Clinical trials: Hyperbaric
Analgesia
Efficacy of Coadministration of Calcitonin and Hyperbaric Bupivacaine in Spinal Anesthesia in Tramadol-abuse Patients
Increasing duration of local anesthetic action is desired for prolongation of postoperative patient comfort, as well as decreasing perioperative opioid consumption and subsequent side effects.
- Trial name
- NCT04445857
- Testing
- Calcitonin presented as Miacalcic® ampoules 100 IU/ml (1ml) intrathecally, Calcitonin presented as Miacalcic® ampoules 100 IU/ml (1ml) intravenously, Normal Saline (NS)
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Diabetic Ulcer
Evaluation of Topical Wound Oxygen (two2) Therapy
The purpose of this study is to evaluate the efficacy of the Topical Wound Oxygen (two2) therapy system on the healing of diabetic lower extremity ulcers.
- Trial name
- NCT00871312
- Testing
- Topical wound oxygen therapy
- Where
- 3 sites in United States, Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- AOTI Ltd.
Neurological Impairments, Leukoencephalopathies
Hyperbaric Oxygen Treatment in Patients With White Matter Hyperintensities
The primary purpose of this study is to assess whether hyperbaric oxygen treatment improves neurological function in patients who exhibit white matter hyperintensities on MRI examination.
- Trial name
- NCT00497432
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- St. Luke's Hospital, Chesterfield, Missouri
Spinal Anesthesia Evaluation, Cesarean Delivery
Dose-to-block Level Relation in Single Shot Spinal Anesthesia for Cesarean Section.
The study is designed to support or deny relation between the dose of hyperbaric bupivacaine given intrathecally and extent of spinal block level.
- Trial name
- SpinDoBlock (NCT06729567)
- Testing
- Spinal block level analysis, data collection
- Where
- Poland
- Volunteers
- 362 people
- Sponsor
- Centre of Postgraduate Medical Education
Exercise Training
Hyperbaric VO2max Study
This study seeks to examine the effectiveness of training while in a hyperoxic-hyperbaric environment for exercise performance at altitude.
- Trial name
- NCT02356900
- Testing
- Hyperoxic hyperbaric interval exercise training, Normoxic, normobaric, interval exercise training, Oxygen
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Duke University
Dexmedetomidine in Subarachnoidal Anesthesia
Subarachnoidal Anesthesia: Dexmedetomidine vs Fentanyl Plus Hyperbaric Bupivacaine for Lower Abdomen Surgery
Dexmedetomidine, highly selective agonist for alpha-2 receptors, enhances the sensory and motor block with prolonged postoperative analgesia without hemodynamic compromise.
- Trial name
- Dex (NCT02582372)
- Testing
- Dexmedetomidine and bupivacaine, Fentanyl and bupivacaine
- Volunteers
- 50 people
- Sponsor
- Hospital Central Dr. Luis Ortega
Radiation Injuries
Study to Determine if Hyperbaric Oxygen Therapy is Helpful for Treating Radiation Tissue Injuries
The principle objective of this research is to more precisely determine the degree of benefit that hyperbaric oxygen therapy affords in the treatment of late radiation tissue injury. The study has eight* components.
- Trial name
- NCT00134628
- Testing
- Hyperbaric Oxygen Therapy
- Where
- 7 sites in United States, Australia and 3 more
- Volunteers
- 248 people
- Sponsor
- National Baromedical Services
Anesthesia, Spinal
Comparison of the Efficacy of 0.5% Bupivacaine, 0.5% Levobupivacaine, and 0.5% Hyperbaric Bupivacaine
About 15 million spinal anesthesia procedures are performed worldwide each year. In the daily practice of the anesthesiologist for intrathecal use there are various local anesthetics such as bupivacaine, hyperbaric solution of…
- Trial name
- BvsLBvsHB (NCT05184465)
- Testing
- spinal anesthesia
- Where
- Belarus
- Volunteers
- 111 people
- Sponsor
- Mogilev Regional Clinical Hospital
Athletic Performance, Hyperbaric Oxygenation
Acute Effects of Post-Exercise Hyperoxia on Recovery in Cycling
This study examines whether exposition to hyperbaric oxygen after a road-race simulation can help competitive cyclists recover and perform better the following day.
- Conditions
- Athletic Performance, Hyperbaric Oxygenation, Physical Endurance, Muscle Fatigue
- Trial name
- NCT07659301
- Testing
- Post-exercise Recovery
- Where
- Belgium
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Pregnant Women
Estimation of the ED95 of Intrathecal Hyperbaric Prilocaine 2% With Sufentanyl for Scheduled Cesarean Delivery
Hyperbaric bupivacaine 0.5% associated with opioids is the local anesthetic the most commonly used for spinal injection in cesarean section.
- Trial name
- NCT03036384
- Testing
- HB Prilocaine 2% (varying dose), HB Prilocaine 2%, Sufentanil
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Anesthesia, Spinal, Nonemergency Cesarean Section
Spinal Anaesthesia for Caesarean Section: Descriptive Multicentre Study
Most of caesarean sections can be performed under spinal anaesthesia. Its major advantages are reliability and fast onset. However, dose of hyperbaric bupivacaine used, combination with adjuvants, hemodynamic management, and…
- Trial name
- CesAR (NCT04719819)
- Testing
- Spinal anaesthesia for caesarean section
- Where
- 11 sites in France
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Stroke, Cognitive Impairment
Effects of Hyperbaric Oxygen Combined With Aerobic Exercise on Working Memory Among Stroke Patients
This single-center randomized controlled trial enrolled stroke patients with working memory impairment. Participants were randomly divided into the hyperbaric oxygen combined low-intensity focused ultrasound intervention group…
- Trial name
- NCT07772947
- Testing
- Conventional rehabilitation therapy, Moderate-intensity aerobic exercise, Hyperbaric Oxygen Therapy (HBOT)
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sixth Hospital of Wuhan, Affiliated Hospital of Jianghan University
Anesthesia
Dosing of Carcinogenic Complexes After Anesthesia With Intrathecal Hyperbaric Prilocaine.
The prilocaine is a very common local anesthetic that has the disadvantage of being metabolized to o-toluidine, a human carcinogen.
- Trial name
- NCT03642301
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Cesarean
Prilocaine or Bupivacaine for Spinal Anesthesiain Pregnant
The planned cesarean section is an intervention with a standard operating time of less than 40 minutes in trained teams. Hyperbaric Bupivacaine is the local anesthetic (LA) reference for these operations.
- Trial name
- Césarcaïne (NCT03433976)
- Testing
- spinal anesthesia
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Montpellier
Autistic Disorder
A Clinical Trial of the Clinical Effects of Hyperbaric Oxygen Therapy in Thai Autistic Children
Autism is a developmental and behavioral pattern which includes the triad of impairments, 1. social interaction 2. social communication 3. imagination.
- Trial name
- VPH (NCT00670891)
- Testing
- oxygen (Hyperbaric Oxygen Therapy)
- Where
- Thailand
- Volunteers
- 7 people
- Sponsor
- Vachira Phuket Hospital
Post COVID-19 Condition, Post-COVID-19 Syndrome
Improving Post COVID-19 Syndrome With Hyperbaric Oxygen Treatments
Over 500 million people have been infected with COVID-19, and to date, more than 6 million people have died. Many individuals who have recovered from COVID-19 continue to experience symptoms even after they have been "cured" of…
- Conditions
- Post COVID-19 Condition, Post-COVID-19 Syndrome, Post-COVID Syndrome, COVID-19
- Trial name
- PCS-HBOT (NCT06082518)
- Testing
- Monoplace Hyperbaric Chamber (Class III medical device).
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Sunnybrook Health Sciences Centre
Autism
Effects of Hyperbaric Oxygen Therapy on Children With Autism
PURPOSE The purpose of this investigation is to evaluate the cognitive and behavioral effects of Hyperbaric Oxygenation Therapy in children who present with a diagnosis of autism spectrum disorder. HYPOTHESIS 1.
- Trial name
- NCT00406159
- Testing
- Hyperbaric Oxygen Therapy
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Thoughtful House
Covid19
Use of Hyperbaric Oxygen Therapy to Treat COVID-19 Patients With Respiratory Distress
Investigate whether hyperbaric oxygen therapy treatment can become a viable treatment option for COVID-19. If successful, providers will be able to provide future COVID-19 patients with mild-to-moderate respiratory distress…
- Trial name
- HBOT (NCT04800120)
- Testing
- Hyperbaric Oxygen Therapy
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Steward St. Elizabeth's Medical Center of Boston, Inc.
Ankle Sprain
the Efficacy of Hyperbaric Oxygen on Acute Ankle Sprain
Investigators recruited 208 patients with acute ankle sprain who were from the Rehabilitation Department of the Second Affiliated Hospital of Zhejiang University, School of Medicine from January 2026 to November 2028.
- Trial name
- NCT07405281
- Testing
- hyperbaric oxygen therapy, non Hyperbaric Oxygen Therapy
- Volunteers
- 208 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Post-Concussion Syndrome
Hyperbaric Oxygen for Post Concussive Syndrome
We would like to see if Hyperbaric Oxygen can help improve the symptoms that result from Post Concussive Syndrome.
- Trial name
- HBOT for PCS (NCT03205215)
- Testing
- Hyperbaric Oxygen Therapy, Waitlist Hyperbaric Oxygen Therapy
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- University of British Columbia