Clinical trials: Hypertension Arterial, open to volunteers
Hypertension, Cardiovascular Diseases
Sympathetic-vascular Dysfunction in Obesity and Insulin Resistance (Vitamin C Study)
The main purpose of research is to examine and understanding the development of hypertension in obese adults with insulin resistance.
- Trial name
- NCT04715022
- Testing
- Ascorbic acid solution (American Regent Laboratories Inc.), Saline
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Kansas Medical Center
Hypertension,Essential
Efficacy of Songling Xuemaikang Capsules on Grade 1 Hypertension: a Randomized Controlled Trial
The purpose of this study is: 1. To evaluate the efficacy of Songling Xuemaikang Capsules(SLXMKC) with grade 1 hypertension. 2. To reveal the potiential effects of SLXMKC on vascular function and structure of patients with grade…
- Trial name
- ESCIHP (NCT06093932)
- Testing
- Songling Xuemaikang Capsules, Lifestyle intervention
- Where
- 5 sites in China
- Volunteers
- 100 people
- Sponsor
- Xiyuan Hospital of China Academy of Chinese Medical Sciences
Neuro-Ophthalmology, Optic Neuropathies
Optic Nerve Head Evaluation Through Multimodal Blood Flow Analysis: a Prospective Observational, Multi-center Study
OCT-A and eco-colordoppler are technologies which enable optic nerve head (ONH) blood perfusion detection. The aim of the study is to assess ONH vascular and structural components in optic neuropathies with and without ONH edema…
- Conditions
- Neuro-Ophthalmology, Optic Neuropathies, Optic Atrophy, Hereditary, Leber, Optic Neuropathy, Anterior Ischemic
- Trial name
- FlowONH (NCT07075887)
- Volunteers
- 70 people
- Sponsor
- Barboni
Pulmonary Arterial Hypertension (PAH)
Randomized Study of Triple Therapy vs Sildenafil Dose Optimization in Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a rare and progressive disease characterized by increased pressure in the pulmonary arteries, leading to right heart failure and premature death.
- Trial name
- ASCEND-PAH (NCT07713914)
- Testing
- Prostacyclin Pathway Agent, Sildenafil Dose Optimization
- Where
- Brazil
- Volunteers
- 196 people
- Sponsor
- University of Sao Paulo General Hospital
Cardiovascular Diseases, Surgery
Pressure Recording Analytical Method Parameters and Their Relationship With Hypotension in Hypertensive Patients
Perioperative anesthesiologists can benefit from easily obtainable hemodynamic variables detecting or quantifying the lack of an adequate compensatory capacity of the cardiovascular system in order to optimize patient management…
- Conditions
- Cardiovascular Diseases, Surgery, Hypotension, Hypotension on Induction
- Trial name
- PRAM-in-HYPO (NCT05960604)
- Testing
- Passive leg raising
- Where
- 5 sites in Turkey (Türkiye)
- Volunteers
- 660 people
- Sponsor
- Recep Tayyip Erdogan University
Blood Pressure Management, Blood Pressure Monitoring, Ambulatory
Impact of Resistance Training Intensity on Blood Pressure
The goal of the clinical trial is to understand the effect of two resistance training protocols employing different loading intensities (% of 1 repetition maximum; 1-RM), but with standardized effort intensity (2 repetitions in…
- Conditions
- Blood Pressure Management, Blood Pressure Monitoring, Ambulatory, Blood Pressure, High, Blood Pressure
- Trial name
- HEART (NCT06845514)
- Testing
- Condition LL-RE, Control, Condition HL-RE
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Cirrhosis, Liver, Splenectomy; Status
The Effect of Laparoscopic Splenectomy and Azygoportal Disconnection on Liver Reserve Function for Cirrhosis Patients
In this study, the investigators compared the improvement of liver reserve function related indicators in patients with liver cirrhosis after laparoscopic splenectomy and azygoportal disconnection.
- Conditions
- Cirrhosis, Liver, Splenectomy; Status, Portal Hypertension
- Trial name
- ELSDL (NCT05325437)
- Testing
- Laparoscopic splenectomy and azygoportal disconnection
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Northern Jiangsu People's Hospital
Dyslipidemia, Hypertension
A Study to Evaluate the Safety and Pharmacokinetics of AD-231 Compared to Coadministration of AD-231A, AD-231D and AD-231C
A Study to Evaluate the Safety and Pharmacokinetics of AD-231 Compared to Coadministration of AD-231A, AD-231D and AD-231C
- Trial name
- NCT07590167
- Testing
- AD-231, AD-231A, AD-231D and AD-231C
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Addpharma Inc.
Blood Pressure, Low Back Pain
Therapeutic Mechanisms of Epidural Spinal Cord Stimulation
The purpose of this study in patients undergoing routine care epidural spinal cord stimulation (SCS) is to determine 1) whether SCS reduces arterial blood pressure (BP) in patients which chronic low back pain and hypertension, 2)…
- Conditions
- Blood Pressure, Low Back Pain, Hypertension
- Trial name
- NCT05556902
- Testing
- Permanent Epidural Spinal Cord Stimulation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Alabama at Birmingham
Glaucoma Open-Angle
Feasibility, Accuracy, and Reproducibility of Virtual Reality Visual Field Testing in Patients With Glaucoma
The goal of this clinical trial is to evaluate the feasibility of using virtual reality based visual field testing to monitor glaucoma in a clinical setting.
- Trial name
- NCT07063537
- Testing
- Virtual Reality Visual Field (VR-VF)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Nova Scotia Health Authority
Uncontrolled Hypertension
Sequential Multiple Assignment Randomized Trial to Reduce Food Insecurity
Food insecurity affects 20% of the 116 million people in the US with hypertension and is associated with poor adherence to evidence-based treatments and disparities in hypertension outcomes.
- Trial name
- SMART (NCT07031739)
- Testing
- Resource information, Community Health Worker (CHW) assistance, Medically-tailored Meals (MTM)
- Where
- United States
- Volunteers
- 224 people
- Sponsor
- Wake Forest University Health Sciences
Obesity, Interstitial Lung Disease
Feasibility of Semaglutide in Advanced Lung Disease
The goal of this clinical trial is to learn whether semaglutide, an FDA-approved treatment for diabetes and obesity, is feasible and tolerable in patients with advanced lung disease. The main question[s] it aims to answer are: 1.
- Conditions
- Obesity, Interstitial Lung Disease, Chronic Obstructive Pulmonary Disease, Sarcoidosis, Pulmonary
- Trial name
- NCT05746039
- Testing
- Semaglutide Pen Injector
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Pennsylvania
Diabetes, Metabolic Disorders
Observational Study for the Characterisation of Patients Affected by Any Type of Diabetes and Endocrine Disorders
The main objective of this retrospective and prospective observational register is to identify anthropometric, clinical, laboratory and/or instrumental markers of disease severity and activity in patients suffering from diabetes…
- Conditions
- Diabetes, Metabolic Disorders, Arterial Hypertension, Dyslipidemia
- Trial name
- DiabRegistry (NCT07206875)
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- IRCCS San Raffaele
COPD Exacerbation (AECOPD), Pulmonary Hypertension
Dynamic Changes in Right Ventricle and Pulmonary Artery Coupling Among COPD Patients With Acute Exacerbation
Chronic obstructive pulmonary disease (COPD) is a common, preventable, and manageable disease characterized by persistent respiratory symptoms and airflow limitation.
- Trial name
- NCT07694713
- Testing
- Echocardiography assessment
- Where
- Egypt
- Volunteers
- 115 people
- Sponsor
- Assiut University
Ascites, Liver Cirrhosis
Proximal Splenic Artery Embolization (PSAE) for the Treatment of Refractory Ascites in Decompensated Cirrhosis
The purpose of this study is to learn whether a procedure called Proximal Splenic Artery Embolization (PSAE) can lower the need for repeat fluid drainage in adults with cirrhosis and a buildup of fluid in the abdomen (ascites)…
- Conditions
- Ascites, Liver Cirrhosis, Hypertension, Portal
- Trial name
- NCT07755059
- Testing
- Proximal Splenic Artery Embolization
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Hypertension, Cardiovascular Disease
Regional Innovation in Chronic Disease and Elderly Care
This project aims to develop a community-based health promotion intervention model for populations at potential risk of metabolic syndrome.
- Conditions
- Hypertension, Cardiovascular Disease, Hyperlipidemia, Hyperglycemia
- Trial name
- NCT07578090
- Where
- Taiwan
- Volunteers
- 1,000 people
- Sponsor
- Fu Jen Catholic University
Postpartum Preeclampsia, Hypertension in Pregnancy
Labetalol or Nifedipine for Control of Postpartum Hypertension: A Randomized Controlled Trial
Randomized trial comparing risk of hospital readmission and hypertensive complications between patients managed on Labetalol compared to Nifedipine.
- Trial name
- NCT05309460
- Testing
- Labetalol Oral Tablet, NIFEdipine ER
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Nebraska Methodist Health System
Alcohol Drinking, Drinking Behavior
Reducing Cardiovascular Risks: The Role of Alcohol Use
The purpose of this study is to learn whether avoiding alcohol can improve heart and blood vessel health in adults who regularly drink alcohol and have high blood pressure.
- Conditions
- Alcohol Drinking, Drinking Behavior, At-risk Drinking, Cardiovascular Risk Factor
- Trial name
- NCT07783061
- Testing
- Alcohol Abstinence, Control arm
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- The University of Texas at Arlington
Hypertension, Hypertension,Essential
Renal Artery Denervation Assessment Without Antihypertensive Medication Regimen (RADAR)
To obtain an assessment of the efficacy and safety of renal denervation by dehydrated alcohol injection, USP administered via the Peregrine System™ Infusion Catheter in hypertensive subjects in the absence of antihypertensive…
- Trial name
- RADAR (NCT07083765)
- Testing
- Dehydrated Alcohol Injection, USP
- Where
- United States
- Volunteers
- 202 people
- Sponsor
- Ablative Solutions, Inc.
Hypertension in Dialysis Patients
Sodium Bicarbonate in Intra-dialytic Hypertension in Chronic Hemodialysis Patients
The study is designed to diminish intra-dialytic hypertension in chrnic hemodialysis patients suffering from metabolic acidosis (low bicarbonate levels).
- Trial name
- NCT07231900
- Testing
- Sodium Bicarbonate (NaHCO3)
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Assaf-Harofeh Medical Center
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