Clinical trials: Hypertension Disorders in Pregnancy
Pre-Eclampsia, Stage 1 Hypertension
Aspirin to Prevent Preeclampsia in Women With Elevated Blood Pressure and Stage 1 Hypertension (ASPPIRE)
To determine if low dose aspirin reduces the incidence of hypertensive disorders of pregnancy (gestational hypertension, preeclampsia, eclampsia, and HELLP syndrome) in pregnant women with stage 1 hypertension and elevated blood…
- Conditions
- Pre-Eclampsia, Stage 1 Hypertension, Elevated Blood Pressure
- Trial name
- NCT04402385
- Testing
- Aspirin 81 mg
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Yale University
Pregnancy Toxemia, Hypertension
Treatment Targets for Chronic Hypertension in Pregnancy
This project is a clinical study of women with high blood pressure who become pregnant. Preeclampsia is a syndrome developing at the end of a pregnancy characterized by an abrupt rise in blood pressure (BP), blood clotting and…
- Conditions
- Pregnancy Toxemia, Hypertension, Proteinuria
- Trial name
- NCT00194974
- Testing
- methyldopa, labetalol, nifedipine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Preeclampsia
Diagnosis and Prediction of Pre-Eclampsia by Using Congo Red Dot Test in Bangladesh and Mexico
A cross sectional study design will evaluate the diagnostic value of the CRD test to the pregnant women attending the Dhaka Medical College Hospital and Hospital Materno-Infantil Inguarán, tertiary level facilities in Bangladesh…
- Trial name
- NCT02381210
- Testing
- Congo Red Dot Test
- Where
- 2 sites in Bangladesh, Mexico
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Preeclampsia
Vascular Endothelial Factor Gene Polymorphism in Preeclampsia
In this study, the investigators assessed one of the released protein factors during the pathophysiology of preeclampsia. They evaluated vascular endothelial growth factor gene mutation which affects the angiogenesis in case of…
- Trial name
- NCT03500588
- Testing
- PCR, Doppler ultrasound
- Where
- Egypt
- Volunteers
- 290 people
- Sponsor
- Beni-Suef University
Pregnancy; Death of Fetus, Early Pregnancy, Uremia in Pregnancy Without Hypertension
Detection and Identification of Preeclampsia Via Volatile Biomarkers
Preeclampsia is a form of hypertension that is unique to human pregnancy. The incidence of the disease ranges between 2 and 7 percent in healthy nulliparous women. The etiology of preeclampsia is unknown.
- Trial name
- DIP (NCT01291342)
- Where
- Israel
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- The Nazareth Hospital, Israel
Preeclampsia
Molecular Study of the Maternal-fetal Interface in Preeclampsia.
Preeclampsia (PE) is a major obstetric complication with short- and long-term consequences for the mother and the fetus. Early screening tools to reduce its mortality and morbidity, as well as to prevent the life-threatening…
- Trial name
- PREMAFE (NCT06232668)
- Testing
- Maternal-fetal interface biopsy and peripheral blood collection in cases group, Maternal-fetal interface biopsy and peripheral blood collection in control group
- Where
- 4 sites in Spain
- Volunteers
- 2,084 people
- Sponsor
- Carlos Simon Foundation
Overactive Bladder
Specified Drug Use-results Survey of Betanis Tablets
To investigate the effects of mirabegron on the symptoms of glaucoma in overactive bladder (OAB) patients with coexisting glaucoma.
- Trial name
- NCT01898624
- Testing
- mirabegron
- Where
- 7 sites in Japan
- Volunteers
- 300 people
- Sponsor
- Astellas Pharma Inc
Preeclampsia, Perinatal Haemorrhage
Aspirin Discontinuation in High-Risk Pregnant Women of Preeclampsia
Low-dose aspirin (LDA) is considered to be the most effective agent to prevent preeclampsia (PE). At present, there is little exploration about the timing of aspirin discontinuation.
- Trial name
- NCT06111079
- Testing
- aspirin discontinuation, aspirin continuation
- Where
- China
- Volunteers
- 1,800 people
- Sponsor
- FANG HE
Chronic Kidney Disease
Effects of a Reduction in Kidney Function on Cardiovascular Structure and Function: A Prospective Study of Kidney Donors
Studies of patients with established kidney disease, even when this is mild, appear to show that they are at high risk of heart failure, stroke and sudden cardiac death.
- Trial name
- NCT01028703
- Where
- United Kingdom
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Albuminuria
Effects of Amlodipine/Benazepril on Albuminuria in Hypertensive Patients With Type 2 Diabetes Mellitus
Type 2 diabetes mellitus is usually associated with high blood pressure, which is a risk factor for kidney disease. Aggressive blood pressure reduction is an important strategy to protect the kidney and reduce urinary protein…
- Trial name
- NCT00136773
- Testing
- amlodipine/benazepril
- Volunteers
- 332 people
- Sponsor
- Novartis
Kidney Failure, Chronic, Diabetic Nephropathies
Effects of Rituximab and Mycophenolate Mofetil (MMF) on Highly Sensitized Patients Awaiting Renal Transplant
This is a 12-month phase 2, prospective, open label study to evaluate the effect of rituximab with mycophenolate mofetil (MMF)on the PRA of 14 highly sensitized patients who just completed an 8 month trial of MMF treatment alone.
- Conditions
- Kidney Failure, Chronic, Diabetic Nephropathies, Glomerulonephritis, IGA, Hypertension, Renal
- Trial name
- NCT00446251
- Testing
- Rituximab, Mycophenolate mofetil (MMF)
- Volunteers
- 14 people
- Sponsor
- University of Washington
Preeclampsia
Esomeprazole in Treatment of Early Onset Preeclampsia (ESOPE Trial)
Pre-eclampsia is one of the most serious complications of pregnancy affecting 3-8 % of pregnancies worldwide. It is a multi-system disorder involving maternal vessels (causing hypertension and endothelial dysfunction), the…
- Trial name
- NCT03213639
- Testing
- Esomeprazole 40 mg Oral Tablet
- Where
- Egypt
- Volunteers
- 205 people
- Sponsor
- Assiut University
Obesity & Overweight, Diabetes Mellitus, Type 2
Chinese Overweight/Obesity Cohort: Metabolic & Comorbidity Risks
This is a nationwide, multi-center, long-term follow-up study of overweight and obese adults in China. The study aims to recruit approximately 26,000 participants across 39 hospitals to better understand how body weight affects…
- Conditions
- Obesity & Overweight, Diabetes Mellitus, Type 2, Hypertension, Non-alcoholic Fatty Liver Disease (MASLD)
- Trial name
- NCT07884903
- Testing
- No intervention; observational assessment only
- Where
- China
- Volunteers
- 25,974 people
- Sponsor
- Shanxi Bethune Hospital
Pre Eclampsia
Transcranial Doppler in Preeclampsia and Its Complications.
Preeclampsia is a leading cause of maternal and perinatal morbidity and mortality. It is defined by new-onset hypertension after 20 weeks of gestation, often associated with proteinuria and/or systemic complications such as…
- Trial name
- DTC-PE (NCT07646561)
- Testing
- Transcranial doppler ultrasound
- Where
- Tunisia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Tunis El Manar
Preterm Birth, PPROM
Antenatal Breastmilk Expression in Pregnant Women at High Risk of Preterm Birth
In this randomized controlled study, the investigators aim to examine if antenatal breastmilk expression (aBME) from week 28 in high-risk pregnancies is a safe and effective method to ensure early access to mother's own milk.
- Conditions
- Preterm Birth, PPROM, Preeclampsia, Previous Preterm Birth
- Trial name
- EXPRESSMOM2 (NCT07191366)
- Testing
- Handstimulation of breast
- Volunteers
- 250 people
- Sponsor
- Odense University Hospital
Essential Hypertension, Liver Cancer
A Multicentre Study on Features of the Gut Microbiota of Patients With Critical Chronic Diseases in China
The human gut microbiome has been associated with many health factors but variability between studies limits the exploration of effects between them.
- Conditions
- Essential Hypertension, Liver Cancer, Nasopharyngeal Cancer, Pancreatic Cancer
- Trial name
- NCT05638269
- Testing
- no intervention
- Where
- 50 sites in China
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Pre-Eclampsia, Frozen Embryo Transfer
Impact of Corpus Luteum Presence or Absence in the Incidence of Preeclampsia After Frozen Embryo Transfer
Identifying modifiable factors that contribute to preeclampsia risk associated with assisted reproduction can improve maternal health.
- Trial name
- PREECLAM-2019 (NCT04092829)
- Testing
- FROZEN EMBRYO TRANSFER IN SUBSTITUTED CYCLE
- Where
- Spain
- Volunteers
- 591 people
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Pregnancy-Induced Hypertension
Slow and Deep Breathing to Lower Blood Pressure in Women With Pregnancy-induced Hypertension
This study evaluates the effect of slow and deep breathing on lowering blood pressure in women with pregnancy-induced hypertension.
- Trial name
- NCT04059822
- Testing
- Slow and deep breathing
- Where
- 2 sites in United Kingdom
- Volunteers
- 1 people
- Sponsor
- Bournemouth University
Pre-Eclampsia
Adipokines, Inflammation, Insulin Resistance and Endothelial Dysfunction in Preeclampsia
The aim of the present study is to evaluate the implication of adipokines, inflammation, insulin resistance and endothelial dysfunction in the pathogenesis of preeclampsia and in pregnancy related complications.
- Trial name
- NCT04455204
- Testing
- Serum asymmetteric dimethyl arginine, serum lipid profiles, Serum vaspin
- Volunteers
- 60 people
- Sponsor
- Tanta University
Safety
Long-Term Safety of Azilsartan Medoxomil and Chlorthalidone Compared to Olmesartan Medoxomil and Hydrochlorothiazide in Participants With Hypertension and Kidney Disease
The purpose of this study is to evaluate long term safety and tolerability of azilsartan medoxomil and chlorthalidone, once daily (QD), compared with olmesartan medoxomil and hydrochlorothiazide in hypertensive participants with…
- Trial name
- NCT01309828
- Testing
- Azilsartan medoxomil and chlorthalidone, Olmesartan medoxomil and hydrochlorothiazide
- Where
- 53 sites in Bulgaria, Germany and 6 more
- Volunteers
- 153 people
- Sponsor
- Takeda
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