Clinical trials: Hypertension, Pregnancy Induced
Pregnancy Complications
Oral Prophylactic Measures on the Occurrence of Pre-eclampsia (OP-PE)
Pre-eclampsia (PE) remains a major source of maternal and perinatal morbidity and mortality especially in low- and middle-income settings.
- Trial name
- OP-PE (NCT04989075)
- Testing
- Oral prophylactic intervention
- Where
- Senegal
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Claude Bernard University
Pre-eclampsia, Pregnancy
Gestational Changes in Hemodynamics and Respiratory Mechanics in Association With Pre-Eclampsia
This study focuses on elucidating the changes of hemodynamics assessed by USCOM and respiratory mechanics assessed by impedance oscillometry (IOS) over the course of pregnancy and the postpartum period.
- Conditions
- Pre-eclampsia, Pregnancy, Post Partum
- Trial name
- TREMOFLO (NCT07695909)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Preeclampsia
The Effect of Loading Dose of Magnesium Sulfate on Uterine, Umbilical, and Fetal Middle Cerebral Arteries Doppler, Biophysical Profile, CTG, Maternal Vital Signs in Women With Severe Preeclampsia
100 women with severe preeclanpsia received Magnesium sulfate 6 grams intravenous over 20 minutes as a loading dose. Resistance index [RI], pulsatility index [PI] and systolic/diastolic [S/D] ratio of the umbilical artery…
- Trial name
- NCT03891498
- Testing
- MgSO4
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Brain Health, Gestational Hypertension
Brain Health in Midlife
The purpose of this study is to learn if hypertensive disorders during pregnancy affects brain health in midlife.
- Conditions
- Brain Health, Gestational Hypertension, Alzheimer Disease, Dementia
- Trial name
- ADORE BRAIN (NCT06640842)
- Testing
- A combination of various tests and biomarkers will be completed to understand the effect of hypertensive disorders of pregnancy on brain health in midlife.
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Preeclampsia
Physical Therapy in Pregnant Women With Preeclampsia
The aim of this study is to evaluate the influence that has a physical therapy protocol in maternal and fetal hemodynamics in relation to blood pressure, maternal and fetal responses and perinatal outcomes.
- Trial name
- FPE (NCT01630772)
- Testing
- Physical therapy, No physical therapy
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
Hypertension in Pregnancy
Effects of Oral L-Arginine on Chronic Hypertension in Pregnancy
The purpose of this study is to evaluate the effects of oral L-Arginine in pregnant women with chronic hypertension.
- Trial name
- NCT00571766
- Testing
- L-Arginine
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Modena and Reggio Emilia
Pre-Eclampsia
Detection of False Positives From First-trimester Preeclampsia Screening (StopPRE) at the Second-trimester of Pregnancy
Pregnant women at a higher risk for pre-eclampsia (PE) should be offered preventive daily treatment with acetylsalicylic acid (ASA) started before 16 weeks of gestation.
- Trial name
- StopPRE (NCT03741179)
- Testing
- ASA-withdrawn group
- Where
- Spain
- Volunteers
- 974 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
HELLP Syndrome (HELLP), Third Trimester, Complement Abnormality
The Use of Eculizumab in HELLP Syndrome
This research study is being performed to see if women diagnosed with early preterm Hemolysis, Elevated Liver Enzymes, Low Platelets (HELLP) syndrome (estimated gestational ages of 23-30 weeks) benefit from a medication called…
- Conditions
- HELLP Syndrome (HELLP), Third Trimester, Complement Abnormality, Morbidity;Newborn, Maternal Injury
- Trial name
- NCT04103489
- Testing
- Eculizumab
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Johns Hopkins University
Pre-Eclampsia
Factors Predicting Transformation of Non Severe Pre-eclampsia Into Pre-eclampsia With Severe Features
Preeclampsia is a multi-system progressive disorder characterized by the new onset of hypertension and proteinuria, or hypertension and significant end-organ dysfunction with or without proteinuria, in the last half of pregnancy…
- Trial name
- NCT05152550
- Testing
- Non-severe pre-eclampsia
- Where
- Egypt
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Ahmed Nagy Abdul-Rahman Younis
Pre-Eclampsia
Cardiovascular Changes in Infants of Preeclampsia Mother
Preeclampsia (hypertension during pregnancy) is a common problem affecting 2-8% of pregnancies worldwide and is typically diagnosed by increased blood pressure and proteinuria.
- Trial name
- NCT04699825
- Testing
- Cardiovascular and immunological changes
- Volunteers
- 20 people
- Sponsor
- Assiut University
Pre-Eclampsia, Hypertension
Collection of Whole Blood Samples for the Evaluation of Preeclampsia (Pre-E) Biomarkers From Pregnant Women
Whole blood sample procurement study from pregnant women with signs and symptoms of Preeclampsia.
- Conditions
- Pre-Eclampsia, Hypertension, Proteinuria in Pregnancy, Thrombocytopenia
- Trial name
- NCT03767803
- Testing
- Non-interventional study
- Where
- 24 sites in United States
- Volunteers
- 344 people
- Sponsor
- Progenity, Inc.
Vitamin D Deficiency Defined as Serum 25OHD < 75 Nmol/l or 30ng/ml, Preeclampsia
Vitamin D and Preeclampsia
Hypothesis : Vitamin D serum concentration is decreased in the first trimester in pregnant women who will develop preeclampsia in the second or third trimester compare to a control group Primary purpose : To determine the vitamin…
- Conditions
- Vitamin D Deficiency Defined as Serum 25OHD < 75 Nmol/l or 30ng/ml, Preeclampsia, Neonatal Hypercalcemia, Pregnancy
- Trial name
- FEPED (NCT01648842)
- Where
- France
- Volunteers
- 3,173 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pressor Response
Lignocaine Nebulization for Attenuation of Intubation Stress Response
To study the effect of lignocaine nebulization on attenuation of the pressor response during induction and emergence of anesthesia in patients with severe pre-eclampsia
- Trial name
- NCT04441073
- Testing
- Lignocaine
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Preeclampsia
Combined Multi-marker Screening and Treatment With Aspirin for Pre-eclampsia Prevention
Phase III two arm double-blinded randomised controlled trial to examine the effect of prophylactic low-dose aspirin from the first-trimester of pregnancy in women at increased risk for PET on the incidence and severity of the…
- Trial name
- ASPRE (NCT02301780)
- Testing
- Aspirin
- Where
- Israel
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
Preeclampsia, Pulmonary Edema
Point-of-care Ultrasound Abnormalities in Early Onset Preeclampsia
The study is planned to describe the prevalence and severity of cardiac, lung and optic-nerve sheath diameter (ONSD) ultrasound abnormalities in women with early onset preeclampsia with severe features.
- Conditions
- Preeclampsia, Pulmonary Edema, Cardiac Function
- Trial name
- NCT05662995
- Testing
- Lung ultrasound
- Where
- South Africa
- Volunteers
- 60 people
- Sponsor
- University of Cape Town
Chronic Kidney Disease, Blood Pressure
Mechanisms of EPO-induced Hypertension
The investigators hypothesize that compared to untreated controls, erythropoietin (EPO) therapy in anemic patients with chronic kidney disease will raise diastolic blood pressure (BP).
- Conditions
- Chronic Kidney Disease, Blood Pressure, Anemia
- Trial name
- EPIC (NCT03810911)
- Testing
- Darbepoetin
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- VA Office of Research and Development
Postpartum Period, Pregnancy
Enhancing Care & Outcomes for Patients During the First Postpartum Year
The United States is in the midst of a maternal mortality and morbidity crisis, with more than half of maternal deaths occurring within the first postpartum year.
- Conditions
- Postpartum Period, Pregnancy, Hypertension, Pregnancy Induced
- Trial name
- NCT06615076
- Testing
- Postpartum Visits
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Maryland, Baltimore
Type 2 Diabetes Mellitus, Obesity
The TRIABETES - ARMMS-T2D Study: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes
This research study is being performed to begin to determine the effectiveness of two dominant bariatric surgery procedures versus an intensive lifestyle intervention to induce weight loss in patients and promote improvements in…
- Trial name
- TRIABETES (NCT01047735)
- Testing
- Roux-en-Y Gastric Bypass Surgery, Laparoscopic Adjustable Gastric Banding, Lifestyle Weight Loss Intervention
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of Pittsburgh
Pre-Eclampsia
Study of the Physiology of Pre-eclampsia and Vascular IUGR With Constitution of a Biological Collection
Preeclampsia and intrauterine growth retardation (IUGR) are serious and frequent pathologies, specific to pregnancy. They represent 70 000 new cases a year, or 9% of pregnancies and cause 50,000 premature births per year in…
- Trial name
- CPVP (NCT03626233)
- Testing
- collect of placenta, blood and urinary samples at delivery
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Severe Preeclampsia
Protocols for Magnesium Sulfate Maintenance Dose in Overweight and Obese Women Diagnosed With Preeclampsia
There is still no evidence of the appropriate dose to be used. Serum magnesium sulfate concentration is not measured regularly, thus we may be using sub-therapeutic level or reaching a toxic level.Overweight and obese women have…
- Trial name
- NCT06486025
- Testing
- maintenance magnesium sulphate1g/h, maintenance magnesium sulphate2g/h
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
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