Clinical trials: Hyperbaric
Traumatic Brain Injury With Brief Loss of Consciousness, Post-Concussion Syndrome
mTBI Mechanisms of Action of HBO2 for Persistent Post-Concussive Symptoms
Purpose of this study is to investigate the mechanisms of action of hyperbaric oxygen therapy for persistent post-concussive symptoms after mild tramatic brain injury
- Trial name
- BIMA (NCT01611194)
- Testing
- Hyperbaric oxygen (HBO2) at 1.5 atms
- Where
- 5 sites in United States
- Volunteers
- 71 people
- Sponsor
- U.S. Army Medical Research and Development Command
Covid19
Hyperbaric Versus Normobaric Oxygen Therapy for COVID-19 Patients
At least 1 in 6 COVID-19 patients admitted to hospital to receive extra oxygen will die of complications. In patients with COVID-19, invasive treatment such as mechanical ventilation (e.g.
- Trial name
- NCT04500626
- Testing
- Oxygen
- Where
- 2 sites in Canada
- Volunteers
- 234 people
- Sponsor
- Ottawa Hospital Research Institute
Spinal Anesthesia Evaluation, Cesarean Delivery
Dose-to-block Level Relation in Single Shot Spinal Anesthesia for Cesarean Section.
The study is designed to support or deny relation between the dose of hyperbaric bupivacaine given intrathecally and extent of spinal block level.
- Trial name
- SpinDoBlock (NCT06729567)
- Testing
- Spinal block level analysis, data collection
- Where
- Poland
- Volunteers
- 362 people
- Sponsor
- Centre of Postgraduate Medical Education
Perianal Surgery
Minimal Effective Dose of Hyperbaric Spinal Bupivacaine for Saddle Block
The optimal anesthetic technique would provide excellent operating conditions, rapid recovery, early discharge, no postoperative side effects, and high patient's satisfaction.
- Trial name
- NCT02299167
- Testing
- Dixon's up-and-down method
- Volunteers
- 35 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
Post Operative Pain
Effects of Intrathecal Dexmedetomidine as an Adjuvant to Low Dose Hyperbaric 0.5% Bupivacaine
Patients will be enrolled in one of the two groups using a computer-generated random number table: Group I will receive 1.5 ml of 0.5% hyperbaric bupivacaine (7.5 mg).
- Trial name
- NCT05993975
- Testing
- Bupivacain 0.5%, Dexmedetomidine Hydrochloride
- Where
- Pakistan
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Sindh Institute of Urology and Transplantation
Covid-19
Management by Hyperbaric Oxygen Therapy of Patients With Hypoxaemic Pneumonia With SARS-CoV-2 (COVID-19)
Several patients with hypoxaemic SARS-CoV2 pneumonia were able to benefit from hyperbaric oxygen treatment (HBOT) in China. In a clinical case published in the Chinese journal of hyperbaric medicine, treatment with repeated HBO…
- Trial name
- OHB10cov (NCT04344431)
- Testing
- Hyperbaric oxygen treatment (HBOT) i.e. inhalation of pressurized oxygen delivered by a hyperbaric chamber (drug/device)
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- Direction Centrale du Service de Santé des Armées
Autism
Effects of Hyperbaric Oxygenation Therapy on Adaptive, Aberrant and Stereotyped Behaviors in Children With Autism
The purpose of this investigation is to evaluate the cognitive and behavioral effects of Hyperbaric Oxygenation Therapy in children who present with a diagnosis of autism and other developmental disabilities.
- Trial name
- NCT00404846
- Testing
- Hyperbaric Oxygenation Therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The Center for Autism and Related Disorders
Fibromyalgia
Hyperbaric Oxygen and Fibromyalgia: Randomised Prospective Clinical Trial
The aim of the study is to evaluate the effect of hyperbaric oxygen therapy (HBOT) on patients suffering from chronic pain syndrome (Fibromyalgia).
- Trial name
- NCT01827683
- Testing
- Hyperbaric oxygen
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Assaf-Harofeh Medical Center
Decompression Sickness, Diving
A Descriptive Analysis of Diving Accidents Treated at the Hyperbaric Chamber of Nice Hospital Between 2014 and 2025
The study aims to describe and analyse the individual parameters of patients treated at the hyperbaric chamber of Nice University Hospital for suspected diving accidents.
- Trial name
- NCT07621354
- Testing
- medical care in a hyperbaric unit
- Volunteers
- 468 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Overweight and Obesity, Insulin Sensitivity
Does Hyperbaric Oxygen Therapy Lead to a Sustained Increase in Insulin Sensitivity?
In a recent series of studies performed by our group, we have shown that exposure to hyperbaric oxygen (HBOT) leads to an increase in insulin sensitivity in male subjects and that this improvement can be measured in all men, not…
- Trial name
- HOTAIR3 (NCT02136615)
- Where
- Australia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Adelaide
Cancer of Head and Neck
Hyperbaric Oxygen and Its Effect on Radiation Induced Long Term Side Effects
The investigators intend to determine if patients that are already undergoing Hyperbaric Oxygen (HBO) therapy one year post treatment with radiation therapy for head and neck cancer, experience improvement in xerostomia and/or…
- Trial name
- NCT02450305
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- State University of New York - Upstate Medical University
Hyperbaric Oxygen Therapy, Acute-graft-versus-host Disease
HBOT in the Treatment and Prevention of aGVHD
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative therapeutic strategy for patients with hematopoietic malignancies.
- Trial name
- NCT05078073
- Testing
- Hyperbaric oxygen therapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shandong Provincial Hospital
Traumatic Brain Injury
The Safety and the Efficiency of Hyperbaric Oxygen in Traumatic Brain Injury
The goal of this observational study is to learn about the safety and long-term effects of hyperbaric oxygen therapy in participants over the age of 18 with traumatic brain injury (TBI).
- Trial name
- NCT06816199
- Testing
- Hyperbaric oxygen exposure
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cesarean Section; Shivering
Dosage of Intrathecal Hyperbaric Bupivacaine and the Incidence of Post Spinal Shivering.
Shivering is very common after spinal anaesthesia. Many studies have investigated the role of adding adjuvants to the local anaesthetics to decrease the incidence of post-spinal shivering.
- Trial name
- NCT03356899
- Testing
- Low dose bupivacaine 0.5% (8mg), High dose bupivacaine 0.5% (10mg)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Menoufia University
Traumatic Brain Injury
The Effects of Hyperbaric Oxygen on Non-acute Traumatic Brain Injury
Traumatic brain injury (TBI) continues to be a major cause of death and disability throughout the world. The reduced cerebral blood flow secondary to the direct trauma-induced damage deregulates cerebral metabolism and depletes…
- Trial name
- NCT05387018
- Where
- China
- Volunteers
- 390 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Ischemic Stroke From Large Vessel Occlusion
HBO After Thrombectomy for AIS With LVO
The purpose of this RCT trial is to evaluate whether the sequential hyperbaric oxygen therapy can improve the 90-day functional outcome in patients with acute large vessel occlusion ischemic stroke after endovascular treatment.
- Trial name
- NCT07626450
- Testing
- Hyperbaric oxygen therapy plus standard medical treatment, Standard medical treatment
- Where
- China
- Volunteers
- 420 people
- Sponsor
- Beijing Tiantan Hospital
Traumatic Brain Injury, Post-Concussive Symptoms
Long-Term Outcomes Following HBOT
This study is designed to better understand the long-term effects of hyperbaric oxygen therapy (HBOT). Our goal is to determine whether improvements after treatment are maintained over time and whether additional benefits appear…
- Conditions
- Traumatic Brain Injury, Post-Concussive Symptoms, Post-Traumatic Stress Disorder
- Trial name
- NCT07732374
- Testing
- Hyperbaric Oxygen Therapy (HBOT)
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Summit Hyperbarics and Wellness
Hypotension Drug-Induced, Spinal Aneshtesia
Effect of Lateral Decubitus Position After Spinal Anesthesia on Hemodynamic Stability in High-Risk Geriatric Patients
Spinal anesthesia is a common and preferred anesthetic technique for lower extremity orthopedic surgery in elderly patients. However, it can cause a significant drop in blood pressure (hypotension), especially in high-risk older…
- Conditions
- Hypotension Drug-Induced, Spinal Aneshtesia, Geriatric, Orthopedic Surgery Patients
- Trial name
- NCT07597148
- Testing
- Lateral Decubitus Positioning, Immediate Supine Positioning
- Volunteers
- 70 people
- Sponsor
- University of Health Sciences Balikesir Hospital Eduation and Research
Diabetic Foot Ulcer, Diabetes
Hyperbaric Oxygen Therapy in Diabetics With Chronic Foot Ulcers and Improvement of Quality of Life
This study evaluated the effect of hyperbaric oxygen therapy (HBOT) on wound healing, inflammation index, glycemic control, amputation rate, survival rate of tissue, bacterial wound cultures, and quality of life (QOL) in diabetic…
- Trial name
- NCT02328508
- Testing
- Hyperbaric oxygen therapy
- Volunteers
- 38 people
- Sponsor
- Chen-Yu Chen
Anesthesia, Spinal, Orthopedic Procedures
Comparison of Low-Dose Versus Standard-Dose Hyperbaric Bupivacaine in Spinal Anesthesia
The goal of this randomized controlled trial is to determine whether low-dose hyperbaric bupivacaine provides better hemodynamic stability and postoperative recovery compared with standard-dose hyperbaric bupivacaine in elderly…
- Conditions
- Anesthesia, Spinal, Orthopedic Procedures, Postoperative Recovery in Elderly Patients, Hemodynamics
- Trial name
- NCT07684989
- Testing
- Low-Dose Hyperbaric Bupivacaine, Standard-Dose Hyperbaric Bupivacaine
- Where
- Pakistan
- Volunteers
- 180 people
- Sponsor
- Mayo Hospital Lahore