Clinical trials: Hypertension, Renal
Pulmonary Arterial Hypertension, Renal Dysfunction
The Effect of Renal Impairment on the Pharmacokinetics of Oral Treprostinil
This is a single-center, open-label, single-dose evaluation of 1 mg UT-15C SR pharmacokinetics, safety, and tolerability in subjects with normal, mild, moderate and end stage renal disease (ESRD; on dialysis).
- Trial name
- NCT01131845
- Testing
- UT-15C SR (treprostinil diethanolamine)
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- United Therapeutics
Renal Artery Obstruction, Hypertension, Renovascular
Endovascular Therapy for Renal Artery Stenosis in China
A multicenter prospective registry planned to recruit more than 5 000 patients with renal artery stenosis was carried out in China.
- Trial name
- ETRAS-China (NCT03080519)
- Testing
- Endovascular Therapy
- Where
- 16 sites in China
- Volunteers
- 5,000 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Pseudotumor Cerebri, Cystinosis
The Role of Susceptibility to Thrombosis in the Pseudotumor Cerebri of Nephropathic Cystinosis: A Case-Control Study
This study will examine whether the tendency to have thrombosis, or the formation of blood clots inside blood vessels, has a role in the development of pseudotumor cerebri (PTC).
- Trial name
- NCT00071903
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Hypertension (HTN), Diabetes (DM)
Team-Based Shared Decision-Making Program in Cardiovascular-Kidney-Metabolic Health (Healthy Heart - CKM)
The investigators are proposing a new team-based shared decision-making (SDM) program. The goal of this study is to see whether this program is practical and whether it may help adults with cardiometabolic risk factors and…
- Conditions
- Hypertension (HTN), Diabetes (DM), Hyperlipidaemia, Kidney Disease
- Trial name
- SDM in CKM (NCT07662616)
- Testing
- Team-based shared decision-making
- Volunteers
- 94 people
- Sponsor
- Johns Hopkins University
Hyperlipidemia, Hypertension
Renal Hemodynamic Effects of the HMG-CoA Reductase Inhibitors in Normal Volunteers and in Patients With Chronic Renal Failure
This study was done to determine whether Simvastatin (a medication commonly used to treat patients with high cholesterol levels in the blood increases blood flow to the kidneys and improves renal function in normal volunteers and…
- Conditions
- Hyperlipidemia, Hypertension, Chronic Renal Failure
- Trial name
- NCT02511418
- Testing
- Simvastatin
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mayo Clinic
Hypertension, Renal Failure
The Efficacy of Color-Doppler Ultrasonography to Assess the Renal Blood Flow With the Estimation of GFR
It is generally assumed that renal blood flow is symmetric in the absence of renal artery stenosis. The importance of studying the function of both kidneys separately is because it cannot be assumed that they are functionally…
- Trial name
- NCT00470769
- Testing
- Color-Doppler Ultrasound, 99mTc-DTPA scintigraphy
- Where
- 3 sites in Italy
- Volunteers
- 2,006 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Uncontrolled Hypertension, Autosomal Dominant Polycystic Kidney Disease
Renal Denervation in ADPKD- RDN-ADPKD Study
RDN-ADPKD is a prospective, randomized (1:1, central randomization), single-center, hypothesis-generating, feasibility study. The purpose of the RDN-ADPKD study is to demonstrate efficacy and document safety of renal denervation…
- Conditions
- Uncontrolled Hypertension, Autosomal Dominant Polycystic Kidney Disease, Renal Denervation
- Trial name
- RDN-ADPKD (NCT05460169)
- Testing
- Renal denervation
- Where
- Germany
- Volunteers
- 44 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Hypertension, Diabetic Nephropathy
Antiproteinuric Effect of Valsartan and Lisinopril
Title: Antiproteinuric effect of valsartan, lisinopril and valsartan versus lisinopril in non-diabetic and diabetic renal disease: a randomized (3:3:1), double blind, parallel group, controlled trial, 5 months follow-up.
- Trial name
- NCT00171574
- Testing
- Valsartan, Valsartan plus HCTZ, Lisinopril
- Where
- Switzerland
- Volunteers
- 124 people
- Sponsor
- Novartis
End-Stage Renal Disease, Hemodialysis
Hemocontrol and Blood Pressure Control in Dialysis Patients
Volume overload contributes significantly to the pathogenesis of hypertension in hemodialysis patients. The Hemocontrol(HC)system (Gambro), which automatically adjusts ultrafiltration rate and dialysate conductivity according to…
- Trial name
- NCT00319774
- Testing
- Hemocontrol Biofeedback System
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Université de Montréal
Cardiovascular Diseases, Cerebrovascular Disease
REnal Denervation After Stroke (REDs) Study - A Randomized Clinical Trial of Renal Denervation in the Subacute Phase of Stroke
The REnal Denervation after stroke (REDs) study is a national, multicenter, investigator-initiated randomized controlled clinical trial designed to assess the efficacy of catheter-based renal denervation (RDN) performed in the…
- Conditions
- Cardiovascular Diseases, Cerebrovascular Disease, Arterial Hypertension, Hypertension
- Trial name
- REDs (NCT07114757)
- Testing
- Renal denervation after stroke
- Where
- Italy
- Volunteers
- 108 people
- Sponsor
- Centro per la Lotta Contro l'Infarto - Fondazione Onlus
Hypertension, Diabetes Mellitus
Community Based Multiple Risk Factors Intervention Strategy
Randomized controlled trial of CORFIS Programme. The study objectives are as follows: 1. To determine the efficacy of a community based multiple risk factors interventional strategy (CORFIS) for a treatment period of 6 months in…
- Conditions
- Hypertension, Diabetes Mellitus, Hyperlipidemia
- Trial name
- CORFIS (NCT00490672)
- Testing
- No Active Intervention., Community Based Multiple Risk Factor Intervention Strategies
- Where
- 78 sites in Malaysia
- Volunteers
- 770 people
- Sponsor
- Ministry of Health, Malaysia
Hyperlipidemia, Hypercholesterolemia
Patient and Provider Assessment of Lipid Management Registry
The purpose of the Patient and Provider Assessment of Lipid Management Registry (PALM) is to gain a better understanding of physicians' cholesterol medication prescribing practices, patient and physician attitudes and beliefs…
- Conditions
- Hyperlipidemia, Hypercholesterolemia, Cardiovascular Disease, Diabetes
- Trial name
- PALM (NCT02341664)
- Where
- 14 sites in United States
- Volunteers
- 7,658 people
- Sponsor
- Duke University
Uncontrolled Hypertension
Renal Denervation by MDT-2211 System in Patients With Uncontrolled Hypertension
The objective of this study is to demonstrate that the MDT-2211 renal denervation system is a safe and effective treatment for uncontrolled hypertension subjects despite treatment with 3 or more anti-hypertensive medications of…
- Trial name
- HTN-J (NCT01644604)
- Testing
- MDT-2211 Renal Denervation System
- Where
- 17 sites in Japan
- Volunteers
- 41 people
- Sponsor
- Medtronic Vascular
High Blood Pressure
The Effect of Amiloride and Spironolactone in Healthy Persons
This study will investigate whether retaining potassium in the body will lead to changes in blood pressure and changes in blood and urine samples.
- Trial name
- SPAS (NCT00857909)
- Testing
- Amiloride, Spironolactone
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Regional Hospital Holstebro
Resistant Hypertension
Renal Sympathetic Denervation and Insulin Sensitivity (RENSYMPIS Study)
Hypertension is a major risk factor for stroke and cardiovascular mortality. Catheter- based renal denervation causes substantial and sustained blood- pressure reduction in patients with resistant hypertension.
- Trial name
- RENSYMPIS (NCT01785732)
- Testing
- Renal Denervation
- Where
- Finland
- Volunteers
- 60 people
- Sponsor
- The Hospital District of Satakunta
Cirrhosis With Ascites
Adrenal Insufficiency in Cirrhotics With Ascites. Effects of Hydrocortisone on Renal and Haemodynamic Function
Relative adrenal insufficiency (RAI) is an well known condition in patients with septic shock. Liver failure (including chronic liver failure)and sepsis are both characterized by hyperdynamic circulatory failure (with low…
- Trial name
- AILD (NCT00657306)
- Testing
- hydrocortisone, dextrose solution 5%
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Turin, Italy
Hypertension
SPP100 (Aliskiren) Regimen in Hypertensive Patients With Renal Dysfunction
Assessing the safety, efficacy and pharmacokinetics of SPP100 (Aliskiren) regimen in hypertensive patients with renal dysfunction
- Trial name
- NCT00299832
- Testing
- Aliskiren
- Where
- Japan
- Volunteers
- 40 people
- Sponsor
- Novartis
Uncontrolled Hypertension
Cystatin C and Uncontrolled Hypertension
Hypertension is an underdiagnosed and undertreated disease in real-life. Blood pressure and kidney functions are known to be closely related.
- Trial name
- NCT02334033
- Testing
- other
- Where
- Turkey (Türkiye)
- Volunteers
- 903 people, healthy volunteers welcome
- Sponsor
- Ankara University
Hypertension
A Trial of Telmisartan Prevention of Cardiovascular Disease
The present research is conducted as a randomized, parallel-group, controlled, open study (using the PROBE method) to primarily verify the effects on various biomarkers in high-risk hypertensive patients treated with ARB…
- Trial name
- ATTEMPT-CVD (NCT01075698)
- Testing
- Non-ARB (standard therapy), ARB (Telmisartan)
- Where
- Japan
- Volunteers
- 1,228 people
- Sponsor
- Kumamoto University
Kidney Diseases, Food/Nutrition Insecurity
Supporting VETerans With Kidney Disease Through Food As Medicine
The goal of this pilot clinical trial is primarily learn if produce boxes improve clinical outcomes among Veterans with kidney disease and food or nutrition insecurity.
- Conditions
- Kidney Diseases, Food/Nutrition Insecurity, Diabetes, Hypertension
- Trial name
- VETFAM (NCT07194733)
- Testing
- VET FAM Product Box and Nutrition Education
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- VA Eastern Colorado Health Care System