Clinical trials: Hyperparathyroidism, Primary
Primary Hyperparathyroidism
18F-choline Positron-emission-tomography - Computed-tomography Compared to Conventional Imaging for Localizing Diseased Parathyroid Glands in Primary Hyperparathyroidism
The goal of this open, single-center, prospective, randomized, clinical study is to compare imaging with [18F]fluoromethyl-dimethyl-2-hydroxyethylammonium (18F-choline) positron-emission-tomography - computed-tomography…
- Trial name
- NCT07138820
- Testing
- Parathyroidectomy
- Where
- Sweden
- Volunteers
- 88 people
- Sponsor
- Region Skane
Primary Hyperparathyroidism Due to Adenoma
Near Infrared Autofluorescence Imaging in Minimally-Invasive Video-Assisted Parathyroidectomy (NIRAF MIVAP Study)
The role of near-infrared autofluorescence (NIRAF)-imaging as an adjunct in thyroid surgery is well established. However, its diagnostic role in hyperparathyroidism surgery is yet to be defined due to the lack of consensus…
- Trial name
- NIRAF MIVAP (NCT06779760)
- Testing
- parathyroidectomy
- Where
- Jordan
- Volunteers
- 24 people
- Sponsor
- Aristotle University Of Thessaloniki
Hyperparathyroidism, Primary, Parathyroidectomy
Alterations in Muscle's Functional Characteristics After Parathyroid Surgery for Primary Hyperparathyroidism.
Protocol title: Alterations in functional characteristics of the muscle tissue following surgery for primary hyperparathyroidism.
- Trial name
- NCT03091140
- Where
- Greece
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Parathyroid Adenomas, Hyperparathyroidism, Primary
Parathyroid Adenoma Detection With Rubidium-82 Imaging
Assess the uptake of rubidium-82 in parathyroid adenomas.
- Trial name
- PARAGON (NCT07099404)
- Testing
- PET/CT imaging with rubidium-82
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- Matthieu Pelletier-Galarneau, MD MSc
Parathyroid Adenoma, Parathyroid Neoplasms
Evaluating Impact of Near Infrared Autofluorescence (NIRAF) Detection for Identifying Parathyroid Glands During Parathyroidectomy
This study will see if the use of near infrared autofluorescence (NIRAF) detection with an FDA-cleared device 'Parathyroid Eye (PTeye)' for identifying parathyroid glands (PGs) during parathyroidectomy (PTx) procedures is better…
- Conditions
- Parathyroid Adenoma, Parathyroid Neoplasms, Parathyroid Cancer, Hypercalcemia
- Trial name
- NCT05022641
- Testing
- PTeye, Standard of Care
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- University of Michigan
Primary Hyperparathyroidism
11C Methionine PET for the Detection of Hyperfunctional Parathyroid Tissues
The overall sensitivity and specificity of 11C-MET PET/CT is superior to 18F-FDG PET/CT and conventional SPECT-CT for the detection of abnormal parathyroid glands.
- Trial name
- NCT01783002
- Testing
- 11C-Methionine PET/CT scanning, 18F-FDG PET/CT scanning, SPECT-CT scanning
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of British Columbia
Hyperparathyroidism, Parathyroid Neoplasms
A Study of an Investigational Medication for Severe Primary Hyperparathyroidism or Parathyroid Cancer
This study will assess an investigational medication for patients with severe primary hyperparathyroidism or parathyroid cancer.
- Trial name
- NCT00037518
- Testing
- AMG 073
- Volunteers
- 46 people
- Sponsor
- Amgen
Pituitary ACTH Hypersecretion, Acromegaly
Vitamin D Metabolism in Patients With Endocrine Disorders
This prospective controlled interventional study aims to reveal the diversity of vitamin D metabolism in patients with certain endocrine disorders (Cushing's disease, acromegaly, primary hyperparathyroidism, diabetes mellitus…
- Conditions
- Pituitary ACTH Hypersecretion, Acromegaly, Diabetes Mellitus, Type 1, Primary Hyperparathyroidism
- Trial name
- NCT04844164
- Testing
- Cholecalciferol 15000 UNT/ML Oral Solution
- Where
- Russia
- Volunteers
- 261 people, healthy volunteers welcome
- Sponsor
- Endocrinology Research Centre, Moscow
Parathyroid Hormone Suppression Test With Cinacalcet
Evaluation of a Cincalcet Suppression Test
The aim of the study is to compare the results of a parathyroid hormone (PTH)suppression test using a single oral tablet of cinacalcet in two groups of subjects: 1- a group of healthy adults in whom the results of the test with…
- Trial name
- NCT01103206
- Testing
- cinacalcet, cinacalcet dose 1, cinacalcet dose 2
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Hyperparathyroidism
Swalqol in Primary Hyperparathyroidism
Swallow related quality of life before and after parathyroidectomy will be evaluated in patients with primary hyperparathyridism.
- Trial name
- NCT03968510
- Testing
- parathyroidectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Uşak University
Hyperparathyroidism, Primary, Parathyroid Neoplasms
WHITE CAP: Intra-operative Parathyroid Tissue Sensor (PTS)-Guided Assessment of Parathyroid Viability and Surgical Decision-Making
Primary hyperparathyroidism is usually cured by removing the single over-active parathyroid adenoma. During surgery, however, surgeons often see a thin rim of normal parathyroid tissue that still "glows" under a near-infrared…
- Conditions
- Hyperparathyroidism, Primary, Parathyroid Neoplasms, Parathyroid Adenoma, Hypocalcemia
- Trial name
- WHITE CAP-PTS (NCT07043010)
- Testing
- Near-Infrared Parathyroid Tissue Sensor Imaging (PTS), Rim-Preservation Technique, En-bloc Resection Technique
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Fujian Medical University
Hyperparathyroidism
Serum Calcium to Phosphorous Ratio (Ca/P) as a Simple, Inexpensive Screening Tool in the Diagnosis of Primary Hyperparathyroidism
Background: Primary hyperparathyroidism (PHPT) is often overlooked and underdiagnosed. At present the diagnosis of PHPT remains challenging and is based on serum calcium (Ca) and PTH.
- Trial name
- NCT03027349
- Testing
- No intervention are provided
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- Azienda USL Modena
Hyperparathyroidism, Hypercalcemia
Studies of Elevated Parathyroid Activity
Observational Phase: Patients whose parathyroid activity is elevated above normal are referred to as having hyperparathyroidism.
- Conditions
- Hyperparathyroidism, Hypercalcemia, Parathyroid Neoplasm, Multiple Endocrine Neoplasia
- Trial name
- NCT00001277
- Testing
- 68Ga-Dotatate, 18F-DOPA
- Where
- United States
- Volunteers
- 1,553 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Primary Hyperparathyroidism
Safety, Pharmacokinetics, and Clinical Effects of Cinacalcet (AMG 073) in Primary Hyperparathyroidism
The primary objective was to assess the safety and tolerability of cinacalcet in adults with primary hyperparathyroidism (HPT) when administered as a single oral once daily doses for 6 consecutive weeks and twice daily for 15…
- Trial name
- NCT03774771
- Testing
- Cinacalcet
- Volunteers
- 48 people
- Sponsor
- Amgen
Primary Hyperparathyroidism, Bone Disease
Bone Architectural Parameters in Postmenopausal Women Affected With Primary Hyperparathyroidism
Bone lesions are frequent in primary hyperparathyroidism (PHPT). Conventional measurement by Dual-Energy X-ray Absorptiometry does not provide enough information about the bone impact of excessive parathyroid hormone (PTH)…
- Trial name
- MicrOs (NCT02539498)
- Testing
- HR-pQCT
- Where
- 3 sites in France
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Primary Hyperparathyroidism
Diagnostic Performance of [11C]Choline PET/CT In the Preoperative Assessment of Primary Hyperparathyroidism
Primary hyperparathyroidism (HPT) ranks as the third most common endocrine disorder, characterized by excessive secretion of parathormone (PTH), a hormone crucial for regulating calcium and phosphorus metabolism within the body.
- Trial name
- NCT06647966
- Testing
- PET/CT
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS San Raffaele
Parathyroid Adenoma, Hyperparathyroidism
Trial Comparing 2 Diagnostic Strategies for Preoperative Localization of Parathyroid Adenoma in Primary Hyperparathyroidism:TEMP / CT With Tc99m-sestaMIBI or PET / CT With F18-choline in First Intention
The investigators hypothesize that positron emission tomography with fluorocholline (F18-choline PET) will reduce the proportion of unnecessary invasive surgery decisions and that the higher cost of positron emission tomography…
- Conditions
- Parathyroid Adenoma, Hyperparathyroidism, F18-choline
- Trial name
- APACH2 (NCT04040946)
- Testing
- MIBI scintigraphy, F18-choline PET
- Where
- 4 sites in France
- Volunteers
- 59 people
- Sponsor
- Centre Francois Baclesse
Primary Hyperparathyroidism Due to Adenoma
Intraoperative Identification of Parathyroid Adenomas Using PTeye™ and FLUOBEAM® LX: a Prospective Cohort Study
The goal of this observational study is to evaluate the efficacy of PTeyeTM device to confirm a parathyroid adenoma on a visually suspected tissue in comparison with the FLUOBEAM®LX device.
- Trial name
- PTeye (NCT06788223)
- Testing
- Parathyroidectomy
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- Aristotle University Of Thessaloniki
Primary Hyperparathyroidism, Primary Hyperparathyroidism Due to Adenoma
A Retrospective Analysis of the Diagnostic Performance of 11C-choline PET/CT in Primary Hyperparathyroidism
The leading cause of primary hyperparathyroidism (pHPT) is a solitary adenoma (89%). The treatment of pHPT is generally surgical removal of the overactive parathyroid gland(s).
- Trial name
- NCT04608253
- Testing
- 11C-choline PET/CT
- Volunteers
- 36 people
- Sponsor
- University Medical Center Groningen
Hyperparathyroidism, Primary, Osteoporosis
The Bone-parathyroid Crosstalk in Primary Hyperparathyroidism
The PARABONE study aims to investigate the interaction between bone and parathyroid glands in patients with primary hyperparathyroidism (HPT).
- Conditions
- Hyperparathyroidism, Primary, Osteoporosis, Parathyroid Neoplasms
- Trial name
- PARABONE (NCT05556499)
- Testing
- Biomarker assays
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio