Clinical trials: Hyperbaric
Dexamethasone, Spinal Anesthesia
Dexamethasone and Duration of Spinal Anesthesia
This study will evaluate whether intravenous dexamethasone affects the duration of spinal anesthesia in patients undergoing lower abdominal surgery.
- Conditions
- Dexamethasone, Spinal Anesthesia, Adjuvant
- Trial name
- NCT07819682
- Testing
- Dexamethasone
- Where
- Pakistan
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Holy Family Hospital, Pakistan
Heart Arrest, Brain Injuries
A Comprehensive Evaluation of Hyperbaric Oxygen Therapy in Resuscitation Medicine - a Pilot Study (HOT-RESUS 1 Trial)
In this prospective pilot study, the effects of hyperbaric oxygen therapy (HBOT) in post-cardiac arrest syndrome will be evaluated. However, the primary outcome of this pilot study will be the feasibility of this approach.
- Trial name
- HOT-RESUS 1 (NCT05646875)
- Testing
- hyperbaric oxygen therapy
- Where
- Belgium
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Eustachian Tube Dysfunction, Middle Ear Barotrauma
Effect of Total Compression Time and Rate (Slope) on Incidence of Symptomatic ETD and MEB: A Phase II Prospective Study.
Eustachian tube dysfunction (ETD) and middle ear barotrauma (MEB) are common reported complications during hyperbaric oxygen treatment.
- Conditions
- Eustachian Tube Dysfunction, Middle Ear Barotrauma, Middle Ear Disease, Middle Ear; Injury
- Trial name
- NCT04776967
- Testing
- Hyperbaric Compression Profile
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Northwell Health
Glioblastomas, Gliosarcoma
Hyperbaric Hyperoxygenation With Radiotherapy and Temozolomide in Adults With Newly Diagnosed Glioblastoma
Standard treatment for glioblastomas includes radiation and chemotherapy with a drug called temozolomide (Temodar); however, glioblastomas frequently develop resistance to standard treatment and recur or progress.
- Trial name
- HBO (NCT00936052)
- Testing
- Hyperbaric Oxygen Therapy
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Neurological Surgery, P.C.
Osteoradionecrosis
The Effect of Hyperbaric Oxygen Treatment in Patients With Osteoradionecrosis.
Osteoradionecrosis (ORN) is a severe delayed radiation-induced injury that can occur in patients whom have been subjected to radiotherapy for head and neck cancer. Hyperbaric oxygen treatment (HBO) is one treatment option.
- Trial name
- ORN (NCT04934644)
- Testing
- Hyperbaric oxygen treatment
- Where
- 2 sites in Sweden
- Volunteers
- 120 people
- Sponsor
- Göteborg University
Healthy, CVA
Development of Automated Analysis to Electroencephelogram (EEG) Data in Patients Treated at the Sagol Hyperbaric Medicine and Research Center at the Years 2017-2019.
DELPhI software developed for the analysis of EEG recordings in response to magnetic stimulation in relation to clinical data.
- Conditions
- Healthy, CVA, Hemorrhage, TBI (Traumatic Brain Injury)
- Trial name
- NCT04095377
- Testing
- No intervention, this is a retrospective study.
- Where
- Israel
- Volunteers
- 875 people, healthy volunteers welcome
- Sponsor
- QuantalX Neuroscience
Fibromyalgia
Transcranial Magnetic Stimulation and Hyperbaric Chamber for Women Fibromyalgia
Fibromyalgia syndrome (FMS) is a multisystem disease, characterized by generalized chronic musculoskeletal pain. In addition, there is a lot of care for fatigue, sleep disorders, morning stiffness, cognitive disorders…
- Trial name
- NCT03801109
- Testing
- Hyperbaric group, Magnetic group, Physical group
- Where
- Spain
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Hyperbaric, Diving Medicine
Reduction of Venous Emboli Load After Breathing Normobaric Oxygen Compared to Air
Primary objective: Assessment of venous gas emboli load post diving when breathing normobaric oxygen compared to air. Secondary objective: Assessment of fluid markers of central nervous system injury in blood post diving…
- Conditions
- Hyperbaric, Diving Medicine, Decompression Sickness, Central Nervous Injury
- Trial name
- NCT02468752
- Testing
- Oxygen, Air
- Where
- 2 sites in Sweden
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Type 2-diabetes
Acute Hyperbaric Oxygen Treatment Increases Hepatic Insulin Sensitivity and Muscle Reactive Oxygen Species in T2D
Diabetes mellitus type 2 (T2D) is characterized by insulin resistance of liver and skeletal muscle, which is at least partly due to impaired muscle mitochondrial function.
- Trial name
- NCT04219215
- Testing
- 100% O2 in oxygen chamber, 21% O2 in oxygen chamber
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- German Diabetes Center
Cesarean Section, Spinal Anesthesia
Low Dose Hyperbaric Bupivacaine and Dexmedetomidine as an Adjuvant, Caesarean Section
The aim of this study is to evaluate the effectiveness of low dose scheme with dexmedetomidine as an adjuvant. Taking in consideration optimum intraoperative surgical conditions, best post-operative pain free experience, and more…
- Conditions
- Cesarean Section, Spinal Anesthesia, Dexmedetomidine
- Trial name
- NCT03775655
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Exercise Recovery
HBOT and Exercise Recovery
The purpose of this pilot study is to investigate the effect of hyperbaric oxygen treatment on recovery from exercise in high performance athletes.
- Trial name
- NCT05924035
- Testing
- HBOT
- Where
- United States
- Sponsor
- Yale University
Carbon Monoxide Poisoning, Neurologic Sequelae
Adjunct Targeted Temperature Management in Acute Severe Carbon Monoxide Poisoning
This randomized trial will investigate important neurocognitive clinical outcomes of patients with acute severe carbon monoxide poisoning (ASCOP) randomized to receive either therapeutic hypothermia or normothermia combined with…
- Conditions
- Carbon Monoxide Poisoning, Neurologic Sequelae, Hypothermia
- Trial name
- NCT04975867
- Testing
- Targeted therapeutic hypothermia, Targeted therapeutic normothermia
- Where
- 2 sites in South Korea
- Volunteers
- 37 people
- Sponsor
- Wonju Severance Christian Hospital
Necrotizing Soft Tissue Infection, Necrotizing Fascitis
Prognosis and Treatment of Necrotizing Soft Tissue Infections: A Prospective Cohort Study
The investigators will analyze biomarkers related to the prognosis and treatment of necrotizing soft tissue infections (NSTI). The focus will be on whether certain endothelial and immune system biomarkers can function as markers…
- Conditions
- Necrotizing Soft Tissue Infection, Necrotizing Fascitis, Gas Gangrene, Fournier Gangrene
- Trial name
- ProTreat (NCT03147352)
- Testing
- Hyperbaric oxygen therapy
- Where
- Denmark
- Volunteers
- 260 people
- Sponsor
- Ole Hyldegaard
Disorders of Consciousness, Vegetative State
AI-Assisted Precision Hyperbaric Oxygen Therapy Based on Dynamic BIS-EEG Feedback for Patients With Disorders of Consciousness
Disorders of consciousness (DoC) are severe neurological conditions characterized by impaired awareness and reduced interaction with the environment.
- Conditions
- Disorders of Consciousness, Vegetative State, Minimally Conscious State
- Trial name
- AI-HBOT-DoC (NCT07855848)
- Testing
- AI-Assisted Personalized Hyperbaric Oxygen Therapy, Conventional Hyperbaric Oxygen Therapy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Boston Intelligent Medical Research Center, Shenzhen United Scheme Technology Co., Ltd.
Autistic Disorder
A Clinical Trial of the Clinical Effects of Hyperbaric Oxygen Therapy in Thai Autistic Children
Autism is a developmental and behavioral pattern which includes the triad of impairments, 1. social interaction 2. social communication 3. imagination.
- Trial name
- VPH (NCT00670891)
- Testing
- oxygen (Hyperbaric Oxygen Therapy)
- Where
- Thailand
- Volunteers
- 7 people
- Sponsor
- Vachira Phuket Hospital
Hyperbaric Oxygen Therapy, Diabetic Foot Ulcer
Short Duration Hyperbaric Oxygen Therapy to Improve HbA1c, Leukocyte, and Serum Creatinine
The investigators want to evaluate the short duration HBOT can improve glycohemoglobin (HbA1c) levels, leukocyte count, and serum creatinine levels in patients with DFU (diabetic foot ulcer) Wagner 3-4.
- Conditions
- Hyperbaric Oxygen Therapy, Diabetic Foot Ulcer, Type II Diabetes Mellitus
- Trial name
- NCT03615755
- Testing
- Hyperbaric Oxygen Therapy (HBOT)
- Volunteers
- 30 people
- Sponsor
- Hendry Irawan
Autism
A Controlled Trial of the Clinical Effects of Hyperbaric Therapy in Autistic Children
Autism is a neurodevelopmental disorder currently affecting as many as 1 out of 166 children in the United States. Autism is considered by many to be a permanent condition with little hope for improvement.
- Trial name
- NCT00335790
- Testing
- Hyperbaric Therapy
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- International Hyperbarics Association
Inflammatory Bowel Disease (IBD), Crohn Disease
Hyperbaric Oxygen Therapy for Perianal Fistulizing Crohn's Disease Not Responsive or Intolerant to Conventional Care: HYPNOTIC Pilot Study
This study aims to test a new treatment called hyperbaric oxygen therapy (HBOT) for a severe type of inflammatory bowel disease called perianal Crohn's disease (PCD).
- Trial name
- HYPNOTIC (NCT06109961)
- Testing
- Oxygen Gas for Inhalation, Standard of care
- Volunteers
- 54 people
- Sponsor
- University of British Columbia
Interstitial Cystitis
Prospective Trial Comparing Response to Hyperbaric Oxygen Treatment in Patients With Interstitial Cystitis
To review the results of Hyperbaric Oxygen therapy (HBOT) on the symptoms of interstitial cystitis (IC). To determine if there is greater symptom improvement in the ulcerative vs the non-ulcerative patients with interstitial…
- Trial name
- NCT01479725
- Testing
- HBOT
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Kenneth Peters, MD
Endometriosis-related Pain
The HEROES Trial: Hyperbaric Oxygen Therapy for Endometriosis-Related Pain
Endometriosis, is a condition where tissue from the uterus, called endometrium, grows outside of the uterus. This effects up to 10% of women, and can lead to long-lasting, moderate to severe pelvic pain, infertility and other…
- Trial name
- HEROES (NCT06579040)
- Testing
- Monoplace Hyperbaric Chamber (Class III medical device)
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- Sunnybrook Health Sciences Centre