Clinical trials: Hypertension, Pregnancy Induced
Preeclampsia
Effect of Rosuvastatin on the Clinical Features of Preeclampsia
The primary outcome will be the effect of rosuvastatin on the resolution of biochemical features associated with severe PE (↑CRP and IL6). .
- Trial name
- NCT04303806
- Testing
- rosuvastatin
- Volunteers
- 80 people
- Sponsor
- Assiut University
Preeclampsia
Vanadium in Late-onset Preeclampsia
Introduction: Cadmium, lead and vanadium important pollutants produced from anthropogenic activities, has been suggested to be embryotoxic and fetotoxic in a lot of studies.
- Trial name
- Vanadium PE (NCT04200222)
- Testing
- cadmium, lead and vanadium measurements and compare
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Cengiz Gokcek Women's and Children's Hospital
Abortion, Spontaneous, Pregnancy Complications
Relation Between Subclinical Hypothyroidism and Outcome of Pregnancy
Studies have demonstrated a relationship between subclinical hypothyroidism and obstetrics complications like preterm delivery, pre-eclampsia, placental abruption and stillbirth.
- Conditions
- Abortion, Spontaneous, Pregnancy Complications, Subclinical Hypothyroidism
- Trial name
- GravThyr (NCT01335802)
- Where
- Denmark
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Naestved Hospital
Preterm Birth Complication, Preterm Birth
Personalized Care for Prenatal Stress Reduction & Prevention of Preterm Birth (PTB) Disparities
The goal of this clinical trial is to learn if a personalized prenatal support program [(Personalized Toolkit Building a Comprehensive Approach to Resource optimization and Empowerment in Pregnancy \& Beyond, (PTBCARE+)] works to…
- Conditions
- Preterm Birth Complication, Preterm Birth, Preterm Birth Recurrence, Preeclampsia
- Trial name
- PTBCARE+ (NCT06915428)
- Testing
- Care coordination, Electronic massage, support gift #1
- Where
- United States
- Volunteers
- 1,228 people
- Sponsor
- University of North Carolina, Chapel Hill
Pregnant With Complication, Preeclampsia
Developing & Evaluating Models for Early Predicting Obstetrical Diseases in Pregnant Women by Non-invasive Prenatal Test
This is Observational study, aiming to investigate the potentiality of cffDNA and cfRNA by a non-invasive test, in combination with clinical characteristics, to establish models for early screening and predicting high-risk…
- Conditions
- Pregnant With Complication, Preeclampsia, Preterm Birth, Gestational Diabetes
- Trial name
- NCT06385366
- Where
- Vietnam
- Volunteers
- 1,105 people
- Sponsor
- Gene Solutions
Pre-Eclampsia, Cardiovascular Diseases
Pre-eclampsia and Future Cardiovascular Health: An Underused Opportunity to Improve Family Health
Background: PE (pre-eclampsia) is a common pregnancy-specific vascular hypertensive disease affecting 3-5% of pregnancies. PE independently increases the risk for premature cardiovascular disease (CVD) in mothers and their…
- Conditions
- Pre-Eclampsia, Cardiovascular Diseases, Cardiovascular Risk Factor, Gestational Hypertension
- Trial name
- FINNCARE (NCT04676295)
- Testing
- Face-to-face and web-based lifestyle intervention
- Where
- Finland
- Volunteers
- 284 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Pregnancy, IUGR
Effects of High Altitude on AMPK Activation
Pregnancy elicits adaptive changes in uteroplacental blood flow, which are altered at high altitude and may contribute to the observed 3-fold increase in intrauterine growth restriction (IUGR) and preeclampsia (PreE).
- Conditions
- Pregnancy, IUGR, Preeclampsia
- Trial name
- NCT02391519
- Testing
- Collection of myometrial, cord blood, and placental tissue samples
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Preeclampsia
Role of the Maternal Microbiota on the Immune Response and Metabolism During Hypertensive Disorders
Preeclampsia (PE) is a significant cause of maternal and fetal morbidity and mortality, characterized by high blood pressure and proteinuria during pregnancy.
- Trial name
- MATER (NCT06421493)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Istituto Clinico Humanitas
PE (Pre-eclampsia) High-risk Population With Gut Microbiota Dysbiosis During Their Pregnancy
Probiotic Supplementation During Pregnancy in Preeclampsia High-risk Groups
In this randomized controlled study, preventive intervention of aspirin combined with probiotics or aspirin combined with placebo would given to PE (pre-eclampsia) high-risk population with gut microbiota dysbiosis during their…
- Trial name
- NCT05554185
- Testing
- aspirin 100mg and probiotics 1 bag
- Volunteers
- 338 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Preterm Birth, Gestational Diabetes Mellitus (GDM)
Evaluation of Maternal and Neonatal Outcomes in Women Are Conceived Through Assisted Reproductive Technology Compared to Other Fertility Treatments and Naturally Conceived Women: It is a Retrospective Cohort Study Conducted Over a 5-year Period at a Fertility Center in a Lebanese Hospital
Background: The number of couples experiencing difficulties conceiving and seeking treatment for infertility has increased dramatically over time.
- Conditions
- Preterm Birth, Gestational Diabetes Mellitus (GDM), Gestational Hypertension
- Trial name
- non (NCT06836843)
- Testing
- Since this is an observational study rather than an interventional study, the exposure type refers to all potential factors influencing pregnancy both before and during pregnancy
- Where
- Lebanon
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Lebanese University
Preeclampsia, Hypertension
Study of Positive Airway Pressure in Preeclampsia to Reduce Blood Pressure
The purpose of this study is to identify whether sleep-disordered breathing - as measured by overnight polysomnography - is associated with pre-eclampsia and to determine whether use of positive airway pressure can improve…
- Trial name
- NCT01029691
- Testing
- Positive Airway Pressure
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- University of Michigan
Preeclampsia
Antenatal Platelet Response On Aspirin and Correlation With HDP (Hypertensive Disorders of Pregnancy)
This proposal has three aims to characterize the relationship between aspirin therapy, platelet function response, and prevention of hypertensive disorders of pregnancy (HDP) through a prospective, cohort study using…
- Trial name
- APROACH (NCT04295850)
- Testing
- Aspirin 81 mg
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Thomas Jefferson University
stage1 Hypertension, Preeclampsia
Pregnancy Outcomes in Normotensive VS stage1 Hypertension: a Prospective Observational Study
In 2017, the American College of Cardiology (ACC) and American Heart Association (AHA) guidelines built on evidence that elevated blood pressure increases cardiovascular mortality in the general population, Reclassification of…
- Trial name
- NCT06339749
- Testing
- blood pressure, Clinical protocols for preeclampsia risk screening
- Where
- China
- Volunteers
- 626 people
- Sponsor
- FANG HE
Anemia in Pregnancy, Preeclampsia
A Retrospective Analysis of Neevo®/Neevo®DHA Compared to a Standard Prenatal Vitamin in Anemia During Pregnancy
This study is a multi-site, retrospective chart review to determine the effect of Neevo® or Neevo®DHA (with higher folate and B12) versus standard prenatal vitamins on hemoglobin (Hgb) levels in pregnant women throughout the…
- Trial name
- NCT01062958
- Testing
- Neevo® (a medical food), Prenatal vitamins (≤1mg folic acid, 27 - 35mg iron, and ≤12mcg vitamin B12)
- Where
- 3 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Pamlab, Inc.
Diabetic Retinopathy, Macular Degeneration
Advancing Understanding of Transportation Options
This Stage II randomized, controlled, longitudinal trial seeks to assess the acceptability, feasibility, and effects of a driving decision aid use among geriatric patients and providers.
- Conditions
- Diabetic Retinopathy, Macular Degeneration, Glaucoma, Retinitis Pigmentosa
- Trial name
- AUTO (NCT04141891)
- Testing
- Driving Decision Aid, Older Drivers Website
- Where
- 3 sites in United States
- Volunteers
- 529 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Hypertension in Pregnancy
Docosahexaenoic Acid Supplementation of Women With Hypertension in Pregnancy to Improve Endothelial Health
The Investigator would like to see if taking a DHA supplement at a dose recommended for heart health will improve brachial artery dilation (relaxation) and help blood pressure.
- Trial name
- DHA-2 (NCT02137408)
- Testing
- Docosahexaenoic acid 200 mg, Docosahexaenoic acid 1000 mg
- Where
- United States
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Pregnancy Complications, Placental Insufficiency
PREdelivery Placental Biomarkers- Pregnancy and Delivery Outcome
The PREPPeD study proposes that predelivery placenta-derived maternal circulating biomarkers reflect placental health, capacity and ageing, and can help predict onset and complications of delivery both in complicated pregnancies…
- Trial name
- PREPPeD (NCT03100084)
- Testing
- Blood sampling
- Where
- Norway
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Pregnancy Disease, Cirrhosis, Liver
Liver Disease in Pregnancy
Liver Diseases in pregnancy represents rare disorders and current data is derived primarily from single centres and retrospective cohorts.
- Conditions
- Pregnancy Disease, Cirrhosis, Liver, HELLP Syndrome, AFLP - Acute Fatty Liver of Pregnancy
- Trial name
- NCT03834285
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- King's College Hospital NHS Trust
Preeclampsia
Exercise Induced Improvement of the Venous Reserve Capacity in Formerly Pre-eclamptic Women
Primary objective: To investigate whether physical exercise prior to pregnancy in formerly preeclamptic women results in a comparable improvement of vascular and endothelial functioning as in women who had an uneventful…
- Trial name
- NCT00900458
- Testing
- Aerobic Exercise training
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Congenital Heart Disease, Pregnancy Complications
Fetal Growth and Pregnancy Complications Among Women With Heart Disease
An increasing proportion of women with heart disease now go through pregnancy and childbirth. More knowledge about the risk of complications and adverse outcomes for the mother and the baby is needed to guide clinical care in…
- Conditions
- Congenital Heart Disease, Pregnancy Complications, Arrhythmias, Cardiac, Hypertension in Pregnancy
- Trial name
- PreCor (NCT03657823)
- Where
- Norway
- Volunteers
- 800 people
- Sponsor
- Oslo University Hospital
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