Clinical trials: Hyperlactacidemia
Hyperlactatemia, Healthy
The Role of Lactate in Lipolysis and Catabolism in Humans
Lactate may have anti-lipolytic effects when plasma concentrations of lactate reach levels similar to those seen during high intensity exercise.
- Conditions
- Hyperlactatemia, Healthy, Lactate
- Trial name
- LILACH (NCT04710875)
- Testing
- Na-lactate, Sodium chloride
- Where
- 2 sites in Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Continuous Renal Replacement Therapy, Hyperlactatemia
RCA for CRRT in Hyperlactatemia Patient With Increased Bleeding Risk
The purpose of this single center, randomized, control, open-labeled study is to evaluate the effect and safety of RCA versus no anticoagulation for CRRT in hyperlactatemia patients with increased bleeding risk.
- Conditions
- Continuous Renal Replacement Therapy, Hyperlactatemia, Bleeding
- Trial name
- NCT04315623
- Testing
- Regional citrate anticoagulation CRRT, No-anticoagulation CRRT
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Air Force Military Medical University, China
Valvular Heart Disease
Effect of Glucose-Insulin-Potassium on Hyperlactatemia in Patients Undergoing Valvular Heart Surgery
Hyperlactatemia, occuring 10-20% in patients undergoing valvular heart surgery, is known to be associated with hemodynamic instability, organ dysfunction and increased postoperative morbidity and mortality.
- Trial name
- NCT01825720
- Testing
- (Glucose-Insulin-Potassium)GIK group, normal saline group
- Where
- South Korea
- Volunteers
- 106 people
- Sponsor
- Yonsei University
HIV Infections
Vitamin B Therapy for Hyperlactatemia
The purpose of this study is to see if vitamin B can treat mild hyperlactatemia (a higher than normal level of lactate in the blood) in patients who take nucleoside reverse transcriptase inhibitors (NRTIs).
- Trial name
- NCT00031057
- Testing
- Thiamine hydrochloride, Riboflavin
- Where
- 3 sites in United States
- Volunteers
- 225 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Blood Lactic Acid Increased, Hip Fractures
Optimal Blood Sampling Site for Point of Care Lactate Assessment
The study was to compare blood Lactate levels between ear lobe and finger against venous forearm blood sample using the electronic hand held lactate device in hip fracture patients with good cognitive function (AMT >/= 7)
- Trial name
- NCT04291989
- Testing
- Optimal Blood Sampling Site for Point of Care Lactate Assessment using the handled Lactate-Pro 2 device
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospitals, Leicester
Septic Shock
Treatment of Septic Shock by Inhibiting Autodigestion and Preserving Gut Integrity With Enteric LB1148
Septic shock is a potentially life-threatening condition that can result in multi-organ dysfunction syndrome (MODS) and mortality.
- Trial name
- SSAIL (NCT02317549)
- Testing
- LB1148
- Where
- 34 sites in United States, Canada
- Volunteers
- 8 people
- Sponsor
- Leading BioSciences, Inc
Congenital Heart Disease, Perioperative/Postoperative Complications
Central Venous to Arterial CO2 Difference and Low Cardiac Output Syndrome Related Outcomes in Children After Cardiac Surgery
The goal of this clinical trial is to compare the capability of 3 different bedside surrogates in children who underwent cardiac surgery and were admitted in intensive care unit.
- Conditions
- Congenital Heart Disease, Perioperative/Postoperative Complications, Lactate Blood Increase
- Trial name
- VACO2 (NCT06292910)
- Testing
- arterial and central venous blood gas analysis, lactate
- Where
- Thailand
- Volunteers
- 136 people
- Sponsor
- Prince of Songkla University
Tissue Hypoxia, Hyperlactatemia
Early Lactate-Directed Therapy in the Intensive Care Unit (ICU)
Blood lactate levels have long been related to tissue hypoxia, a severe condition in critically ill patients associated with the development of organ system failure and subsequent death.
- Trial name
- NCT00270673
- Testing
- Early lactate-directed therapy
- Where
- 5 sites in Netherlands
- Volunteers
- 350 people
- Sponsor
- Erasmus Medical Center
Septic Shock, Hyperlactatemia
Early Goal Directed Therapy Using a Physiological Holistic View. The ANDROMEDA-SHOCK Study
Septic shock is a highly lethal condition associated with a mortality risk of 30 to 60%. Optimizing tissue perfusion and oxygenation is the aim to decrease mortality and morbidity in septic shock patients.
- Conditions
- Septic Shock, Hyperlactatemia, Peripheral Perfusion
- Trial name
- ANDROMEDA (NCT03078712)
- Testing
- Peripheral Perfusion guided resuscitation, Lactate guided resuscitation
- Where
- Chile
- Volunteers
- 424 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Hyperlactatemia
Effect of Metformin on Lactate Metabolism
The main objective of this study is to evaluate the influence of metformin on lactate metabolism. The main outcome is the lactate production following an exogenous lactate overload in healthy male subjects without metformin and…
- Trial name
- NCT00390273
- Testing
- Metformin
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre de Recherche en Nutrition Humaine Rhone-Alpe
Exercise Training, BDNF
Effects of Different Types of Exercise on BDNF and Cognitive Performance (Exercise-BDNF)
Purpose The purpose of this study is to determine the acute effects of different exercise intensities (low, moderate, high) on brain-derived neurotrophic factor (BDNF) levels, trail making test performance, and perceived…
- Conditions
- Exercise Training, BDNF, Cognitive Functions, Lactate Blood Increase
- Trial name
- Exercise-BDNF (NCT07137611)
- Testing
- Low Exercise, Moderate-Intensity Exercise, HIIT Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Aksaray University Training and Research Hospital
Lactate Blood Increase, Trauma Blunt
Lactate Monitoring in Traumatic Long Bone Fractures Requiring Emergent Surgical Intervention
Serum lactate has been utilized as a standard in guiding management of orthopedic injuries. Elevated preoperative lactate has been associated with a higher likelihood of postoperative complications.
- Conditions
- Lactate Blood Increase, Trauma Blunt, Trauma, Secondary, Injury Traumatic
- Trial name
- NCT05611398
- Testing
- Orthopedic Surgery
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Arrowhead Regional Medical Center
Lactate Blood Increase, Fluid Overload
Goal-directed Fluid Therapy in Elderly Patients Undergoing Lumbar Surgery
This is a randomized controlled clinical trial which investigates whether goal directed fluid therapy( GDT ) would show the evidence of benefit from GDT in terms of lactate kinetics then may reduce postoperative complications in…
- Conditions
- Lactate Blood Increase, Fluid Overload, Postoperative Complications
- Trial name
- NCT03974906
- Testing
- Applying goal-directed fluid therapy by continuous hemodynamic monitoring system (LiDCO）
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Peking Union Medical College Hospital
Hyperlactatemia, Actue Circulatory Failure
Treatment of Hyperlactatemia in Acute Circulatory Failure Based on Analysis of CO2: a Prospective Randomized Superiority Study (The LACTEL Study)
The management of a patient with shock is based on improving tissue oxygenation through hemodynamic optimization. Lactate is a marker of tissue hypoperfusion commonly used in the ICU.
- Trial name
- LACTEL (NCT05032521)
- Testing
- collection of biological data, collection of demographic, ventilatory, cardiac echocardiography, arterial and venous gas data, Standard treatment
- Where
- France
- Volunteers
- 180 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Renal Insufficiency, Chronic
Metformin in Moderate and Severe Renal Failure (CKD 3-4): A Follow-up Study
To validate on the mid-term in moderate and severe renal failure (CKD 3-4) a nomogram to adapt a fixed metformin daily posology according to renal function on the basis of the first short-term study made by the investigators.
- Trial name
- METsuiviIRC (NCT02848508)
- Testing
- Metformin
- Where
- France
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Acute Kidney Injury
Hyperlactatemia in Critically Ill Patients With Acute Kidney Injury
The aim of the research is to determine the prevalence of patients with acute kidney injury in the intensive care unit, the role of dialysis treatment in the treatment of these patients.
- Trial name
- NCT06565403
- Where
- Slovenia
- Volunteers
- 250 people
- Sponsor
- University Medical Centre Maribor
Surgical Procedure, Unspecified, Postoperative Complications
Hyperlactacidemia in Major Abdominal Surgery and Monocarboxylate Receptors
The goal of this clinical trial is to identify those situations in which the increase of lactate levels is not clinically relevant since it is associated with altered genetic polymorphism of the genes involved in the membrane…
- Conditions
- Surgical Procedure, Unspecified, Postoperative Complications, Hyperlactatemia, Abdomen Disease
- Trial name
- NETTUNO (NCT06222021)
- Testing
- Genetic analysis of polymorphism of membrane receptors involved in lactate transport
- Where
- Italy
- Volunteers
- 109 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Syncope, Lactate Blood Increase
Serum Lactate in Convulsive Syncopes Compared to Non-convulsive Syncopes
The investigators compared the serum lactate, serum prolactin and serum creatine kinase concentrations following convulsive and non-convulsive syncopes.
- Trial name
- NCT03062683
- Testing
- Lactate, prolactin and creatine kinase conc.
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- RWTH Aachen University
Hyperlactacidemia
Sodium Bicarbonate Ringer's Solution for Preventing and Treating Hyperlactacidemia During Hepatectomy
A variety of reasons lead to a sharp increase in lactic acid levels in patients undergoing liver resection, while leading to hyperlactic acidemia, resulting in decreased cardiac output, elevated blood potassium, and response to…
- Trial name
- NCT04547296
- Testing
- Sodium Bicarbonate Ringer's Solution
- Where
- 7 sites in China
- Volunteers
- 484 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
HIV Infections, Insulin Resistance
Effects of Uridine Supplementation on Metabolic Side Effects of Stavudine and Zidovudine
The purpose of this study is to determine whether uridine supplementation will improve insulin sensitivity and overall carbohydrate metabolism in HIV-positive subjects who are currently undergoing treatment with antiretroviral…
- Conditions
- HIV Infections, Insulin Resistance, Hyperlactatemia
- Trial name
- NCT00471614
- Testing
- NucleomaxX (contains uridine)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)