Clinical trials: Hypertensive Disorders of Pregnancy, open to volunteers
- Condition Hypertensive Disorders of Pregnancy
- Status Open to volunteers
- Accepts healthy volunteers yes
Cardiovascular Diseases
Continuation of the nuMoM2b Heart Health Study
Cardiovascular disease (CVD) is the leading cause of mortality and morbidity in U.S. women at all ages, and large knowledge gaps exist in CVD predictive and preventative strategies for women.
- Trial name
- nuMoM2b-HHS2 (NCT05472597)
- Where
- 14 sites in United States
- Volunteers
- 4,048 people, healthy volunteers welcome
- Sponsor
- RTI International
Pregnancy, Blood Pressure Measurement in Pregnancy
Arm Position and Blood Pressure Measurement Accuracy During Pregnancy
Accurate blood pressure measurement is essential during pregnancy, as blood pressure readings guide clinical decisions related to the diagnosis and management of hypertensive disorders of pregnancy.
- Conditions
- Pregnancy, Blood Pressure Measurement in Pregnancy, Hypertensive Disorder of Pregnancy
- Trial name
- NCT07405723
- Testing
- Arm Supported at Heart Level, Arm Supported on Lap, Arm Unsupported at Side
- Where
- Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Preeclampsia (PE), Hypertensive Disorder of Pregnancy
Endothelial Dysfunction for Prognosis In Patients With preeClampSia
Preeclampsia is a pregnancy-specific hypertensive disorder and can progress rapidly to severe adverse outcomes affecting both the mother and the fetus.
- Trial name
- EPICS (NCT06912477)
- Testing
- Hyperspectral imaging, Further markers of endothelial dysfunction
- Where
- Germany
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Pre-Eclampsia, Intrauterine Growth Restriction
PEPPI Study: Identification of Women at Risk for Placental Dysfunction
The main purpose of this study is to evaluate Fetal Medicine Foundation's pre-eclampsia risk calculator using maternal characteristics, first trimester serum placental growth factor (PlGF) and mean arterial pressure (MAP) in a…
- Conditions
- Pre-Eclampsia, Intrauterine Growth Restriction, Polycystic Ovary Syndrome, Iron-deficiency
- Trial name
- NCT06115122
- Testing
- Pre-eclampsia screening program
- Where
- Finland
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Oulu University Hospital
Hypertensive Disorder of Pregnancy, Pulmonary Arterial Hypertension
A Prospective Longitudinal Observational Cohort Study of Pregnant Women Residing at High Altitude in Bolivia
In this study, the investigators will follow two small cohorts of pregnant women: a cohort of healthy women with uncomplicated pregnancies residing at high altitude, a control group of healthy women with uncomplicated pregnancies…
- Conditions
- Hypertensive Disorder of Pregnancy, Pulmonary Arterial Hypertension, Intrauterine Growth Restriction
- Trial name
- NCT07312227
- Where
- 2 sites in United States, Bolivia
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Hypertensive Disorders of Pregnancy, Pre-eclampsia
Ophthalmic Artery Doppler in the Puerperium After Hypertensive Disorders of Pregnancy (OPHELIA-PP)
Hypertensive disorders of pregnancy frequently fail to resolve at delivery. A substantial proportion of women remain hypertensive at the six-week postnatal review, postpartum eclampsia occurs days to weeks after birth, and a…
- Conditions
- Hypertensive Disorders of Pregnancy, Pre-eclampsia, Postpartum Hypertension, Puerperal Disorders
- Trial name
- OPHELIA-PP (NCT07841795)
- Where
- Italy
- Volunteers
- 366 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Hypertensive Disorders of Pregnancy, Postpartum Hypertension
Cardiometabolic Risk in Pregnancy and Postpartum
The goal of this study is to evaluate changes in blood pressure and early cardiovascular risk markers and to determine whether a postpartum education intervention can improve cardiovascular risk monitoring among pregnant women in…
- Conditions
- Hypertensive Disorders of Pregnancy, Postpartum Hypertension, Cardiovascular Disease Risk, High Blood Pressure
- Trial name
- NCT07420465
- Testing
- Postpartum Cardiovascular Disease (CVD) Risk Reduction Program, Enhanced Postpartum Care
- Where
- Ghana
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Forgive Avorgbedor
Hypertension, Pregnancy Induced, Hypertension Complicating Pregnancy
Optimizing Cardiovascular Preventive Care for Women Following Hypertensive Disorders of Pregnancy
Cardiovascular disease is the leading cause of death among women in the United States, and women with hypertensive disorders of pregnancy have a 2-fold higher risk for cardiovascular disease later in life compared to women with…
- Conditions
- Hypertension, Pregnancy Induced, Hypertension Complicating Pregnancy, Preeclampsia, Cardiovascular Diseases
- Trial name
- NCT05826925
- Testing
- Decision aid
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Utah
Pre-Eclampsia, Pregnancy Induced Hypertension
Clinical Antenatal Randomised Study to CharactErise Key Roles of TetrahydroFOLate in HyperTensive Pregnancies
Study background High blood pressure during pregnancy is a worldwide health problem that can be dangerous to mothers and commonly causes premature birth and small babies.
- Conditions
- Pre-Eclampsia, Pregnancy Induced Hypertension, Pregnancy Related
- Trial name
- CAREFOL-HT (NCT05434195)
- Testing
- Arcofolin® 5-Methyltetrahydrofolate
- Where
- 2 sites in United Kingdom
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Hypertensive Disorder Complicating Pregnancy
Multivariate Analysis and Prediction of Hypertensive Disorder Complicating Pregnancy and Its Related Mechanism
Hypertensive disorder complicating pregnancy (HDP) is a unique disease during pregnancy, accounting for about 5.2% ~ 8.2% of pregnant women in the world, which seriously threatens the health and life safety of mothers and…
- Trial name
- NCT06995456
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Preeclampsia (PE), Hypertension ,Pregnancy
Retinal and Choroidal Microcirculation in Preeclampsia: An OCTA Study
Preeclampsia is a multisystemic and multifactorial disorder that complicates pregnancy and is characterized by new-onset hypertension after the 20th week of gestation accompanied by proteinuria or systemic findings such as renal…
- Conditions
- Preeclampsia (PE), Hypertension ,Pregnancy, Retinal Microvascular Changes, Hypertensive Disorders of Pregnancy
- Trial name
- PE-OCTA (NCT07874191)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Muğla Sıtkı Koçman University
Pregnancy, Pregnancy - Prenatal Testing
Effect of Isometric Handgrip Exercise on Blood Pressure in Pregnant Women
Hypertension during pregnancy is a major public health concern, increasing the risk of cardiovascular complications for both the mother and the fetus.
- Conditions
- Pregnancy, Pregnancy - Prenatal Testing, Hypertension (HTN)
- Trial name
- GRIP4HEALTH (NCT07607795)
- Testing
- Isometric Handgrip Exercise, Control Rest
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Poitiers
Preeclampsia, Gestational Hypertension
Evaluation of sFlt-1/PlGF Ratio ,OPG and sEng as Predictive Biomarkers in the Diagnosis and Treatment Evaluation of Preeclampsia
his study investigates the effectiveness of three specific biological markers (biomarkers) in the blood-the sFlt-1/PlGF ratio, soluble endoglin (sEng), and osteoprotegerin (OPG)-to better diagnose and monitor preeclampsia.
- Conditions
- Preeclampsia, Gestational Hypertension, Hypertensive Disorders of Pregnancy
- Trial name
- PE-POSS (NCT07349277)
- Where
- Iraq
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ammar Jassim Abed
Gestational Hypertension, Cardiovascular Pregnancy Complication
Physical Activity and Cardiovascular Profile of Pre-conceptional Women At Risk for GHD
To compare the cardiovascular profile of pre-conceptional women at risk for developing Gestational Hypertensive Disorders in subsequent pregnancy before and after physical activity.
- Trial name
- SPORTY (NCT05888467)
- Testing
- supervised infrared exercise group, supervised non-infrared exercise group, Control group
- Where
- Belgium
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Preeclampsia, Eclampsia
The Preeclampsia Registry
The purpose of The Preeclampsia Registry is to collect and store medical and other information from women who have been medically diagnosed with preeclampsia or a related hypertensive (high blood pressure) disorder of pregnancy…
- Conditions
- Preeclampsia, Eclampsia, HELLP Syndrome, Toxemia
- Trial name
- TPR (NCT06377878)
- Where
- United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Preeclampsia Foundation
Hypertension Disorders in Pregnancy, Blood Pressure Measurement in Pregnancy
Breathing for Two: Inspiratory Muscle Strength Training for Supporting Healthy Blood Pressure in Pregnancy
This is an interventional study that will test whether a breathing exercise called Inspiratory Muscle Strength Training (IMST) can safely and effectively lower blood pressure during late pregnancy.
- Conditions
- Hypertension Disorders in Pregnancy, Blood Pressure Measurement in Pregnancy, Inspiratory Strength Training (IST), Pregnancy
- Trial name
- NCT07687745
- Testing
- Exercise at 15% PI max, Exercise at 50% PI max
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Preeclampsia, Hypertensive Disorder of Pregnancy
Multiparametric Assessment of Maternal Vascular Function in the Prediction of Hypertensive Disorders of Pregnancy
The present study is a single-centre prospective study that will enrol pregnant women during their first trimester of pregnancy (11+0 - 13+6 weeks of gestation).
- Trial name
- EDIPE (NCT05999851)
- Testing
- Arterial applanation tonometry, In vivo endothelial glycocalyx measurement, Serum markers of angiogenesis and endothelial dysfunction
- Where
- Italy
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Preeclampsia, Hypertensive Disorder of Pregnancy
Progesterone Preeclampsia
This randomized controlled trial evaluates whether nightly vaginal micronized progesterone (400 mg) initiated before 12 weeks' gestation reduces the incidence of preeclampsia in low-risk pregnant individuals.
- Trial name
- NCT07448597
- Testing
- Progesterone supplementation
- Where
- United States
- Volunteers
- 642 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina