Clinical trials: Hyperglycaemia
Postprandial Hyperglycemia
Is Mid-morning Breakfast as Healthy as Early-morning Breakfast for Blood Sugar Control in Adolescent Girls?
Repeated, elevated levels of glucose (sugar) within the blood after eating can lead to type 2 diabetes. In adults, eating breakfast lowers blood glucose responses to subsequent meals when compared with skipping breakfast.
- Trial name
- NCT05000944
- Testing
- breakfast omission (BO), early-morning breakfast consumption (EM-BC), mid-morning breakfast consumption (MM-BC)
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Necrotizing Fasciitis
Hyperglycemia in Surgical Infections
The primary purpose of this study is to evaluate two glycemic control regimens on clinical outcome in patients with necrotizing soft tissue infections.
- Trial name
- NCT00353275
- Testing
- Strict Glycemic control, Conventional Glycemic Control
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- The University of Texas Health Science Center, Houston
Metastatic Breast Cancer, Hyperinsulinism
A Pilot Study of Monitoring Insulin Levels and Treating Hyperinsulinemia and Hyperglycemia With Pioglitazone in Patients Treated With Alpelisib for Metastatic Breast Cancer.
The goal of this study is to test whether monitoring insulin levels and using pioglitazone to treat hyperglycemia and hyperinsulinemia in patients treated with Alpelisib for metastatic breast cancer is feasible and safe, and to…
- Conditions
- Metastatic Breast Cancer, Hyperinsulinism, Hyperglycemia Drug Induced
- Trial name
- NCT05753657
- Testing
- Pioglitazone
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Rambam Health Care Campus
Adrenocortical Carcinoma
Study of Relacorilant in Combination With Pembrolizumab for Patients With Adrenocortical Carcinoma Which Produces Too Much Stress Hormone (Cortisol)
This study will investigate the safety and efficacy of Relacorilant in combination with Pembrolizumab for Patients with Adrenocortical Carcinoma which Produces Too Much Stress Hormone (Cortisol).
- Trial name
- NCT04373265
- Testing
- Relacorilant, Pembrolizumab
- Where
- 6 sites in United States
- Volunteers
- 15 people
- Sponsor
- Corcept Therapeutics
Type 2 Diabetes Mellitus (T2DM), Hyperglycemia Due to Type 2 Diabetes Mellitus
Multilingual Voice Calls to Adjust Long-Acting Insulin for Adults With Type 2 Diabetes and Low Health Literacy in Pakistan
This study will evaluate whether a multilingual, feature-phone interactive voice response (IVR) system with human-verified basal insulin titration improves glycemic control compared with standard clinic-based insulin titration…
- Trial name
- VOICE-TITR-PK (NCT07729501)
- Testing
- Multilingual IVR-Supported Basal Insulin Titration, Standard Clinic-Based Basal Insulin Titration
- Where
- Pakistan
- Volunteers
- 220 people
- Sponsor
- Shifa International Hospital
Hyperglycaemia (Diabetic)
Investigating the Role of the Polyol Pathway in the Central Nervous System Production of Fructose
To investigate whether longer-term improvement of glycemic control in poorly controlled diabetes patients with a 12-week intensified insulin treatment regimen will lead to decreased polyol pathway activity.
- Trial name
- NCT03469492
- Testing
- Insulin, exercise, Dietary counseling
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Yale University
Pre Diabetes, Type2 Diabetes
Diabetes Prevention AI: Enhancing Prevention Strategies Using Personalized Nutrition and Fitness Coaching for the Next Generation
This study is testing an artificial intelligence (AI) chatbot designed to help adults at risk for type 2 diabetes adopt healthier lifestyles.
- Trial name
- NCT07824154
- Testing
- AI-Powered Diabetes Prevention Chatbot
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Emory University
Diabetes Mellitus Type 2, Pre-diabetes
Iowa Produce Prescription Program
The goal of this study is to understand how a Produce Prescription Program paired with a behavioral nutrition intervention affect nutrition and overall health in low-income Iowans with type 2 diabetes or pre-diabetes.
- Trial name
- I-PPP (NCT06837805)
- Testing
- Iowa Produce Prescription Program (I-PPP), Produce Your Path Behavioral Nutrition Intervention (PYP)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Iowa State University
Pre Diabetic
Xinqiao High-risk Cohort of Diabetes(NICE)
Objective: 1. To systematically screen the high-risk population of diabetes in Xinqiao area, understand the characteristics of early glucose metabolism changes and pancreatic islet function changes in the high-risk population and…
- Trial name
- NCT07281170
- Where
- 2 sites in China
- Volunteers
- 7,000 people
- Sponsor
- Shanghai General Hospital, China
Hyperglycemia
Glycemic Instability After Spine Surgery
Analyzing peri operative changes in blood glucose levels from non-diabetic patients undergoing spine surgery
- Trial name
- GLYRACH (NCT01975883)
- Where
- France
- Volunteers
- 91 people
- Sponsor
- Beaujon Hospital
Diabetes Mellitus, Diabetes Mellitus Progression
Rare and Atypical Diabetes Network
RADIANT is a network of 14 clinical sites and several laboratories dedicated to the study of atypical diabetes. The objective of this study is to define new forms of diabetes and the unique mechanisms underlying these forms of…
- Conditions
- Diabetes Mellitus, Diabetes Mellitus Progression, Glucose Intolerance, Glucose Metabolism Disorders
- Trial name
- RADIANT (NCT05544266)
- Where
- 13 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- University of South Florida
Hypoxic Ischemic Encephalopathy of Newborn, Hyperglycemia
Continuous Glucose Monitoring in HIE
The aim of the study is to examine whether the use of continuous glucose monitoring (CGM) to guide the clinical management of glycaemic control will result into an increased time in the target glucose concentration.
- Conditions
- Hypoxic Ischemic Encephalopathy of Newborn, Hyperglycemia, Hypoglycemia
- Trial name
- NCT06563687
- Testing
- Dexcom ONE+
- Where
- 3 sites in Italy
- Volunteers
- 70 people
- Sponsor
- University of Campania Luigi Vanvitelli
Arterial Stiffness, Dietary Modification
Egg Protein Hydrolysate and Vascular Function
The incidence of type 2 diabetes mellitus (T2DM) is rapidly growing. Patients with T2DM are at increased risk of developing long term micro- and macrovascular complications.
- Conditions
- Arterial Stiffness, Dietary Modification, Impaired Glucose Tolerance, Type 2 Diabetes Mellitus
- Trial name
- NCT01559896
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Maastricht University Medical Center
Hyperglycaemia (Diabetic), Liver Transplantation
Insulin Therapy for Postreperfusion Hyperglycemia
Glycemic control during liver transplantation is challenging especially after reperfusion of the liver graft. Insulin dose to treat postreperfusion hyperglycemia is retrospectively analyzed using historical data.
- Trial name
- INS_LTPL (NCT03152890)
- Testing
- Insulin
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Seoul National University Hospital
Insulin Resistance, Hyperglycemia
Biomarkers of Prednisolone Treatment (P05888)
Primary objective: To identify a biomarker or biomarker-set for the adverse metabolic effects of various doses of prednisolone treatment. Secondary objectives: To describe the PK of prednisolone and PD of a series of biomarkers.
- Conditions
- Insulin Resistance, Hyperglycemia, Glucose Intolerance
- Trial name
- NCT00971724
- Testing
- Prednisolone
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Diabetes, PreDiabetes
Study of Diabetes' Risk Factors and Accelerated Aging According to Socio-economic Status in a Population From the North of France
Populations in precarious situations or with low socio-economic status have an increased risk of diabetes and accelerated aging.
- Trial name
- PREVENDIAB (NCT05717491)
- Testing
- Biological analysis, Physical examination and Questionnaires, Physical examination and Questionnaires
- Where
- France
- Volunteers
- 2,014 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur de Lille
Type 1 Diabetes Mellitus, Hypoglycemia
FreeStyle Libre FGM During Summer Camp for Children With Type 1 Diabetes
A randomized, double-blinded, single center, parallel design pediatric study, on 45 subjects with type 1 diabetes (T1D), aged six to 15 (inclusive) years, measuring sensor time in glucose values within range 3.9 - 10 mmol/l (70 …
- Conditions
- Type 1 Diabetes Mellitus, Hypoglycemia, Hyperglycemia
- Trial name
- NCT03182842
- Testing
- FreeStyle Libre FGM, SMBG - Blinded Sensor
- Where
- Slovenia
- Volunteers
- 45 people
- Sponsor
- University of Ljubljana, Faculty of Medicine
Acute Coronary Syndromes, Hyperglycemia
Monitoring Glucose Levels in Patients With Myocardial Infarction
To evaluate the OptiScanner® for continuous glucose monitoring as a tool to optimize glucose levels in patients hospitalized for acute coronary syndromes
- Conditions
- Acute Coronary Syndromes, Hyperglycemia, Hypoglycemia
- Trial name
- COMGAMI (NCT03107806)
- Testing
- OptiScanner®
- Where
- Sweden
- Volunteers
- 14 people
- Sponsor
- Lars Ryden
Obesity, Abdominal Obesity
Adiponectin, ICAM-1, VCAM-1 Levels and Metabolic Syndrome in Obese Adolescents
Adipose tissue secreting a number of adipokines which regulate insulin sensitivity, energy metabolism and vascular homeostasis, so the dysfunction of adipose tissue is linked with the incidence of obesity accompanied with insulin…
- Conditions
- Obesity, Abdominal Obesity, Metabolic Syndrome, Hypertension
- Trial name
- ICAM; VCAM (NCT05685017)
- Testing
- Nur Aisiyah Widjaja
- Where
- Indonesia
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Universitas Airlangga
Overweight, Obesity
Effects of a Wholegrain Diet on Body Composition and Energy Balance
The purpose of this study is to compare a diet containing whole grains versus an energy matched diet using refined grains on body composition and metabolism.
- Conditions
- Overweight, Obesity, Pre-diabetic
- Trial name
- NCT01411540
- Testing
- Whole grains
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic