Clinical trials: Hypersensitivity, Food
Allergy, Peanut
Study of Efficacy, Safety and Tolerability of Remibrutinib in Adult Participants With an Allergy to Peanuts
A study to evaluate the safety, efficacy and tolerability of remibrutinib at three doses versus placebo in adult participants who have a confirmed allergy to peanuts.
- Trial name
- NCT05432388
- Testing
- LOU064
- Where
- 24 sites in United States
- Volunteers
- 76 people
- Sponsor
- Novartis Pharmaceuticals
Food Hypersensitivity
Omalizumab for the Treatment of Food Allergy in Patients With Elevated Total IgE Levels
In this project, the investigators would like to learn if 24 weeks (about 5 and a half months) of omalizumab injections, given every 2 weeks, will be safe and effective for food allergic people who have a total immunoglobulin E…
- Trial name
- NCT06934200
- Testing
- Omalizumab
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Johns Hopkins University
Food Protein-Induced Enterocolitis Syndrome
Immunologic Basis of Food Protein-Induced Enterocolitis Syndrome
This is a phase I multicenter clinical trial that aims to find the optimal dose for conducting a novel low-dose, multi-day oral food challenge (OFC) protocol for diagnosing food protein-induced enterocolitis syndrome (FPIES).
- Trial name
- INFINITY (NCT06683521)
- Testing
- Supervised Low-Dose Oral Food Challenge (OFC), At-Home Low-Dose Oral Food Challenge (OFC), Supervised High-Dose Oral Food Challenge (OFC)
- Where
- 2 sites in United States
- Volunteers
- 72 people
- Sponsor
- NYU Langone Health
Hypersensitivity, Food Allergy
Clinical Study Using Biologics to Improve Multi OIT Outcomes (COMBINE)
Food allergy is a serious public health concern that causes potentially-life threatening reactions in affected patients. The prevalence of food allergy in the United States (U.S.) has increased substantially and now affects 15…
- Conditions
- Hypersensitivity, Food Allergy, Hypersensitivity, Food, Peanut Hypersensitivity
- Trial name
- NCT03679676
- Testing
- Omalizumab, Dupilumab
- Where
- 3 sites in United States
- Volunteers
- 130 people
- Sponsor
- Stanford University
Allergic Diseases, Food Allergy
Systems Biology of Early Atopy
The goal of this study is to establish a birth cohort that collects prenatal and early life biosamples and environmental samples and rigorously phenotypes young children for food allergy and Atopic Dermatitis (AD) to identify…
- Conditions
- Allergic Diseases, Food Allergy, Atopic Dermatitis
- Trial name
- SUNBEAM (NCT04798079)
- Where
- 13 sites in United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Food Allergy in Children, Food Allergy Peanut
Pathway to Peanut Tolerance
While rigorous clinical trials have established peanut OIT as a promising therapy capable of inducing desensitization and even remission, its transition to routine clinical practice requires robust real-world evidence.
- Trial name
- NCT07592780
- Testing
- Peanut Oral Immunotherapy (OIT)
- Where
- Hong Kong
- Volunteers
- 125 people
- Sponsor
- Chinese University of Hong Kong
Allergy to Peanut
Predictors of Persistent Peanut Allergy at Age 5 Years
The purpose of this study is to determine if avoidance of peanut by children with positive allergy testing to peanut in the first 5 years of life increases the likelihood of developing a persistent peanut allergy by age 5 years.
- Trial name
- NCT02497261
- Volunteers
- 200 people
- Sponsor
- University of Manitoba
Food Allergy in Children, Food Allergy
Boiled Tree Nut for Oral Immunotherapy in Food-allergic Children
As the global prevalence of food allergy steadily increases, tree nut (TN) becomes one of the main triggers of food-allergic reactions and food anaphylaxis.
- Trial name
- NCT06467994
- Testing
- Cashew oral immunotherapy
- Where
- Hong Kong
- Volunteers
- 75 people
- Sponsor
- Chinese University of Hong Kong
Type 1 Diabetes, Asthma
EmoTIChealth: Promoting Adolescent Health Through a Serious Game.
The intervention program targets adolescents between 12 and 16 years of age. The intervention program is designed for adolescents during a critical developmental stage marked by significant life transitions, where building strong…
- Conditions
- Type 1 Diabetes, Asthma, Allergic Rhinitis, Food Allergy
- Trial name
- NCT07212530
- Testing
- EmoTIChealth
- Where
- Spain
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Food Allergy, Food Allergy in Infants
The Egg Up Trial - Testing a New Treatment Pathway for Infants With Newly Diagnosed Egg Allergy
The goal of this study is to test the safety and feasibility of a change in management approach for infants with newly diagnosed egg allergy.
- Trial name
- NCT06273605
- Testing
- Egg Ladder
- Where
- Australia
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Murdoch Childrens Research Institute
Food Allergy, Cow Milk Allergy
Stepwise Heat-Denaturated Protein Introduction for Tolerance Induction in Food Allergy
This interventional study aims to validate an early heated protein introduction protocol in cow's milk allergic children who already developed tolerance towards extensively heated cow's milk, in order to speed up the development…
- Trial name
- TEHITI (NCT06380673)
- Testing
- Implementation of cow's milk in decreasingly heated forms, Implementation of heated cow's milk, No intervention
- Where
- 5 sites in Belgium
- Volunteers
- 90 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Food Hypersensitivity, Immune System Diseases
Oral Immunotherapy in Food Allergy in Finland
The outcomes of oral immunotherapy (OIT) in food allergy study will provide more knowledge of oral immunotherapy. So far the OIT has showed in clinical experiments to be a interesting way to increase the unresponsiveness in…
- Conditions
- Food Hypersensitivity, Immune System Diseases, Anaphylaxis
- Trial name
- NCT02640014
- Testing
- Milk
- Where
- Finland
- Volunteers
- 250 people
- Sponsor
- Helsinki University Central Hospital
Food Allergy, Anaphylaxis
PK/PD Study of IN-001 Sublingual Spray in Healthy Adults
This is an open-label, three-part study to assess the pharmacokinetics (PK) and pharmacodynamics (PD) of epinephrine administered as a single dose of L-dipivefrin (IN-001) sublingual spray or drop in healthy adults.
- Conditions
- Food Allergy, Anaphylaxis, Food Hypersensitivity, Food Allergy Peanut
- Trial name
- NCT07210320
- Testing
- Epinephrine Auto-Injector 0.3 mg/0.3 mL, Epinephrine 0.3 mg intramuscular manual injection via a syringe and needle, IN-001 9.06 mg Sublingual Spray
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Insignis Therapeutics, Inc.
Food Allergy
Multi OIT to Test Immune Markers After Minimum Maintenance Dose
Few studies have been conducted to optimize safety of multiple food allergen oral immunotherapy (OIT) in conjunction with Omalizumab as well as to identify the immunological mechanism(s) underlying any long-lasting effects of…
- Trial name
- NCT03181009
- Testing
- Omalizumab, Food Flour Allergens
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Andrew Long, PharmD
Allergy;Food, Allergy to Shrimp
Food Allergen OIT for Shrimp and Cashew
A prospective Phase 2, single-center, single-allergen OIT of cashew or shrimp in participants with proven allergies to either cashew or shrimp, respectively.
- Conditions
- Allergy;Food, Allergy to Shrimp, Allergy to Cashew Nut (Disorder)
- Trial name
- MOTIF (NCT03504774)
- Testing
- Cashew or Shrimp Oral Immunotherapy
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Sayantani B. Sindher
Allergy;Food, Adherence, Treatment
The Food Allergy Superheroes Training (FAST) Program
Among children with a food allergy, strict avoidance (e.g., elimination of allergenic foods from one's diet) is the only intervention capable of preventing potentially devastating health-related sequelae including anaphylaxis and…
- Conditions
- Allergy;Food, Adherence, Treatment, Child, Only
- Trial name
- NCT04400214
- Testing
- Food Allergy Superheroes Training (FAST) Program, Food Allergy Knowledge Intervention
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Kent State University
Food Allergy in Children
Nutritional and Anthropometric Characteristics of Children With Food Allergy
This observational study evaluates the nutritional habits and anthropometric measurements of children aged 0-6 years with food allergy (FA). Children with FA (case group) and healthy children (control group) were included.
- Trial name
- NCT07530861
- Where
- Turkey (Türkiye)
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Peanut Allergy
Food Oral Immunotherapy for Peanut Allergy
This is an open label observational single center study of clinical food oral immunotherapy outcomes with biomarker samples and participant and/or caregiver-completed questionnaires in participants between 6 months and 65 years…
- Trial name
- NCT04222491
- Testing
- Peanut oral immunotherapy
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Massachusetts General Hospital
Food Allergy Suspected
Comparison of Skin Prick Testing, Extract-specific IgE Antibody Testing and Component Resolved Diagnosis in Diagnosing of Legume Allergy
The study is aimed at improving the diagnosis of food allergy, specifically allergy to commonly consumed legumes such as peas, lentils, chickpeas or green beans.
- Trial name
- CRD (NCT06923878)
- Where
- Czechia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital Pilsen
IgE Mediated Food Allergy
Impact of the Therapeutic Education on the Quality of Life of the Child Suffering of Food Allergy IgE-mediated
The purpose of the study is to determine whether therapeutic education can improve the quality of life of the child from 8 to 12 years old suffering of food allergy.
- Trial name
- EducAA (NCT02106169)
- Testing
- Therapeutic education group
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris