Clinical trials: Hypersensitivity Reactions
Severe Asthma
Follow-up of Children With Severe Asthma at Adult Age
Most of clinical cohorts focused on the course of asthma over time and on the different phenotypes of asthma have investigated children and adults separately. The passage from childhood to adulthood is scarcely explored.
- Trial name
- S2AEA (NCT05032209)
- Testing
- follow-up of children with severe asthma in adulthood
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COPD, Asthma
Participatory Action Research to Evaluate the Delivery of the MISSION ABC Service Model and Assess Health Service and Clinical Outcomes
Innovations aimed at improving new patient identification, diagnosis, nonpharmacological treatment, supported self-management, and remote monitoring, together with new methods of clinical support could improve outcomes in…
- Conditions
- COPD, Asthma, Breathlessness
- Trial name
- NCT03096509
- Testing
- MISSION ABC Integrated Care clinic
- Where
- United Kingdom
- Volunteers
- 342 people
- Sponsor
- Portsmouth Hospitals NHS Trust
Chronic Spontaneous Urticaria (CSU), Chronic Idiopathic Urticaria
A Study to Assess the Efficacy and Safety of THB335 in Adults With Chronic Spontaneous Urticaria (CSU)
THB335-201 is a Phase 2, randomized, double-blind, placebo-controlled, parallel-group, multicenter study in adults with CSU who remain symptomatic despite standard-of-care treatment.
- Trial name
- NCT07766499
- Testing
- THB335 Lower Dose, THB335 Higher Dose
- Volunteers
- 81 people
- Sponsor
- Calixis Inc.
Dermatitis, Atopic, Eczema
Comparative Study of Crisaborole vs. Tacrolimus in Atopic Dermatitis
This study will compare the efficacy and safety of crisaborole ointment with tacrolimus ointment, in the treatment of patients with mild-to-moderate atopic dermatitis.
- Trial name
- NCT07367932
- Testing
- Application of crisaborole twice daily, Tacrolimus ointment in atopic dermatitis
- Volunteers
- 30 people
- Sponsor
- Cairo University
Allergy
Direct Oral Challenges in Private Practice Setting to Delabeling Children With Beta-lactam Allergy
The purpose of this study is to demonstrate the feasibility of direct oral challenge performed in private practice setting for children with suspected benign delayed allergy to beta-lactams.
- Trial name
- Betalactaville (NCT07002814)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Asthma
Study of Oglemilast for the Treatment of Asthma
The purpose of this study is to determine whether oglemilast is safe and effective in the treatment of allergen-induced asthma.
- Trial name
- NCT00322686
- Testing
- Oglemilast
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Forest Laboratories
Asthma, COPD
Prehospital Emergency Care of Obstructive Respiratory Emergencies With the Use of Teleconsultation
The aim of the study is to investigate the quality of prehospital emergency care in acute respiratory emergencies, when paramedics are supported telemedically by an EMS physician.
- Trial name
- NCT01644045
- Testing
- Teleconsultation
- Where
- Germany
- Volunteers
- 17 people
- Sponsor
- RWTH Aachen University
Bronchial Asthma
Antiepileptic Drug Carbamazepine in Treatment of Bronchial Asthma
The purpose of this study was evaluation the efficacy of antiepileptic drug carbamazepine in the treatment of mild-to-severe bronchial asthma.
- Trial name
- NCT00207428
- Testing
- Carbamazepine
- Volunteers
- 65 people
- Sponsor
- Centre of Chinese Medicine, Georgia
Asthma
BI 443651 Methacholine Challenge
The primary objective of this study is to investigate safety and tolerability of three consecutive administrations, 12 hours apart, at three different dose-levels of BI 443651 administered via oral inhalation in male and female…
- Trial name
- NCT03135899
- Testing
- BI 443651
- Where
- United Kingdom
- Volunteers
- 37 people
- Sponsor
- Boehringer Ingelheim
Seasonal Allergic Rhinitis
Can a Nasal Decongestant Test Predict Treatment Outcomes in Seasonal Allergic Rhinitis?
We hypothesize that those patients with purely seasonal allergic rhinitis will decongest better than those subjects with another cause contributing to their symptoms.
- Trial name
- NCT00618332
- Testing
- mometasone furoate nasal spray
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Chicago
Asthma, Obesity
Contributing Factors in the Pathobiology of Airway Remodeling in Obesity
There are two aims for this study. The purpose of this study is to determine the effects of body weight and hormones on airway fibrosis (scarring) and lung function in obese \& lean asthma subjects compared to obese \& lean…
- Conditions
- Asthma, Obesity, Obesity, Morbid, Bariatric Surgery Candidate
- Trial name
- NCT03115632
- Where
- 2 sites in United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Duke University
Food Allergy
Multi Immunotherapy to Test Tolerance and Xolair
This is a phase 2 randomized, double-blind, placebo controlled study which will be conducted at multiple centers in the U.S. All subjects will receive oral immunotherapy for their specific food allergies (limited to 5 of those…
- Trial name
- M-TAX (NCT02626611)
- Testing
- Omalizumab, Food Flour Buildup
- Where
- 7 sites in United States
- Volunteers
- 70 people
- Sponsor
- Kari Christine Nadeau
Asthma
Outcomes in Patients Taking Fluticasone Propionate/Salmeterol Combination or Other Inhaled Corticosteroids
The objective of this study is to compare healthcare utilization and costs in asthma patients who receive fluticasone propionate/salmeterol combination 100mcg/50mcg ("FSC 100/50") or inhaled corticosteriods in typical clinical…
- Trial name
- NCT01332344
- Testing
- Fluticasone propionate/salmeterol combination, Inhaled corticosteroids
- Volunteers
- 5,180 people
- Sponsor
- GlaxoSmithKline
Sarcoidosis, Rickettsia Infections
Rickettsial Genesis to Sarcoidosis in Denmark
One study has suggested a connection between an infection with Rickettsia species and sarcoidosis finding molecular evidence of rickettsial deoxyribonucleic acid (DNA) in two patients.
- Trial name
- NCT00326534
- Where
- Denmark
- Volunteers
- 36 people
- Sponsor
- Statens Serum Institut
Asthma
Study Evaluating the Safety and Effects of MN-221 in Subjects With Moderate to Severe Asthma
The purpose of this study is to evaluate the safety and tolerability of MN-221 at two different dosing rates administered through a continuous infusion in subjects diagnosed with moderate to severe asthma.
- Trial name
- NCT00679263
- Testing
- MN-221
- Where
- 4 sites in United States
- Volunteers
- 17 people
- Sponsor
- MediciNova
Asthma, Wheeze
The Development of Novel Clinical Tests to Diagnose and Monitor Asthma in Preschool Children
The study will ascertain the ability of preschool lung function tests to distinguish healthy children from those with wheeze, and to differentiate phenotypes of wheezy children (high and low risk for asthma as defined by API) in…
- Conditions
- Asthma, Wheeze, Obstructive Sleep Apnea, Food Allergy
- Trial name
- WheezyER (NCT02743663)
- Testing
- Bronchodilator response, Allergy Skin Test, Multiple-Breath Washout
- Where
- Canada
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Allergic Rhinitis, Sleep Disorder
Establishing the Collaborative Care Model for Pediatric Allergic Rhinitis With Sleep Disorder
The purpose of study is to compared the impact of the integrative care clinic to ordinary western medicine among patients of moderate persistent allergic rhinitis combined with sleep disorder and establishing the collaborative…
- Trial name
- NCT05031793
- Testing
- TCM, Western medicine
- Where
- Taiwan
- Volunteers
- 35 people
- Sponsor
- China Medical University Hospital
Asthma
Study of Physiopathological Mechanisms and Results of Treatment With Bronchial Thermoplasty in Severe Asthma
The purpose of this study is to evaluate clinical and histological response to bronchial thermoplasty in severe asthma patients.
- Trial name
- NCT01974921
- Testing
- ALAIR Catheter. Radiofrequency system.
- Where
- Spain
- Volunteers
- 15 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Asthma, Chronic Obstructive Pulmonary Disease
PK of BDP/FF/GB Single-inhaler Triple Therapy in Japanese vs. Caucasians
The purpose of conducting this study is to obtain PK data of Beclometasone Dipropionate (BDP)/Beclometasone-17-MonoPropionate (B17MP), Formoterol Fumarate (FF) and Glycopyrronium Bromide (GB) after inhalation of CHF 5993 in…
- Trial name
- NCT03859414
- Testing
- Therapeutic Dose 1, Therapeutic Dose 2, Supra-therapeutic Dose
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Chiesi Farmaceutici S.p.A.
Asthma
The Study of Soy Isoflavones in Asthma
The trial is designed to study the effects of soy supplements on asthma control.
- Trial name
- SOYA (NCT01052116)
- Testing
- Soy isoflavone supplement
- Where
- 18 sites in United States
- Volunteers
- 386 people
- Sponsor
- American Lung Association Asthma Clinical Research Centers