Clinical trials: Hypertensive Patients
Essential Hypertension
Use of the Combination of Olmesartan and Hydrochlorothiazide in Essential Hypertension
The study will evaluate the blood pressure lowering effects of two different dosages of the combination of olmesartan and hydrochlorothiazide in patients with moderate or severe high blood pressure.
- Trial name
- NCT00430508
- Testing
- olmesartan medoxomil (OM)/hydrochlorothiazide (HCTZ) tablets, olmesartan medoxomil/hydrochlorothiazide tablets
- Where
- 55 sites in Bulgaria, Czechia and 5 more
- Volunteers
- 972 people
- Sponsor
- Daiichi Sankyo
Hypertension
Valsartan/Hydrochlorothiazide Combination in Hypertensive Patients Not Controlled With Valsartan Alone
This study will test the effectiveness and safety of a combination treatment in patients whose blood pressure is not controlled with a single medication.
- Trial name
- NCT00170989
- Testing
- valsartan plus hydrochlorothiazide
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 2,714 people
- Sponsor
- Novartis
Hypertension
Chlorthalidone Compared to Hydrochlorothiazide on Endothelial Function
Chlorthalidone will result in improved endothelial function compared to hydrochlorothiazide as measured by flow mediated vasodilatation.
- Trial name
- NCT01822860
- Testing
- Chlorthalidone 12.5 mg, Hydrochlorothiazide 25 mg
- Where
- United States
- Sponsor
- Creighton University
Diastolic Dysfunction, Hypertension
To Find Out Whether Valsartan With or Without Other Blood Pressure Medications Would Improve the Ability of the Heart to Fill and Empty, and the Ability of the Heart Muscle to Relax Adequately in People With High Blood Pressure.
Patients who have had high blood pressure for a long time may have diastolic dysfunction. Diastolic Dysfunction is when your heart has difficulty filling and emptying, and relaxing adequately.
- Trial name
- NCT00170924
- Testing
- Valsartan
- Where
- United States
- Volunteers
- 317 people
- Sponsor
- Novartis
Hypertension, Cardiovascular Disease
Combination of OLMesartan and CCB or Low Dose Diuretics in High Risk Elderly Hypertensive Patients Study (COLM-Study)
The purpose of this study is to investigate which combination therapy is more effective in reducing the incidence of cardiovascular events in Japanese elderly high-risk hypertensive patients: AT1 subtype angiotensin II receptor…
- Conditions
- Hypertension, Cardiovascular Disease, Diabetes
- Trial name
- NCT00454662
- Testing
- olmesartan medoxomil / amlodipine or azelnidipine, olmesartan medoxomil / low dose thiazide type drug
- Where
- Japan
- Volunteers
- 5,141 people
- Sponsor
- COLM Study Research Organization
Spinal Anesthesia-Induced Hypotension
Predictors of Spinal Anesthesia-Induced Hypotension in Hypertensive Patients
This prospective observational study aims to evaluate predictive factors for spinal anesthesia-induced hypotension (SASH) in hypertensive patients undergoing elective surgery.
- Trial name
- NCT06749184
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Konya City Hospital
Hypertension
Effectiveness and Safety of Combination of Amlodipine and Zofenopril in Hypertensive Patients Versus Each Monotherapy
Study to assess the anti-hypertensive efficacy and safety of the extemporaneous combination of Zofenopril 30 mg in combination with Amlodipine 5 mg or AML 10 mg in lowering the sitting diastolic BP after 8 weeks of treatment in…
- Trial name
- Masolino (NCT05279807)
- Testing
- Zofenopril, Amlodipine
- Where
- Hungary
- Volunteers
- 277 people
- Sponsor
- Menarini International Operations Luxembourg SA
Hypertension
Testing the Efficacy of Different Dosages of Lercanidipine to Reduce Hypertensive Blood Pressure in Normal Weight and Obese Patients
A double blind study to examine the safety and efficacy of different dosages of lercanidipine in normal weight and obese patients with hypertension
- Trial name
- NCT00160498
- Testing
- Lercanidipine
- Volunteers
- 180 people
- Sponsor
- UCB Pharma
Type 2 Diabetes Mellitus, Hypertension
N-Acetylcysteine and Arginine Administration in Diabetic Patients
It has been demonstrated that the nitric oxide production is reduced in type 2 diabetic patients and that cardiovascular complications represent 80% of the causes of death in these patients.
- Trial name
- NACARGPAO (NCT00569465)
- Testing
- Arginine, Acetylcysteine
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- University of Turin, Italy
Hypertension, Hemodialysis
Marinobufagenin as a Target for DIGIBIND in Hypertensive Patients With End-stage Renal Disease
The purpose of this study is to examine the effects of the digibind drug on hemodialysis patients with high blood pressure. Digibind is used to treat toxicity from digoxin and digoxin-like molecules which may contribute to high…
- Trial name
- NCT00852787
- Testing
- Digoxin immune fab
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute on Aging (NIA)
Chronic Kidney Disease, Hypertension
Aliskiren and Muscle Sympathetic Nerve Activity
The central hypothesis of this project is that Aliskiren causes a substantial decrease in MSNA in hypertensive patients with CKD.
- Conditions
- Chronic Kidney Disease, Hypertension, Muscle Sympathetic Nerve Activity
- Trial name
- MSNA (NCT00719316)
- Testing
- Aliskiren
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- UMC Utrecht
Airway Stress Response
Dexmedetomidine vs Labetalol for Airway Stress in Hypertensive Craniotomy Patients
This randomized trial compares dexmedetomidine and labetalol in controlling airway and hemodynamic stress during extubation in hypertensive patients undergoing craniotomy.
- Trial name
- NCT07034898
- Testing
- Dexmedetomidine, Labetalol
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Hypertension, Cardiovascular Diseases
OlmeSartan and Calcium Antagonists Randomized (OSCAR) Study
The purpose of this study is to investigate whether high-dose angiotensin II receptor blocker (ARB) monotherapy or combination therapy with ARB and calcium channel blockers is more effective in reducing the incidence of…
- Trial name
- NCT00134160
- Testing
- Olmesartan medoxomil, Calcium channel blockers (amlodipine, azelnidipine)
- Where
- 2 sites in Japan
- Volunteers
- 1,000 people
- Sponsor
- OSCAR Study
Hypertension and Left Ventricular Hypertrophy (Thickening of the Main Pumping Chamber of the Heart)
Losartan Intervention For Endpoint Reduction in Hypertension (LIFE) Study (0954-133)
The LIFE study was conducted from 1995-2001. This study was conducted in 9193 patients with high blood pressure and thickening of the main pumping chamber of the heart.
- Trial name
- NCT00338260
- Testing
- MK0954, /Duration of Treatment : 5 Years, Comparator : atenolol /Duration of Treatment : 5 Years
- Volunteers
- 496 people
- Sponsor
- Organon and Co
Periodontitis, Hypertension
Acute-phase Response & Periodontal Treatment in Patients With Hypertension
The aim of this study is to compare quadrant scaling and root planing (Q-SRP) versus full-mouth treatment (FM-SRP) in terms of acute-phase responses following non surgical periodontal treatment in patients affected by…
- Trial name
- PERIO-HYPERTEN (NCT03122990)
- Testing
- FM-SRP, Q-SRP
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Pisa
Hypertension
Effect of Solar Salt Diet in Elderly Hypertensive Patients
High sodium intake causes hypertension. Various efforts for reducing salt consumption are proceeding all over the world. Solar salt contains reduced sodium and abundant mineral, such as calcium, potassium, and magnesium…
- Trial name
- NCT01102023
- Testing
- ordinary salt based- diet
- Where
- South Korea
- Sponsor
- Chung-Ang University Hospital
Intracranial Hemorrhage, Hypertensive
Intravenous Immunoglobulin for Acute Intracranial Hemorrhage
This pilot study aims to investigate whether intravenous immunoglobulin is safe and effective in alleviating perihematomal edema and neurologic deficits in patients with intracranial hemorrhage.
- Trial name
- NCT02782897
- Testing
- Immunoglobulin Therapy, Standard management
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Wei Wang
Microalbuminuria, Proteinuria
To Assess the Effects of Valsartan on Albuminuria/Proteinuria in Hypertensive Patients With Type 2 Diabetes Mellitus
This study is designed to assess the efficacy of the different dosage forms of Valsartan[80, 160, and 320 mg] in reducing microalbuminuria/proteinuria in hypertensive patients with type 2 diabetes.
- Trial name
- NCT00550095
- Testing
- valsartan
- Where
- Egypt
- Volunteers
- 509 people
- Sponsor
- Novartis
Microvascular Angina, Hypertension
Effects of Intensive Long-Term Vasodilation in Hypertensive Patients With Microvascular Angina Pectoris
The purpose of this study is to determine if long-term vasodilatory treatment is more effective than the standard treatment in hypertensive patients with microvascular angina pectoris
- Trial name
- NCT00424801
- Testing
- Lercanidipine, Valsartan, Nicorandil
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Hypertension
Efficacy and Safety of Valsartan/Amlodipine Combination in Hypertensive Patients Not Controlled With Valsartan Alone
This study will test the effectiveness and safety of a combination treatment in patients whose blood pressure is not controlled with a single medication
- Trial name
- NCT00170963
- Testing
- valsartan/amlodipine
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 1,018 people
- Sponsor
- Novartis