effects of Adrenal Artery Ablation and Adrenalectomy in Patients With Primary Aldosteronism
Primary aldosteronism (PA) is the main cause of secondary hypertension, affecting 5-15% of the general hypertensive population. Early diagnosis and treatment are of crucial importance as patients with PA are more susceptible to…
- Trial name
- NCT04269928
- Testing
- Endovascular chemical ablation of adrenal gland
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Third Military Medical University