Clinical trials: Hypertensive Disorders
Spinal Anesthesia-Induced Hypotension
Predictors of Spinal Anesthesia-Induced Hypotension in Hypertensive Patients
This prospective observational study aims to evaluate predictive factors for spinal anesthesia-induced hypotension (SASH) in hypertensive patients undergoing elective surgery.
- Trial name
- NCT06749184
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Konya City Hospital
Hypertension
The Potential Role of Testosterone on Target Organ Damage in Postmenopausal Hypertensive Women
The incidence of CVD-related deaths is generally higher in women than men. Postmenopausal changes in estrogen/androgen ratio that induce a relative androgen excess have been proposed as important factors in the higher prevalence…
- Trial name
- NCT03451747
- Volunteers
- 322 people
- Sponsor
- LanZhou University
Hypertension, Breakfast Skipper
Early Time-Restricted Eating for Cardiovascular Health
This study will examine whether eating earlier in the day within a consistent 8-hour eating window can improve heart and blood vessel health in older adults with high blood pressure who often skip breakfast.
- Trial name
- ALIGN (NCT07634926)
- Testing
- Early Time-Restricted Eating (eTRE)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Alabama at Birmingham
Hypertension
Study to Characterize the Long-term Clinical Experience of Atacand in Hypertensive Children Ages 1 to<11 Years (Hypertension in Pediatrics)
The HIP study is designed to follow the clinical experience of young hypertensive children receiving candesartan cilexetil (Atacand) who are between the ages of 1 and less than 11 years old.
- Trial name
- HIP (NCT00690612)
- Testing
- candesartan cilexetil
- Where
- 13 sites in Belgium, France and 4 more
- Volunteers
- 35 people
- Sponsor
- AstraZeneca
Intracerebral Hemorrhage
Prevention of Hypertensive Injury to the Brain by Intensive Treatment of Blood Pressure After Intracerebral Haemorrhage (PROHIBIT-ICH)
PROHIBIT-ICH will randomise participants (target=112) to compare a strategy of intensive blood pressure (BP) treatment (target <120/80 mm Hg) guided by remote telemetric home BP monitoring, versus standard primary care, in adult…
- Trial name
- PROHIBIT-ICH (NCT03863665)
- Testing
- A&D BP Digital Blood Pressure Monitor (UA-767PBT-Ci) CE Declaration UA-767PBT-Ci
- Where
- 16 sites in United Kingdom
- Volunteers
- 86 people
- Sponsor
- University College, London
Glaucoma, Ocular Hypertension
Safety Assessment of T4090 Eye Drops in Ocular Hypertensive or Glaucomatous Patients.
The study purpose is to evaluate the safety of T4090.
- Trial name
- NCT05389267
- Testing
- Kinezodianone R hydrochloride
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Laboratoires Thea
Hypertension
Effectiveness and Safety of Combination of Nebivolol and Amlodipine in Hypertensive Patients Versus Each Monotherapy
Study to assess the anti-hypertensive efficacy and safety of the extemporaneous combination of Nebivolol 5 mg in combination with Amlodipine 5 mg or AML 10 mg in lowering the sitting diastolic BP after 8 weeks of treatment…
- Trial name
- Botticelli (NCT05513937)
- Testing
- Nebivolol, Amlodipine
- Where
- Bulgaria
- Volunteers
- 301 people
- Sponsor
- Menarini International Operations Luxembourg SA
Hypertension
Kanagawa Combination Anti-hypertensive Therapy (K-CAT)
The purpose of this study is to compare the effect and safety of the antihypertensive combination therapies between losartan/amlodipine and fixed dose drug of losartan/hydrochlorothiazide.
- Trial name
- NCT00492128
- Testing
- Losartan/amlodipine or losartan/hydrochlorothiazide
- Where
- Japan
- Volunteers
- 196 people
- Sponsor
- Yokohama City University Medical Center
Hypertensive Intracerebral Hemorrhage
Efficacy and Safety Study of Urapidil Alone or With Esmolol in Treating Acute Hypertensive Intracerebral Hemorrhage
The objective of this study is to investigate the efficacy and safety of urapidil monotherapy versus the combination of esmolol in treating participants with acute hypertensive intracerebral hemorrhage through a prospective…
- Trial name
- NCT06635707
- Testing
- Urapidil, Urapidil and Esmolol
- Volunteers
- 600 people
- Sponsor
- Qianfoshan Hospital
Hypertension
Efficacy of a Combination of Amlodipine/Valsartan on 24H Blood Pressure Control With One Nocturnal or Diurnal Intake a Day
This study was a multicenter, randomized, PROBE-type (prospective, randomized, open label, blinded end-point) study of 12 weeks duration comprising four visits, carried out in patients with essential arterial hypertension not…
- Trial name
- NCT00700271
- Testing
- Amlodipine, Valsartan
- Where
- 2 sites in France, Tunisia
- Volunteers
- 478 people
- Sponsor
- Novartis Pharmaceuticals
Hypertension
Nesiritide in Hypertension
Hypertension remains a global burden in cardiovascular disease leading to stroke, myocardial infarction, and heart failure. Its myocardial complications result from increased mechanical load on the heart.
- Trial name
- TENSE1 (NCT02608996)
- Testing
- Nesiritide
- Where
- 3 sites in Norway
- Volunteers
- 15 people
- Sponsor
- Oslo University Hospital
Hypertension
Compare the Effect of Aliskiren Plus Valsartan Versus Angiotensin-Converting Enzyme Inhibitor (ACEi) Plus Angiotensin Receptor Blocker (ARB) [Ramipril Plus Telmisartan] on the Renin-Angiotensin-Aldosterone System (RAAS) in Hypertensive Patients
This study is designed as a mechanistic study to compare the effect of two different combinations of anti-hypertensive treatments (aliskiren and valsartan vs.
- Trial name
- NCT00939588
- Testing
- Aliskiren/ Valsartan, Telmisartan/ Ramipril
- Where
- Russia
- Volunteers
- 88 people
- Sponsor
- Novartis Pharmaceuticals
Hypertension, CKD - Chronic Kidney Disease
The Effects of Dietary Nitrate in Patients With Hypertensive Kidney Injury
The study aims to study the effects of diatery nitrate in patients with hypertension and hypertensive kidney injury. The study is a randomized, placebo-controlled, double-blinded crossover trial.
- Trial name
- DINO-CKD (NCT07290842)
- Testing
- Beetroot Juice - Active
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Gødstrup Hospital
Hypertension
Hypertensive Treatment Pattern Survey for Type II Diabetes Mellitus Patients With Complication and Hypertension
This study will address the treatment rate and control rate of hypertension, treatment pattern and factors to affect blood pressure control by examining (retrospective) medical records of Type II DM patients with DM related…
- Trial name
- CRYSTAL-CO (NCT00771069)
- Where
- 13 sites in South Korea
- Volunteers
- 2,000 people
- Sponsor
- AstraZeneca
Hypertension, Heart Failure
The Transition From Hypertension to Hypertensive Heart Disease and Heart Failure, the PREFERS Hypertension Study
AIMS Despite evidence-based therapeutic approaches, target blood pressure is obtained by less than half of patients with hypertension.
- Conditions
- Hypertension, Heart Failure, Hypertensive Heart Disease, Diastolic Dysfunction
- Trial name
- NCT04190420
- Where
- Sweden
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Hypertension
Aliskiren Study of Safety and Efficacy in Senior Hypertensives
This study is designed to compare the blood pressure lowering efficacy of aliskiren, a combination of aliskiren plus amlodipine, and ramipril in elderly patients with mild to moderate hypertension.
- Trial name
- ASSESS (NCT01922141)
- Testing
- Aliskiren, Amlodipine, Ramipril
- Sponsor
- Novartis Pharmaceuticals
Hypertension, Patient Engagement
Roy Adaptation Model in Hypertensive Patients
The aim of this study was to determine the effect of training given according to the Roy Adaptation Model on medical treatment and physiological, psychological and social adaptation to the disease in individuals with hypertension.
- Conditions
- Hypertension, Patient Engagement, Nurse-Patient Relations
- Trial name
- NCT05221424
- Testing
- Patient Education
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Muş Alparslan University
Hypertension
Effect of the Angiotensin II Receptor Antagonist Irbesartan on Biochemical and Functional Markers of Endothelial Dysfunction in Patients With Hypertension
Primary: To evaluate the impact of irbesartan on endothelial function in hypertensive patients with metabolic syndrome. Secondary: To evaluate the oxidative stress status in patients with hypertension with metabolic syndrome.
- Trial name
- NCT00529750
- Testing
- IRBESARTAN, Atenolol
- Volunteers
- 108 people
- Sponsor
- Sanofi
Hypertension
Effects and Underlying Mechanism of Lipid Lowering Intervention on Vascular Protection in Hypertensive Patients
The purpose of EMINENT study is to evaluate the efficacy of Xuezhikang or atorvastatin in hypertensive patients at low/moderate cardiovascular risk.
- Trial name
- NCT02254824
- Testing
- Xuezhikang, Atorvastatin, Lifestyle modification
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Arterial Hypertension, HTN
Evaluation of the Antihypertensive effectIveness, Tolerability, and Adherence With Amlodipine/ Indapamide/ Perindopril Triple Single-pill Combination in Hypertensive Patients Without Concomitant Antihypertensive Therapy (TRIPTYCH)
This is a multi-centre, observational, ambispective study, which will retrospectively and prospectively collect clinical and socio-demographic data from medical records of outpatients with arterial hypertension (HTN) initiated…
- Trial name
- TRIPTYCH (NCT06259175)
- Testing
- Amlodipine 5 mg + indapamide 1.25 mg + perindopril 5 mg, Amlodipine 5 mg + indapamide 2.5 mg + perindopril 10 mg, Amlodipine 10 mg + indapamide 2.5 mg + perindopril 10 mg
- Where
- Russia
- Volunteers
- 396 people
- Sponsor
- Servier Russia