Clinical trials: Hypertension, Pregnancy Induced
Midazolam, Pre-eclampsia
Midazolam Efficacy/Safety in Pre-Eclamptic C-Section Sedation
This study will compare four different doses of midazolam (0 mg/kg, 0.01 mg/kg, 0.02 mg/kg, and 0.03 mg/kg) administered intravenously to women with pre-eclampsia undergoing cesarean section.
- Conditions
- Midazolam, Pre-eclampsia, Cesarean Section, Efficacy
- Trial name
- NCT07021521
- Testing
- 0 mg/kg Midazolam (Control Group), 0.01 mg/kg Midazolam Group, 0.02 mg/kg Midazolam Group
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Zhuji People's Hospital of Zhejiang Province
Pre-Eclampsia, Obesity
Weight Loss Following an Episode of Pre-eclampsia Using a Dissociated or Hypocaloric Diet in Overweight or Obese Patients
In view of the known link between pre-eclampsia, overweight/obesity and chronic kidney disease, the aim is to offer for obese and overweight patients to reduce their BMI without reducing lean body mass.
- Trial name
- POPADIPE (NCT06067906)
- Testing
- Hypocaloric diet, Dissociated diet
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier le Mans
Severe Preeclampsia
Study of the Efficacy and Safety of AMAG-423 (Digoxin Immune Fab) in Antepartum Subjects With Severe Preeclampsia
This study evaluates the use of AMAG-423 (Digoxin Immune Fab) in addition to expectant management in the treatment of severe preeclampsia as compared to placebo.
- Trial name
- NCT03008616
- Testing
- AMAG-423 (digoxin immune fab)
- Where
- 18 sites in United States, Poland and 1 more
- Volunteers
- 58 people
- Sponsor
- AMAG Pharmaceuticals, Inc.
Preeclampsia
Vitamin D3 Supplementation Regimens and Preeclampsia Risk
This study is a randomized controlled trial with two parallel groups connected at Al-Thawra Modern General Hospital in Sana'a, Yemen.
- Trial name
- VitD-PE-RCT (NCT07648706)
- Testing
- Vitamin D3
- Where
- Yemen
- Volunteers
- 268 people
- Sponsor
- Sana'a University
Gestational Complications, Body Mass Index
Antenatal Body Shape Index and Pregnancy Complications
Background/aim: Gestational diabetes (GDM), gestational hypertension (GHT) and preeclampsia are common complications of pregnancy.
- Conditions
- Gestational Complications, Body Mass Index, Waist Circumference, Gestational Hypertension
- Trial name
- NCT07022158
- Testing
- The patients participating in the study were between 6 and 16 weeks of pregnancy. Height, body weight, and waist circumference were measured at the first antenatal visit at 2 weeks.
- Where
- Turkey (Türkiye)
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Pre-eclampsia, Intra-uterine Growth Restriction
Observational Study in UTERO - Placental 3D Doppler Examination: Interest for Pre-eclampsia Screening During Pregnancy
Pre-eclampsia and intra uterine growth restriction (IUGR) represent major complications for pregnant women, with a high related maternal and fetal morbidity and mortality.
- Conditions
- Pre-eclampsia, Intra-uterine Growth Restriction, Placental Insufficiency, 3D Doppler Ultrasound
- Trial name
- PLACENTA3D (NCT00930397)
- Where
- France
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypertension
Central Blood Pressure
The aim of the study is to check standard screening blood pressure in the arm and central blood pressure, the blood pressure at the heart in pregnant women.
- Trial name
- NCT03026010
- Testing
- central blood pressure
- Volunteers
- 100 people
- Sponsor
- St. Louis University
Severe Preeclampsia
Risk Prediction Models for Adverse Maternal and Neonatal Outcomes in Preeclampsia
This proposal describes a single centre retrospective cross-sectional study which will address the need to further develop and test statistical risk prediction models for adverse maternal and neonatal outcomes in low-resource…
- Trial name
- NCT04058405
- Testing
- Observational
- Where
- Zimbabwe
- Volunteers
- 549 people
- Sponsor
- Mpilo Central Hospital
Pre-Eclampsia
Diagnostic Value of MicroRNA 210 In Preeclampsia
Pre-eclampsia is a disorder of pregnancy characterized by hypertension (defined as systolic blood pressure 140mmHg or diastolic blood pressure ⩾90 mmHg) and proteinuria (300 mg or greater in a 24 h urine specimen and/or protein…
- Trial name
- NCT03193554
- Where
- 2 sites in Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Pregnancy Complications, Delivery Complications
CoPPer Study - Complications of Polycystic Ovary Syndrome (PCOS) Pregnancy: Evaluating Risk
The CoPPer study is a follow-up study of women diagnosed with Polycystic Ovary Syndrome (PCOS). Women will be included pre-conceptional and followed-up until after delivery.
- Conditions
- Pregnancy Complications, Delivery Complications, Neonatal Complications
- Trial name
- CoPPer (NCT00821379)
- Where
- Netherlands
- Volunteers
- 300 people
- Sponsor
- UMC Utrecht
Preeclampsia, Preterm Birth
Prediction of Preeclampsia and Other Pregnancy Complications Following Combined Iterative Screening
Preterm birth (PTB), preeclampsia (PE), fetal growth restriction (FGR) and intra-uterine fetal death (IUFD) constitutes the main causes of perinatal morbidity and mortality and are called "Great Obstetrical Syndromes".
- Conditions
- Preeclampsia, Preterm Birth, Fetal Growth Restriction, Intra Uterine Fetal Death
- Trial name
- PREDICTION2 (NCT03067298)
- Where
- Canada
- Volunteers
- 805 people, healthy volunteers welcome
- Sponsor
- Emmanuel Bujold
Pre-Eclampsia, IUGR
Fetal Doppler Indices in Predicting Perinatal Outcome Among Severely Hypertensive Pregnant Patients.
60 pregnant women with singleton living fetus between 34 -38 wks gestation known to have severe hypertension in the current pregnancy were included.
- Trial name
- NCT03515759
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Hypertension in Pregnancy
Persistent Postpartum Hypertension Pilot Trial
This study is a pilot, open-label, randomized controlled trial of postpartum women with hypertensive disorders pregnancy and persistent non-severe blood pressure.
- Trial name
- NCT04349124
- Testing
- Nifedipine Extended-Release Tablets
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Duke University
Preeclampsia
New Therapeutic Strategy Against Preeclampsia
Preeclampsia is a hypertensive disorder of pregnancy associated with important maternal and perinatal mortality. It complicates 2 to 5% of pregnancies and causes more than 70 000 maternal deaths each year worldwide.
- Trial name
- APHERESE2 (NCT06464159)
- Testing
- Biological collection
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pregnancy, Preeclampsia
Effects of Progressive Muscle Relaxation Exercise and Finger Grip Exercise on Stress, Anxiety, Fatigue, Sleep Quality, and Physiological Parameters in Pregnant Women With Preeclampsia
The aim of this study is to examine the effects of progressive muscle relaxation exercise and finger grip exercise on stress, anxiety, sleep quality, fatigue and physiological parameters in preeclamptic pregnant women.
- Trial name
- NCT07630623
- Testing
- Progressive Muscle Relaxation Exercise, Finger Grip Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hatice Nur Nefes Pala
Hypertension, Pregnancy-Induced, Pre-Eclampsia
Early Vascular Adjustments During Hypertensive Pregnancy
Paradoxical fetal and maternal results of studies have led to inconsistent use of antihypertensive drugs or no treatment at all in mild to moderate gestational hypertension in the Netherlands.
- Trial name
- EVA (NCT02531490)
- Testing
- Labetalol, Nifedipine, Methyldopa
- Where
- Netherlands
- Volunteers
- 368 people
- Sponsor
- Maastricht University Medical Center
Preeclampsia (PE)
Comparing the Efficacy of 75mg Versus 150mg Aspirin for the Prevention of Preeclampsia in High-Risk Pregnant Women
This study aims to evaluate the effectiveness of 75 mg aspirin versus 150 mg aspirin in preventing preeclampsia among individuals with high risk for the condition.
- Trial name
- NCT07041385
- Testing
- Aspirin 75 mg, Aspirin 150 mg
- Where
- Pakistan
- Volunteers
- 340 people
- Sponsor
- Shalamar Hospital
Small for Gestational Age (Disorder), Pre-Eclampsia
Establishing First Trimester Markers for the Identification of High Risk Twin
The purpose of this study is to determine whether we can establish different markers suc as mean arterial pressure , flow in the uterine arteries, biochemical markers in maternal blood and more un the first trimester, in order to…
- Trial name
- NCT02031393
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Assaf-Harofeh Medical Center
Pre-Eclampsia
Hydroxychloroquine May be Beneficial for Preeclampsia
The purpose of this research is to investigate the impact of hydroxychloroquine on the incidence of hypertensive pregnancy disorders in women with a history of recurrent spontaneous abortion (RSA).
- Trial name
- NCT06020378
- Testing
- Hydroxychloroquine
- Where
- China
- Volunteers
- 462 people
- Sponsor
- RenJi Hospital
Preeclampsia, Coagulation Disorder
Thromboelastogram in Postdelivery Preeclamptic Patients
There are no studies evaluating the effect of aging on hemostasis of preeclamptic patients. Additionally, although there are some studies that establish normal reference values for TEG profiles in healthy term pregnant patients…
- Conditions
- Preeclampsia, Coagulation Disorder, Pregnancy Complications
- Trial name
- NCT03555630
- Testing
- Thromboelastogram
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Augusta University
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