Clinical trials: Hypersensitivity Dentin
Dentin Sensitivity
A Real-World Evidence Study Evaluating Oral Health Related Quality Of Life With Use Of A Stannous Fluoride Anti-Sensitivity Toothpaste For Dentin Hypersensitivity Management
This study will evaluate the impact of long-term use of a desensitizing toothpaste containing 0.454 percent (%) stannous fluoride (SnF2) on oral health related quality of life (OHrQoL) in a population of self-reported dentin…
- Trial name
- NCT06045026
- Testing
- Stannous fluoride
- Where
- United States
- Volunteers
- 536 people
- Sponsor
- HALEON
Dentin Hypersensitivity
The Efficacy of a Toothpaste to Reduce Sensitivity
Hypersensitivity
- Trial name
- NCT00763269
- Testing
- Triclosan, Silicon dioxide, fluoride, Triclosan, fluoride
- Where
- United States
- Volunteers
- 626 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Dentin Sensitivity
Exploratory Clinical Study to Investigate the Ability of an Experimental Combination Dentifrice to Protect Sensitive Teeth
This proof of principle (PoP) study will evaluate the ability of an experimental combination toothpaste formulation to protect sensitive teeth from dentine hypersensitivity.
- Trial name
- NCT05243745
- Testing
- 3% PVM/MA + 5% KNO3 Combination, 3% PVM/MA only, 5% KNO3 Only
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- HALEON
Dentin Sensitivity
Effects of an Oxalate Containing Product on Dentinal Hypersensitivity With Dental Prophylaxis
This study will assess sensitivity during a dental prophylaxis with or without the use of a potassium oxalate salt solution.
- Trial name
- NCT02481557
- Testing
- Oxalate Salt Solution
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Dental Hypersensitivity
Dentin Hypersensitivity Reduction Efficacy Clinical
The objective of this study is to assess clinical efficacy of a toothpaste containing stannous fluoride (Colgate-Palmolive Company, New York, NY, USA) to provide dental hypersensitivity relief (tactile and air blast) in…
- Trial name
- NCT07738198
- Testing
- 0.454% stannous fluoride toothpaste, 5% potassium nitrate, 0.76% sodium monofluorophosphate
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Dentin Hypersensitivity
A Study Evaluating Oral-Health-Related Quality of Life and Treatment Patterns Among Dentin Hypersensitivity Sufferers
The primary purpose of this study is to characterize changes in Oral-Health-Related Quality of Life (OHrQoL), as measured by the Dentin Hypersensitivity Experience Questionnaire (DHEQ) over a 12-month period.
- Trial name
- NCT07337109
- Where
- United States
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- HALEON
Dentin Sensitivity
Efficacy of Two Experimental Oral Rinses in Providing Long Term Relief From Dentinal Hypersensitivity
This study will investigate the longitudinal efficacy of two experimental oral rinses containing 1.5% weight/weight (w/w) dipotassium oxalate monohydride (KOX), formulated at pH 4.5 and pH 7 respectively, for the relief of…
- Trial name
- NCT02542943
- Testing
- Experimental Oral Rinse 1, Experimental Oral Rinse 2, Standard fluoride toothpaste
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dentin Sensitivity
The Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity(DH)
This single centre, comparative design study will be used to investigate the efficacy of an experimental stannous fluoride containing dentifrice in relieving dentinal hypersensitivity (DH) after short term use compared with a…
- Trial name
- NCT02751450
- Testing
- Stannous Fluoride dentifice, Sodium Monofluorophosphate dentifrice
- Where
- United Kingdom
- Volunteers
- 263 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dentin Sensitivity
A Study of the Relief of Tooth Sensitivity of an Experimental Mouthrinse Device
This study is for people with sensitive teeth and involves going to the dentist for 4 visits over 6 weeks. During the first 2 weeks, you will just brush your teeth two times a day with the fluoride toothpaste provided.
- Trial name
- NCT01345292
- Testing
- Mouthwash, Potassium nitrate toothpaste, Sodium fluoride toothpaste
- Where
- United States
- Volunteers
- 226 people
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Dentin Sensitivity
A Study to Investigate Efficacy of Two Experimental Oral Rinses in Providing Long Term Relief From Pain Derived From Exposed Dentine in Response to Chemical, Thermal, Tactile, or Osmotic Stimuli.
This will be a single center, eight week, randomized, double blind, three treatment arm, parallel design, stratified (by mean baseline Schiff Sensitivity Score of the two selected test teeth) study in healthy participants.
- Trial name
- NCT02651467
- Testing
- Experimental Oral Rinse 1 (1.5% w/w KOX, 0ppm F, pH 7.0), Experimental Oral Rinse 2 (2.0% w/w KOX, 45ppm F, pH 4.5)
- Where
- United States
- Volunteers
- 221 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dentin Hypersensitivity
A Study to Investigate the Tooth Whitening and Dentin Hypersensitivity Effectiveness of Two Experimental Toothpastes
The aim of this exploratory clinical study is to investigate the tooth whitening potential, Dentin Hypersensitivity (DH) efficacy, and oral tolerability of two experimental toothpastes in a DH population with appropriate tooth…
- Trial name
- NCT07297732
- Testing
- Test Toothpaste 1, Test Toothpaste 2, Reference Toothpaste
- Where
- United States
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- HALEON
Caries, Dental, Tooth Decay
Efficacy of Solventum™ Vitrebond™ Pulp Protect Liner/Base Used as a Liner/Base Under Dental Restorations
This is a clinical study evaluating a new dental product called Solventum™ Vitrebond™ Pulp Protect Liner/Base. This new product is designed to be used as a liner or base between the tooth and the dental filling, as well as for a…
- Conditions
- Caries, Dental, Tooth Decay, Dental Decay, Tooth Sensitivity
- Trial name
- NCT07261137
- Testing
- Vitrebond™ Pulp Protect Liner/Base, Vitrebond™ Plus (comparator)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Solventum US LLC
Dentine Hypersensitivity, Dental Pain
Dose Response of a Tubule Occlusion Agent
To evaluate the efficacy of two different concentrations of a tubule occlusion agent - calcium sodium phosphosilicate in treatment of dentine hypersensitivity
- Trial name
- NCT01075256
- Testing
- 5% calcium sodium phosphosilicate toothpaste, 7.5% calcium sodium phosphosilicate toothpaste
- Where
- United States
- Volunteers
- 195 people
- Sponsor
- GlaxoSmithKline
Dentinal Hypersensitivity
Dentinal Hypersensitivity Reduction
The objective of this clinical study is to assess the efficacy of a dentifrice containing stannous fluoride (Colgate-Palmolive Company, New York, NY, USA) as compared to a commercially-available potassium-based toothpaste…
- Trial name
- NCT06244290
- Testing
- Colgate SNF, Sensodyne Extra Whitening, Colgate Fluoride (CDC)
- Where
- United States
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Dentinal Sensitivity, Dentinal Hypersensitivity
Comparative Efficacy of Different Dentin Occluding Toothpaste Technologies
The purpose of this clinical study is to evaluate and compare how well three different types of toothpaste technologies work to relieve tooth sensitivity, also known as dentin hypersensitivity.
- Trial name
- SENSBZ (NCT07664592)
- Testing
- 8% arginine + Zinc toothpaste, 5% Calcium Sodium Phosphosilicate toothpaste, 8% arginine toothpaste
- Where
- Brazil
- Volunteers
- 132 people
- Sponsor
- Colgate Palmolive
Dentine Hypersensitivity
Efficacy of Potassium Nitrate Solution in Reducing Dentinal Hypersensitivity
An exploratory study investigating the direct application of potassium nitrate (KNO3) solutions of different concentrations in reducing dentine hypersensitivity.
- Trial name
- NCT01115452
- Testing
- 5% Potassium nitrate, 2.5% Potassium nitrate, Sterile water
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- GlaxoSmithKline
Dentine Hypersensitivity
Study to Investigate the Effect of Changes in Dentinal Hypersensitivity on Oral Health Parameters
This exploratory study will investigate the effect of long-term management of Dentine Hypersensitivity (DH) by use of a sensitivity toothpaste on selected oral health parameters, such as changes in oral hygiene (as measured by…
- Trial name
- NCT07768969
- Testing
- Test Toothpaste
- Where
- United Kingdom
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- HALEON
Dentin Hypersensitivity
Clinical Study to Investigate the Antihypersensitivity Efficacy of a Novel Dentifrice
The aim of this clinical study is to demonstrate the superior antihypersensitivity efficacy of a novel stannous fluoride (SnF2) and potassium nitrate (KNO3) dentifrice (Investigational Product), compared to SnF2 only, KNO3 only…
- Trial name
- NCT07215767
- Testing
- Stannous fluoride and Potassium nitrate Dentifrice, Stannous fluoride Dentifrice, Potassium nitrate Dentifrice
- Where
- 3 sites in United States
- Volunteers
- 688 people, healthy volunteers welcome
- Sponsor
- HALEON
Dentine Hypersensitivity
The Efficacy of a Dentifrice in Providing Relief From the Pain of Dentinal Hypersensitivity
A study to compare the efficacy of a test dentifrice against a control dentifrice in reducing dentinal hypersensitivity over an eight week treatment period.
- Trial name
- NCT01592864
- Testing
- Stannous Fluoride, Sodium Monofluorophosphate
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dentin Sensitivity
Study to Investigate the Efficacy of an Occluding Dentifrice in Providing Relief From Dentine Hypersensitivity
This will be a single centre, two week, randomised, examiner blind, two treatment arm, parallel design, stratified (by maximum baseline Schiff sensitivity score of the two selected test teeth), controlled study, in participant…
- Trial name
- NCT02773758
- Testing
- Stannous Fluoride Dentifrice, Sodium monofluorophosphate Dentifrice
- Where
- Canada
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline