Clinical trials: Hyperglycemia
Pre Diabetes, Obesity
Latinos Combating Diabetes
The investigators plan to test two different strategies for weight loss and diabetes prevention in the Latino community in and around Forsyth County, North Carolina.
- Conditions
- Pre Diabetes, Obesity, Metabolic Syndrome
- Trial name
- La Comunidad (NCT01831921)
- Testing
- Lifestyle Weight Loss, Counseling
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- Wake Forest University Health Sciences
Type 1 Diabetes
Liraglutide Versus Insulin Mono-therapy in the Closed Loop Setting
Hypothesis: In type 1 diabetes mellitus, in the setting of a closed loop glucose control system: adjunctive therapy with Liraglutide will afford better post-prandial glycemic excursions than insulin mono-therapy.
- Trial name
- NCT01755416
- Testing
- Closed loop with sensor and Insulin, Closed loop with sensor, Insulin and Liraglutide
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Albert Einstein College of Medicine
Diabetes Mellitus, Type 2
GLP-1 Receptor Agonist Lixisenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation in Monotherapy
The purpose of this study is to evaluate the benefits and risks of lixisenatide (AVE0010), in comparison to placebo, used in a 2-step dose titration regimen in monotherapy, over a period of 12 weeks of treatment.
- Trial name
- GETGOAL-MONO (NCT00688701)
- Testing
- Lixisenatide (AVE0010), Pen auto-injector
- Where
- 12 sites in United States, Belgium and 10 more
- Volunteers
- 361 people
- Sponsor
- Sanofi
Pre-diabetes
Reducing Risk of Type 2 Diabetes: Hydroxychloroquine Use in Pre-Diabetes
The purpose of this study is to determine the short-term effects of the antimalarial medication, hydroxychloroquine (HCQ), compared with placebo using frequently sampled intravenous glucose tolerance testing (FSIGTT) methodology…
- Trial name
- NCT01326533
- Testing
- hydroxychloroquine
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Pittsburgh
Pre-diabetes
Effectiveness Study of Community-Based, Peer-Led Education on Weight Loss and Diabetes
The purpose of this study is to compare the effectiveness of a peer-led community-based lifestyle intervention, versus usual care, in achieving weight loss and prevention of diabetes among overweight adults with pre-diabetes in…
- Trial name
- HEED (NCT01004848)
- Testing
- Peer-Led Lifestyle Education on Weight Loss
- Where
- United States
- Volunteers
- 402 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Type 2 Diabetes, Hyperglycemia
Basal Bolus Versus Basal Insulin in Type 2 Diabetes Mellitus (T2DM)
The study is a prospective randomized study comparing safety and effectiveness of a basal-bolus regimen with glargine once daily and glulisine before meals, a basal plus regimen with glargine once daily and supplemental doses of…
- Trial name
- Basal-Plus (NCT00979628)
- Testing
- sliding scale regular insulin (SSRI), Basal Bolus, Basal Plus
- Where
- 5 sites in United States
- Volunteers
- 375 people
- Sponsor
- Guillermo Umpierrez, MD
Pre-diabetes, Overweight
Fit and Trim for Diabetes Prevention
Filipino Americans (FA) are the second largest (3.4 million) Asian group in the US. and have one of the highest prevalences of obesity and type 2 diabetes mellitus compared to non-Hispanic whites, African Americans and Hispanics.
- Conditions
- Pre-diabetes, Overweight, Obese
- Trial name
- NCT02278939
- Testing
- Filipinos Fit and Trim Weight Loss Program
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Hyperglycemia, Critical Illness
Computerized Glucose Control in Critically Ill Patients
The aim of the study is to determine whether the use of the CGAOtm software is associated with a decrease in 90-day mortality when compared with the use of standard care methods for glucose control with target blood glucose…
- Trial name
- CGAO-REA (NCT01002482)
- Testing
- CGAO-based Glucose Control, Standard-Care Glucose Control
- Where
- 35 sites in France
- Volunteers
- 2,684 people
- Sponsor
- Centre Hospitalier of Chartres
Glucose Intolerance, Sleep Deprivation
Influence of Nocturnal Light Exposure on the Impairment of Glucose Tolerance Induced by Chronic Sleep Restriction
This project is designed to test for the first time whether glucose metabolism is differentially impaired by sleep restriction with and without additional exposure to artificial light at night (ALAN).
- Conditions
- Glucose Intolerance, Sleep Deprivation, Sleep
- Trial name
- NCT04868539
- Testing
- Sleep Restriction with ALAN first, then Sleep Restriction without ALAN, Sleep Restriction without ALAN first, then sleep restriction with ALAN
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Type 1 Diabetes, Hypoglycemia
Reduction of Nocturnal Hypoglycemia and Hyperglycemia in the Home Using Predictive Algorithms, Pump Suspension, and Insulin Dosing in Children and Young Adolescents
Objective: to gain experience in children and younger adolescents with in-home use of an algorithm that will dose insulin to minimize projected hyperglycemia overnight in addition to suspending the pump if hypoglycemia is…
- Conditions
- Type 1 Diabetes, Hypoglycemia, Hyperglycemia, Artificial Pancreas
- Trial name
- PHM3 (NCT02714972)
- Testing
- Hyperglycemia Minimization Algorithm
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- Jaeb Center for Health Research
Pre-diabetes
Preventing Diabetes in the Deep South: Extending Partnerships and Adapting Interventions to Reach Rural Communities at High Risk.
Diabetes is responsible for a huge and growing burden of patient suffering and social costs, and the impact of this disease is shared disproportionately by minorities and in rural resource-challenged communities, particularly in…
- Trial name
- NCT04343872
- Testing
- Receive lifestyle modification alone, Metformin therapy
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Aging
SGLT2 Inhibition in Older Obese Adults With Pre-diabetes
Inhibitors of the sodium-glucose co-transporter (SGLT2) are FDA-approved for the treatment of type 2 diabetes (T2DM). Their mechanism of action involves lowering of blood glucose concentration secondary to increased glucose…
- Trial name
- SGLT2i (NCT04401904)
- Testing
- Dapagliflozin 10 mg, Nutritional counseling
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Bariatric Surgery Candidate, Glucose Intolerance
Effect of Dexmedetomidine on Postoperative Glucose and Insulin Levels.
This study investigated the effect of dexmedetomidine in obese patients undergoing bariatric surgery.
- Conditions
- Bariatric Surgery Candidate, Glucose Intolerance, Insulin Resistance
- Trial name
- NCT03809182
- Testing
- Dexmedetomidine, 0.9% Sodium-chloride, Fentanyl
- Volunteers
- 40 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Type 2 Diabetes Mellitus
The Study of Exenatide Action on Vessel Function in Type 2 Diabetes and Prediabetes
The purpose of this investigation is to evaluate whether exenatide, a type 2 diabetes medication, will improve the function of the innermost part of the arterial wall called the endothelium after a fat-enriched meal and to…
- Trial name
- NCT01181986
- Testing
- Exenatide SC, Exenatide IV, Exendin-9
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Carl T. Hayden VA Medical Center
Prediabetes, Cardiovascular Disease
Cardioprotective Activities Of Whole Eggs On Vascular Endothelial Function In Prediabetic Adults
Cardiovascular disease (CVD) is largely a lifestyle-related condition that is the #1 killer of adults in the United States. Our work is aimed at understanding how short-term increases in blood sugar, like those that accompany…
- Trial name
- NCT02364570
- Testing
- Glucose (100g), Glucose (75g), Whole Eggs
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Diabetes Mellitus, Type 2
GLP-1 Receptor Agonist Lixisenatide Versus Exenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Metformin
The purpose of this study is to compare the benefits and risks of lixisenatide (AVE0010) in comparison to exenatide (Byetta®), as an add-on treatment to metformin, over a period of 24 weeks of treatment, followed by an extension.
- Trial name
- GETGOAL-X (NCT00707031)
- Testing
- Lixisenatide (AVE0010), Pen auto-injector, Exenatide
- Where
- 18 sites in United States, Argentina and 16 more
- Volunteers
- 639 people
- Sponsor
- Sanofi
Obesity, Hypertension
The Effects of Metformin on Blood Vessel Structure and Function
The purpose of this study is to evaluate whether the drug Metformin has beneficial effects on the blood vessels of individuals with the Metabolic Syndrome (MeS).
- Conditions
- Obesity, Hypertension, Hypercholesterolemia, Hyperglycemia
- Trial name
- NCT00105066
- Testing
- Metformin
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- National Institute on Aging (NIA)
Congestive Heart Failure, Diabetes Mellitus
Intensive Glycemic Control for Congestive Heart Failure Exacerbation
Patients with heart failure often have high blood sugar (glucose).
- Trial name
- NCT00812253
- Testing
- Intravenous insulin, Subcutaneous insulin
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Kathleen Dungan
Healthy
A Study to Evaluate the Effect of Genetic Variation on Beta-cell Function During Fasting and Hyperglycemia in Nondiabetics
The GLP-1 receptor (GLP1R) gene is found on the beta cells of the pancreas. Its role is in the control of blood sugar level by enhancing insulin secretion from the pancreas after eating a meal.
- Trial name
- NCT04466566
- Testing
- Saline, Exendin-9,39, Liraglutide
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Adrian Vella
Pre-Diabetes
Interventional Bioremediation of Microbiota in Metabolic Syndrome
The purpose of this study is to determine whether changing the microbial composition in the colon can improve metabolism of sugar in people who are on the verge of developing diabetes (pre-diabetics).
- Trial name
- NCT02730962
- Testing
- Vancomycin, Neomycin, Clindamycin
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Minnesota