Clinical trials: Hypertensive Disorder of Pregnancy
Hypertension, CKD - Chronic Kidney Disease
A Randomized Trial of Six-Channel RF Ablation System for Renal Denervation in Uncontrolled Hypertension and Chronic Kidney Disease
Prospective, Multi-Center, Randomized, Parallel-Controlled, Uptake clinical trial to evaluate the efficacy and safety of the six-channel radiofrequency（RF) renal denervation system-comprising the six-channel radiofrequency…
- Trial name
- NCT07130955
- Testing
- Six-channel RF Renal Denervation System
- Where
- China
- Volunteers
- 236 people
- Sponsor
- Shanghai Golden Leaf MedTec Co. Ltd
Preeclampsia, Gestational Hypertension
Exploring the Effect of Discharge Education, Blood Pressure Cuffs, and Postpartum Bracelets to Improve Health Among Newly Diagnosed Gestational Hypertension and Preeclampsia Patients During the Postpartum Period.
This pilot, exploratory qualitative, descriptive study will examine whether standard postpartum discharge education, a free home blood pressure cuff, and an "At-Risk Postpartum" bracelet support self-management among postpartum…
- Conditions
- Preeclampsia, Gestational Hypertension, Postpartum
- Trial name
- NCT07807098
- Testing
- Education, Blood Pressure Cuff, and Visual Cue Bracelet
- Volunteers
- 40 people
- Sponsor
- Memorial Hermann Health System
Preeclampsia
The Effect of Loading Dose of Magnesium Sulfate on Uterine, Umbilical, and Fetal Middle Cerebral Arteries Doppler, Biophysical Profile, CTG, Maternal Vital Signs in Women With Severe Preeclampsia
100 women with severe preeclanpsia received Magnesium sulfate 6 grams intravenous over 20 minutes as a loading dose. Resistance index [RI], pulsatility index [PI] and systolic/diastolic [S/D] ratio of the umbilical artery…
- Trial name
- NCT03891498
- Testing
- MgSO4
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Systemic Sclerosis, Preeclampsia
Is a History of Pre-eclampsia a Risk Factor for Vascular Phenotype in Women With Systemic Sclerosis?
Background: Pre-eclampsia, defined by the association of an arterial hypertension and significant proteinuria after 20 weeks of gestation, complicates 1 to 2% of pregnancies in France.
- Conditions
- Systemic Sclerosis, Preeclampsia, Vascular Complications
- Trial name
- PREVASCLERO (NCT04363021)
- Where
- 10 sites in France
- Volunteers
- 378 people
- Sponsor
- University Hospital, Brest
Preeclampsia, Recurrence
Effects of Recurrent PE on Women and Offspring
The purpose of this study is to evaluate the risk factors of recurrent preeclampsia and compare the short-term and long-term adverse outcomes of women and their offspring.
- Conditions
- Preeclampsia, Recurrence, Hypertension
- Trial name
- RPOH (NCT05134285)
- Testing
- blood pressure,BMI, blood sample
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Dunjin Chen
Preeclampsia (PE)
Prevention of Preeclampsia in Denmark: A National Implementation Study
The goal of this clinical study is to learn if a new first-trimester screening program can better find pregnant women who are at high risk of developing preeclampsia and help prevent the condition with early treatment.
- Trial name
- PREPRED (NCT07485140)
- Testing
- First trimester screening for preeclampsia
- Where
- 3 sites in Denmark
- Volunteers
- 80,000 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital at Herlev
Patients With Cardiovascular Disease, Healthy Participants
OCTA in Cardiovascular Disease and Healthy Controls
This prospective clinical study will involve the non-invasive assessment of retinal vessels using OCTA (Cirrus OCT 6000 AngioPlex) and scanning laser Doppler flowmetry (SLDF) in patients with cardiovascular disease and healthy…
- Trial name
- NCT07359664
- Testing
- Retinal vascular assessment using OCTA and SLDF
- Where
- Germany
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Preeclampsia, Preterm Birth
Prediction of Preeclampsia and Other Pregnancy Complications Following Combined Iterative Screening
Preterm birth (PTB), preeclampsia (PE), fetal growth restriction (FGR) and intra-uterine fetal death (IUFD) constitutes the main causes of perinatal morbidity and mortality and are called "Great Obstetrical Syndromes".
- Conditions
- Preeclampsia, Preterm Birth, Fetal Growth Restriction, Intra Uterine Fetal Death
- Trial name
- PREDICTION2 (NCT03067298)
- Where
- Canada
- Volunteers
- 805 people, healthy volunteers welcome
- Sponsor
- Emmanuel Bujold
Preeclampsia
Minimally-invasive Assessment of Cardiac Output in Severe Preeclampsia
Severe preeclampsia often presents with uncontrolled hypertension and therefore requires close monitoring of blood pressure and cardiac performance.
- Trial name
- NCT00465114
- Testing
- Hemodynamic Monitoring
- Where
- Canada
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Polycystic Kidney, Autosomal Dominant
Effect of Statin Therapy on Disease Progression in Autosomal Dominant Polycystic Kidney Disease (ADPKD)
The purpose of this study is to determine whether the medication pravastatin will ameliorate renal and cardiovascular disease over a 3-year period in children and young adults with autosomal dominant polycystic kidney disease…
- Trial name
- NCT00456365
- Testing
- pravastatin
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of Colorado, Denver
Hypertension Disorders in Pregnancy, Gestational Hypertension
Vascular Biomarkers Predictive of the Progression From Hypertensive Disorders in Pregnancy to Preeclampsia in Pregnant Women
Hypertension during pregnancy remains a leading cause of maternal and fetal morbidity and mortality. The frequency (5 to 10% of pregnancies) and potential severity of these diseases, both for the mother and the child, are reasons…
- Conditions
- Hypertension Disorders in Pregnancy, Gestational Hypertension, Pre-Eclampsia
- Trial name
- BIOVASC-PreHTA (NCT04520048)
- Testing
- Determination of the UEMP levels, Aortic central pressure and the carotid-femoral pulse wave velocity, Vascular biomarker assay
- Where
- 3 sites in France
- Volunteers
- 110 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Gestational Diabetes Mellitus (GDM), Pregnancy Induced Hypertension (PIH)
mHealth Integrated Model of Hypertension, Diabetes and Antenatal Care in India and Nepal
Our research aims to address a critical gap in the provision of quality antenatal care (ANC) in India and Nepal, by developing and evaluating an intervention comprising of a tablet-based electronic decision support system (EDSS).
- Conditions
- Gestational Diabetes Mellitus (GDM), Pregnancy Induced Hypertension (PIH), Anemia
- Trial name
- NCT03700034
- Testing
- mHealth Integrated Model of Antenatal Care
- Where
- 6 sites in India, Nepal
- Volunteers
- 1,320 people, healthy volunteers welcome
- Sponsor
- Public Health Foundation of India
Immobilization, Tonic, Fasting
A New Model of Acute Febrile Disease
The investigators want to establish a new model of acute febrile disease by mimicking the conditions seen in hospitalized patients in regards to inflammation, immobilisation and fasting.
- Conditions
- Immobilization, Tonic, Fasting, Endotoxemia, Metabolism
- Trial name
- NCT03158363
- Testing
- LPS, 36 hour immobilization and fast
- Where
- Denmark
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Sepsis
Cortisol Control of Human Inflammatory Responses to Endotoxin
The purpose of the research is to study a common and dangerous medical condition called 'septic shock' that often occurs in critically ill patients.
- Trial name
- NCT00396344
- Testing
- Çontrol, Hydrocortisone
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Pre-Eclampsia, Obesity
Evaluating the Effectiveness of a Food is Medicine Community Health Worker Program for Pregnant Women
The purpose of this study is to conduct a pilot randomized controlled trial of a food is medicine community health worker intervention called the Women's Health Delaware Food Farmacy compared to the usual standard of care among…
- Conditions
- Pre-Eclampsia, Obesity, Gestational Diabetes, Gestational Hypertension
- Trial name
- NCT06180811
- Testing
- Women's Health Delaware Food Farmacy, Usual Standard of Care
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Christiana Care Health Services
Vitamin D Deficiency, Obesity
D-tecting Disease - From Exposure to Vitamin D During Critical Periods of Life
Vitamin D deficiency is common among otherwise healthy pregnant women and may have consequences for them as well as the early development and long-term health of their children.
- Conditions
- Vitamin D Deficiency, Obesity, Diabetes Mellitus, Pre-Eclampsia
- Trial name
- D-tect (NCT03330301)
- Testing
- D-tect
- Where
- Denmark
- Volunteers
- 222,776 people
- Sponsor
- Bispebjerg Hospital
Chronic Kidney Disease
Effect of Arotinolol Hydrochloride on Cardiovascular Events in Hypertensive Haemodialysis Patients
The purpose of this study is to ascertain whether Arotinolol Hydrochloride reduces mortality and cardiovascular events in chronic kidney disease stage 5 patients with hypertension.
- Trial name
- AHOCEP (NCT01351636)
- Testing
- Arotinolol Hydrochloride, Non arotinolol group
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Marubeni Pharmaceuticals (Suzhou) Co., Ltd.
Severe Septic Syndrome, Septic Shock
Community Acquired Sepsis Cohort
The aim of this project is to constitute a prospective cohort of all the patients presenting to the adult emergencies of the University Hospital Centre (CHU) of Rennes for a septic syndrome of community origin.
- Trial name
- CASC (NCT03280992)
- Where
- France
- Volunteers
- 796 people
- Sponsor
- Rennes University Hospital
Pulmonary Arterial Hypertension, Renal Dysfunction
The Effect of Renal Impairment on the Pharmacokinetics of Oral Treprostinil
This is a single-center, open-label, single-dose evaluation of 1 mg UT-15C SR pharmacokinetics, safety, and tolerability in subjects with normal, mild, moderate and end stage renal disease (ESRD; on dialysis).
- Trial name
- NCT01131845
- Testing
- UT-15C SR (treprostinil diethanolamine)
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- United Therapeutics
Renal Artery Obstruction, Hypertension, Renovascular
Endovascular Therapy for Renal Artery Stenosis in China
A multicenter prospective registry planned to recruit more than 5 000 patients with renal artery stenosis was carried out in China.
- Trial name
- ETRAS-China (NCT03080519)
- Testing
- Endovascular Therapy
- Where
- 16 sites in China
- Volunteers
- 5,000 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital