Clinical trials: Hyperalimentation and Obesity
Bardet Biedl Syndrome (BBS), Bardet Biedl Syndrome
Real-World Effects of MC4R Agonist Therapy in BBS and Severe Genetic Obesity
Bardet-Biedl syndrome (BBS) and other rare disorders associated with impairment of the melanocortin-4 receptor (MC4R) pathway are characterized by severe early-onset obesity, hyperphagia, and substantial morbidity.
- Conditions
- Bardet Biedl Syndrome (BBS), Bardet Biedl Syndrome, Bardet-Biedl Syndrome (BBS), Alstrom Syndrome
- Trial name
- REAL-MC4 (NCT07674290)
- Testing
- Setmelanotide
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Tom Hühne
Obesity, Childhood, Hyperphagia
Early Genetic Identification of Obesity
TITLE: Whole genetic approach in Early Genetic Identification of Obesity (WEGIO) DESIGN: Multicenter epidemiological study STUDY POPULATION: Participants at risk for a syndromic or a monogenic genetic obesity, incl.
- Conditions
- Obesity, Childhood, Hyperphagia, Retinopathy, Syndactyly
- Trial name
- WEGIO (NCT06239064)
- Testing
- Genetic testing via blood collection
- Where
- 37 sites in Germany
- Volunteers
- 1,000 people
- Sponsor
- Rolfs Consulting und Verwaltungs-GmbH (RCV)
Overweight, Obesity and Other Hyperalimentation
Taking Action to Thrive - A Healthy Lifestyle Intervention Pilot Study
There have been some preliminary studies, primarily in animals, that suggest that exposure to some of the chemicals in our everyday environment, such as the chemicals found in plastics, may cause weight gain.
- Trial name
- THRIVE (NCT03478345)
- Testing
- endocrine disruptor chemical reduction intervention
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- George Washington University
Binge Eating, Pediatric Obesity
Working Memory in Overweight Children With and Without Loss of Control Eating
Loss of control (LOC) eating in children is associated with multiple physical and mental health impairments, including obesity and eating disorders.
- Trial name
- NCT04117542
- Testing
- Observational
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The Miriam Hospital
Over-eating, Obesity
The Breathe Light Study
The purpose of this study is to develop a novel, non-invasive method that will provide personalized feedback during dietary interventions as a marker for compliance.
- Trial name
- NCT01976455
- Testing
- 20% fewer calories, 40% fewer calories
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- USDA Grand Forks Human Nutrition Research Center
Pediatric Obesity, Inhibition
Brain Mechanisms of Overeating in Children
The proposed research will follow healthy weight children who vary by family risk for obesity to identify the neurobiological and appetitive traits that are implicated in overeating and weight gain during the critical…
- Conditions
- Pediatric Obesity, Inhibition, Decision Making, fMRI
- Trial name
- RO1 (NCT03341247)
- Where
- United States
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- Penn State University
Obesity
Environmental Strategies & Behavior Change to Reduce Overeating in Obese Children
There is a need for effective weight control methods for obese children. Environmental strategies such as reducing the size of dishware and serving utensils, storing food out of view and reducing food consumption while watching…
- Trial name
- NCT01221220
- Testing
- Standard Packard Pediatric Weight Control Program, Standard Packard Pediatric Weight Control Program plus Home-based advising on environmental changes
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Stanford University
Insulin Resistance, Obesity
Pilot Study of GLY-LOW Supplementation in Postmenopausal Women With Obesity
A combination of generally regarded as safe (GRAS) compounds named GLY-LOW, which included: alpha lipoic acid, pyridoxamine, nicotinamide, piperine and thiamine, were examined in pre-clinical experiments.
- Conditions
- Insulin Resistance, Obesity, Cardiovascular Diseases, Cognitive Impairment
- Trial name
- NCT06242535
- Testing
- GLY-LOW
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Hoskinson Health and Wellness Clinic
Overweight (BMI > 25), Obesity and Overweight
The Effect of a ChatGPT-Supported Online Group-Guided Self-Help Program on Uncontrolled and Emotional Eating Behaviors and Body Image in Overweight and Obese Woman Nurses
Nurses with overweight and female gender characteristics often experience disruptions in their eating behaviors due to stressful working conditions.
- Conditions
- Overweight (BMI > 25), Obesity and Overweight, Emotional Eating, Binge Eating
- Trial name
- NCT06653673
- Testing
- ChatGPT supported Online Guided Self-Help Program (GSHP)
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Dokuz Eylul University
Prader-Willi Syndrome, Obesity
Understanding the Role of Gut Microbiota in Hyperphagia in Prader-Willi Syndrome
This study aims to use a high-fiber supplementation, an intervention known to create shifts in the gut microbiota towards a healthier structure, to explore the relationship between gut microbiota, appetite control and feeding…
- Trial name
- PWSGUT (NCT05541003)
- Testing
- NBT-NM108
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Prader-Willi Syndrome, Obesity
Double-Blind, Placebo Controlled, Phase 3 Trial of ZGN-440 (Beloranib) in Obese Subjects With Prader-Willi Syndrome
The purpose of this study is to evaluate efficacy and safety of ZGN-440 (beloranib) in obese adolescent and adult subjects with Prader-Willi Syndrome.
- Trial name
- bestPWS (NCT02179151)
- Testing
- ZGN-440 for Injectable Suspension
- Where
- 15 sites in United States
- Volunteers
- 108 people
- Sponsor
- Zafgen, Inc.
Prader-Willi Syndrome, Excessive Daytime Sleepiness
Impact of Bright Light Therapy on Prader-Willi Syndrome
This is a placebo controlled clinical trial to assess the utility of light therapy as a sufficient treatment for excessive daytime sleepiness in patients with Prader-Willi Syndrome
- Conditions
- Prader-Willi Syndrome, Excessive Daytime Sleepiness, Hyperphagia, Body Weight
- Trial name
- PWS-LT (NCT05939453)
- Testing
- Bright Light Therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Maimonides Medical Center
Obesity
A 35 Day Study to Investigate the Effects of GSK1521498 on Bodyweight in Obese Subjects With Over-Eating Behaviours.
The purpose of this study is to determine whether GSK1521498 will cause weight loss in obese but otherwise healthy subjects with over-eating behaviours.
- Trial name
- NCT01195792
- Testing
- GSK1521498
- Where
- 3 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- GlaxoSmithKline
Obesity, Overeating
Biobehavioral Reward Responses Associated With Consumption of Nutritionally Diverse Ultra-Processed Foods
The changing food environment, with increasingly abundant ultra-processed food (UPF) options, may directly contribute to rising rates of obesity, though it is unknown which ingredients in UPF elevate their reinforcing nature in a…
- Conditions
- Obesity, Overeating, Food Addiction
- Trial name
- NCT05437809
- Testing
- Intake of nutritionally diverse ultra-processed foods
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Oregon Research Institute
Obesity, Overweight
Preventing Excessive Weight Gain in Adolescent Girls at High-Risk for Adult Obesity
This study will examine whether interpersonal psychotherapy (IPT) can help reduce excessive weight gain in adolescent girls. It will compare the effectiveness of IPT with a teen health education program in preventing weight gain.
- Conditions
- Obesity, Overweight, Binge Eating
- Trial name
- NCT00680979
- Testing
- Interpersonal Psychotherapy, Health Education
- Where
- 2 sites in United States
- Volunteers
- 166 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Prader-Willi Syndrome, Obesity
A Study of Setmelanotide in Patients With Prader-Willi Syndrome
This is a Phase 2, open-label study designed to assess the safety and efficacy of setmelanotide in patients with obesity due to Prader-Willi Syndrome (PWS) who are 6 to 65 years of age.
- Conditions
- Prader-Willi Syndrome, Obesity, Hyperphagia
- Trial name
- NCT06772597
- Testing
- Setmelanotide
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Rhythm Pharmaceuticals, Inc.
Ileal Brake, Satiety
Location Specific Differences in Intestinal Brake Activation
The appearance of intact macronutrients in the small intestine can result in the activation of an intestinal brake; a negative feedback mechanism from different parts of the intestine to the stomach, the small intestine and to…
- Conditions
- Ileal Brake, Satiety, Overweight, Obesity
- Trial name
- NCT02500069
- Testing
- Casein (in duodenum), Casein (in jejunum), Casein (in ileum)
- Where
- Netherlands
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Binge Eating Disorder, Obesity
Treatment for Obesity and Binge Eating Disorder
This study is a test of cognitive behavioral therapy(CBT) and behavioral weight loss (BWL) treatments for obese patients with binge eating disorder (BED).
- Trial name
- NCT00537758
- Testing
- Cognitive Behavior Therapy, CBT and BWL, Behavioral Weight Loss Treatment
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Yale University
Overweight Adolescents, Overweight or Obesity
Problematic Decision-Making and Adolescent Weight Loss
This study evaluates the associations between baseline decision-making processes, engagement in problematic dietary practices, and post-intervention weight loss outcomes among adolescents.
- Conditions
- Overweight Adolescents, Overweight or Obesity, Impulsive Behavior, Overeating
- Trial name
- REACH (NCT04848532)
- Testing
- Weight loss treatment
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Drexel University
Overweight and Obesity
Solutions for Hunger And Regulating Eating
The objective of this proposed study is to collect efficacy data on ROC+ compared to an active comparator (AC) and to Behavioral Weight Loss (BWL) for participants who are high in Food Responsiveness.
- Trial name
- SHARE (NCT05004883)
- Testing
- Regulation of Cues Enhanced, Behavioral Weight Loss, Nutrition Education, Stress Management and Social Support
- Where
- United States
- Volunteers
- 293 people
- Sponsor
- University of California, San Diego