Clinical trials: Hypertensive Patients
High Blood Pressure, Metabolic Syndrome
Comparison of Aliskiren and Amlodipine on Insulin Resistance and Endothelial Dysfunction in Patients With Hypertension and Metabolic Syndrome
The purpose of this study was to determine the effects of Aliskiren on insulin resistance (IR) and endothelial dysfunction (ED) in patients with high blood pressure and metabolic syndrome.
- Conditions
- High Blood Pressure, Metabolic Syndrome, Insulin Resistance, Endothelial Dysfunction
- Trial name
- NCT00417170
- Testing
- Aliskiren, Amlodipine
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Novartis Pharmaceuticals
Hypertension
Sacubitril/Allisartan for Hypertensive Patients With Overweight or Obesity
To compare the efficacy and safety of sacubitril/Allisartan versus amlodipine in the antihypertensive treatment of overweight/obese patients with primary hypertension
- Trial name
- SHOT (NCT07241338)
- Testing
- sacubitril/allisartan, Amlodipine
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Jing Liu
Essential Hypertension
Amlodipine VaLsartan Efficacy in Hypertensive Patients.A Real World Trial
To determine the efficacy of valsartan/amlodipine 80/5 mg once daily dose is reducing mean sitting systolic blood pressure (MSSBP) and mean sitting diastolic blood pressure (MSDBP) after 8 weeks of therapy.
- Trial name
- ALERT (NCT03371797)
- Testing
- Valsartan, Amlodipine -
- Where
- Pakistan
- Volunteers
- 800 people
- Sponsor
- PharmEvo Pvt Ltd
Hypertension
Nicotinamide Mononucleotide in Hypertensive Patients
Cardiovascular and cerebrovascular diseases are most terrible killers endangering the health of Chinese residents, and hypertension is the most important risk factor.
- Trial name
- NCT04903210
- Testing
- Nicotinamide mononucleotide supplied as 400mg capsule, Lifestyle modification
- Where
- China
- Volunteers
- 20 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Hypertension
Efficacy and Safety of Aliskiren 300 mg Compared to Telmisartan 80 mg After 1 Week of Treatment Withdrawal
This study was specifically designed to provide additional information on the mechanism of action of direct renin inhibition postulating the higher-level RAS cascade inhibition.
- Trial name
- ASSERTIVE (NCT00865020)
- Testing
- Aliskiren, Telmisartan
- Where
- 16 sites in Brazil, Canada and 14 more
- Volunteers
- 822 people
- Sponsor
- Novartis
Hypertension
Telmisartan in Mild to Moderate Hypertensive Patients
To evaluate the efficacy and tolerability of telmisartan, given once a day to patients with mild to moderate hypertension, as well as to assess the 24-hour blood pressure profile with ABPM
- Trial name
- NCT02260089
- Testing
- Low dose of telmisartan, High dose of telmisartan
- Volunteers
- 134 people
- Sponsor
- Boehringer Ingelheim
Hypertension
Losartan and Simvastatin in Hypertensive Obeses With Liver Steatosis
Angiotensin II has been proposed as a lipid metabolism regulator. It is known that adipocytes secrete a variety of protein, such as TNFα, plasminogen activator inhibitor (PAI)-1, leptin, resistin and adiponectin; these proteins…
- Trial name
- NCT00669435
- Testing
- Losartan + Simvastatin, Amlodipine + Simvastatin
- Where
- Italy
- Volunteers
- 75 people
- Sponsor
- University of Pavia
Hypertensive Patients
Pharmacometric Modeling of a Hospital Preparation
Pediatric prescribers are very often faced with a lack of suitable therapies, particularly oral ones. This represents a major public health problem and necessitates adjustments to dosage or pharmaceutical form using medications…
- Trial name
- PEDIATENS (NCT07372560)
- Testing
- Evaluation of the pharmacokinetic parameters of an oral formulation of nicardipine hydrochloride
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Rouen
Hypertension, Dyslipidemias
Reduction Efficacy of OLOMAX for Blood Pressure and Low-density Lipoprotein Cholesterol in Hypertensive Patients With Dyslipidemia
This study is a large-scale, prospective, multi-center, and non-interventional observation study to observe blood pressure and blood lipid changes and safety during administration of olomax tablets for 24 weeks in hypertensive…
- Trial name
- NCT05660135
- Testing
- Olmesartan Medoxomil/ Amlodipine Besylate/ Rosuvastatin Ca
- Where
- South Korea
- Volunteers
- 4,000 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Hypertension
Telmisartan 80mg+Hydrochlorothiazide (HCTZ) 25 mg in Hypertension: an Observational Study
It is a national, retrospective , observational study in hypertensive patients treated for at least 8 weeks with the fixed dose combination of telmisartan 80 mg and hydrochlorothiazide 25 mg.
- Trial name
- NCT00909038
- Where
- 915 sites in France
- Volunteers
- 2,411 people
- Sponsor
- Boehringer Ingelheim
Hypertension, Endothelial Dysfunction
CPAP and Nebivolol in Hypertensive Obstructive Sleep Apnea (OSA) Patients.
The aim of this study is to examine how effective CPAP treatment and treatment with nebivolol are respectively on reducing blood pressure and on endothelial dysfunction in patients suffering from obstructive sleep apnea and…
- Conditions
- Hypertension, Endothelial Dysfunction, Obstructive Sleep Apnea
- Trial name
- NEBOSA (NCT01771406)
- Testing
- Nebivolol, Continuous positive airway pressure (CPAP)
- Where
- Belgium
- Volunteers
- 36 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Hypertension
Spironolactone Versus Indapamide in Obese and Hypertensive Patients
Most recent guidelines continue to recommend thiazide diuretics as first-line agents for patients with hypertension in spite of the potential metabolic side effects, while mineralocorticoid receptor antagonists (MRAs), such as…
- Trial name
- NCT03626506
- Testing
- Spironolactone, Indapamide, Amlodipine
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Peking University Third Hospital
Open Angle Glaucoma, Ocular Hypertension
Efficacy and Safety Assessment of T2347 Versus Xalacom® in Ocular Hypertensive or Glaucomatous Patients
The objective of the study is to assess the efficacy and safety of T2347 (Latanoprost 0.005% + Timolol 0.5% unpreserved eye drops) versus Xalacom® in ocular hypertensive or glaucomatous patients initially treated, stabilised by…
- Trial name
- NCT02278614
- Testing
- T2347, Xalacom
- Where
- France
- Volunteers
- 242 people
- Sponsor
- Laboratoires Thea
Hypertension With Hyperlipidemia
Efficacy/Safety of Telmisartan/Amlodipine/Rosuvastatin in Hypertensive Patients With Hyperlipidemia
A Randomized, Double-blind, Multi-center Phase III Clinical Trial to Evaluate the Efficacy and Safety of Telmisartan/Amlodipine and Rosuvastatin Co-administration in Hypertensive Patients with Hyperlipidemia
- Trial name
- NCT03566316
- Testing
- Telmisartan/Amlodipine, Rosuvastatin, Telmisartan
- Where
- South Korea
- Volunteers
- 134 people
- Sponsor
- IlDong Pharmaceutical Co Ltd
Diabetic Nephropathy, Hypertensive Nephropathy
Ayurvedic Management of Chronic Kidney Disease
The purpose of this study is to determine the effect of multi-dimentional ayurvedic treatment in the patients of various types of chronic kidney disease.
- Trial name
- NCT02477163
- Testing
- Ayurveda treatment
- Where
- India
- Volunteers
- 521 people
- Sponsor
- J.S. Ayurveda College
Hypertension
BIBR 277 Capsules in Hypertensive Patients With Nephropathy
The antihypertensive effect, safety and usefulness of treatment with BIBR 277 capsules were evaluated in hypertensive patients with nephropathy
- Trial name
- NCT02187484
- Testing
- BIBR 277
- Volunteers
- 23 people
- Sponsor
- Boehringer Ingelheim
Obstructive Sleep Apnea, Masked Hypertension
Masked Hypertensive Patients With Obstructive Sleep Apnea
The general objective is to evaluate the effect of continuous positive airway pressure (CPAP) treatment in patients with masked hypertension.
- Trial name
- Masked-OSA (NCT04251975)
- Testing
- CPAP treatment
- Where
- Spain
- Volunteers
- 16 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Hypertension, Diabetes Type 2
Evaluating the Effect of Aliskiren Versus HCTZ on Coronary Flow Reserve in Hypertensive Type II Diabetics
The purpose of this study is to assess the effect of Tekturna (aliskiren), in combination with an ACE and calcium channel blocker in hypertensive patients diagnosed with Type II diabetes.
- Trial name
- NCT00994253
- Testing
- Aliskiren, Hydrochlorothiazide
- Where
- United States
- Sponsor
- Corewell Health East
Hypertension
ConfidenHT System for Diagnostic Electrical Mapping of Renal Nerves
To evaluate the safety and performance of the ConfidenHT System
- Trial name
- RDN (NCT02777216)
- Testing
- ConfidenHT system
- Where
- 3 sites in Greece, Netherlands
- Volunteers
- 20 people
- Sponsor
- BlueWind Medical
Hypertension
Tadalafil Effects in Left Ventricle Diastolic Dysfunction in Resistant Hypertensive Patients
Left ventricle diastolic dysfunction (LVDD) is associated with resistant hypertension. In addition, brain natriuretic peptide (BNP) levels are elevated when LVDD is present.
- Trial name
- NCT01743911
- Testing
- sugar pill, Tadalafil
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Campinas, Brazil