Clinical trials: Hypercholesterolemia, completed
Dyslipidemia
LDL-Cholesterol Lowering Effect of KB2115 as Add on to Statin
Thyroid hormones are known to reduce cholesterol levels through regulation of a number of key enzymes involved in synthesis, degradation, and lipid transport.
- Trial name
- NCT00593047
- Testing
- KB2115
- Where
- Sweden
- Volunteers
- 180 people
- Sponsor
- Karo Bio AB
Hypercholesterolemia
Intervention With Lupin Protein-enriched Foods in Hypercholesterolemic Subjects
The objective of the study is to elucidate the effects of lupin protein (Lupinus angustifolius Boregine) as part of a mixed diet on cardiovascular risk factors and to clarify the role of arginine, one of the most abundant amino…
- Trial name
- NCT01598649
- Testing
- Fabricated foods with lupin protein, Mannitol, Arginine
- Where
- Germany
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Jena
Hypercholesterolemia
Diet and Plant Sterols in the Control of Cholesterolemia (DESCO)
DESCO is a randomized clinical trial, controlled against placebo, performed to evaluate the effect of a phytosterol-based product (2.5 g/day), after 3 weeks of intake, on the lipid profile, also in relation to the quality of the…
- Trial name
- DESCO (NCT05265455)
- Testing
- Plant sterols 2.5 g/day
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Bologna
Homozygous Familial Hypercholesterolemic
Cardiovascular Evaluation of Patients With High Cholesterol and Normal Volunteers
Homozygous familial hypercholesterolemia is a rare inherited disease of metabolism. It occurs in less than 1 in 1 million people within the United States.
- Trial name
- NCT00001204
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Familial Hypercholesterolemia
Alirocumab and Plaque Burden In Familial Hypercholesterolaemia
Low-level, open-label, multicenter clinical trial to evaluate the effect of alirocumab on the volume, architecture and composition of atherosclerotic plaque in patients with Familial hypercholesterolemia from the SAFEHEART…
- Trial name
- ARCHITECT (NCT05465278)
- Testing
- Alirocumab
- Where
- Spain
- Volunteers
- 104 people
- Sponsor
- Fundación Hipercolesterolemia Familiar
Hypercholesterolemia
Comparison of the Efficacy of Plant Sterol-Enriched Soymilk Versus Plain Soymilk in Volunteers With High LDL-Cholesterol
This was a multicenter, prospective, randomized, double-blinded, controlled-trial study in hypercholesterolemic volunteers (serum LDL-C > 130 mg/dL).
- Trial name
- sterols (NCT02459314)
- Testing
- plant sterol and soluble fiber-enriched soymilk, soymilk
- Where
- Thailand
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Chiang Mai University
Cholesterol, Elevated, Clinical Decision Support
Statin Reminders for Improving Prescribing in Primary Care
Statins reduce cardiovascular events and mortality, but only 30% of eligible primary care patients nationally are on statins. Clinical decision support (CDS) interventions in the electronic health record (EHR) can deliver…
- Conditions
- Cholesterol, Elevated, Clinical Decision Support, Education
- Trial name
- NCT06456658
- Testing
- Interruptive Reminder, Non-interruptive Reminder, No Reminder
- Where
- United States
- Volunteers
- 3,332 people
- Sponsor
- Vanderbilt University Medical Center
Hypercholesterolemia
To Evaluate Ezetimibe/Simvastatin and Niacin (Extended Release Tablet) in Patients With Type IIa or Type IIb Hyperlipidemia (0653A-091)(COMPLETED)
To evaluate the efficacy and safety of ezetimibe/simvastatin and niacin in patients with high cholesterol.
- Trial name
- NCT00271817
- Testing
- Comparator: ezetimibe/simvastatin + niacin (ER), Comparator: niacin (ER) tablet, Comparator: ezetimibe (+) simvastatin
- Volunteers
- 1,220 people
- Sponsor
- Organon and Co
Atherosclerotic Cardiovascular Disease, Symptomatic Atherosclerosis
An Extension Trial of Inclisiran in Participants With Cardiovascular Disease and High Cholesterol
This clinical study was designed to assess the efficacy, safety, and tolerability of long-term dosing of inclisiran and evolocumab given as subcutaneous injections in participants with high cardiovascular risk and elevated…
- Conditions
- Atherosclerotic Cardiovascular Disease, Symptomatic Atherosclerosis, Type2 Diabetes, Familial Hypercholesterolemia
- Trial name
- ORION-3 (NCT03060577)
- Testing
- Inclisiran, Evolocumab
- Where
- 52 sites in United States, Canada and 3 more
- Volunteers
- 382 people
- Sponsor
- Novartis Pharmaceuticals
Primary Hypercholesterolemia
A Study of SCH 58235 (Ezetimibe) When Added to Ongoing Therapy With a Statin in Participants With Primary Hypercholesterolemia, Known Coronary Heart Disease, or Multiple Cardiovascular Risk Factors (P02173)
This is a study to evaluate the lipid-altering efficacy, safety, and tolerability of ezetimibe when added to ongoing therapy with an 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitor (statin) in participants…
- Trial name
- NCT03882905
- Testing
- Ezetimibe, Simivastatin, Statin
- Volunteers
- 769 people
- Sponsor
- Organon and Co
Familial Hypercholesterolemia
Greek Registry - Familial Hypercholesterolaemia
Familial hypercholesterolemia (FH) [heterozygous (heFH) or homozygous FH (hoFH)] is a common genetic disorder, characterized by elevated plasma low density lipoprotein (LDL) cholesterol concentration leading (if untreated) to…
- Trial name
- GRegistry-FH (NCT03140605)
- Where
- Greece
- Volunteers
- 1,000 people
- Sponsor
- Hellenic College of Treatment of Atherosclerosis
Hypertension, Elevated Cholesterol
The Medication Experience Study
The purpose of this study is to evaluate whether participation in an Internet-based intervention helps improve medication use.
- Conditions
- Hypertension, Elevated Cholesterol, Diabetes, Depression
- Trial name
- NCT01702883
- Testing
- Internet Survey
- Where
- United States
- Volunteers
- 186 people
- Sponsor
- Wake Forest University
Hypercholesterolemia
Gut Flora and Lipid Metabolism
It is well known that metabolic responses to diet and drugs are affected by genetic and environmental factors. Still, a large part of differences in responses between individuals remains unexplained.
- Trial name
- NCT01566266
- Testing
- Amoxicillin
- Where
- Netherlands
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Hypercholesterolemia, Cardiovascular Disease
Centralised Pan-Algerian Survey on the Undertreatment of Hypercholesterolemia
Centralized Pan-Algerian Survey on the undertreatment of hypercholesterolemia. The purpose of this study is to establish the proportion of patients on lipid-lowering pharmacological treatment reaching the LDL-C goals according to…
- Conditions
- Hypercholesterolemia, Cardiovascular Disease, Hypertension, Diabetes
- Trial name
- CEPHEUS (NCT01768403)
- Volunteers
- 1,236 people
- Sponsor
- AstraZeneca
Hypercholesterolemia
Oil Consumption and Cholesterol
More than 31 million U.S. adults have high total cholesterol and over 73 million U.S. adults have high LDL cholesterol. Cottonseed oil (CSO) is found readily in our food supply, and recent research has shown improvements in blood…
- Trial name
- NCT04397055
- Testing
- Cottonseed Oil, Olive Oil
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- University of Georgia
Hypertension, Type 2 Diabetes
Project WHADE: A Partner-Based Physical Activity Program for Women
This study is designed to test the feasibility and acceptability of a new method for supporting physical activity among women ages 40-65 who have risk factors for cardiovascular disease.
- Conditions
- Hypertension, Type 2 Diabetes, Metabolic Syndrome, Smoking
- Trial name
- NCT06350604
- Testing
- Project WHADE: A Partner-Based Physical Activity Program for Women
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Rowan University
Hypercholesterolemia, Dyslipidemia
Study to Compare the Efficacy and Safety of Pitavastatin and Simvastatin
The purpose of this study is to compare the efficacy and safety of pitavastatin with that of simvastatin.
- Trial name
- NCT00309777
- Testing
- Pitavastatin, Simvastatin
- Where
- 42 sites in Finland, Italy and 3 more
- Volunteers
- 857 people
- Sponsor
- Kowa Research Europe
Dyslipidemia, Hypercholesterolemia
A Dose-Finding Study in Japanese Patients to Evaluate the Effect of Obicetrapib as an Adjunct to Stable Statin Therapy.
This study will be a placebo-controlled, double-blind, randomized, phase 2 dose-finding study in Japanese patients to evaluate the efficacy, safety, and tolerability of obicetrapib as an adjunct to stable statin therapy.
- Conditions
- Dyslipidemia, Hypercholesterolemia, High Cholesterol
- Trial name
- NCT05421078
- Testing
- Obicetrapib
- Where
- 10 sites in Japan
- Volunteers
- 102 people
- Sponsor
- NewAmsterdam Pharma
Dyslipidemia
A Study to Assess the Efficacy and Safety of ETC-1002 in Subjects With Elevated Blood Cholesterol and Either Normal or Elevated Triglycerides
This Phase 2 proof-of-concept study will assess the lipid regulating efficacy and safety of ETC-1002 in subjects with hypercholesterolemia and either normal or elevated triglycerides.
- Trial name
- NCT01262638
- Testing
- ETC-1002
- Where
- 11 sites in United States
- Volunteers
- 177 people
- Sponsor
- Esperion Therapeutics, Inc.
Homozygous Familial Hypercholesterolemia
Safety, Tolerability and Efficacy of Microsomal Triglyceride Protein (MTP) Inhibitor
The primary objective of this study is to evaluate the safety and tolerability of 4 doses of lomitapide (AEGR-733; BMS-201038) given as an initial low dose and then escalated through an additional 3 dose levels over a 16-week…
- Trial name
- NCT01556906
- Testing
- Lomitapide
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Aegerion Pharmaceuticals, Inc.