Clinical trials: Hypertension, Pregnancy Induced
Preeclampsia
Comparison of Pregnancy Outcomes in Primigravida Receiving Low-Dose Aspirin for the Prevention of Preeclampsia.
Local data on the effectiveness of low-dose aspirin in high-risk primigravida are limited. The present study was planned to compare pregnancy outcomes between high-risk primigravida receiving low-dose aspirin (75 mg/day) from 12…
- Trial name
- NCT07852585
- Testing
- Low-dose aspirin, No-Aspirin
- Where
- Pakistan
- Volunteers
- 160 people
- Sponsor
- Muhammad Aamir Latif
Heart Failure, Cardiovascular Diseases
Heart Failure and Related Risk-factors After Preeclampsia
This study is a cross-sectional case-control study where classical as well as more innovative risk factors for CVD will be explored.
- Conditions
- Heart Failure, Cardiovascular Diseases, Pre-Eclampsia
- Trial name
- QoH (NCT02347540)
- Where
- Netherlands
- Volunteers
- 2,580 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Preeclampsia, Gestational Hypertension
Spironolactone to Improve Pregnancy-Associated Hypertension Trajectories
The hypertensive disorders of pregnancy (preeclampsia and gestational hypertension) are associated with increased long-term maternal risk of developing cardiovascular disease.
- Trial name
- IMPACT-HT (NCT07041281)
- Testing
- spironolactone 25 mg orally once daily
- Where
- 3 sites in United States
- Volunteers
- 204 people
- Sponsor
- Massachusetts General Hospital
Preeclampsia
Haptoglobin and Preeclampsia
The purpose of this study is to show that a certain protein called haptoglobin protects against preeclampsia which is a common pregnancy complication.
- Trial name
- NCT01027130
- Where
- Israel
- Sponsor
- Bnai Zion Medical Center
Healthy Lifestyle, Preeclampsia
Efficiency of the Web-Based Support Program Based on the Health Promotion Model in Pregnant Women With Preeclampsia
In the literature, it has been reported that health promotion model-based care approaches are beneficial in gaining positive healthy lifestyle behaviors, taking responsibility for the individual's health and increasing the…
- Conditions
- Healthy Lifestyle, Preeclampsia, Pregnancy; Renal Disease
- Trial name
- preeclampsia (NCT05021692)
- Testing
- Web-based support program for pregnant women with preeclampsia based on the Health Promotion Model
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Istanbul University - Cerrahpasa
Renal Cell Carcinoma, Cardiotoxicity
A Prospective Study of Acute Cardiovascular Effects of First-line Sunitinib in Metastatic Renal Cell Carcinoma Patients (SUnitinib Prospective CardiovasculaR Effect)
While sunitinib can be very helpful to treat kidney cancer, these medications can also cause side effects, including heart damage.
- Conditions
- Renal Cell Carcinoma, Cardiotoxicity, Heart Failure, Hypertension
- Trial name
- SUPER (NCT01014065)
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- AHS Cancer Control Alberta
Blood Pressure Disorders, Pregnancy Induced Hypertension
Concordance Between the Systolic Foot-to-Apex Interval and the Auscultatory Method for Measuring Brachial Systolic Pressure in Pregnant Women With or Without Blood Pressure Disorders and Search for Markers of Arterial Stiffness in Pre-eclampsia.
The investigators hypothesize that the Systolic Foot-to-Apex Time Interval (SFATI) method is an accurate means of measuring systolic blood pressure in pregnant women at a risk of pre-eclampsia.
- Trial name
- SFATI GROPE (NCT04943133)
- Testing
- Blood pressure measurement and collection of the oscillometric curve for later SFATI analysis, Blood pressure measurement with the usual equipment used in the department, systematic measurement of pulse wave velocity (aortic and brachial)
- Where
- France
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
alpha1 Anti-trypsin, Pre-Eclampsia
Maternal alpha1 Antitrypsin as a Marker of Intrauterine Growth Restriction in Pre-eclamptic Women
Intrauterine growth restriction (IUGR) is defined as a velocity of fetal growth less than the normal fetus growth potential for a specific neonate as per the race and gender.
- Conditions
- alpha1 Anti-trypsin, Pre-Eclampsia, Intrauterine Growth Restriction
- Trial name
- NCT05622838
- Testing
- Alpha1 -Antitrypsin level
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Assiut University
Pre-Eclampsia, Maternal Health
Virtual Reality-Based and Face-to-Face Relaxation Programs in Pregnant Women With Preeclampsia
Preeclampsia, affecting 2-8% of pregnancies globally, is a leading hypertensive disorder in pregnancy. It is clinically characterized by elevated blood pressure (≥140/90 mmHg) after the 20th gestational week, often accompanied by…
- Conditions
- Pre-Eclampsia, Maternal Health, Relaxation, Virtual Reality
- Trial name
- NCT06893510
- Testing
- Virtual Reality Based Progressive Muscle Relaxation, Face-to-Face Progressive Muscle Relaxation
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Istanbul University - Cerrahpasa
Pre-Eclampsia
Measuring Practice Pattern Changes and Clinical Utility of a Novel Test for Preeclampsia
This study will collect high-quality data on how practicing obstetricians across the U.S. currently manage patients showing signs and/or symptoms of preeclampsia and how the results of Progenity's test change clinical decision…
- Trial name
- NCT04204018
- Testing
- Experimental Arm
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Qure Healthcare, LLC
Pre-Eclampsia
Optic Nerve Sheath Diameter in Preeclampsia
Severe preeclampsia is associated with an elevation in intracranial pressure (ICP). Optic nerve sheath diameter is a non-invasive surrogate of invasive ICP measurement.
- Trial name
- NCT04004897
- Testing
- Optic nerve sheath diameter measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Gestational Hypertension
Digital Solutions to Reduce Maternal Morbidity and Mortality in Pregnant Refugee Women
The goal of this observational study is to use digital health tracking to improve how high blood pressure and other health issues are detected in pregnant refugee women.
- Trial name
- NCT06647511
- Testing
- Nokia-Withings BPM Connect Blood Pressure Monitor, Smartwatch Devices
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Pre-eclampsia
Safety and Efficacy of RLX030 in Pregnant Women With Pre- Eclampsia
This study is designed in two parts. Part 1 will assess the safety and tolerability of different doses of RLX030 when given to pregnant women with pre- eclampsia (elevated blood pressure with protein in urine).
- Trial name
- NCT01566630
- Testing
- RLX030
- Where
- 5 sites in United States, Italy
- Volunteers
- 3 people
- Sponsor
- Novartis Pharmaceuticals
Severe Pre-eclampsia
Intravenous Labetalol vs Phentolamine for the Management of Severe Preeclampsia.
The only effective treatment of severe preeclampsia is delivery of the fetus but immediate antihypertensive treatment is given to stabilize the patient and prevent further complications.
- Trial name
- NCT06385600
- Testing
- Labetalol, Phentolamine
- Volunteers
- 200 people
- Sponsor
- Assiut University
Pregnancy, Preeclampsia (PE)
Progesterone to Enhance the Efficacy and Success of Expectantly Managed Preterm Severe/Superimposed Preeclampsia
The purpose of this study is to learn if giving 17-hydroxyprogesterone caproate (17 OHPC) to mothers with preeclampsia diagnosed before 34 weeks gestation improves mother and baby outcomes.
- Trial name
- PROGRESS (NCT02989025)
- Testing
- 17 OHPC
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Mississippi Medical Center
Pre-eclampsia
Efficacy Study of Digibind for Treatment of Severe Preeclampsia
The purpose of this study is to determine whether a commercially available anti-digoxin antibody, Digibind, can delay delivery in patients with severe pre-eclampsia.
- Trial name
- NCT00158743
- Testing
- Anti-digoxin antibody (FAB fragment), sodium chloride
- Where
- 8 sites in United States
- Volunteers
- 51 people
- Sponsor
- BTG International Inc.
Hemorrhagic Stroke, Eclampsia
Investigation of Genetic Disease Marker Associated With Spontaneous Haemorrhagic Stroke Complicating Severe Pre-eclampsia in Pregnancy
To search for a genetic marker of hemorrhagic stroke complicating severe eclampsia, a single nucleotide polymorphism (SNP) analysis of DNA obtained from the peripheral blood of patients with hemorrhagic stroke and normal control…
- Trial name
- NCT05121415
- Testing
- SNP analysis of the DNA
- Where
- Kazakhstan
- Volunteers
- 100 people
- Sponsor
- Asfendiyarov Kazakh National Medical University
Pregnancy Induced Hypertension
Breathing Exercise in Pregnancy-induced Hypertension
To determine the effects of Breathing control vs Alternate nostril breathing on maternal cardiovascular parameters in pregnancy and to determine the effect of breathing control vs Alternate nostril breathing on Fetal Heart rate.
- Trial name
- NCT05828615
- Testing
- Group A, Group B
- Where
- Pakistan
- Volunteers
- 46 people
- Sponsor
- Riphah International University
Preeclampsia, Eclampsia
The Preeclampsia Registry
The purpose of The Preeclampsia Registry is to collect and store medical and other information from women who have been medically diagnosed with preeclampsia or a related hypertensive (high blood pressure) disorder of pregnancy…
- Conditions
- Preeclampsia, Eclampsia, HELLP Syndrome, Toxemia
- Trial name
- TPR (NCT06377878)
- Where
- United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Preeclampsia Foundation
Preeclampsia
Cardiovascular Risk After Preeclampsia
Investigation of cardiovascular risk 5-15 years after early or late-onset preeclampsia by adenosine stress Magnetic Resonance Imaging and non-invasive methods like retinal vessel analysis, skin measurement of advanced glycation…
- Trial name
- NCT05277233
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
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