Clinical trials: Hyperbilirubinemia
Bilirubinemia
Fluid in Neonatal Hyperbilirubinemia
Hyperbilirubinemia is a common neonatal problem. bilirubin is potentially toxic to central nervous system and can cause serious permanent complication called kernicterus, in which brain stem nuclei and basal ganglia are…
- Trial name
- NCT03684499
- Testing
- fluid supplementation, breast feeding
- Volunteers
- 40 people
- Sponsor
- Assiut University
Type 1 Diabetes Mellitus
A Pilot Study of Moderate Hyperbilirubinemia in Type 1 Diabetes Mellitus
Specific Aim: To establish the feasibility of studying the change in endothelial function caused by induced moderate hyperbilirubinemia in type 1 diabetes.
- Trial name
- NCT01421355
- Testing
- Atazanavir
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Brigham and Women's Hospital
Bile Duct Neoplasms Malignant
Stenting Malignant Jaundice for Quality of Life
Endoscopic stent insertion is considered the method of choice for palliation of malignant bile duct obstruction (MBDO). However, it can cause complications and requires periodic stent exchanges.
- Trial name
- NCT01459965
- Testing
- ERCP with 10 French biliary plastic stent placement, ERCP with 11.5 French biliary plastic stent
- Volunteers
- 164 people
- Sponsor
- Indiana University
Hyperbilirubinemia, Neonatal
Effectiveness of Phototherapy With and Without Probiotics
Raised serum bilirubin levels can cause kernicterus and premature infants are at increased risk due to metabolic immaturity. The standard treatment for neonatal jaundice is phototherapy but probiotics along with it can reduce the…
- Trial name
- NCT06173856
- Testing
- LED phototherapy
- Where
- Pakistan
- Volunteers
- 76 people
- Sponsor
- Fatima Jinnah Medical University
Obstructive Jaundice
The Effect of Ursodeoxycholic Acid in Liver Functional Restoration of Patients With Obstructive Jaundice
ABSTRACT: In patients with obstructive jaundice, multi-organ dysfunction may develop. The aim of this study is to evaluate the effect of ursodeoxycholic acid on liver functional restoration on patients with obstructive jaundice…
- Trial name
- NCT01688375
- Testing
- Ursodeoxycholic Acid
- Where
- 3 sites in Serbia
- Volunteers
- 54 people
- Sponsor
- University Clinical Centre of Kosova
Urea Cycle Disorders, Crigler Najjar Syndrome
Safety Study of HepaStem for the Treatment of Urea Cycle Disorders (UCD) and Crigler-Najjar Syndrome (CN)
The purpose of this study is to assess the safety and to appraise the efficacy of one cycle of Hepastem (Heterologous Human Adult Liver-derived Progenitor Cells, HHALPC) infusions in paediatric patients suffering from CN or UCD.
- Trial name
- HEP001 (NCT01765283)
- Testing
- HepaStem
- Where
- 11 sites in Belgium, France and 3 more
- Volunteers
- 20 people
- Sponsor
- Cellaion SA
Crigler-Najjar Syndrome
Clinical Assessment Study in Crigler-Najjar Syndrome
This is a Pre-Phase 1 prospective, non-interventional clinical assessment study to evaluate Crigler-Najjar syndrome subjects requiring daily phototherapy, aged 1 year and older.
- Trial name
- LUSTRO (NCT03078881)
- Where
- 4 sites in United States, Israel and 1 more
- Volunteers
- 8 people
- Sponsor
- Audentes Therapeutics
Crigler Najjar Syndrome, Children
New Phototherapy Device to Treat Patients With Crigler-Najjar Disease
Evaluating the efficacity of a new device phototherapy by comparing it with conventional phototherapy. Jaundice occurs in many newborns, and is, in most cases benign, However, owing to the potential neurotoxicity of unconjugated…
- Trial name
- DRAP (NCT02356978)
- Testing
- Arm1 homemade phototherapy treatment, DRAP
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Lymphoblastic Leukemia, Hyperbilirubinemia
Levocarnitine and Vitamin B Complex in Treating PEG-Asparaginase or Inotuzumab Ozogamicin-Induced Hyperbilirubinemia in Patients With Acute Lymphoblastic Leukemia
This phase II trial studies how well levocarnitine and vitamin B complex works in treating abnormal high liver enzyme levels (hyperbilirubinemia) caused by treatment with PEG-asparaginase or inotuzumab ozogamicin in patients with…
- Trial name
- NCT03564678
- Testing
- Levocarnitine, Vitamin B Complex
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- M.D. Anderson Cancer Center
Hyperbilirubinemia
High Intensity Phototherapy: Double vs. Single
Intensive phototherapy in form of double light is used worldwide in the treatment of severe neonatal hyperbilirubinemia. It has been debated if there is an upper limit on the efficiency of phototherapy.
- Trial name
- NCT02805296
- Testing
- Light irradiance
- Volunteers
- 83 people
- Sponsor
- Aalborg University Hospital
Hyperbilirubinemia, Neonatal
Efficacy and Safety of Probiotics in Neonatal Hyperbilirubinemia
Neonatal Jaundice occurs in 60% of term infants and 80% of premature infants. Although it is transient, it is associated with high rate of readmission of patients in the first week of infancy.
- Trial name
- NCT03266913
- Testing
- Probiotic
- Where
- Iran
- Volunteers
- 126 people
- Sponsor
- Hormozgan University of Medical Sciences
Neonatal Jaundice
Efficacy of Zinc in Reducing Hyperbilirubinemia Among High Risk Neonates - A Double Blind Randomized Trial
The purpose of this study is to determine the effect of 10 mg of oral zinc given daily between days 2 and 7 of life to term or near term neonates with serum bilirubin levels of more than 6 mg/dL at 24 ± 6 hours of life on…
- Trial name
- NCT00692224
- Testing
- zinc gluconate
- Where
- India
- Volunteers
- 294 people
- Sponsor
- All India Institute of Medical Sciences
Pancreatic Cancer, Periampullary Carcinoma
Evaluation of Preoperative Biliary Drainage Before Pancreatoduodenectomy
The purpose of this study is to evaluate the efficacy of preoperative biliary drainage (PBD) which is performed prior to pancreatoduodenectomy candidates with obstructive jaundice by observing the prevalence of drainage and…
- Trial name
- NCT01941342
- Testing
- Pancreatoduodenectomy, ENBD and Pancreatoduodenectomy, EBD and Pancreatoduodenectomy
- Where
- China
- Volunteers
- 274 people
- Sponsor
- Southwest Hospital, China
Neonatal Jaundice
the Difference of Follow-up Methods of Neonatal Jaundice
The goal of this observational study is to compare the effectiveness and efficiency for precaution of severe hyperbilirubinemia in neonate by different follow-up methods of neonatal jaundice.
- Trial name
- NJFU (NCT06075290)
- Testing
- internet plus model, control
- Where
- 3 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Guizhou Provincial People's Hospital
Obstructive Jaundice, Pancreatic Cancer
Trial Comparing Metal Versus Plastic Stents for Preoperative Biliary Decompression
Compare the performance of full covered metal stents and plastic stents for preoperative biliary decompression
- Trial name
- NCT01675908
- Testing
- Stent Dysfunction, Complications
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- AdventHealth