Clinical trials: Hypertension (HTN)
Hemodynamic Instability
Prophylactic Norepinephrine and Phenylephrine Infusion for Hemodynamic Effects in Patients With Preeclampsia
The purpose of this study is to investigate the maternal cardiac output response to prophylactic norepinephrine and phenylephrine infusion for postspinal anesthesia hypotension in parturients with preeclampsia undergoing cesarean…
- Trial name
- NCT05035498
- Testing
- Phenylephrine, Norepinephrine
- Where
- China
- Volunteers
- 72 people
- Sponsor
- General Hospital of Ningxia Medical University
Intrahepatic Bile Duct Cancer, Intrahepatic Cholangiocarcinoma (Icc)
Additional Chemotherapy Administered Directly Into the Liver Using a Chemo Pump in Patients With Bile Duct Cancer Inside the Liver Treatable by Surgery
The goal of this clinical trial is to learn if additional chemotherapy by means of a chemo pump can prevent return of disease in adult patients with bile duct cancer in the liver that can be treated with surgery.
- Conditions
- Intrahepatic Bile Duct Cancer, Intrahepatic Cholangiocarcinoma (Icc), Intrahepatic Bile Duct Carcinoma, Intrahepatic Cholangiocarcinoma
- Trial name
- PUMP IV (NCT06888063)
- Testing
- Hepatic Arterial Infusion Pump chemotherapy with floxuridin
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Erasmus Medical Center
Hypertension
CKD-330 Drug-Drug Interaction Study (Candesartan)
The purpose of this study is to evaluate a pharmacokinetic drug interaction and safety of Candesartan between free combination of Candesartan and Amlodipine and Candesartan monotherapy.
- Trial name
- CKD-330(C) (NCT02064621)
- Testing
- Candesartan 32mg, Candesartan 32mg/Amlodipine 10mg
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Primary Hyperparathyroidism, Primary Hyperparathyroidism Due to Adenoma
Aldosterone Variations in Patients With Primary Hyperparathyroidism After Surgery
Primary hyperparathyroidism is a disorder of calcium and phosphorus metabolism linked to dysfunction of one or more parathyroid glands.
- Trial name
- ALDOPARA2 (NCT07388914)
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Central Hospital, Nancy, France
Pulmonary Arterial Hypertension, Interstitial Lung Disease
Treprostinil Therapy For Patients With Interstitial Lung Disease And Severe Pulmonary Arterial Hypertension
Our hypothesis is that IV or SQ Treprostinil can improve 6 minute walk distance, hemodynamics and quality of life in patients with interstitial lung disease and severe secondary pulmonary arterial hypertension.
- Conditions
- Pulmonary Arterial Hypertension, Interstitial Lung Disease, Idiopathic Pulmonary Fibrosis
- Trial name
- NCT00705133
- Testing
- Treprostinil
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Rajan Saggar
Mental Stress, Hypertension
Impact of a Health and Mental Health Promotion Intervention Among Jordanians and Syrians.
Given the heightened risk of NCDs and mental health issues, it is critical for Jordanians and Syrian refugees to have access to prevention based health services.
- Conditions
- Mental Stress, Hypertension, Diabetes
- Trial name
- NCT03721848
- Testing
- Healthy community clinic NCD+MH, Healthy community clinic NCD
- Where
- Jordan
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Chronic Kidney Diseases, Hypertension
Integrated Diagnosis and Treatment of CKD on Outcomes
Objective: To establish a study cohort and follow up of patients with CKD in our hospital, and evaluate the status of integrated CKD diagnosis and treatment according to guidelines in the real world, as well as the clinical…
- Conditions
- Chronic Kidney Diseases, Hypertension, Hyperglycemia, Hyperlipidemias
- Trial name
- NCT05242055
- Testing
- Integrated diagnosis and treatment for CKD
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Capital Medical University
Hypertension
Safety and Efficacy of Valsartan and Amlodipine Combined and Alone in Hypertensive Patients
This trial will compare valsartan and amlodipine combination therapies to valsartan and amlodipine monotherapy,and placebo for treating patients with hypertension
- Trial name
- NCT00409643
- Testing
- valsartan+amlodipine combination, valsartan, amlodipine
- Where
- 2 sites in United States, Germany
- Volunteers
- 1,259 people
- Sponsor
- Novartis
Maternal Health, Infant Health
Stress Reactivity and Mother-Infant Cardiovascular Disease Risk
Prenatal Mindfulness training (MT) shows promise as a preventive intervention against hypertensive disorders of pregnancy (HDP) and may reduce risk for offspring cardiovascular disease (CVD).
- Conditions
- Maternal Health, Infant Health, Hypertension, Behavioral Medicine
- Trial name
- NCT06805799
- Testing
- Follow up to Mindfulness RCT using a Still Face Paradigm
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Lifespan
Overweight and Obesity, Cardiovascular Risk Factor
The Emirates Heart Health Project: A Family-based Diet and Exercise Intervention in Obese and Overweight Patients
Data from Abu Dhabi's Department of Health document that the leading cause of death among the population of the emirate of Abu Dhabi is cardiovascular disease (CVD).
- Trial name
- EHHP (NCT04688684)
- Testing
- Family-based diet and exercise intervention
- Where
- United Arab Emirates
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- United Arab Emirates University
Anemia, Diabetes
A Comparative Clinical Trial of the TensorTip, a Novel Non Invasive Device for Measurement Blood Parameters
1. Aim: The aim of the clinical trial is to study the accuracy of the TensorTip device compared with registered (FDA-approved) invasive and non-invasive devices. 2.
- Conditions
- Anemia, Diabetes, Heart Disease, High Blood Pressure
- Trial name
- NCT01196533
- Testing
- Non invasive peripheral blood monitoring
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Cnoga Medical Ltd.
Hypertension
A Long-term Study of the Safety of MK-0954A in Patients With Essential Hypertension (MK-0954A-351)
This study is being conducted to evaluate the safety of MK-0954A (L100/H12.5 mg) in essential hypertension participants who are uncontrolled with MK-954H (L50/H12.5 mg).
- Trial name
- NCT01307033
- Testing
- MK-0954A, MK-954H
- Volunteers
- 278 people
- Sponsor
- Organon and Co
Ocular Hypertension, Open Angle Glaucoma
A Study of Open Angle Glaucoma or Ocular Hypertension in Patients Within the United Kingdom
Study PhXA41 for its non-inferiority compared with timolol in lowering intra-ocular pressure
- Trial name
- NCT00751049
- Testing
- timolol, PhXA41
- Where
- 12 sites in United Kingdom
- Volunteers
- 294 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Type2Diabetes, Hypertension
Digital Care for Holistic Health in Older Adults With Diabetes and Multimorbidity
The purpose of this study was to explore the effectiveness of the "Digital Care Community Common Good" program in improving disease control indicators, self-management abilities, depression, and quality of life among patients…
- Conditions
- Type2Diabetes, Hypertension, Dyslipidemia, CKD
- Trial name
- NCT07310849
- Testing
- Digital Care Community Common Good Program, Usual Care
- Where
- Taiwan
- Volunteers
- 169 people
- Sponsor
- Chang Gung University of Science and Technology
stage1 Hypertension, Preeclampsia
Pregnancy Outcomes in Normotensive VS stage1 Hypertension: a Prospective Observational Study
In 2017, the American College of Cardiology (ACC) and American Heart Association (AHA) guidelines built on evidence that elevated blood pressure increases cardiovascular mortality in the general population, Reclassification of…
- Trial name
- NCT06339749
- Testing
- blood pressure, Clinical protocols for preeclampsia risk screening
- Where
- China
- Volunteers
- 626 people
- Sponsor
- FANG HE
Preeclampsia, Nursing Care
The Effect of Augmented Reality Based Training on Preeclampsia Case
However, no study has been found in the care of preeclampsia, which is highly effective on maternal and fetal health. Therefore, this study was planned to determine the effect of augmented reality-based training on the diagnosis…
- Conditions
- Preeclampsia, Nursing Care, Pregnancy, Augmented Reality
- Trial name
- preeclamside (NCT06730048)
- Testing
- Experimental Group
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Inonu University
Severe Hypertension
Study of CS-3150 in Patients With Severe Hypertension
To examine antihypertensive effect and safety of administration of CS-3150 in patients with severe hypertension (Grade III).
- Trial name
- NCT02808026
- Testing
- CS-3150
- Where
- Japan
- Volunteers
- 20 people
- Sponsor
- Daiichi Sankyo Co., Ltd.
Prediabetic State, Insulin Resistance
Macronutrient Effects on Alzheimer's Disease (MEAL-2)
This study compares the effects of a one-month diet high in saturated fat (SF), glycemic index (GI), and salt (Na+) to a diet low in these nutritional parameters on memory and other cognitive functions, on MRI measures of brain…
- Conditions
- Prediabetic State, Insulin Resistance, Middle Age, Prehypertension
- Trial name
- MEAL-2 (NCT02463084)
- Testing
- Low Diet, High Diet
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Eisenmenger Syndrome, Pulmonary Arterial Hypertension of Congenital Heart Disease
A Study of Sotatercept for Patients With Eisenmenger Syndrome or Unrepaired Shunt-Associated Pulmonary Arterial Hypertension Resistant to Vasodilator Therapy
What is this study about? This study will test whether adding sotatercept to usual medicines for pulmonary arterial hypertension (PAH) can help adults who have PAH due to unrepaired congenital heart defects (atrial or ventricular…
- Trial name
- SuMILE (NCT07356778)
- Testing
- Sotatercept, vasodilator-based PAH therapy
- Where
- 10 sites in Japan
- Volunteers
- 36 people
- Sponsor
- Kazuya Hosokawa
Glaucoma, Medication Adherence
The iD2: A Smart Eye Drop Cap Monitor for Eye Drop Adherence
Most patients with glaucoma use eye drops to lower their intraocular pressure. However, poor adherence to prescribed eye drop regimens can lead to significant loss of vision-related quality of life.
- Trial name
- NCT07664943
- Testing
- Eye drop cap monitor
- Volunteers
- 100 people
- Sponsor
- Universal Adherence LLC