Clinical trials: Hyperbilirubinemia
Hyperbilirubinemia, Neonatal
Screening and Follow-up Study of Neonatal Jaundice Based on Mobile Network
At least 13 hospitals in China will participate in the study, which aims to clarify the natural history of jaundice in Chinese healthy newborns，and decrease the incidence of severe hyperbilirubinemia and acute bilirubin…
- Trial name
- NCT04251286
- Where
- China
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Nanjing Medical University
Obstructive Jaundice, Pancreatic Cancer
Endoscopic Ultrasound-guided Biliary Drainage for Malignant Biliary Obstruction After Failed ERCP
In this study the investigators retrospectively report outcomes of direct transluminal EUS-BD in a series of patients with malignant biliary obstruction after failed ERCP as the experience of a single Italian center
- Trial name
- (EUS-BD) (NCT03510754)
- Testing
- Eus guided biliary drainage
- Volunteers
- 36 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Liver Dysfunction, Hepatectomy
The Effects of Dexamethasone Administration on Jaundice Following Liver Resection
The investigators were aiming to evaluate whether dexamethasone administration accelerates the recovery from hepatectomy-related jaundice and decreases the rates of post-hepatectomy liver failure and its safety in the subjects…
- Conditions
- Liver Dysfunction, Hepatectomy, Bilirubinaemia, Jaundice
- Trial name
- NCT02991339
- Testing
- Dexamethasone
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Shanghai Zhongshan Hospital
Breast Feeding, Exclusive
Supplemental Nursing System Compared to Bottle Supplementation
This is a randomized controlled trial comparing the SNS to bottle feeding. This study will compare exclusive breastfeeding rates and breast milk feeding rates at discharge, day of life 14, and day of life 28 between neonates…
- Trial name
- NCT04638075
- Testing
- Supplemental Nursing System
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Parenteral Nutrition Associated Cholestasis
Prospective Randomized Clinical Trial of Intravenous Lipids and Cholestasis
The Investigators hypothesize that increased cumulative amount of lipid intake causes PNAC in late preterm and term neonates with major GI surgical disorders
- Trial name
- NCT01555957
- Testing
- intravenous lipid
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Rochester
Jaundice Neonatal
The Risk of Hyperbilirubinemia in Term Newborns After Placental Transfusion
Delayed cord clamping (DCC) has been a subject of extensive research for the last couple of years. Based on published data, numerous neonatal benefits have been suggested such as increased hemoglobin and ferritin levels both at…
- Trial name
- NCT02625688
- Testing
- Delayed cord clamping, Cord milking, Early cord clamping
- Where
- Poland
- Volunteers
- 400 people
- Sponsor
- Princess Anna Mazowiecka Hospital, Warsaw, Poland
Type 1 Diabetes Mellitus
A Pilot Study of Moderate Hyperbilirubinemia in Type 1 Diabetes Mellitus
Specific Aim: To establish the feasibility of studying the change in endothelial function caused by induced moderate hyperbilirubinemia in type 1 diabetes.
- Trial name
- NCT01421355
- Testing
- Atazanavir
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Brigham and Women's Hospital
End Stage Liver Disease, Jaundice
SSM Predicts Outcomes of CLD Inpatients With Acute Liver Injury
In this study, a single non-invasive tool, spleen stiffness measurement (SSM), was used to monitor the disease regression of inpatients with chronic liver disease (CLD) and acute liver injury.
- Conditions
- End Stage Liver Disease, Jaundice, Liver Dysfunction, Portal Hypertension
- Trial name
- NCT06173947
- Testing
- FibroScan® Expert 630
- Where
- China
- Volunteers
- 411 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Anemia Neonatal, Polycythemia Secondary
Influence of Umbilical Cord Clamping Time in the Newborn
This study compares two umbilical cord clamping times; the early one, up to a minute (ECC) and the late or delayed one, when the cord stop beating (DCC).
- Conditions
- Anemia Neonatal, Polycythemia Secondary, Hyperbilirubinemia, Neonatal
- Trial name
- NCT03624335
- Testing
- ECC, DCC, Blood Test 6hours
- Where
- Spain
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Pascual Gregori Roig
Biliary Stricture, Biliary Tract Diseases
Percutaneous Biodegradable Biliary Stents for the Treatment of Benign Biliary Strictures.
To assess safety and effectiveness in the long term of percutaneous insertion of Biodegradable (BD) Biliary Stents for the treatment of benign biliary strictures, in a single center experience.
- Conditions
- Biliary Stricture, Biliary Tract Diseases, Bile Duct Stricture, Bile Duct Injury
- Trial name
- NCT05556668
- Testing
- Percutaneous placement of biodegradable biliary stents
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Corporacion Parc Tauli
Adenocarcinoma of the Pancreas, Advanced Solid Tumors
QUILT-2.014: Gemcitabine and AMG 479 in Metastatic Adenocarcinoma of the Pancreas
AMG 479 is an investigational fully human monoclonal antibody that targets type 1 insulin-like growth factor receptor (IGF-1R). Signaling through IGF-1R plays an important role in the regulation of cell growth and survival.
- Conditions
- Adenocarcinoma of the Pancreas, Advanced Solid Tumors, Cancer, Cancer of Pancreas
- Trial name
- GAMMA (NCT01231347)
- Testing
- AMG 479, gemcitabine
- Where
- 152 sites in United States, Australia and 30 more
- Volunteers
- 800 people
- Sponsor
- NantCell, Inc.
Hyperbilirubinemia
Long-Term Clinical Follow-Up of Children Enrolled in Stannsoporfin Clinical Trial Protocol No. 64,185-06-2(W)
The purpose of this protocol is to provide a mechanism to collect Long Term Clinical Data from those babies who participated in the primary Study 64,185-06-2(W)(WS)(ISNHP) "An Open-Label Study Of The Safety And Clinical…
- Trial name
- NCT02685189
- Testing
- Previous exposure to stannsoporfin
- Volunteers
- 55 people
- Sponsor
- InfaCare Pharmaceuticals Corporation, a Mallinckrodt Company
Obstructive Jaundice
Diagnostic Accuracy of Magnetic Resonance Cholangiopancreatography in Patients With Obstructive Jaundice
Evaluate the diagnostic accuracy of Magnetic Resonance Cholangiopancreatography (MRCP) compared with Ultrasound and Computed Tomography (CT) in patients with obstructive jaundice taking findings of ERCP/ PTC and histopathology as…
- Trial name
- NCT06754397
- Testing
- Magnetic Resonance Cholangiopancreatography
- Volunteers
- 50 people
- Sponsor
- Sohag University
Jaundice, Neonatal, Neonatal Hyperbilirubinemia
Comparison of Phototherapy Using Neolight Skylife Versus Standardized Phototherapy for Hyperbilirubinemia in Newborns
Phototherapy has served as a primary treatment for hyperbilirubinemia in newborn populations. The light emitted through phototherapy interacts with bilirubin at the skin level to transform it into water-soluble products…
- Conditions
- Jaundice, Neonatal, Neonatal Hyperbilirubinemia, Neonatal Disorder
- Trial name
- NCT03599258
- Testing
- Skylife, Standard Therapy
- Where
- 2 sites in United States
- Volunteers
- 72 people
- Sponsor
- HonorHealth Research Institute
Hyperbilirubinemia, Neonatal
A Safety and Efficacy Trial of Stannsoporfin in Neonates With Hyperbilirubinemia
It is a normal process in the human body for red blood cells to die, which makes bilirubin. Bilirubin is cleared away through the liver.
- Trial name
- NCT00850993
- Testing
- Stannsoporfin, PhotoTherapy (as needed)
- Where
- 23 sites in United States, Poland and 2 more
- Volunteers
- 58 people
- Sponsor
- InfaCare Pharmaceuticals Corporation, a Mallinckrodt Company
Hyperbilirubinemia
Effect of Vitamin-D as an Adjuvant to Phototherapy in Reduction of Indirect Serum Bilirubin
The study aimed at filling the gaps by evaluating the effectiveness of vitamin-D as an adjuvant to phototherapy in reduction of indirect serum bilirubin among neonates with exaggerated physiological hyperbilirubinemia.
- Trial name
- NCT07098234
- Testing
- Vitamin D3, Phototherapy
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- Muhammad Aamir Latif
Hyperbilirubinemia, Neonatal Indirect
The Efficacy of Ursodeoxycholic Acid (UDCA) as Adjuvant Therapy to Phototherapy in the Management of Neonatal Indirect Hyperbilirubinemia
This is a prospective, open-label, randomized controlled trial conducted at Lattakia University Hospital (Tishreen University), aiming to evaluate the efficacy of Ursodeoxycholic Acid (UDCA) as an adjuvant to triple phototherapy…
- Trial name
- UDCA-Neo (NCT07110987)
- Testing
- Phototherapy, ursodeoxycholic acid (UDCA)
- Where
- Syria
- Volunteers
- 70 people
- Sponsor
- Tishreen University Hospital
Obstructive Jaundice
Ultrasonography as a Single Tool for Guided Percutaneous Transhepatic Biliary Drainage in Obstructive Jaundice
Obstructive jaundice may be of malignant and benign etiologies. Carcinoma of the gall bladder, cholangiocarcinoma, pancreatic adenocarcinoma, metastasis, and lymph nodal compression of common bile duct (CBD) constitute the…
- Trial name
- NCT05246176
- Testing
- nephrostomy set
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Neonatal Hyperbilirubinemia
Investigation Into the Dynamic Variations of End-Tidal Carbon Monoxide Concentration (ETCOc) in Neonates Utilizing Non-Dispersive Infrared Spectroscopy and Its Implications for Jaundice Management
The objective of this study is to ascertain the diagnostic threshold of end-tidal carbon monoxide (ETCOc, adjusted for ambient CO levels) within the first three days postpartum, stratified by neonatal age at birth.
- Trial name
- ETCO (NCT07346976)
- Testing
- Erythrocyte Life Span Tester
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Newborn Jaundice
Effect of Tub Bathing on Skin and Bilirubin Levels in Infants Undergoing Tunnel and LED of Phototherapy
The study was conducted as a randomized controlled study to determine effect of tube bathing on skin and bilirubin levels in infants undergoing tunnel and LED of phototherapy.
- Trial name
- NCT04962113
- Testing
- TUBE BATH
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Istanbul University - Cerrahpasa