Clinical trials: Hypercapnic Respiratory Failure
Type 2 Respiratory Failure, Hypercapnic Respiratory Failure
Transcutaneous CO2 Measurement - From Hospital to Home
Long-term non-invasive ventilation (LT-NIV) is the main treatment modality for chronic hypercapnic respiratory failure.To assess the adequacy of alveolar ventilation during sleep and potential sleep hypoventilation, nocturnal…
- Trial name
- NCT06694870
- Testing
- Transcutaneous CO2 monitoring
- Where
- Norway
- Volunteers
- 129 people
- Sponsor
- University of Oslo
Chronic Obstructive Pulmonary Disease, Hypercapnic Respiratory Failure
NPPV Added Inspiratory Muscle Training in Severe COPD
The aim of this study is to determine whether noninvasive positive pressure ventilation with inspiratory muscle training can improve quality of life and respiratory muscle strength than noninvasive positive pressure ventilation…
- Trial name
- NCT01926275
- Testing
- NPPV+IMT, NPPV, IMT
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Acute Respiratory Distress Syndrome, Acute Hypoxemic Respiratory Failure
The Effects of Music Therapy on Adult Patients Requiring Mechanical Ventilation in the ICU
While most studies in the medical literature that indicate "music" as an intervention may recognize its impact and capacity to decrease pain perception, anxiety, and/or its role in the regulation of cardiac and respiratory…
- Conditions
- Acute Respiratory Distress Syndrome, Acute Hypoxemic Respiratory Failure, Acute Hypercapnic Respiratory Failure
- Trial name
- NCT03642002
- Testing
- Toning, Ocean drum & SOK melody, SOK
- Where
- 3 sites in United States
- Volunteers
- 178 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Hypercapnic Respiratory Failure
Use of EtCO2 as a PaCO2 Predictor Under Non Invasive Ventilation (NIV) in Cases of Acute Hypercapnic Respiratory Failure
In patients treated by Non invasive ventilation (NIV) due to acute hypercapnic respiratory failure, the interest of using the End-tidal Co2 measurement device "Capnostream" to evaluate PaCo2 and PaCo2 variations over time will be…
- Trial name
- NCT01489150
- Where
- Switzerland
- Volunteers
- 11 people
- Sponsor
- University of Lausanne Hospitals
Postoperative Pulmonary Complications, Diaphragm
Perioperative Diaphragm Point of Care Ultrasound
It is a prospective observational study of a cohort of patients who underwent brachial plexus blockage above the clavicle, and in which diaphragmatic function is observed in both hemidiaphragms by ultrasound (using Diaphragm…
- Conditions
- Postoperative Pulmonary Complications, Diaphragm, Brachial Plexus Block
- Trial name
- DPOCUS (NCT03688724)
- Where
- Spain
- Volunteers
- 65 people
- Sponsor
- Hospital General Universitario de Valencia
Chronic Obstructive Pulmonary Disease, Chronic Respiratory Hypercapnic Failure
A Study to Investigate the Effects of Heated Humidification During Non-Invasive Ventilation
Noninvasive ventilation (NIV) is a form of ventilation delivered by a mask and is an important mode of treatment in patients with both acute and chronic respiratory (breathing) failure.
- Conditions
- Chronic Obstructive Pulmonary Disease, Chronic Respiratory Hypercapnic Failure, Neuromuscular Disease, Obesity Hypoventilation Syndrome
- Trial name
- NCT01372072
- Testing
- non-invasive ventilation heated humidification (Fisher-Paykel MR810 and MR850 humidifiers)
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Chronic Obstructive Pulmonary Disease Patients, Chronic Respiratory Failure
Effect of Extracorporeal CO2 Removal in Stable Hypercapnic COPD Patients
Chronic hypercapnic respiratory failure is common in stable COPD patients in a terminal phase of their disease In an attempt to correct or slow down the rate of rise of PaCO2, long-term noninvasive mechanical ventilation (NIV)…
- Trial name
- NCT02260583
- Testing
- extracorporeal CO2 device
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Hypercapnic Respiratory Failure
Mathematically Arterialised Testing of Hypercapnic Subjects Study
Prospective observational cohort study of patients admitted to hospital with suspected hypercapnic respiratory failure and requiring treatment with non-invasive ventilation (NIV) as part of standard, routine management.
- Trial name
- MATHS (NCT04072848)
- Where
- United Kingdom
- Volunteers
- 84 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Ventilatory Failure
Individualised Weaning From Mechanical Ventilation in General ICU
Patients residing in the intensive care unit typically receive mechanical ventilatory support. Selecting the appropriate level of mechanical ventilation is not trivial, and it has been shown that lung protective settings can…
- Trial name
- iCareWean_CW (NCT03249623)
- Testing
- Beacon Caresystem
- Where
- United Kingdom
- Volunteers
- 274 people
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Chronic Obstructive Pulmonary Disease, Acute Exacerbation of Chronic Obstructive Airways Disease
Home Non Invasive Ventilation (NIV) Treatment for COPD-patients After a NIV-treated Exacerbation
Background: In chronic obstructive pulmonary disease, the prognosis for patients who have survived an episode of acute hypercapnic respiratory failure due to an exacerbation is poor.
- Conditions
- Chronic Obstructive Pulmonary Disease, Acute Exacerbation of Chronic Obstructive Airways Disease, Chronic Hypercapnic Respiratory Failure
- Trial name
- NCT01513655
- Testing
- LTNIV
- Where
- 4 sites in Denmark
- Volunteers
- 150 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Bariatric Surgery Candidate, Obesity, Morbid
Prophylactic Use of Noninvasive Ventilation in the Postoperative Period of Bariatric Surgery
Comorbidities associated with severe obesity determine an important public health problem. Few methods are considered potentially effective for the treatment of severe obesity and the clinical relevance of bariatric surgery is…
- Conditions
- Bariatric Surgery Candidate, Obesity, Morbid, Ventilatory Failure
- Trial name
- NCT04805476
- Testing
- Non invasive mechanical ventilation, GP
- Where
- Brazil
- Volunteers
- 31 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Exacerbation Copd, Acute Respiratory Distress
High Flow Nasal Cannula Versus Non-Invasive Ventilation in Exacerbations of Chronic Obstructive Pulmonary Disease
Chronic obstructive lung disease is a disabling disease that affects people usually after several years of smoke tobacco exposure and affects millions of patients worldwide.
- Conditions
- Exacerbation Copd, Acute Respiratory Distress, Acute Hypercapnic Respiratory Failure
- Trial name
- HiFOLD (NCT03033251)
- Testing
- Non Invasive Ventilation, High Flow Oxygen Cannula 50, High Flow Oxygen Cannula 30
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
Post-extubation Failure, Persistent Weaning Failure
Effects of Mechanical Insufflation-Exsufflation in Preventing Respiratory Failure After Extubation
Weaning protocols that include the use of noninvasive ventilation (NIV), decreases the incidence of re-intubation and ICU length of stay. However, the role of NIV in post-extubation failure is still not clear.
- Conditions
- Post-extubation Failure, Persistent Weaning Failure, Secretion Encumbrance, Weak Cough
- Trial name
- MIEICU (NCT01424202)
- Testing
- Mechanical Insufflation Exsufflation
- Where
- Portugal
- Volunteers
- 92 people
- Sponsor
- Hospital Sao Joao
Obesity Hypoventilation Syndrome, Ketogenic Dieting
Ketogenic Diet for Obesity Hypoventilation Syndrome
Obesity hypoventilation syndrome (OHS) is a condition that occurs in small percentage of obese people that causes high carbon dioxide and low oxygen levels in the blood.
- Conditions
- Obesity Hypoventilation Syndrome, Ketogenic Dieting, Hypercapnic Respiratory Failure
- Trial name
- KETOHS (NCT04108819)
- Testing
- Ketogenic Diet
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Respiratory Failure
Non-Invasive Ventilation After Extubation in Hypercapnic Patients
The purpose of this study is to assess the efficacy of noninvasive ventilation in the prevention of extubation failure and mortality in patients with chronic respiratory disorders and hypercapnic respiratory failure during…
- Trial name
- NCT00539708
- Testing
- Non-invasive ventilation
- Where
- Spain
- Volunteers
- 106 people
- Sponsor
- Hospital Clinic of Barcelona
Ventilatory Failure
Neo RQI: The Effect of Neonatal Resuscitation Quality Improvement Cart Booster Training Skills Retention
This is a prospective multicenter randomized control trial to assess percentage mask leak six months post instructor led positive pressure ventilation skills training in providers who undergo booster training compared to those…
- Trial name
- NCT05147922
- Testing
- Booster Training with the Neonatal Resuscitation Quality Improvement Cart
- Where
- United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center