Clinical trials: Hyperlipoproteinemia
Severe Hypertriglyceridemia
Epanova® for Lowering Very High Triglycerides
The primary objective of the study is to determine the efficacy of Epanova (omefas) compared to placebo in lowering serum triglycerides in subjects with severe hypertriglyceridemia.
- Trial name
- EVOLVE (NCT01242527)
- Testing
- omefas
- Where
- 68 sites in United States, Denmark and 5 more
- Volunteers
- 399 people
- Sponsor
- AstraZeneca
Hyperlipoproteinemia
Safety, Tolerability,Pharmacokinetics(PK)and Pharmacodynamics(PD)Assessment of LCQ908 in Patients With Severe Hypertriglyceridemia
This study will assess safety, tolerability, and effect of LCQ908 on blood lipids in patients with severe hypertriglyceridemia.
- Trial name
- NCT01146522
- Testing
- LCQ908
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- Novartis Pharmaceuticals
Hyperlipidemia
The Safety, Tolerability and Efficacy of Multiple Subcutaneous Injections of SHR-1209 in Subjects With Hyperlipidemia
This is a randomized, double-blind, placebo- controlled phaseⅠb/Ⅱclinical study. Totally 108 subjects are planned to enrolled with 36 subjects in three low-dose groups (group 1, group 2 and group 3) and 72 subjects in three…
- Trial name
- NCT03944109
- Testing
- SHR-1209
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Lysosomal Acid Lipase Deficiency
A Study to Identify and Characterize LAL-D Patients in High-risk Populations
The objective of this study is to determine the frequency of Lysosomal Acid Lipase Deficiency (LAL D) by lysosomal acid lipase (LAL) enzyme activity assay in patients who are considered to be at risk.
- Trial name
- NCT02345421
- Where
- 15 sites in United States
- Volunteers
- 640 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Low-Density-Lipoprotein-Type [LDL] Hyperlipoproteinemia
Extracts of Amla, Walnut Leaf, Red Yeast Rice and Olive in Cardiovascular Prevention
The aim of this study is to evaluate whether the use of a commercially available standardized combination preparation (Cholesfytol NG®), containing extracts of amla, walnut leaf, red yeast rice and olive, in individuals with…
- Trial name
- AmWaRO (NCT06333158)
- Testing
- Cholesfytol NG
- Where
- Belgium
- Volunteers
- 36 people
- Sponsor
- Nina Hermans
Drug Induced Hyperglycemia, Secondary Hyperlipidemia
Long Term Antihypertensive Exposure and Adverse Metabolic Effects: PEAR Follow-Up Study
This is a research study of the long term effects on blood sugar and cholesterol of blood pressure lowering medications. People are invited to participate in this research study if they participated in the Pharmacogenomic…
- Trial name
- NCT01409434
- Testing
- Oral Glucose Tolerance Test
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Florida
Hyperlipidemia, Pregnancy
Lipid Profile as Predictor of Adverse Maternal and Neonatal Outcomes: A Pilot Study
The purpose of this study is to ascertain lipid profiles during pregnancy, specifically during the 24-28 week gestation and again near term at 36 weeks gestation.
- Trial name
- NCT05535660
- Testing
- Lipid panel
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Familial Hypercholesterolaemia, Hypercholesterolaemia
Specified Drug-use Survey of Leqvio for s.c. Injection.
The objective of this study is to evaluate the long-term safety of Leqvio in patients with familial hypercholesterolaemia or hypercholesterolaemia in post-marketing clinical practice
- Trial name
- NCT06275724
- Testing
- inclisiran
- Where
- 107 sites in Japan
- Volunteers
- 585 people
- Sponsor
- Novartis Pharmaceuticals
Hyperlipidemias
To Explore the Treatment Effect of Various Commercially Available Statins on Patients With Hyperlipidemia
The primary objective is to survey the efficacy of various commercially available statins (a class of lipid-lowering agents, for example, rosuvastatin, atorvastatin, simvastatin, lovastatin, pravastatin and fluvastatin) under…
- Trial name
- NCT00726362
- Where
- 8 sites in Taiwan
- Volunteers
- 3,270 people
- Sponsor
- AstraZeneca
Hyperlipidemia in Children
Virtual Reality Intervention in Children With Hyperlipidemia
Children with hyperlipidemia have elevated blood lipid levels, which increase the risk of developing cardiovascular diseases later in life.
- Trial name
- NCT07344389
- Testing
- Virtual Reality Training, Conventional Physiotherapy
- Volunteers
- 32 people
- Sponsor
- Hacettepe University
Mixed Hyperlipidemia
Comparison of the Efficacy and Safety of AtorVastatin mOnotherapy vs. Combination Atorvastatin/Fenofibric Acid
The purpose of this study is to compare combination atorvastatin/fenofibric acid 10/135mg with atorvastatin 20mg monotherapy in the mixed hyperlipidemia who were not at lipid goals with atorvastatin 10mg monotherapy.
- Trial name
- AVOCADO (NCT01974297)
- Testing
- Atorvastatin 10mg, fenofibric acid 135mg, atorvastatin 20mg
- Where
- South Korea
- Volunteers
- 194 people
- Sponsor
- Sang Hak Lee
Hyperlipidemia
Study of Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Inclisiran in Chinese Participants With Elevated Serum LDL-C
Study to evaluate the pharmacokinetics and pharmacodynamics of inclisiran treatment given as single subcutaneous injection in Chinese participants with elevated low-density lipoprotein cholesterol (LDL-C) despite treatment with…
- Trial name
- ORION-14 (NCT04774003)
- Testing
- 100 mg inclisiran sodium (equivalent to 94.5 mg inclisiran), 300 mg inclisiran sodium (equivalent to 284 mg inclisiran)
- Where
- 3 sites in China
- Volunteers
- 40 people
- Sponsor
- Novartis Pharmaceuticals
Familial Hypercholesterolemia, Cardiac Event
Detection of Familial Hypercholesterolaemia in Cardiovascular Disease Registry
Familial hypercholesterolaemia (FH) is an autosomal dominant somatic mutation commonly located on the LDL-receptor, APOB, and PCKS9 gene.
- Conditions
- Familial Hypercholesterolemia, Cardiac Event, Percutaneous Coronary Intervention
- Trial name
- NCT02778646
- Volunteers
- 1,622,948 people
- Sponsor
- University College, London
Microalbuminuria, Microalbuminuria /Creatinine Ratios ACR
New Taipei City 888 Digital Medical AI Platform for Prevention and Care of the Three Highs and Cardio-Renal-Vascular Diseases
Non-communicable diseases (NCDs), or chronic diseases, are a major public health burden globally and in Taiwan, and control of the "three highs" (hypertension, dyslipidemia, and hyperglycemia) is a national priority.
- Conditions
- Microalbuminuria, Microalbuminuria /Creatinine Ratios ACR, Cardiovascular Disease Risk Factor, Cardiovascular Disease Prevention
- Trial name
- DIGICARE-DREAM (NCT07588256)
- Testing
- Interactive digital modules, Antihypertensive Medication Management
- Where
- Taiwan
- Volunteers
- 4,162 people
- Sponsor
- New Taipei City Medical Association
Amyotrophic Lateral Sclerosis
Hyperlipidemia and Statin Therapy in Amyotrophic Lateral Sclerosis
The role of hyperlipidemia and lipid lowering therapy (LLT) in Amyotrophic Lateral Sclerosis (ALS) pathophysiology and its impact on disease progression and survival is unclear.
- Trial name
- NCT01592084
- Where
- United States
- Volunteers
- 267 people
- Sponsor
- The Methodist Hospital Research Institute
Hyperlipidemia, Insulin Resistance
Relationship Between Insulin Resistance and Statin Induced Type 2 Diabetes, and Integrative Personal Omics Profiling
Background: There is general agreement that statin-treatment of patients to lower plasma cholesterol levels can increase the incidence of type 2 diabetes mellitus (T2D) in some individuals1-5.
- Conditions
- Hyperlipidemia, Insulin Resistance, Type 2 Diabetes
- Trial name
- NCT02437084
- Testing
- Atorvastatin
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Stanford University
HIV Infections, Lipodystrophy
Safety and Effectiveness of Fenofibrate and Pravastatin in HIV-Positive Patients With Abnormal Blood Lipids
The purpose of this study is to compare the safety and effectiveness of fenofibrate and pravastatin in treating HIV-positive patients who have abnormal levels of fat (lipids) in the blood.
- Trial name
- NCT00006412
- Testing
- Pravastatin sodium, Fenofibrate
- Where
- 58 sites in United States, Puerto Rico
- Volunteers
- 630 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hypercholesterolemia
Study of MB07811 in Subjects With Hypercholesterolemia
A Phase 2 randomized, placebo controlled study assessing the efficacy, safety, and tolerability of MB07811 given orally to subjects with primary hypercholesterolemia for 12 weeks followed by a 6-week off drug phase.
- Trial name
- NCT00879112
- Testing
- MB07811
- Where
- 11 sites in United States
- Volunteers
- 80 people
- Sponsor
- Ligand Pharmaceuticals
Hyperlipoproteinemia
Plasma Triglyceride Lipolysis in Multifactorial Chylomicronemia
Purpose: The mechanism of most of the multifactorial chylomicronemia (MCM) remains elusive. In order to decipher the mechanisms involved in the occurrence of this disease, plasma TG lipolysis characteristics will be monitored for…
- Trial name
- NCT02933138
- Volunteers
- 62 people
- Sponsor
- Hospices Civils de Lyon
Hypercholesterolemia, Familial, Heterozygous Familial Hypercholesterolemia
A Study of Extended-release (ER) Niacin/Laropiprant in Adolescents With Heterozygous Familial Hypercholesterolemia (MK-0524A-158)
The purpose of this study is to determine the pharmacokinetics of laropiprant following administration of a single dose of 1 (Panel A) and 2 (Panel B) combination tablets of MK-0524A in adolescents with heterozygous familial…
- Trial name
- NCT01583647
- Testing
- MK-0524A
- Volunteers
- 10 people
- Sponsor
- Merck Sharp & Dohme LLC
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