Clinical trials: Hypertension, Pregnancy Induced
Pregnancy, Pre Eclampsia
Pre-Eclampsia Prediction By Doppler Screening Of Uterine Arteries And Angiogenic Factors In Second Trimester Of Pregnancy
BACKGROUND: Pre-eclampsia complicates about 2% of pregnancies. It accounts for at least 50 000 maternal deaths per year worldwide and is the second most common cause of maternal death in the developing world.
- Trial name
- NCT00725660
- Where
- Israel
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center
Hypertension, Pregnancy-Induced, HELLP Syndrome
PROTECT-Africa: Biomarker Validation for Preeclampsia Triage
Preeclampsia is a serious high blood pressure condition that can develop during pregnancy. It is one of the leading causes of death and illness for mothers and babies in Africa.
- Conditions
- Hypertension, Pregnancy-Induced, HELLP Syndrome, Eclampsia, Fetal Growth Retardation
- Trial name
- PROTECT-Africa (NCT07810439)
- Where
- Zimbabwe
- Volunteers
- 1,106 people
- Sponsor
- Africa Clinical Research Network (ACRN)
Severe Preeclampsia, Eclampsia Preeclampsia
Levetiracetam Compared to Magnesium Sulfate for Prevention of Eclamptic Seizure
The goal of this study is to compare levetiracetam to magnesium sulfate for the prevention of eclamptic seizures in pregnant persons with severe preeclampsia that are 32 or more weeks pregnant.
- Trial name
- LEVMag (NCT07220902)
- Testing
- Levetiracetam, magnesium sulfate
- Where
- United States
- Volunteers
- 1,240 people
- Sponsor
- Nebraska Methodist Health System
Adverse Effect
Norepinephrine Prophylaxis for Postspinal Anesthesia Hypotension in Parturients With Preeclampsia.
The purpose of this study is to investigate the suitable infusion dose of norepinephrine for prophylaxis against postspinal anesthesia hypotension in parturients with preeclampsia undergoing cesarean section.
- Trial name
- NCT04556370
- Testing
- Normal saline, Norepinephrine
- Where
- China
- Volunteers
- 180 people
- Sponsor
- General Hospital of Ningxia Medical University
Gestational Hypertension
Angiogenic Factors in the Conservative Management of Gestational Hypertension
Hypertensive disorders of pregnancy (HPT) are an important cause of maternal-feto-neonatal morbidity and mortality, being one of the three leading causes of maternal death in our country and in developing countries.
- Trial name
- NCT06123377
- Testing
- Angiogenic factor
- Where
- Panama
- Volunteers
- 150 people
- Sponsor
- Saint Thomas Hospital, Panama
Preeclampsia, Pregnancy Complications
The Correlation Between Immunological Reaction of the Seminal Fluid in the Mother's Blood and Pregnancy Complications
It is known that if there isn't an efficient exposure to the paternal antigens before conception, there is an increased risk for the pre-eclampsia (PE) cascade and other pregnancy complications to take place.
- Conditions
- Preeclampsia, Pregnancy Complications, Insemination; Complication, Immune Tolerance
- Trial name
- NCT04314518
- Where
- 2 sites in Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Preeclampsia, Preeclampsia Postpartum
Optimizing Preeclampsia Postpartum With Point-of-care Ultrasound
This study explores a novel approach to improving care for postpartum patients with preeclampsia, a pregnancy-related condition characterized by high blood pressure, protein in the urine, and organ dysfunction.
- Conditions
- Preeclampsia, Preeclampsia Postpartum, Preeclampsia Severe or Mild
- Trial name
- PPPOCUS (NCT07167862)
- Testing
- Butterfly iQ3 ultrasound system for determination of postpartum volume status, Oral furosemide, Intravenous furosemide
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- University of California, Irvine
Birth Weight, Small for Gestational Age at Delivery
Drinking Water PFAS, Pregnancy Outcome and Maternal Morbidity
The aim of the project is to assess the association between exposure to per- and polyfluoroalkyl substances (PFAS) via drinking water in pregnancy and birth outcomes (i.e.
- Conditions
- Birth Weight, Small for Gestational Age at Delivery, Large for Gestational Age at Delivery (Macrosomia), Diabetes, Gestational
- Trial name
- NCT05810545
- Testing
- Per- and polyfluoroalkyl substances (PFAS)
- Volunteers
- 256,659 people
- Sponsor
- Karolinska Institutet
Severe Pre-eclampsia, Magnesium Level
Serum Magnesium Level Administration in Severe Pre-eclampsia Obese Pregnancy
Comparison of the magnesium level in difference continuous rate in women who were diagnosed severe pre-eclampsia obese
- Trial name
- NCT03661775
- Testing
- Magnesium sulfate administration
- Where
- Thailand
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Hypertension, Pregnancy-Induced
Arm and Finger Measurement for Blood Pressure Surveillance
Accurate blood pressure (BP) measurement is critical in peripartum care. The cuff and bladder sizes affects the accuracy of BP measurement.
- Trial name
- ARMFIN (NCT04012151)
- Testing
- Physical measurement, Cuff size fitting
- Where
- Singapore
- Volunteers
- 300 people
- Sponsor
- KK Women's and Children's Hospital
Pre-eclampsia, Pregnancy
Evaluation of the Efficacy of Citrulline Supplementation on the Delay of Delivery for Women Hospitalized for Pre-eclampsia (CITRUPE)
Pre-eclampsia (PE) complicates 2-8 % of pregnancies and is associated with high maternal and fetal morbidity and mortality. The early clinical manifestations are the occurrence of a maternal blood pressure and proteinuria.
- Trial name
- CITRUPE (NCT02801695)
- Testing
- Citrulline
- Where
- 2 sites in France
- Volunteers
- 116 people
- Sponsor
- Nantes University Hospital
Pre-eclampsia
Efficacy Of Supplemental L-Arginine in Preventing Preeclampsia in Pregnant Women
This study was designed to assess whether daily L-arginine supplementation could prevent preeclampsia in pregnant women at increased risk.
- Trial name
- NCT07912866
- Testing
- L-Arginine
- Where
- Pakistan
- Volunteers
- 108 people
- Sponsor
- Quaid-e-Azam Medical College
Pre-Eclampsia
sFlt-1/PlGF Ratio: Impact on the Management of Patients With Suspected Pre-eclampsia
Pre-eclampsia is a specific pathology of pregnancy classically associating arterial hypertension with proteinuria. Its prevalence in industrialized countries is 3 to 8% of pregnancies, which makes it a frequent pathology, and it…
- Trial name
- PROSPE (NCT05228002)
- Testing
- sFlt-1/PlGF ratio - Active Comparator: Standard, sFlt-1/PlGF ratio - Experimental: Biomarkers
- Where
- France
- Volunteers
- 43 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Pre-Eclampsia
State of Coagulation in Pre-eclampsia: Comparing Sonoclot Signature Analysis With Conventional and Specific Haemostasis Assays
Detection of the presence or absence of coagulopathy in cases with pre-eclampsia. Investigate the value of global hemostasis studies (Sonoclot signature analysis) in cases of pre-eclampsia and if there a correlation between it…
- Trial name
- NCT05625763
- Testing
- sonoclot signature analysis
- Volunteers
- 55 people
- Sponsor
- Assiut University
Preeclampsia
The Efficacy of Aspirin Combined With Hydroxychloroquine Treatment in High Risk Pregnancies for Preeclampsia
This study is prospective, single arm group ,open label, and multicenter trial (with two parallel-group [Hydroxychloroquine 200mg with Aspirin 100mg or Aspirin 100mg])
- Trial name
- HUGS (NCT05287321)
- Testing
- Hydroxychloroquine
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Samsung Medical Center
Pregnancy
Cardiovascular an Echocardiographic Assessment in Hypertension During Pregnancy
Cardiovascular \& echocardiographic assessment in pregnant women with hypertension during their pregnancy in comparison to Pregnant normotensive women.
- Trial name
- CREATION-P (NCT01068002)
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- HaEmek Medical Center, Israel
Preeclampsia
Analyses of Interleukin-6, Presepsin and Pentraxin-3 in the Diagnosis and Severity of Late-onset Preeclampsia
Introduction: The etiology/pathophysiology of preeclampsia remains an enigma. Cellular immunity is a key factor in the etiology of late-onset preeclampsia (L-PrE).
- Trial name
- Presepsin&PE (NCT04126902)
- Testing
- interleukin-6, presepsin and pentraxin-3
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cengiz Gokcek Women's and Children's Hospital
Hypertension, Pregnancy-Induced
Postpartum Hypertension: Remote Patient Monitoring
The purpose of this study is to see if Honeywell Genesis Android Touch Bluetooth System (mobile health) can improve patient satisfaction and quality of care provided to women experiencing complications due to high blood pressure…
- Trial name
- NCT03111095
- Testing
- Mobile Health
- Where
- United States
- Volunteers
- 428 people
- Sponsor
- University of Wisconsin, Madison
High Risk Pregnant Women, Placental Insufficiency
Low Weight Heparin prOphylaxis for Placental-Mediated Complications of PrEgnancy
This is a Multicenter, randomized, open-label, parallel groups study to test the hypothesis that prophylactic low molecular weight heparin (LMWH) (enoxaparin) initiated before 14 weeks of gestation could improve maternal and…
- Conditions
- High Risk Pregnant Women, Placental Insufficiency, Preeclampsia
- Trial name
- HOPPE (NCT01388322)
- Testing
- Enoxaparin
- Where
- 4 sites in Spain
- Volunteers
- 361 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Pregnancy Transient Hypertension
Melatonin in Pregnancy Compared to Non-pregnant
Melatonin is well known for its role in the sleep-wake cycle but it is less well known as an effective antioxidant. It has been reported to be synthesised in the placenta and may have both receptor mediated and non-receptor…
- Trial name
- MEL-P (NCT03014245)
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
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