Clinical trials: Hyperkeratosis
- Condition Hyperkeratosis
- Funder type Industry (pharma, biotech, devices)
- Accepts healthy volunteers yes
Actinic Keratosis
A Study to Evaluate the Photoirritation Potential of PEP005 (Ingenol Mebutate) Gel, 0.01% in Healthy Volunteers
This Phase 1 study is designed to determine the photoirritation potential of PEP005 Gel, 0.01% when application is followed by light exposure.
- Trial name
- NCT00850811
- Testing
- PEP005 (ingenol mebutate) Gel
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Peplin
Netherton Syndrome
A Study to Assess the Safety and Pharmacokinetics of Multiple Ascending Subcutaneous Doses of DS-2325a in Healthy Subjects
Netherton syndrome (NS) is a rare autosomal recessive disease and no systemic treatment or standard of care currently exists for patients with NS.
- Trial name
- NCT05583669
- Testing
- DS-2325a
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Daiichi Sankyo
Lesion Skin, Seborrheic Keratosis
Nano-Pulse Stimulation (NPS) in Seborrheic Keratosis Study
The primary purpose of this trial is to evaluate Nano-Pulse Stimulation (NPS) to clear or remove Seborrheic Keratosis (SK) lesions from off-facial areas of healthy adult subjects.
- Trial name
- NCT03846531
- Testing
- Nano-Pulse Stimulation (NPS)
- Where
- 4 sites in United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Pulse Biosciences, Inc.
Healthy, Actinic Keratosis
PEP005 Gel - Evaluation of Local Tolerability After Exposure to Ingenol Mebutate Gel Followed by Hand Washing in Healthy Subjects
The purpose of this phase 1 trial is to investigate the local tolerability on the finger following exposure to PEP005 Gel 0.015% or 0.05% and hand washing once daily, for 2 or 3 consecutive days.
- Trial name
- NCT01302925
- Testing
- PEP005 Gel
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Peplin
Actinic Keratoses
Bioequivalence Study of Generic Fluorouracil 0.5% Cream and 0.5% Carac® and Placebo
This is a double-blind, randomized, placebo-controlled, three treatment parallel study in which normal, healthy men and women (age 45-85) with actinic keratosis will be treated on the face once daily for two weeks with…
- Trial name
- NCT01354717
- Testing
- Brand Carac, Generic 0.5% 5-fluorouracil cream
- Volunteers
- 377 people, healthy volunteers welcome
- Sponsor
- Spear Pharmaceuticals
Glycemic Index, Glycemic Load
Determination of the Glycemic Index of Products Varying in Levels of Refined and Whole Grain Corn
Interest in identifying low GI foods and the food factors responsible for the low GI of foods has increased. Three corn products with varying levels of refined and whole grain corn will be compared to each other and to a dextrose…
- Trial name
- NCT07427654
- Testing
- Corn snack containing 25 grams available carbohydrate, Dextrose control
- Where
- Canada
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Atopic Dermatitis (AD), Psoriasis
A Clinical Evaluation of Marula-Derived Ceramide Cream on Skin Barrier Function Enhancement
Previously, the investigators have demonstrated in vitro the excellent efficacy of marula oil-derived ceramide NPs in enhancing skin barrier function.
- Conditions
- Atopic Dermatitis (AD), Psoriasis, Acne Vulgaris, Contact Dermatitis
- Trial name
- NCT07066150
- Testing
- Apply a cream containing 0.05% marula oil-derived ceramide NPs
- Where
- China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Shanghai Chicmax Cosmetic Co., Ltd.
Keratosis
Study to Assess the Safety and Efficacy of Imiquimod 5% Cream for the Treatment of Actinic Keratosis on the Arms and Hands
The purpose of this study is to evaluate the safety and efficacy of imiquimod 5% cream compared to vehicle cream in the treatment of Actinic Keratosis (AK) on the arm and/or hand when the cream is applied once daily 2 days per…
- Trial name
- NCT00115154
- Testing
- Aldara (imiquimod) cream, 5%
- Where
- 18 sites in United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Graceway Pharmaceuticals, LLC
Healthy Volunteers, Atopic Dermatitis
A Study Evaluating the Safety and Efficacy of Topical BPR277 for the Treatment of Atopic Dermatitis and Netherton Syndrome
The study is divided in 3 parts, starting with the safety assessment of BPR277 ointment in Healthy volunteers (Part 1). If found to be well tolerated in Part 1, BPR277 ointment will be assessed in two different patients groups to…
- Conditions
- Healthy Volunteers, Atopic Dermatitis, Netherton Syndrome
- Trial name
- 3 (NCT01428297)
- Testing
- BPR277 ointment (controlled application), BPR277 ointment, BPR277
- Where
- 4 sites in United States, Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Netherton Syndrome
A Study to Assess the Safety and Pharmacokinetics of Single Ascending Subcutaneous and Intravenous Doses of DS-2325a in Healthy Subjects
Netherton syndrome (NS) is a rare autosomal recessive disease and no systemic treatment or standard of care currently exists for patients with NS.
- Trial name
- NCT05388903
- Testing
- DS-2325a
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Daiichi Sankyo
Actinic Keratosis
Efficacy and Safety of Ingenol Mebutate Gel for Actinic Keratosis Applied on Large Area on Face, Scalp or Chest
The objective of the trial is to investigate efficacy and safety of ingenol mebutate gel for actinic keratosis applied to large treatment areas once daily for three consecutive days on face, scalp or chest.
- Trial name
- NCT02361216
- Testing
- Ingenol Mebutate, Vehicle
- Where
- United States
- Volunteers
- 729 people, healthy volunteers welcome
- Sponsor
- LEO Pharma
Actinic Keratosis
Multicenter, Double-blind, Placebo Controlled Comparing Test Fluorouracil Cream to Carac Cream in Actinic Keratosis
This study is to evaluate the efficacy and safety of a generic formulation of fluorouracil 0.5% cream against the brand product (Carac) in participants with actinic keratoses.
- Trial name
- NCT02616601
- Testing
- Generic Fluorouracil Cream, Carac® (Fluorouracil) Cream, Vehicle Cream
- Where
- 17 sites in United States
- Volunteers
- 422 people, healthy volunteers welcome
- Sponsor
- Actavis Inc.
Keratosis, Actinic, Actinic Lesion
A Pre-market Study to Evaluate the Performance and Safety of a Skin Preparation Device for Removal of Dry Crusty Skin
In this clinical one-site investigation the performance and safety of a skin preparation device will be evaluated for removing hyperkeratotic skin prior to further medical treatment.
- Conditions
- Keratosis, Actinic, Actinic Lesion, Solar Keratosis/Sunburn, Hyperkeratosis
- Trial name
- NCT05356572
- Testing
- Investigational Skin Preparation Device, GMDN 47102 / Electrode Skin Abrasive Pad, UMDNS 13-230 / Biopsy punch (Dermal Curette)
- Where
- Finland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Mirka Ltd
Actinic Keratoses
An Open-Label 18-Month Safety Study of Fluorouracil Cream 0.5% for the Treatment of Actinic Keratoses
This study is being undertaken to: 1. assess the safety of fluorouracil cream for the treatment of actinic keratoses ("AKs") on other common skin surface areas (e.g., posterior scalp, ears, neck, lips, arms and hands); 2.
- Trial name
- NCT00377273
- Testing
- fluorouracil cream 0.5%
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Sanofi
Actinic Keratosis
A Study to Evaluate the Photoallergic Potential of PEP005 (Ingenol Mebutate) Gel, 0.01% in Healthy Volunteers
This Phase 1 study is designed to determine the photoallergic potential of PEP005 Gel, 0.01% and it's vehicle on normal skin.
- Trial name
- NCT00850681
- Testing
- PEP005 (ingenol mebutate) Gel
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Peplin
Disorder of Middle Ear, Otosclerosis of Middle Ear
Objective Measurement of Ossicular Chain Mobility Using a Palpating Instrument Intraoperatively
Feasibility of the objective measurement of the ossicular chain mobility, by using a force-measuring device based on a fiber optics sensors (PalpEar).
- Conditions
- Disorder of Middle Ear, Otosclerosis of Middle Ear, Cholesteatoma, Middle Ear
- Trial name
- PalpEar (NCT02554422)
- Testing
- PalpEar
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Sensoptic SA
Actinic Keratosis
A Clinical Study to Evaluate the Sensitizing Potential of LEO 43204 Gel
This is a randomized, single-center, controlled, within-subject comparison study assessing the sensitization potential of the investigational product, LEO 43204 gel under open conditions in healthy volunteers.
- Trial name
- NCT02650505
- Testing
- LEO 43204, LEO 43204 Vehicle
- Where
- United States
- Volunteers
- 233 people, healthy volunteers welcome
- Sponsor
- LEO Pharma
Actinic Keratosis
Trial to Investigate GZ21T in Healthy Volunteers
This is a double-blind, randomised, placebo-controlled trial designed to evaluate safety, tolerability, and pharmacokinetics (PK) after topical administration of single ascending doses of GZ21T in healthy volunteers.
- Trial name
- NCT06888362
- Testing
- GZ21T
- Where
- Sweden
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Genzada Pharmaceuticals USA, Inc.
Keratosis
1-Year Follow up to the 1473-IMIQ Study
This is a 1-year follow-up study to evaluate the long-term effects in subjects who completely cleared their actinic keratosis (AK) lesions in the 1473-IMIQ study.
- Trial name
- NCT00114023
- Testing
- Imiquimod 5% cream
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Graceway Pharmaceuticals, LLC
Netherton Syndrome
A Study of the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of BCX17725
This is a first-in-human, Phase 1/1b, 4-part study that includes the evaluation of safety, tolerability, pharmacokinetics (PK), and immunogenicity of BCX17725 when administered via single and multiple doses in healthy adult…
- Trial name
- NCT06539507
- Testing
- BCX17725
- Where
- 12 sites in United States, Australia and 3 more
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- BioCryst Pharmaceuticals