Clinical trials: Hypercholesterolemia, completed
Hypercholesterolemia, Atherosclerosis
Ezetimibe Plus Atorvastatin Versus Atorvastatin Alone in Subjects With Primary Hypercholesterolemia (Study P03406)
To compare the efficacy of ezetimibe 10 mg added daily to ongoing treatment with atorvastatin 10 mg daily versus ezetimibe placebo added daily to ongoing treatment with atorvastatin 10 mg daily in reducing the concentration of…
- Trial name
- NCT00651404
- Testing
- Ezetimibe
- Volunteers
- 137 people
- Sponsor
- Organon and Co
Diet, Healthy, Diabetes Mellitus
The Impact of Chokeberry Bioproducts on Metabolic Parameters and Antioxidant Potential
Chokeberry can be used both in the prevention and treatment of various metabolic disorders due to its high antioxidant properties.
- Conditions
- Diet, Healthy, Diabetes Mellitus, Hypertension, Obesity
- Trial name
- NCT06435130
- Testing
- Dietary intervention with chokeberry juices, Dietary intervention with chokeberry juices and fibers
- Where
- Poland
- Volunteers
- 102 people
- Sponsor
- Medical University of Bialystok
Hypercholesterolemia, Medication Adherence
Pilot Program to Improve Statin Adherence and Lower Cholesterol in Older Adults
The purpose of this study is to pilot test a behavioral medication adherence (MA) intervention compared to control condition in older adults with low adherence to medication for hypercholesterolemia.
- Trial name
- NCT01227330
- Testing
- Medication adherence intervention, Attention-control
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Missouri-Columbia
Hypercholesterolemia
Effect of the Consumption of a Fermented Milk Enriched With Plant Sterols
The purpose of this study is to investigate the cholesterol lowering effect of a drinkable low fat fermented milk enriched with plant sterol after 3 and 6 weeks of daily consumption in midly hypercholesterolemic people not…
- Trial name
- NCT01340287
- Testing
- 1- plain low-fat dairy fermented product (drinkable) enriched with plant sterols-esters (1,6g /day equivalent as free sterols)., 2- plain low-fat dairy fermented product (drinkable) without plant sterols-esters
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Danone Global Research & Innovation Center
Hypercholesterolemia
Hypocholesterolemic Effect of a Phytosterol-enriched Spreadable Cream Prepared With Virgin Olive Oil
This study aims to evaluate the effect of the enriched extra virgin olive oil spread in plant sterols from the olive itself and demonstrate its effect anticholesterolemic and cardioprotective in children and adolescents with…
- Trial name
- NCT05460208
- Testing
- Enriched spread, Control spread
- Where
- 2 sites in Spain
- Volunteers
- 50 people
- Sponsor
- Universidad de Granada
Hypercholesterolemia, Atherosclerotic Cardiovascular Disease
Evaluation of the Efficacy and Safety of Bempedoic Acid (ETC-1002) in Patients With Hyperlipidemia and Statin Intolerant
The purpose of this study is to determine if bempedoic acid (ETC-1002) is effective and safe versus placebo in patients with elevated LDL cholesterol and who are statin-intolerant.
- Conditions
- Hypercholesterolemia, Atherosclerotic Cardiovascular Disease, Statin Adverse Reaction
- Trial name
- CLEAR Serenity (NCT02988115)
- Testing
- bempedoic acid
- Where
- 67 sites in United States, Canada
- Volunteers
- 345 people
- Sponsor
- Esperion Therapeutics, Inc.
Hypercholesterolemia
Special Drug Use-Results Survey of Lipitor Tablets
This study is to evaluate the controlling effect of atrovastatin on plasma lipid to achieve the category-specific targeted lipid levels.
- Trial name
- ALWAYS (NCT01446679)
- Testing
- atrovastatin
- Where
- 8 sites in Japan
- Volunteers
- 24,050 people
- Sponsor
- Astellas Pharma Inc
Hypercholesterolemia
Efficacy and Safety of Colesevelam in Pediatric Patients With Genetic High Cholesterol
This study will evaluate the lipid-lowering effect and safety of colesevelam therapy administered to heterozygous familial pediatric patients 10 through 17 years of age who are on a stable dose of a pediatric-approved statin…
- Trial name
- NCT00145574
- Testing
- colesevelam HCl
- Where
- 25 sites in United States, Australia and 6 more
- Volunteers
- 194 people
- Sponsor
- Daiichi Sankyo
Hypercholesterolemia
A Phase 3 Clinical Trial to Evaluate the Efficacy and Safety of AG2304T and AG2304R
A Phase 3 Clinical Trial to Evaluate the Efficacy and Safety of AG2304T and AG2304R in Patients with Primary Hypercholesterolemia
- Trial name
- NCT06717360
- Testing
- AG2304T, AG2304R
- Where
- South Korea
- Volunteers
- 158 people
- Sponsor
- Ahn-Gook Pharmaceuticals Co.,Ltd
Mildly Hypercholesterolemic Subjects
Effect of the Consumption of a Fermented Milk Enriched With Plant Sterols (Italy)
The purpose of this study is to investigate the cholesterol lowering effect of a drinkable low fat fermented milk enriched with plant sterol after 3 and 6 weeks of daily consumption in mildly hypercholesterolemic people treated…
- Trial name
- NCT01574482
- Testing
- 1- plain low-fat dairy fermented product (drinkable) enriched with plant sterols-esters (1,6g /day equivalent as free sterols)., 2- plain low-fat dairy fermented product (drinkable) without plant sterols-esters
- Where
- Italy
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Danone Global Research & Innovation Center
Hypercholesterolemia
Study to Evaluate the Efficacy and Safety of an Every Four Weeks Treatment Regimen of Alirocumab (REGN727/ SAR236553) in Patients With Primary Hypercholesterolemia (ODYSSEY CHOICE 1)
To determine the efficacy, long-term safety, and tolerability of alirocumab 300 mg every 4 weeks (Q4W), in comparison with placebo, as well as its potential as a starting regimen.
- Trial name
- NCT01926782
- Testing
- Alirocumab, Statin
- Where
- 83 sites in United States, Bulgaria and 6 more
- Volunteers
- 803 people
- Sponsor
- Regeneron Pharmaceuticals
Hypercholerolemia
A Study to Evaluate Ezetimibe in Korean Patients With Primary Hypercholesterolemia (0653-042)
Patients undergo 4-week placebo lead-in and diet period, and 12-week treatment period. Clinical efficacy and safety is evaluated at weeks 4, 8 and 12.
- Trial name
- NCT00157911
- Testing
- MK0653; ezetimibe / Duration of Treatment: 12 weeks, Comparator: simvastatin / Duration of Treatment: 12 weeks
- Volunteers
- 136 people
- Sponsor
- Organon and Co
Hypercholesterolemia, Hypertension
Evaluation of ETC-1002 in Participants With Hypercholesterolemia and Hypertension
This Phase 2 study will assess the efficacy and safety of ETC-1002 monotherapy versus placebo in participants with hypercholesterolemia and hypertension.
- Trial name
- NCT02178098
- Testing
- ETC-1002
- Where
- 43 sites in United States
- Volunteers
- 143 people
- Sponsor
- Esperion Therapeutics, Inc.
Hypercholesterolaemia
Rosuvastatin Efficacy and Safety Evaluation in Hypercholesterolaemic Patients
This is a single-arm, phase IV, open-label, prospective, non interventional study to evaluate the efficacy, tolerability and safety of rosuvastatin administered for 24 weeks in approximately 900 Greek subjects with…
- Trial name
- RESEARCH (NCT00695539)
- Where
- 6 sites in Greece
- Volunteers
- 810 people
- Sponsor
- AstraZeneca
Familial Hypercholesterolemia
Return of Actionable Variants Empirical Study
This is a genomic implementation project with ancillary studies to understand the impact on patients' health and well-being of returning genomic results to them and depositing those results in the medical record.
- Trial name
- RAVE (NCT03640234)
- Volunteers
- 418 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Cholesterol, Hypercholesterolaemia
Efficacy of Lactobacillus Mucosae DPC6426 on Blood-lipids
Cardiovascular disease (CVD) is the leading cause of death and morbidity in the EU. Among the recommendations to avoid heart disease is the maintenance of normal blood cholesterol levels, by ingesting a cardioprotective diet and…
- Trial name
- NCT07519967
- Testing
- Lactobacillus mucosae DPC6426
- Where
- Ireland
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University College Cork
Hypertension, Hyperlipidemia
Amlodipine/Atorvastatin Combination to Reduce the Health Risk of High Blood Pressure and High Cholesterol Levels
The purpose of the study is to measure the effect of the amlodipine/atorvastatin combination pill in reducing both elevated blood pressure and cholesterol levels to levels suggested by guidelines
- Trial name
- GEMINI-AALA (NCT00143234)
- Testing
- Amlodipine/atorvastatin single pill
- Where
- 118 sites in Argentina, Australia and 25 more
- Volunteers
- 1,825 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Hypertension, Hypercholesterolemia
Open Label Study To Evaluate The Long-Term Safety Profiles Of Caduet In Japanese Patients
The primary objective is to investigate the safety of Caduet (2.5 mg/5 mg, 2.5 mg/10 mg, 5 mg/5 mg or 5 mg/10 mg as dose of Amlodipine/Atorvastatin) during 52 weeks treatment period in Japanese patients with both of hypertension…
- Conditions
- Hypertension, Hypercholesterolemia, Angina Pectoris
- Trial name
- NCT01190007
- Testing
- Caduet
- Where
- 20 sites in Japan
- Volunteers
- 159 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Familial or Severe Hypercholesterolemia
Flaxseed Compared With Placebo in Patients With Hypercholesterolemia
The aim of this study is to determine if thirty grams per day of flaxseed consumption for 4 weeks could potentially reduce the serum lipid levels in children and adolescents with familial or severe hypercholesterolemia compared…
- Trial name
- NCT01007344
- Testing
- flaxseed, whole wheat flour
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- The Hospital for Sick Children
Hypercholesterolemia, Mixed Dyslipidemia
A Study to Assess the Real-World Effectiveness of Inclisiran and PCSK9 mAbs in Chinese Hypercholesterolemia Adult Patients
The purpose of this study was to describe the effectiveness of inclisiran and proprotein convertase subtilisin/kexin type 9 (PCSK9) monoclonal antibodies (mAbs) in the real-world setting in China.
- Trial name
- NCT07409636
- Where
- United States
- Volunteers
- 11,991 people
- Sponsor
- Novartis Pharmaceuticals