Clinical trials: Hypertension, Pregnancy Induced
Pre-Eclampsia, Severe, HELLP Syndrome
Immature Platelet Fraction as a Promising Biomarker in Prediction Outcome of HELLP Syndrome
Immature platelet fraction is a non-invasive test of real time thrombopoiesis. High IPF% has been suggested as an indicator of thrombocytopenia due to rapid platelet consumption.
- Conditions
- Pre-Eclampsia, Severe, HELLP Syndrome, Microangiopathy
- Trial name
- NCT03232359
- Testing
- immature platelets fraction
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- AYMAN ABDELKADER MOHAMED ABDELKADER
Hypertensive Disorder of Pregnancy, Preeclampsia
Remote Monitoring and Follow-up for Postpartum Hypertensive Disorders of Pregnancy
The literature unequivocally supports follow-up in the postpartum period post hospital discharge in hypertensive patients, compared to uncomplicated delivery follow-up recommendations of 4-6 weeks postpartum, leading to decreased…
- Conditions
- Hypertensive Disorder of Pregnancy, Preeclampsia, Gestational Hypertension
- Trial name
- NCT05124327
- Testing
- QI project- usage of RPM
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Cedars-Sinai Medical Center
Hypertension in Pregnancy
STAMPP-HTN in a High-risk Rural Population of Women
The purpose of this study is to determine if monitored blood pressure paired with education reduces maternal mortality and morbidity during the post-partum period in a high-risk rural population of women.
- Trial name
- NCT04570124
- Testing
- Home Blood Pressure Telemonitoring
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Mississippi Medical Center
Severe Preeclampsia
Furosemide vs Placebo in Severe Preeclampsia Postpartum
This randomized, double-blind, placebo-controlled trial evaluates whether oral furosemide 40 mg, initiated 12 hours postpartum, reduces hospital length of stay compared to placebo (folic acid 5 mg) in postpartum women with severe…
- Trial name
- FUROPE (NCT07648251)
- Testing
- Furosemide, Folic Acid 5 MG
- Where
- Honduras
- Volunteers
- 186 people
- Sponsor
- Universidad Nacional Autonoma de Honduras
Preeclampsia
Hydroxychloroquine in Prevention of Preeclampsia
Pre-eclampsia complicates up to 8% of pregnancies and is a major contributor to maternal mortality and morbidity The only effective treatment is delivery, which leads to significant neonatal morbidity and mortality if carried out…
- Trial name
- NCT04755322
- Testing
- Hydroxychloroquine, Folic acid, Low-dose aspirin
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Cardiovascular Diseases, Heart Diseases
Renin and Prorenin in Pregnancy
To determine the role of the prorenin-renin-angiotensin-aldosterone system (RAAS) in normal and hypertensive pregnancy.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension, Pregnancy Toxemias
- Trial name
- NCT00005207
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Pregnancy Complications, Pregnancy Outcome
BioThrax® (Anthrax) Vaccine in Pregnancy Registry
The purpose of this study is to determine if inadvertent receipt of the BioThrax vaccine during pregnancy is independently associated with adverse maternal, pregnancy, or infant health outcomes.
- Conditions
- Pregnancy Complications, Pregnancy Outcome, Congenital Abnormalities
- Trial name
- NCT01653392
- Testing
- Observational Intervention
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Emergent BioSolutions
Urinary Tract Infection (Diagnosis), Preeclampsia
Association of Urinary Tract Infection With Preeclampsia During Pregnancy
Urinary tract infections (UTIs) are a major clinical issue, especially in pregnant women, due to physiological changes that increase susceptibility.
- Trial name
- NCT06962644
- Testing
- Preeclampsia developed
- Where
- Pakistan
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Pakistan Air Force (PAF) Hospital Islamabad
Pre-Eclampsia
Placental Growth Factor as a Predictor of Adverse Pregnancy Outcomes in Preeclamptic Women
Background: Preeclampsia is one of the leading causes of maternal and perinatal morbidity and mortality worldwide, and it affects 3% to 8% of all pregnancies.
- Trial name
- NCT04374604
- Testing
- Placental growth factor
- Where
- Nigeria
- Volunteers
- 140 people
- Sponsor
- Johnbosco Ifunanya Nwafor
Preeclampsia
Thiol/Disulphide Homeostasis and Preeclampsia
Objective: To evaluate serum evaluate thiol/ disulfide levels in preeclampsia and address its relationship with its severity. Methods: This prospective study will include 50 pregnancies complicated with preeclampsia and 50…
- Trial name
- thiols&PE (NCT03927014)
- Testing
- thiol/disulfide levels
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cengiz Gokcek Women's and Children's Hospital
Pre-Eclampsia, Pregnancy Related
Study of Nicotinamide in Early Onset Preeclampsia
Phase II Study of 2.5 gm of nicotinamide, given daily in 3 divided doses, to measure effect on maternal blood pressure in women with early onset preeclampsia and to determine peak and trough levels of nicotinamide.
- Trial name
- NCT03419364
- Testing
- nicotinamide
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of North Carolina, Chapel Hill
Hypertension in Pregnancy
Postpartum Evaluation of Nifedipine and Enalapril for Hypertension
This is an open label, randomized controlled trial designed to compare nifedipine and enalapril in the management of postpartum hypertension.
- Trial name
- PEACE (NCT07023003)
- Testing
- Enalapril 10mg QD, Nifedipine 30mg XL BID
- Where
- United States
- Volunteers
- 850 people
- Sponsor
- Nebraska Methodist Health System
Preeclampsia, Pregnant With Complication
Feasibility of a Telemonitoring Program for Pregnant Women at High-Risk for Preeclampsia in Pakistan
High maternal mortality from preeclampsia/eclampsia results from a lack of early identification and management of pregnant women at high risk for preeclampsia.
- Trial name
- NCT05662696
- Testing
- Raabta Telemonitoring Program (Mobile Application)
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- University Health Network, Toronto
Preeclampsia, Fullpairs
fullPIERS Model in the Prediction of Adverse Maternal Outcomes in Preeclampsia
Apredictive formula, fullPIERS (Pre-eclampsia Integrated Estimate of Risk Score), can be used to estimate the risk of suffering an adverse outcome using information obtained within 48 hours of admission with pre-eclampsia.
- Trial name
- Aprospective (NCT07316140)
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Pre-Eclampsia, Hypertension, Pregnancy-Induced
Low Dose Calcium to Prevent Preeclampsia
The purpose of this study is to assess, in pregnant women with calcium-poor diets, what is the effectiveness of low-dose (500 mg/day) calcium supplements associated with an educational intervention, compared to the educational…
- Conditions
- Pre-Eclampsia, Hypertension, Pregnancy-Induced, Dietary Calcium Deficiency
- Trial name
- AMCAL (NCT02338687)
- Testing
- calcium, Educational sessions
- Where
- Brazil
- Volunteers
- 1,040 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Gestational Hypertension, Toxemia
A Randomized Control Trial of Vitamin D Prophylaxis in the Prevention of Hypertensive Disorders of Pregnancy
The investigators aim to determine if Vitamin D prophylaxis in pregnancy reduces the incidence of hypertensive disorders of pregnancy.
- Conditions
- Gestational Hypertension, Toxemia, Superimposed Preeclampsia, Eclampsia
- Trial name
- NCT02920593
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 412 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Preeclampsia, Hypertensive Disorders of Pregnancy (HDP)
Clinician Notification to Increase Aspirin Prophylaxis for Preeclampsia Prevention
Preeclampsia is a leading cause of maternal morbidity and mortality. Low-dose aspirin prophylaxis reduces preeclampsia risk among high-risk pregnant individuals but remains underused in routine clinical practice.
- Conditions
- Preeclampsia, Hypertensive Disorders of Pregnancy (HDP), Pregnancy Complications, Aspirin Prophylaxis
- Trial name
- NCT07614893
- Testing
- Clinician notification of elevated preeclampsia risk
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Massachusetts General Hospital
Preeclampsia, Anxiety
Comparing Different Methods of Patient Education on Preeclampsia
Preeclampsia is a life-threatening condition unique to pregnancy which occurs in 5-8% of all pregnancies. It contributes to a large proportion of maternal mortality worldwide and these deaths largely result from delayed…
- Conditions
- Preeclampsia, Anxiety, Hypertension, Pregnancy
- Trial name
- NCT02765906
- Testing
- Graphic card, Video
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Geisinger Clinic
Gestational Hypertension
The CHIPS Trial (Control of Hypertension In Pregnancy Study)
The investigators do not know which approach to treatment of non-severe high blood pressure in pregnancy is better for women and babies.
- Trial name
- NCT01192412
- Testing
- Intervention is blood pressure management approach, Intervention is blood pressure management approach.
- Where
- 111 sites in United States, Argentina and 13 more
- Volunteers
- 987 people
- Sponsor
- University of British Columbia
Sleep Apnea, Obstructive
Correlation Between Preeclampsia and Positive for Obstructive Sleep Apnea Screening Test: STOPBANG Questionnaire
The purpose of this study is to find the correlation between high risk OSA (obstructive sleep apnea) patient, based on Stop-bang screening tool and preeclampsia
- Trial name
- NCT02800798
- Testing
- Preeclampsia positive
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Ramathibodi Hospital
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