Clinical trials: Hypertension, Pregnancy Induced
Pre-Eclampsia, Asymptomatic Bacteriuria
Prevalence of Asymptomatic Bacteriuria Among Pregnant Women With Pre-eclampsia in Women Health Hospital Assiut University
Pre-eclampsia is a hypertensive disorder of pregnancy that can lead to significant health complications for both the mother and the fetus.
- Trial name
- NCT07866196
- Volunteers
- 129 people
- Sponsor
- Assiut University
Venous Thromboembolism, Postpartum Period
Pilot PARTUM Trial: Postpartum Aspirin to Reduce Thromboembolism Undue Morbidity
The pilot PARTUM trial is a randomized, multicenter, placebo-controlled trial. Women who are at modest risk of VTE (as defined by the inclusion criteria) will be identified during pregnancy, labor and delivery and up to 48 hours…
- Conditions
- Venous Thromboembolism, Postpartum Period, Aspirin
- Trial name
- PARTUM (NCT04153760)
- Testing
- Aspirin 81 mg
- Where
- 7 sites in Canada, France and 2 more
- Volunteers
- 257 people
- Sponsor
- University of Calgary
Postpartum Preeclampsia
Postpartum Preeclampsia Early Detection and Treatment: Nepal Pilot Study
The goal of this study is to address the significant morbidity associated with preeclampsia diagnosed after delivery. All participants will undergo biomarker evaluation with soluble fms-like tyrosine kinase-1 and placental growth…
- Trial name
- PREDiCT-NPL (NCT07185204)
- Testing
- Early detection and management of postpartum preeclampsia bundle
- Where
- 2 sites in United States, Nepal
- Volunteers
- 60 people
- Sponsor
- Medical College of Wisconsin
Preeclampsia
Inflammatory Markers in Preeclampsia
This is an investigation of inflammatory markers in women destined to develop preeclampsia.
- Trial name
- NCT01385813
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Preeclampsia, Pregnancy Biomarker
MATERNAL SERUM CADHERİN-6 AS A PREDİCTOR OF PREECLAMPSİA
Preeclampsia is a pregnancy-specific hypertensive disorder that remains one of the leading causes of maternal and perinatal morbidity and mortality worldwide.
- Conditions
- Preeclampsia, Pregnancy Biomarker, Cadherin-6
- Trial name
- NCT07467226
- Testing
- Maternal serum cadherin-6 measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Samsun University
Pre-Eclampsia, Gestational Diabetes
Lifestyle Intervention for Women With Recent Pre-eclampsia or Gestational Diabetes Mellitus ('Mom's Healthy Heart')
The aim of this pilot intervention study is to develop and test a tailored web-based lifestyle modification program for women with recent preeclampsia or gestational diabetes. Women will start the study 3-15 months postpartum.
- Trial name
- NCT03993145
- Testing
- Web-based lifestyle intervention
- Where
- 2 sites in Norway
- Volunteers
- 44 people
- Sponsor
- Norwegian University of Science and Technology
Intrauterine Growth Restriction, Preeclampsia
Low Dose Aspirin for Preventing Intrauterine Growth Restriction and Preeclampsia in Sickle Cell Pregnancy (PIPSICKLE)
Pregnancy in sickle cell disease (SCD) is fraught with many complications including preeclampsia (PE) and intrauterine growth restriction (IUGR).
- Conditions
- Intrauterine Growth Restriction, Preeclampsia, Sickle Cell Disease, Pregnancy Complications
- Trial name
- PIPSICKLE (NCT05253781)
- Testing
- Low-dose aspirin
- Where
- 16 sites in Nigeria
- Volunteers
- 476 people, healthy volunteers welcome
- Sponsor
- University of Lagos, Nigeria
Hypertension
Cardiac Effects of Mineralocorticoid Receptor Antagonism After Hypertensive Disorders of Pregnancy
The goal of this clinical trial is to determine if the medication eplerenone yields greater improvements in coronary microvascular function than chlorthalidone in women who experienced hypertension during pregnancy and…
- Trial name
- CARDAMOM (NCT07238400)
- Testing
- Eplerenone 100 mg daily, Chlorthalidone 25 mg daily, Potassium Chloride
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Massachusetts General Hospital
Pre-Eclampsia
Role of Anti-C1q Autoantibodies in Pregnancy
Preeclampsia (PE) is a very frequent obstetric complication. C1q, the first recognition molecule of the classical pathway of complement system (C), represents a double-edged molecule in determining pregnancy outcomes.
- Trial name
- NCT06317467
- Testing
- Blood sampling
- Where
- Italy
- Volunteers
- 54 people
- Sponsor
- IRCCS Burlo Garofolo
Gestational Diabetes Mellitus (GDM), Pregnancy Induced Hypertension (PIH)
mHealth Integrated Model of Hypertension, Diabetes and Antenatal Care in India and Nepal
Our research aims to address a critical gap in the provision of quality antenatal care (ANC) in India and Nepal, by developing and evaluating an intervention comprising of a tablet-based electronic decision support system (EDSS).
- Conditions
- Gestational Diabetes Mellitus (GDM), Pregnancy Induced Hypertension (PIH), Anemia
- Trial name
- NCT03700034
- Testing
- mHealth Integrated Model of Antenatal Care
- Where
- 6 sites in India, Nepal
- Volunteers
- 1,320 people, healthy volunteers welcome
- Sponsor
- Public Health Foundation of India
Pregnancy; Pre-eclampsia, Mild
Role of Placental Growth Factor (PlGF) in the Management of Non-Severe Preeclampsia
Preeclampsia is an important disease that develops during pregnancy and it is one of the main contributors to maternal and fetal complications. The only known definitive treatment is delivery.
- Trial name
- MAP (NCT02373839)
- Testing
- Measurement of PlGF
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Fetal Medicine Research Center, Spain
sFlt1 Mediated Preterm Preeclampsia, Preeclampsia
A Study to Investigate the Safety, Pharmacodynamic and Pharmacokinetic Characteristics of CBP-4888 in Hospitalized Participants With Preterm Preeclampsia and Their Children up to 24 Months
This study is a dose finding study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of subcutaneous CBP-4888 in hospitalized participants with Preterm Preeclampsia receiving Standard of Care, Expectant…
- Conditions
- sFlt1 Mediated Preterm Preeclampsia, Preeclampsia, Preterm Preeclampsia
- Trial name
- NCT07282171
- Testing
- CBP-4888
- Where
- 3 sites in Australia
- Volunteers
- 60 people
- Sponsor
- Comanche Biopharma
Hypertension in Pregnancy
Mindfulness & Mechanisms Study
Hypertensive disorders of pregnancy (HDP) are the most common medical condition affecting pregnancy and a leading cause of maternal morbidity and mortality in the Unites States.
- Trial name
- NCT04626245
- Testing
- Mindfulness training
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Lifespan
Pre-eclampsia, Pregnancy, High Risk
Placental Growth Factor Assessment of Women With Suspected Pre-eclampsia
The primary aim is to establish the effectiveness of plasma PlGF measurement in reducing maternal morbidity (with assessment of perinatal safety in parallel) in women presenting with suspected pre-eclampsia prior to 37 weeks'…
- Conditions
- Pre-eclampsia, Pregnancy, High Risk, Pregnancy Complications
- Trial name
- PARROT (NCT02881073)
- Testing
- Maternal plasma PlGF quantification
- Where
- 7 sites in Ireland
- Volunteers
- 2,313 people
- Sponsor
- Irish Centre for Fetal and Neonatal Translational Research
Preeclampsia
Placental Expression of EG-VEGF and Its PROKR1 and PROKR2 Receptors in Preeclampsia Patients.
The pathophysiology of preeclampsia (PE) is thought to be endothelial dysfunction responsible for the maternal signs of de novo hypertension and proteinuria after 20 weeks.
- Trial name
- PRE-EVE (NCT04846686)
- Testing
- Placenta pathological examination
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Preeclampsia
Oral Progesterone and Low Dose Aspirin in the Prevention of Preeclampsia
This study investigates whether low dose aspirin combined with progesterone will decrease the risk of preeclampsia in pregnant women with a history of preeclampsia in a previous pregnancy.
- Trial name
- NCT00719537
- Testing
- Aspirin, Progesterone
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- John Uckele
Hypertension in Pregnancy
Amlodipine Versus Nifedipine ER for the Management of Postpartum Hypertension
A significant number of pregnancies are complicated by hypertensive disorders. Hypertension often worsens in the postpartum period and many women need started on medications.
- Trial name
- NCT04790279
- Testing
- Amlodipine, NIFEdipine ER
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- Prisma Health-Upstate
Preeclampsia, Labor, Premature
Use of Nitrous Oxide Donor for Labor Induction in Women With PreEclampsia
A randomized controlled trial (RCT) of nitric-oxide donor (NOD) isosorbide mononitrate (IMN) versus placebo as an adjuvant to misoprostol/ intra-cervical Foley bulb for induction of labor to decrease rate of cesarean deliveries…
- Trial name
- NOPE (NCT03171480)
- Testing
- Monoket Pill
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- Ohio State University
Preeclampsia
Longitudinal Study: Diagnosis and Prediction of Pre-Eclampsia by Using Congo Red Dot Test in Bangladesh and Mexico
A population-based prospective cohort design will evaluate the progression of urine congophilia in pregnancy using the Congo Red Dot test by following patients longitudinally across gestation in Bangladesh and Mexico City.
- Trial name
- NCT02381197
- Testing
- Congo Red Dot test
- Where
- 2 sites in Bangladesh, Mexico
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Pre-Eclampsia
Vascular Changes in Pre-Eclamptic Patients and Its Impact on Pregnancy Outcome.
Normal pregnancy is associated with vasodilation and decreased peripheral resistance, which is detected as early as 5 weeks' gestation .
- Trial name
- PE (NCT03111576)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Beni-Suef University
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