Clinical trials: Hypertensive Disorders of Pregnancy
Pregnancy, Maternal Anemia
Better Birth Outcomes Through Technology, Education, and Reporting
This is a pragmatic randomized control trial to evaluate the BETTER intervention compared to standard obstetrical care (control) to determine whether it helps to reduce maternal anemia and other adverse pregnancy outcomes.
- Conditions
- Pregnancy, Maternal Anemia, Pre-Term Birth, Hypertensive Disorders
- Trial name
- BETTER (NCT06261398)
- Testing
- BETTER: motivational interviewing and text messaging, Standard of care
- Where
- 3 sites in United States
- Volunteers
- 550 people
- Sponsor
- Ohio State University
End-stage Renal Disease
Effects of Strict Volume Control in Hypertensive Hemodialysis Patients on Cardiac Structure and Chronic Inflammation
This study aims mainly to investigate the effects of two approaches to control blood pressure in hypertensive hemodialysis patients; using antihypertensive drugs versus strict volume control (by strict dietary salt restriction…
- Trial name
- NCT00307463
- Testing
- strict volume control policy, antihypertensive drugs administration
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 258 people
- Sponsor
- Ege University
Hypertensive Disorders of Pregnancy
Nursing Intervention for Knowledge and Self-care Behaviors in the Face of Hypertensive Disorders of Pregnancy
Hypertensive disorders of pregnancy (HDP) are a leading cause of maternal and fetal morbidity and mortality worldwide. The lack of knowledge and self-care behaviors by the pregnant woman in the face of THE could be associated…
- Trial name
- EducaTHE (NCT05837962)
- Testing
- Nursing intervention to improve knowledge and self-care behaviors in the face of HDP
- Where
- Colombia
- Volunteers
- 60 people
- Sponsor
- Universidad de Antioquia
Cardiovascular Diseases, Pregnancy
Biomarkers of CVD Dysfunction in Hypertensive Disorders of Pregnancy
Profound and concomitant cardiovascular hemodynamic changes, necessary to support fetoplacental development and its increasing supply demands, occur during a physiological pregnancy characterized by an increase in cardiac output…
- Trial name
- NCT05806372
- Where
- Italy
- Volunteers
- 128 people
- Sponsor
- IRCCS Burlo Garofolo
Preeclampsia
Study of Maternal and Fetal Cardiovascular Function in Hypertensive States of Pregnancy
The pharmacological treatment strategy is then tailored to the underlying hemodynamic phenotype of each patient. That is, rather than applying a one-size-fits-all treatment for all patients, therapy is tailored to the specific…
- Trial name
- CARDIAC-OAT (NCT06858345)
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia
Hypertensive Disorder of Pregnancy, Vitamin D Deficiency
Vitamin D Deficiency With Selected Vitamin D Receptor Gene Polymorphism in Gestational Hypertension
This study aim to look into the prevalence of Vitamin D deficiency among Malaysian pregnant women and its associated risk factors.
- Trial name
- NCT05659173
- Testing
- Blood taking
- Where
- Malaysia
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Hypertensive Disorders of Pregnancy (HDP)
Postpartum Home Visiting (HEART at Home)
The goal of this clinical trial is to learn whether HEART at Home (Home-based Engagement And Remote Treatment for Hypertension), a home-based postpartum hypertension care program, is feasible and acceptable for people with high…
- Trial name
- HEART at Home (NCT07833904)
- Testing
- HEART at Home
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Washington University School of Medicine
Hypertension
A Study to Describe Vascular and Renal Effects and Safety of Valsartan in Patients With High Blood Pressure
One hundred twenty patients with arterial hypertension and albuminuria (some amount of albumin in urine) are given valsartan 80 mg and then160 mg to normalize blood pressure.
- Trial name
- NCT00171353
- Testing
- valsartan
- Where
- Switzerland
- Volunteers
- 109 people
- Sponsor
- Novartis
Hypertensive Disorder of Pregnancy
Thriving Hearts: Healing-Centered, Integrated, Community Maternity Care
The overarching goal of Thriving Hearts is to implement a multi-level program through Local Health Departments (LHDs) that cultivates conditions for mothers and birthing people to not only survive pregnancy, but to thrive.
- Trial name
- NCT06744231
- Testing
- Usual Care, Thriving Hearts
- Where
- United States
- Volunteers
- 17,500 people
- Sponsor
- University of North Carolina, Chapel Hill
Pre-Eclampsia, IUGR
Fetal Doppler Indices in Predicting Perinatal Outcome Among Severely Hypertensive Pregnant Patients.
60 pregnant women with singleton living fetus between 34 -38 wks gestation known to have severe hypertension in the current pregnancy were included.
- Trial name
- NCT03515759
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Hypertensive Disorders of Pregnancy (HDP), Hypertension, Pregnancy Induced
Community Support and Mobile Apps to Help Black Women Control High Blood Pressure After Pregnancy
The goal of this randomized clinical trial is to evaluate the effectiveness of a collaborative care intervention, consisting of remote blood pressure monitoring and support from community health workers, in improving blood…
- Conditions
- Hypertensive Disorders of Pregnancy (HDP), Hypertension, Pregnancy Induced, Severe Maternal Morbidity, Postpartum Hypertension
- Trial name
- PRIME CARE (NCT07606027)
- Testing
- Collaborative care, Standard of Care (SOC)
- Volunteers
- 404 people
- Sponsor
- University of Nebraska
Hypertension, Pregnancy
Effects of Dietary Nitrate in Hypertensive Pregnant Women
High blood pressure in pregnancy affects around 10% of pregnancies, and is associated with serious adverse outcomes for both mother and baby.
- Trial name
- NCT02520687
- Testing
- Beetroot juice, Nitrate-depleted beetroot juice
- Where
- United Kingdom
- Volunteers
- 44 people
- Sponsor
- University of Manchester
Cardiovascular Diseases
Reexamining Her Cardiovascular Risk - Ottawa WomeN's Longitudinal Cohort Study
The full HER CROWN will be a prospective cohort study to propose a novel, women-specific cardiovascular risk score/ algorithm in the prediction of hard cardiovascular outcomes (myocardial infarction, unstable angina, coronary…
- Trial name
- HER-CROWN (NCT05632601)
- Testing
- PET scan
- Where
- Canada
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
Autosomal Dominant Polycystic Kidney, Hypertension
Effect of Beetroot Juice on Reducing Hypertension in Autosomal Dominant Polycystic Kidney Disease
People with autosomal dominant polycystic kidney disease (ADPKD) develop high blood pressure and kidney disease. Previous studies have shown that a commonly occurring chemical, nitric oxide (NO), is reduced in ADPKD, and may…
- Conditions
- Autosomal Dominant Polycystic Kidney, Hypertension, Endothelial Dysfunction
- Trial name
- BEET-PKD (NCT05401409)
- Testing
- Beetroot juice, Nitrate-depleted beetroot juice
- Where
- 2 sites in Australia
- Volunteers
- 60 people
- Sponsor
- Western Sydney Local Health District
Preeclampsia
Role of the Maternal Microbiota on the Immune Response and Metabolism During Hypertensive Disorders
Preeclampsia (PE) is a significant cause of maternal and fetal morbidity and mortality, characterized by high blood pressure and proteinuria during pregnancy.
- Trial name
- MATER (NCT06421493)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Istituto Clinico Humanitas
Hypertension, Pregnancy Induced, Hypertension Complicating Pregnancy
Optimizing Cardiovascular Preventive Care for Women Following Hypertensive Disorders of Pregnancy
Cardiovascular disease is the leading cause of death among women in the United States, and women with hypertensive disorders of pregnancy have a 2-fold higher risk for cardiovascular disease later in life compared to women with…
- Conditions
- Hypertension, Pregnancy Induced, Hypertension Complicating Pregnancy, Preeclampsia, Cardiovascular Diseases
- Trial name
- NCT05826925
- Testing
- Decision aid
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Utah
Kidney Injury, Acute, Cardiac Function Failed
Effect of Vasopressin on Kidney and Cardiac Function in Septic Shock
Septic shock is a syndrome characterized by tissue hypoperfusion and hypotension secondary to an uncontrolled infection. It is a frequent cause of admission to the intensive care unit (ICU) and has an associated mortality around…
- Trial name
- NCT06125184
- Testing
- Vasopressor test
- Where
- Chile
- Volunteers
- 50 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Hypertension Disorders in Pregnancy, Blood Pressure Measurement in Pregnancy
Breathing for Two: Inspiratory Muscle Strength Training for Supporting Healthy Blood Pressure in Pregnancy
This is an interventional study that will test whether a breathing exercise called Inspiratory Muscle Strength Training (IMST) can safely and effectively lower blood pressure during late pregnancy.
- Conditions
- Hypertension Disorders in Pregnancy, Blood Pressure Measurement in Pregnancy, Inspiratory Strength Training (IST), Pregnancy
- Trial name
- NCT07687745
- Testing
- Exercise at 15% PI max, Exercise at 50% PI max
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Preeclampsia
CercaTest™ Red Urine Test for Predicting Preeclampsia
The goal of this observational study is to predict preeclampsia in pregnant women aged 18 years or older with a singleton pregnancy at 20 or more weeks of gestation who present with suspected signs or symptoms of preeclampsia.
- Trial name
- PRE-CERCA (NCT07625501)
- Where
- Hong Kong
- Volunteers
- 1,000 people
- Sponsor
- Chinese University of Hong Kong
Infection, Heart Failure
Prediction of Expected Length of Hospital Stay Using Machine Learning
This is a retrospective observational study drawing on data from the Brigham and Women's Home Hospital database. Sociodemographic and clinic data from a training cohort were used to train a machine learning algorithm to predict…
- Conditions
- Infection, Heart Failure, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT04784351
- Where
- 2 sites in United States
- Sponsor
- Brigham and Women's Hospital