Clinical trials: Hypertension With Renal Dysfunction
Multimorbidity, Hypertension
Development and Validation of a Comprehensive Management Service Package for Older Adults With Multimorbidity
This study aims to test a new comprehensive management service package for older adults with two or more chronic conditions (multimorbidity).
- Conditions
- Multimorbidity, Hypertension, Diabetes Mellitus, Coronary Artery Disease
- Trial name
- COMPASS (NCT07151430)
- Testing
- Service Package Group
- Volunteers
- 358 people
- Sponsor
- Xuanwu Hospital, Beijing
Chronic Kidney Diseases, Hypertension
Inspiratory Muscle Strength Training in Chronic Kidney Disease
More than 80% of individuals with chronic kidney disease have concomitant hypertension and the majority fail to achieve blood pressure control <130/80 mmHg, leading to high risk of cardiovascular diseases and end-stage kidney…
- Conditions
- Chronic Kidney Diseases, Hypertension, Aging, Blood Pressure
- Trial name
- NCT04911491
- Testing
- IMST
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- University of Colorado, Denver
Chronic Kidney Diseases, Hypertension
Remote Ischaemic Conditioning on Blood Pressure Control in Chronic Kidney Disease Patients
Chronic kidney disease (CKD) is one of the leading causes of death and disability in Singapore and worldwide. Hypertension is commonly inadequately controlled in patients with CKD and this is associated with CKD progression and…
- Conditions
- Chronic Kidney Diseases, Hypertension, Cardiovascular Diseases
- Trial name
- ERIC-BP-CKD (NCT03236350)
- Testing
- Active autoRIC® (CRIC Treatment)
- Where
- Singapore
- Volunteers
- 85 people
- Sponsor
- Singapore General Hospital
Autosomal Dominant Polycystic Kidney, Hypertension
Effect of Beetroot Juice on Reducing Hypertension in Autosomal Dominant Polycystic Kidney Disease
People with autosomal dominant polycystic kidney disease (ADPKD) develop high blood pressure and kidney disease. Previous studies have shown that a commonly occurring chemical, nitric oxide (NO), is reduced in ADPKD, and may…
- Conditions
- Autosomal Dominant Polycystic Kidney, Hypertension, Endothelial Dysfunction
- Trial name
- BEET-PKD (NCT05401409)
- Testing
- Beetroot juice, Nitrate-depleted beetroot juice
- Where
- 2 sites in Australia
- Volunteers
- 60 people
- Sponsor
- Western Sydney Local Health District
Chronic Kidney Disease, Hypertension (HTN)
Investigating Vascular Properties of HEMI and SPG Signals in Individuals With or at Risk for Chronic Kidney Disease
This prospective, single-center clinical investigation conducted in France will evaluate two non-invasive investigational devices (HEMI and SPG-NINOX) designed to assess microcirculation in adults.
- Conditions
- Chronic Kidney Disease, Hypertension (HTN), Type 2 Diabetes Mellitus (T2DM)
- Trial name
- STIMULUS-CKD (NCT07604922)
- Testing
- HEMI device, SPG-NINOX device
- Where
- France
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Chronic Kidney Disease(CKD), Nocturnal Hypertension
Protecting Renal Function in Chronic Kidney Disease Patients with Isolated Nighttime Hypertension
Hypertension guidelines recommend the application of ambulatory blood pressure monitoring in the diagnosis and treatment of patients with hypertension.
- Trial name
- PRECISE (NCT06780865)
- Testing
- Antihypertensive treatment with Arotinolol or Amlodipine or Clonidine
- Volunteers
- 200 people
- Sponsor
- Shanghai Institute of Hypertension
Atherosclerosis, Cardiovascular Disease
A Study of Clazakizumab (LY5724886) in Adults With Elevated hsCRP and at Increased Risk for Cardiovascular Event
The purpose of this study is to measure the change in high-sensitivity C-reactive protein (hsCRP), a marker of inflammation in the body, with clazakizumab compared with placebo in adults who have elevated hsCRP and at increased…
- Conditions
- Atherosclerosis, Cardiovascular Disease, Obesity, Hypertension
- Trial name
- CLARITY-CRP (NCT07783802)
- Testing
- Clazakizumab
- Where
- 46 sites in United States, Argentina and 2 more
- Volunteers
- 120 people
- Sponsor
- Eli Lilly and Company
Patients With Cardiovascular Disease, Healthy Participants
OCTA in Cardiovascular Disease and Healthy Controls
This prospective clinical study will involve the non-invasive assessment of retinal vessels using OCTA (Cirrus OCT 6000 AngioPlex) and scanning laser Doppler flowmetry (SLDF) in patients with cardiovascular disease and healthy…
- Trial name
- NCT07359664
- Testing
- Retinal vascular assessment using OCTA and SLDF
- Where
- Germany
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Hypertension, Diabetes Mellitus, Type 2
ENCOMPASS: Expansion Study A, RCT
Some patients living with multiple long-term health conditions have difficulty accessing the services they need, despite available primary care and community resources.
- Conditions
- Hypertension, Diabetes Mellitus, Type 2, Chronic Kidney Diseases, Ischemic Heart Disease
- Trial name
- ENCOMPASS (NCT04790604)
- Testing
- Community Health Navigator Program
- Where
- Canada
- Volunteers
- 96 people
- Sponsor
- University of Calgary
Chronic Kidney Diseases, Hypertension
Chronotherapy in Children With Chronic Kidney Disease
This is a pilot, crossover trial in which the investigator will determine if retiming of one anti-hypertensive medication from morning to evening can effectuate normal blood pressure dipping patterns in children and adolescents…
- Trial name
- NCT05353335
- Testing
- Re-timing of anti-hypertensive drug, Current regimen
- Where
- United States
- Sponsor
- Yale University
Chronic Kidney Disease, Hypertension
Arterial Stiffness in Children and Young People With Hypertension and Chronic Kidney Disease
Age related stiffening and hardening of the arteries is often a slow process, but some conditions such as chronic kidney disease (CKD), seem to increase the rate at which the arteries stiffen even during childhood.
- Trial name
- ART-KIDS (NCT07768865)
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- King's College London
Chronic Kidney Disease, Hypertension
A Study in Male and Female Participants (After Menopause) With Mild to Moderate High Blood Pressure to Learn How Safe the Study Treatment BAY3283142 is, How it Affects the Body and How it Moves Into, Through and Out of the Body After Taking Single and Multiple Doses
Researchers are looking for a better way to treat people who have chronic kidney disease (CKD), a progressive decrease in the kidneys' ability to work properly.
- Trial name
- NCT05491642
- Testing
- BAY3283142
- Where
- 4 sites in Bulgaria, Germany
- Volunteers
- 56 people
- Sponsor
- Bayer
Chronic Kidney Diseases, Pregnancy
Kynurenine Concentrations During Pregnancy in Women With or Without Chronic Kidney Disease - A Prospective Multicenter Study
Chronic kidney disease (CKD) affects more than 10% of the population worldwide and represents the second most important risk factor for preeclampsia, a life-threatening complication of pregnancy responsible for approximately…
- Conditions
- Chronic Kidney Diseases, Pregnancy, Preeclampsia
- Trial name
- KIDNEY-MOM (NCT07411937)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 204 people
- Sponsor
- CHU de Reims
Children, Chronic Renal Failure
Effect of Strict Blood Pressure Control and ACE-Inhibition on Progression of Chronic Renal Failure in Pediatric Patients
In children with chronic kidney disease, progression to end-stage renal failure is associated with high patient morbidity and poor quality of life.
- Conditions
- Children, Chronic Renal Failure, Hypertension, Acquired Kidney Disease
- Trial name
- ESCAPE (NCT00221845)
- Testing
- ACE Inhibition, Intensified Blood Pressure Control, Add-on Angiotensin Receptor Blockade
- Where
- 33 sites in Czechia, France and 10 more
- Volunteers
- 400 people
- Sponsor
- Heidelberg University
Cardiovascular Disease, Chronic Kidney Disease
Effects of an Exercise Program in Patients With Hypertensive Chronic Kidney Disease
Introduction: Chronic kidney disease (CKD) is now an important public health issue. While 0.1% of the population is on dialysis, approximately 4.5% of subjects have renal dysfunction (glomerular filtration rate <60 ml/min/1.73…
- Conditions
- Cardiovascular Disease, Chronic Kidney Disease, Chronic Renal Disease, Hypertension
- Trial name
- NCT01155128
- Testing
- exercise aerobic
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- Federal University of Pelotas
Hypertension, Chronic Kidney Disease
RAS Quantification in Patients With Aliskiren or Candesartan
Forced blockade of the renin-angiotensin-system (RAS) by using direct renin inhibition (DRI) has long been propagated to effectuate beneficial outcomes.
- Conditions
- Hypertension, Chronic Kidney Disease, Proteinuria
- Trial name
- RASQAL (NCT01827202)
- Testing
- RAS blockade discontinuation, Aliskiren, Candesartan
- Where
- Austria
- Volunteers
- 24 people
- Sponsor
- Medical University of Vienna
Pulmonary Hypertension, End-Stage Renal Disease
Impact of Hemo-dialysis Therapy on Blood Levels of Treprostenil in End Stage Renal Disease Patients With Pulmonary Hypertension
Remodulin (Treprostenil sodium) is synthetic prostacyclin analog available as a solution for administration in the intravenous route.
- Conditions
- Pulmonary Hypertension, End-Stage Renal Disease, Hemo-dialysis Therapy
- Trial name
- NCT01234571
- Volunteers
- 5 people
- Sponsor
- Rambam Health Care Campus
Renal Insufficiency, Chronic, Hypertension
Urinary Concentration and Diluting Ability in Patients With Chronic Renal Disease and/ or Hypertension
The investigators want to test the hypothesis that patients with chronic renal disease have a poorer ability to preserve water after being thirsty and a poorer ability to excrete water after a load of fluid.
- Trial name
- NCT00313430
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Erling Bjerregaard Pedersen
Proteinuria, Hypertension
Specific Blockage of Angiotensine 2 and Podocyturia in Glomerular Nephropathies With Hypertension and Proteinuria
Chronic glomerular diseases are one of the main causes leading to end stage renal disease (ESRD). Hypertension and proteinuria are two modifiable factors promoting the progression of ESRD.
- Conditions
- Proteinuria, Hypertension, End Stage Renal Disease
- Trial name
- NCT00369538
- Testing
- losartan, hydrochlorothiazide, hydrochlorothiazide, losartan
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Strasbourg, France
Chronic Kidney Diseases
Efficacy and Safety of KBP-5074 in Uncontrolled Hypertension and Moderate or Severe Chronic Kidney Disease (CKD)
This Phase 3, randomized, Double-blind, placebo-controlled, 2-arm, parallel-group, multicenter study with randomized withdrawal will evaluate the efficacy, safety, and durability of KBP-5074 in adult participants who have stage…
- Trial name
- Clarion-CKD (NCT04968184)
- Testing
- KBP-5074
- Where
- 215 sites in United States, Australia and 20 more
- Volunteers
- 652 people
- Sponsor
- KBP Biosciences