Clinical trials: Hyperalgesia
Pain
Rofecoxib to Prevent Pain After Third Molar (Wisdom Tooth) Extraction
This study will evaluate the ability of a new non-steroidal anti-inflammatory drug (NSAID) called rofecoxib to prevent pain following third molar (wisdom tooth) extraction.
- Trial name
- NCT00026819
- Testing
- Rofecoxib
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Neuropathic Pain
Prediction of Inter-individual Differences in the Response to Morphine Versus Milnacipran in Patients With Sciatica
Clinical, psychophysical, behavioral or genetic factor will predict the response to opioid treatment in patients with chronic neuropathic pain.
- Trial name
- NCT01914042
- Testing
- Morphine, Milnacipran
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Rambam Health Care Campus
Serratus Plane Block, Postoperative Hyperalgesia
Effect of Liposome Bupivacaine Serratus Plane Block on Postoperative Hyperalgesia and Chronic Post-surgical Pain in Patients Undergoing Radical Mastectomy
Radical mastectomy is currently the mainstream surgical treatment for breast cancer. Patients often experience significant postoperative pain, and some may develop chronic pain.
- Conditions
- Serratus Plane Block, Postoperative Hyperalgesia, Chronic Post-surgical Pain, Liposomal Bupivacaine
- Trial name
- NCT07289178
- Testing
- Serratus Plane block (single injection)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- First Affiliated Hospital of Kunming Medical University
Nerve Growth Factor, Exercise
Cortical Neuroplasticity by Muscle Pain of Pain-induced Plasticity
The purpose of this study is to investigate the sensory-motor cortical excitability response to delayed onset muscle soreness (DOMS) on Extensor Carpi Radialis (ECR) muscle during muscle hyperalgesia provoked by nerve growth…
- Conditions
- Nerve Growth Factor, Exercise, Motor Activity, Abnormality of SSEPs
- Trial name
- NCT03354624
- Testing
- Sterile solutions of recombinant human nerve growth factor (NGF)
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Acute Pain, Hyperalgesia
IV Acetaminophen as an Adjunct Analgesic in Cardiac Surgery
Patients undergoing cardiac surgery experience significant postoperative pain, which may impact postoperative outcomes. The aim of this single center, double-blind, randomized, placebo controlled trial is to determine if…
- Trial name
- CarDolMev (NCT01544062)
- Testing
- IV acetaminophen
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of Washington
Hyperalgesia, Pain
Effect of High Dose Naloxone on Secondary Hyperalgesia
Recent studies have focused on the role of endogenous opioids on central sensitization. Central sensitization is known to be impaired or altered in chronic pain conditions, as fibromyalgia or chronic tension headache.
- Conditions
- Hyperalgesia, Pain, Naloxone, Opioid Antagonist
- Trial name
- NCT01935206
- Testing
- Naloxone (2 mg/kg)
- Where
- 2 sites in Denmark
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Non-Cardiac Chest Pain
The Role of Visceral Hyperalgesia, Gastroesophageal Reflux Disease (GERD) and Esophageal Motility Disorder (EMD) in NCCP Patients
Noncardiac chest pain (NCCP) is a common clinical problem worldwide. In Hong Kong, it has been estimated that about 20% of patients with chest pain are misdiagnosed to have coronary heart disease.
- Trial name
- NCT00164814
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Pain
The Effect of Ultra-low-dose Naloxone on Remifentanil-induced Postoperative Hyperalgesia - A Randomized Controlled Study
High-dose remifentanil infused intraoperative ironically results in postoperative hyperalgesia. Ultra-low dose nalxone is demonstrated to prevent these opioid-induced hyperalgesia in animal model.
- Trial name
- NCT02856087
- Testing
- High dose Remifentanil, Naloxone, Low dose remifentanil
- Where
- South Korea
- Volunteers
- 92 people
- Sponsor
- Seoul National University Hospital
Pain, Thermal Injury
Pilot Study to Compare Topical Voriconazole to Placebo as a Pain Reducing Agent
This study seeks to test if the study drug (voriconazole), when applied topically to a burn wound on the skin will help to reduce pain.
- Conditions
- Pain, Thermal Injury, Burns, Hyperalgesia
- Trial name
- NCT02689713
- Testing
- Voriconazole (topical)
- Where
- United States
- Sponsor
- Kenneth Hargreaves
Opioid-induced Hyperalgesia
Hyperalgesia in Methadone Patients: Can it be Treated?
In the proposed study, we will build upon our previous studies validating and characterizing hyperalgesia in MM samples to explore it's underlying mechanism from a pharmacological perspective.
- Trial name
- NCT00333242
- Testing
- dextromethorphan
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Pain
The Effect of Ablation of Epidermal Nerve Fibers Using Capsaicin Cream
This is a study of epidermal (the outer most layer) nerve fibers (ENFs) in the skin of the body; counts of which are used to determine a disease of nerves called "small nerve fiber neuropathy." Capsaicin is approved by the Food…
- Trial name
- NCT01883102
- Testing
- Capsaicin 0.1%
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Mayo Clinic
Hyperalgesia, Neurodynia
GW406381 In Patients With Peripheral Nerve Injury
The findings from preclinical animal models confirm the peripheral anti-inflammatory/analgesic activity of GW406381 and also suggest contribution of a central site of action to the anti-hyperalgesic efficacy that may not be…
- Conditions
- Hyperalgesia, Neurodynia, Pain, Trauma
- Trial name
- NCT00279032
- Testing
- GW406381
- Where
- 5 sites in United Kingdom
- Volunteers
- 40 people
- Sponsor
- GlaxoSmithKline
Chronic Low Back Pain, Lumbar Radiculopathy
Low-Dose Naltrexone and Acetaminophen Combination in the Treatment of Chronic Low Back Pain (ANODYNE-4)
Treatment of chronic low-back pain with low-dose naltrexone and acetaminophen combination: a small, randomized, double-Blind, and placebo-controlled clinical trial with an open-label extension for none-responders
- Trial name
- NCT03201393
- Testing
- Low-dose naltrexone and acetaminophen combination
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Allodynic Therapeutics, Inc
Postoperative Pain
Factors Predicting Postoperative Cesarean Section Pain
In spite of identical analgesic protocols, parturients suffer different levels of pain postoperative lay. In this study we hope to identify factors which influence the perception of pain including preoperative anxiety, sleep…
- Trial name
- NCT02033304
- Where
- 2 sites in Israel
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
Arthroplasty, Replacement, Hip
Ketamine Associated With Morphine PCA After Total Hip Arthroplasty
Ketamine (an analgesic drug often associated with morphine in the treatment of Opioid Induced Hyperalgesia) is often mixed in Morphine PCA syringe.
- Trial name
- KETAMINE (NCT00797264)
- Testing
- Ketamine-Morphine, Morphine, Postoperative PCA of Ketamine and morphine
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Healthy
Association Between Heat Pain Detection Threshold and Area of Secondary Hyperalgesia
The purpose of this prospective study is to investigate how close Heat Pain Detection Threshold is associated with the area of secondary hyperalgesia, elicited by the clinical pain model Brief Thermal Sensitization.
- Trial name
- NCT02527395
- Testing
- Brief thermal sensitization, Pain during 1 min. thermal stimulation, Heat pain detection threshold
- Where
- Denmark
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Chronic Pain
Increased Sensitivity to Pain Caused by Opioids in People Who Have Abused Prescription Opioids
Managing pain in patients who abuse prescription opioids presents many challenges, including the development of opioid-induced hyperalgesia (OIH).
- Trial name
- NCT01821430
- Testing
- Pregabalin
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Georgetown University
Knee Osteoarthritis
TENS Effectiveness and Knee Osteoarthritis in Humans
TENS is a non pharmacological intervention to control pain. Both high (>50 Hz) and low (<10 Hz) frequency TENS are used in the clinic and it is thought that each type works through different mechanisms (see for review Sluka and…
- Trial name
- TOPS (NCT01354054)
- Testing
- High Frequency TENS, Low frequency TENS
- Where
- 3 sites in United States, Brazil and 1 more
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Pro-inflammatory Activity, Immunologic Activity Alteration
Pain, Opioids and Pro-Inflammatory Immune Responses
Providing pain management to the patient who abuses prescription opioids presents a clinical challenge, not only due to concerns about "drug-seeking", but because they have increased sensitivity to pain, a phenomenon identified…
- Trial name
- NCT01210066
- Testing
- Fentanyl, Cold pressor test, Fentanyl plus cold pressor test
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Hyperalgesia, Pain Response
Interaction Between NGF and Acute Exercise-induced Ischemia
The purpose of this study is to investigate pain evoked responses and facilitation of NGF-induced mechanical muscle hyperalgesia over time following an acute exercised-induced ischemic condition in a NGF-sensitized muscle.
- Conditions
- Hyperalgesia, Pain Response, Healthy Subjects
- Trial name
- NCT03470038
- Testing
- NGF, Isotonic saline
- Where
- Denmark
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Aalborg University