Clinical trials: Hyperoxia
Hypoxemia, Hyperoxia
Oximeters and Skin Pigment: Impact of Skin Pigmentation on Accuracy of Pulse Oximetry
Finger pulse oximetry SpO2 is widely used to estimate arterial oxygen saturation SaO2. Current Spo2 targets do not take into consideration the many variables that affect that correlation in particular skin pigmentation.
- Conditions
- Hypoxemia, Hyperoxia, Pigment Skin
- Trial name
- NCT05690269
- Testing
- SpO2 and SaO2 comparison
- Where
- United States
- Volunteers
- 232 people
- Sponsor
- University of Cincinnati
IVH- Intraventricular Hemorrhage, Extreme Prematurity
Delayed Cord Clamping With Oxygen In Extremely Low Gestation Infants
This study is being conducted to compare the incidence of preterm infants (up to 28+6 weeks GA) who achieve a peripheral oxygen saturation of 80 percent by 5 minutes of life (MOL) given mask CPAP/PPV with an FiO2 of 1.0 during…
- Conditions
- IVH- Intraventricular Hemorrhage, Extreme Prematurity, Hypoxia Neonatal, Hyperoxia
- Trial name
- DOXIE (NCT04413097)
- Testing
- Delayed Cord Clamping with Low Oxygen concentration, Delayed Cord Clamping with High Oxygen concentration
- Where
- 3 sites in United States
- Volunteers
- 140 people
- Sponsor
- Sharp HealthCare
Healthy
The Validity of Retinal Blood Flow Measurements During Hyperoxia in Humans Using Fourier Domain Color Doppler Optical Coherence Tomography (CDOCT)
Noninvasive monitoring of blood flow in retinal circulation may elucidate the progression and treatment of ocular disorders, including diabetic retinopathy, age-related macular degeneration and glaucoma.
- Trial name
- NCT00431600
- Testing
- 100% Oxygen
- Where
- Austria
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Neuropathic Foot Ulcer, Foot Ulcer
Vaporous Hyperoxia Therapy (VHT) in the Treatment of Foot Wounds
The purpose of this study is to evaluate the effectiveness of Vaporous Hyperoxia Therapy (VHT), previously named Misty (WTS-1000) for the treatment of chronic foot ulcers.
- Trial name
- VHT1 (NCT04244201)
- Testing
- Vaporous Hyperoxia Therapy
- Volunteers
- 31 people
- Sponsor
- Vaporox
Premature Infant, Oxygen Therapy
Servo Controlled Oxygen Targeting Study
Most premature babies require oxygen therapy. There is uncertainty about what oxygen levels are the best. The oxygen levels in the blood are measured using a monitor called a saturation monitor and the oxygen the baby breathes is…
- Conditions
- Premature Infant, Oxygen Therapy, Hypoxia, Hyperoxia
- Trial name
- SCO2T (NCT04177992)
- Testing
- Servo control
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- University of Edinburgh
Chronic Obstructive Pulmonary Disease
Effect of Supplemental Oxygen on Maximal Oxygen Consumption in Patients With Chronic Obstructive Pulmonary Disease
Maximal consumption of oxygen (VO2max) during exercise is used in patients with chronic obstructive pulmonary disease (COPD) to stratify perioperative risk.
- Trial name
- NCT01294033
- Testing
- Fractional inspired oxygen (FiO2) 0.21, Fractional inspired oxygen 0.28
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Hyperoxia, Postoperative Complication
Individualized Perioperative Open-lung Ventilatory Strategy With High Versus Conventional Inspiratory Oxygen Fraction (iPROVE-O2).
The iPROVE-O2 trial aims at comparing the efficacy of high and conventional FiO2 within a perioperative individualized ventilatory strategy to reduce the overall incidence of SSI.
- Conditions
- Hyperoxia, Postoperative Complication, Surgical Site Infection
- Trial name
- iPROVE-O2 (NCT02776046)
- Testing
- High FiO2, Conventional FiO2
- Where
- Spain
- Volunteers
- 756 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Hypovolemia, Hyperoxia
Supplemental Oxygen in Hypovolemia
Supplemental oxygen is frequently administered in acutely and critically ill patients, specifically, it is often administered in trauma patients to avoid arterial hypoxemia and tissue hypoxia.
- Trial name
- NCT05150418
- Testing
- Oxygen gas, Air
- Where
- Norway
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
PaO2/FiO2 Ratio
The Effect of FiO2 on PaO2/FiO2 Ratio
The PaO2/FiO2 ratio is frequently used to determine the severity of lung injury in mechanically ventilated patients. However, several mathematical models have shown that PaO2/FiO2 ratio depends on FiO2.
- Trial name
- NCT03156218
- Testing
- Modulation of FiO2
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Amsterdam UMC, location VUmc
Traumatic Brain Injury
Comparison Between Different Types of Oxygen Treatment Following Traumatic Brain Injury
The purpose of this study is to study the effects of EARLY (no more than 24 four hours from injury) administration of extra amounts of oxygen on traumatic brain injury.
- Trial name
- NCT00170352
- Testing
- Hyperbaric Oxygen Treatment (HBOT), Enhanced Oxygen Treatment (Enhanced FiO2)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Hennepin Healthcare Research Institute
Cognition
Acute Effects of Supplemental Oxygen on Memory Testing in Healthy Adult Volunteers
Forty healthy adults (i.e., not recruited with respect to any particular diagnosis) are each alternately provided with supplemental oxygen and air via nasal cannula at about 6 Liters per Minute (LPM), while completing memory…
- Trial name
- NCT06555484
- Testing
- Cross Over Assignment Supplemental Oxygen and Supplemental Air
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Inogen Inc.
Stroke, Acute
Normobaric Hyperoxia Combined With Reperfusion for Acute Ischemic Stroke
NBO is a nonpharmacological measure of neuroprotection. The purpose of our study is to evaluate the safety and efficiency of NBO（Normobaric hyperoxia) in the acute ischemic stroke patients who received endovascular treatment.
- Trial name
- NCT03620370
- Testing
- Normobaric oxygen therapy
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Capital Medical University
Cardiac Surgery
Risk of Oxygen During Cardiac Surgery Trial
The investigators will recruit and randomize 200 elective cardiac surgery patients to receive physiologic oxygenation (normoxia) or hyper-oxygenation (hyperoxia) during surgery to test the hypothesis that intraoperative…
- Trial name
- ROCS (NCT02361944)
- Testing
- Oxygen - normoxia, Oxygen - hyperoxia
- Where
- United States
- Volunteers
- 213 people
- Sponsor
- Vanderbilt University
Oxygen Toxicity, Oxidative Stress
Effect of Hydrogen Gas on Hyperbaric Oxygen Toxicity
The goal of this trial is to investigate whether adding a small fraction of hydrogen gas to an oxygen-enriched breathing mixture can reduce pulmonary oxygen toxicity (POT) in healthy and active divers from the Swedish Armed…
- Conditions
- Oxygen Toxicity, Oxidative Stress, Hyperoxia, Hyperbaric Oxygen
- Trial name
- NCT07263399
- Testing
- Inhaled Hydrogen-Enriched Oxygen Gas, Inhaled Nitrogen-Enriched Oxygen Gas
- Where
- 2 sites in Sweden
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Blekinge Institute of Technology
Response to Hyperoxia, Hypocapnia
The Role of Perioperative Ventilation (Gas Exchange) During Intrabdominal Surgery on Cognitive Function
Abdominal surgery commonly requires perioperative relaxation and therefore controlled mechanical ventilation. However, respiratory support can be associated with minor, yet clinically significant changes in blood gas content.
- Trial name
- ACDYS (NCT02267031)
- Testing
- mechanical ventilation
- Where
- Russia
- Volunteers
- 109 people
- Sponsor
- Northern State Medical University
Nervous System Diseases, Respiratory Tract Diseases
Normal Oxygenation Versus Hyperoxia in the Intensive Care Unit (ICU)
Oxygen administration is a common practice in intensive care units, although concern is growing about oxygen toxicity. The aim of the study is to access whether a rigorous maintenance of a state of normal oxygenation in…
- Conditions
- Nervous System Diseases, Respiratory Tract Diseases, Cardiovascular Diseases, Immune System Diseases
- Trial name
- OXYGEN-ICU (NCT01319643)
- Testing
- Oxygen
- Where
- Italy
- Volunteers
- 660 people
- Sponsor
- University of Modena and Reggio Emilia
Intensive Care Units
ORI2 : ORI for hyperOxia Reduction in ICU
Recently, hyperoxia has been recognized as being potentially deleterious for critically ill patients, with increased duration of mechanical ventilation and even with increased mortality rates.
- Trial name
- ORI2 (NCT02878460)
- Testing
- monitoring with ORI + SpO2, monitoring with SpO2
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Angers
Intraocular Pressure
The Response of Intraocular Pressure to Systemic Hypercapnia and Hyperoxia
The purpose of this study is to determine how intraocular pressure responds to changes in the levels of carbon dioxide or oxygen that a healthy individual inspires.
- Trial name
- NCT01325285
- Testing
- RespirAct
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Oxygen, Hyperoxemia
Cerebral Hemodynamic Effects of Oxygen and Antioxidants (CHEOXANT)
This study is called CHE-OX-ANT (Cerebral Hemodynamic Effects of Oxygen and Antioxidants). It is a single-center, academic research project led by the Department of Intensive Care at Erasme Hospital (Université Libre de…
- Conditions
- Oxygen, Hyperoxemia, Antioxidant, Cerebral Autoregulation
- Trial name
- CHEOXANT (NCT07369232)
- Testing
- Oxygen, Vitamin C (Ascorbic Acid)
- Where
- Belgium
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Erasme University Hospital
Chronic Obstructive Pulmonary Disease
Helium-Hyperoxia and 6MWT Distance in COPD
We assessed the effect of altering inspired gas on the 6MWT distance in COPD. We hypothesized that HeO2 would improve walking distance and reduce shortness of breath compared to both RA and O2, and potentially improve quality of…
- Trial name
- NCT00394225
- Testing
- Oxygen, Helium
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- University of Saskatchewan