Clinical trials: Hypertension, Pregnancy Induced
Pre-Eclampsia, Hypertension in Pregnancy
Furosemide vs. Placebo for Severe Antepartum Hypertension
Primary objective: To determine whether the addition of intravenous furosemide with usual antihypertensives is associated with a reduction in mean systolic blood pressure from baseline compared to treatment with placebo plus…
- Conditions
- Pre-Eclampsia, Hypertension in Pregnancy, Pregnancy Complications, Hypertension, Pregnancy-Induced
- Trial name
- NCT04615624
- Testing
- Furosemide
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Melanie Maykin, MD
Placental Vascular Pathologies, Venous Thromboembolism Diseases
Prediction of the Risk of Placental Vascular Pathology and Venous Thromboembolic Disease
Venous thromboembolic (VTE) disease is the first cause of maternal mortality in the world. Some other pregnancy pathologies called Placental Vascular Pathologies (PVP) are linked to VTE by biological thrombophilia and are the…
- Trial name
- AngioPred (NCT00695942)
- Where
- 3 sites in France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Pregnancy in Diabetics
Blood Pressure, Antihypertensive Treatment and Preeclampsia in Pregnant Wom-en With Pre-existing Diabetes
Aim: First, to investigate the prevalence of a) confirmed hypertension, b) white coat hypertension and c) normal blood pressure in pregnant women with pre-existing diabetes.
- Trial name
- NCT02890836
- Testing
- Antihypertensiva, mainly Metyldopa
- Where
- Denmark
- Volunteers
- 513 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Adverse Pregnancy Outcomes, Cardiovascular Diseases
A Study to Lower Blood Pressure One Year After Childbirth in Women Who Had Preeclampsia
GESTA-SCORE is a prospective, randomized clinical trial designed to evaluate whether an early, personalized cardiovascular prevention strategy can achieve a clinically meaningful 6 mmHg reduction in systolic blood pressure at one…
- Trial name
- GESTA-SCORE (NCT06798649)
- Testing
- The intervention in the GESTA-SCORE study involves providing detailed feedback from vascular imaging to women who have experienced adverse pregnancy outcomes (APOs).
- Volunteers
- 150 people
- Sponsor
- Maternal-Infantil Vall d´Hebron Hospital
Pregnancy, Venous Thrombosis
Free DNA and Nucleosome Concentrations in Pathological Pregnancies
The primary objective of this study is to demonstrate that plasma concentrations of nucleosomes and free DNA differ between three groups: 1.
- Conditions
- Pregnancy, Venous Thrombosis, Pulmonary Embolism, Hypertension, Pregnancy-Induced
- Trial name
- NCT01736826
- Testing
- Bloodwork, baseline, Blood work, Months 1 & 2, Bloodwork, Months -1 to -6
- Where
- France
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Pre-Eclampsia, Volume Overload
PREDICTION OF FLUID RESPONSIVENESS WITH PASSIVE LEG RISING IN PREGNANT PATIENTS WITH SEVERE PREECLAMPSIA
BACKGROUND: A cornerstone of treatment in preeclampsia is to correct the potential hypovolemia with intravascular optimisation, which is usually performed as a fluid challenge.
- Conditions
- Pre-Eclampsia, Volume Overload, Hemodynamic Instability
- Trial name
- NCT03755843
- Testing
- PASSIVE LEG RISING
- Where
- Mexico
- Volunteers
- 35 people
- Sponsor
- RAUL CARRILLO ESPER
Preeclampsia
Ravulizumab in Pregnancies Complicated by Severe Hypertensive Disorders
The researchers are testing a medication named ravulizumab for the treatment of severe preeclampsia and Hemolysis, Elevated Liver enzymes, Low Platelets (HELLP) syndrome.
- Trial name
- NCT06333652
- Testing
- Ravulizumab
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Mayo Clinic
Preeclampsia, Preeclampsia Severe
Nudge to Drive Transitions of Care
Hypertensive disorders of pregnancy (HDP) are stress tests which may identify women at high risk of future cardiovascular disease (CVD), the leading cause of death among women.
- Conditions
- Preeclampsia, Preeclampsia Severe, Gestational Hypertension, Hypertensive Disorder of Pregnancy
- Trial name
- REMIND (NCT04660032)
- Testing
- Nudge
- Where
- United States
- Volunteers
- 224 people
- Sponsor
- University of Pennsylvania
Hypertension in Pregnancy, Postpartum Preeclampsia
Oral Combined Hydrochlorothiazide/Lisinopril Versus Oral Nifedipine for Postpartum Hypertension
The purpose of this study is to see if a combined pill of Angiotensin-converting enzyme (ACE) inhibitors (a medication that helps relax your veins and arteries to lower your blood pressure) with diuretics (sometimes called water…
- Trial name
- ACE (NCT05049616)
- Testing
- ACE Inhibitors and Diuretics, NIFEdipine ER
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- The University of Texas Health Science Center, Houston
Preeclampsia, Postpartum
MSC Exosome Therapy for Post-Preeclampsia Endothelial Dysfunction
--- Why Is This Study Being Done? Women who have preeclampsia during pregnancy face a much higher risk of heart disease later in life.
- Conditions
- Preeclampsia, Postpartum, Endothelial Injury, Exosome Multiomics
- Trial name
- EXITPE (NCT07183384)
- Testing
- Mesenchymal Stem Cell-Derived Exosomes
- Where
- Indonesia
- Volunteers
- 80 people
- Sponsor
- Universitas Padjadjaran
Preeclampsia
The Effect of Two Aspirin Dosing Strategies for Obese Women at High Risk for Preeclampsia
Low dose aspirin (LDA) is used for preeclampsia (PE) prevention in high risk women, but the precise mechanism and optimal dose is not known.
- Trial name
- NCT03735433
- Testing
- 162mg aspirin dose
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- Ohio State University
Preeclampsia
Angiotensin II and Chronic Inflammation in Persistent Microvascular Dysfunction Following Preeclampsia
Women who develop preeclampsia during pregnancy are more likely to develop cardiovascular disease later in life, even if they are otherwise healthy.
- Trial name
- NCT03482440
- Testing
- Salsalate Oral Tablet
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Pre-eclampsia or Eclampsia With Pre-existing Hypertension
Evaluation of a Physical Therapy Protocol on Quality of Life Musculoskeletal Pain and Anxiety in Women With Preeclampsia
The purpose of this study is to verify that the implementation of a protocol physiotherapy musculoskeletal pain and reduces anxiety and improves quality of life in patients hospitalized at the clinic of high-risk pregnancies at…
- Trial name
- NCT01925508
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
Severe Preeclampsia
The Association Between Different Markers With Development of Maternal and Neonatal Complications in Women With Severe Preeclampsia
pregnant women diagnosed with severe preeclampsia were subjected to • Full history taking including a detailed history of the hypertension state during the current pregnancy (onset, course, current medication, and whether the…
- Trial name
- NCT07125599
- Where
- Egypt
- Volunteers
- 284 people
- Sponsor
- Cairo University
Severe Preeclampsia, Postpartum Hemorrhage
Carbetocin vs. Oxytocin for Prevention of Postpartum Bleeding in Patients With Severe Preeclampsia
Postpartum hemorrhage is an important cause of maternal morbidity and mortality. In patients with severe preeclampsia there is an increased risk of postpartum hemorrhage but the hemodynamic changes associated with this pathology…
- Trial name
- NCT01382732
- Testing
- Carbetocin, Oxytocin
- Where
- Panama
- Volunteers
- 636 people
- Sponsor
- Saint Thomas Hospital, Panama
Preeclampsia
Post-Pregnancy Cardio Trial
Preeclampsia is a systemic pregnancy disorder and is associated with an increased cardiovascular risk later in life. This study will characterize myocardial tissue in patients after preeclampsia compared to controls and…
- Trial name
- PPC1 (NCT03313063)
- Where
- Germany
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Medication Adherence, Preeclampsia
Adherence to Universal Aspirin Compared to Screening Indicated Aspirin for Prevention of Preeclampsia
There are data showing that a majority of pregnant women may not be accurately identified as high risk through screening and therefore, not receiving prophylactic low dose aspirin as recommended.
- Trial name
- NCT04797949
- Testing
- Low-dose aspirin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Women and Infants Hospital of Rhode Island
Pre-Eclampsia, Gestational Hypertension
Neonatal Sleep Intervention to Improve Postpartum Hypertension
The investigators are conducting a single center, randomized controlled trial testing the impact of a neonatal sleep intervention, the SNOO, on reducing maternal blood pressure (BP) in the postpartum period in women with…
- Conditions
- Pre-Eclampsia, Gestational Hypertension, Sleep
- Trial name
- NCT04864249
- Testing
- SNOO, Safe sleep education in the postpartum period
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Alisse Hauspurg
Cardiovascular Diseases, Heart Diseases
Oral Calcium in Pregnant Women With Hypertension
To determine of providing calcium supplementation to women with pre-existing hypertension reduces the level of blood pressure, requirement for antihypertensive drugs, and incidence of pre-eclampsia.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension, Pre-Eclampsia
- Trial name
- NCT00000543
- Testing
- dietary supplements, calcium
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Preeclampsia
Increased Salt Sensitivity of Ambulatory Blood Pressure in Women With a History of Severe Preeclampsia
Cardiovascular diseases are the principal cause of death in women in developed and developing countries and are importantly promoted by hypertension.
- Trial name
- NCT01874990
- Testing
- high sodium diet, low-salt diet
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
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