Clinical trials: Hypertensive Patients
Pre-hypertension, Hypertension
Potassium-Magnesium Citrate as a Blood Pressure Lowering Agent in Hypertensive Patients
The goal of this study is to compare the effects of Potassium Magnesium Citrate to Potassium Chloride on blood pressure among patients with pre-hypertension or mild hypertension.
- Trial name
- NCT01074918
- Testing
- Potassium, Magnesium, Citrate, Potassium Chloride
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Essential Hypertension
A Study to Evaluate the Effectiveness and Safety of a Fixed Dose Combination of Azilsartan Medoxomil and Chlorthalidone in Patients With High Blood Pressure Who do Not Achieve Target Blood Pressure Following Treatment With Azilsartan Medoxomil Alone
The purpose of this study is to evaluate the efficacy and safety of the fixed dose combinations of azilsartan medoxomil plus chlorthalidone (40/12.5 and 40/25 mg), once daily, in participants with grades 2 or 3 essential…
- Trial name
- NCT01456169
- Testing
- Azilsartan medoxomil - chlorthalidone
- Where
- 108 sites in Bulgaria, Estonia and 12 more
- Volunteers
- 507 people
- Sponsor
- Takeda
Hypertension
The Effect of Smart Phone Application Supported Nursing Care Program
Hypertension is an important public health problem in our country and in the world. For success in hypertension treatment, timely and accurate diagnosis of patients, effective implementation of lifestyle changes, timely…
- Trial name
- NCT05392140
- Testing
- Health belief model-based smartphone-assisted nursing care program application will be installed on the phones of the patients who will be in the intervention group., Standart care
- Volunteers
- 102 people
- Sponsor
- Kastamonu University
Metabolic Syndrome
A Clinical Trial of YMC017 in Hypertensive and Hypercholesterolemic Patients With Metabolic Syndrome
This is a Randomized, open-label, 2 groups, parallel design.
- Trial name
- NCT02968160
- Testing
- Telmisartan 40mg + Rosuvastatin 20mg, Telmisartan 80mg + Rosuvastatin 20mg, Telmisartan 40mg, 80 mg
- Where
- South Korea
- Volunteers
- 55 people
- Sponsor
- Yuhan Corporation
Hypertension, Acute Myocardial Infarction
PCI and Renal Denervation in Hypertensive Patients With Acute Coronary Syndromes
Research hypothesis: Is the treatment with renal denervation (RDN) early post ACS safe and effective and does it leads to improved cardiac function and attenuation of pathologic left ventricular remodelling? In a following study…
- Trial name
- COMBI-RDN (NCT02272920)
- Testing
- Renal denervation
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Sahlgrenska University Hospital
Hypertension (HTN)
Tension and Trauma Releasing Exercises on Hypertensive Patients
The aim of this study is to investigate the effect of Tension and Trauma Releasing Exercises (TRE) on the quality of life and sleep in hypertensive patients.
- Trial name
- NCT07242651
- Testing
- Tension and trauma releasing exercises
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Portal Hypertension, Variceal Hemorrhage
Vonoprazan Efficacy to Prevent Post Variceal Band Ligation Ulcer
Endoscopic variceal ligation (EVL) is used to control and prevent variceal bleeding in patients with liver cirrhosis, but it can be complicated by bleeding from post-EVL ulcers.
- Conditions
- Portal Hypertension, Variceal Hemorrhage, Ulcer Hemorrhage
- Trial name
- NCT05227833
- Testing
- Vonoprazan fumarate (Vonaspire), Pantoprazole 40mg
- Where
- Egypt
- Volunteers
- 284 people
- Sponsor
- Alexandria University
Essential Hypertension
A Phase III Clinical Study of Valsartan Oral Solution for the Treatment of Hypertension in Children and Adolescents
This study was an randomized, double-Blind, placebo-controlled, multicenter Phase II/III study.
- Trial name
- NCT06863987
- Testing
- Valsartan Oral Solution
- Where
- China
- Volunteers
- 342 people
- Sponsor
- Shandong New Time Pharmaceutical Co., LTD
Hypertension
Antihypertensive Efficacy and Safety of Approved Drugs in Japanese Patients With Essential Hypertension (Banyu Study)(0954A-302)
The purpose of this study is to evaluate antihypertensive (lowering blood pressure) effectiveness of three combinations of approved study drugs compared to both study drugs being given alone.
- Trial name
- NCT00092209
- Testing
- MK0954A, hydrochlorothiazide (+) losartan potassium
- Volunteers
- 840 people
- Sponsor
- Organon and Co
Glomerulonephritis, IGA, Hypertension
A Prospective Study of the Kidney Protective Effect of Aliskiren in Hypertensive Patients With IgA Nephropathy
The purpose of this study is to evaluate the effect of aliskiren, a novel direct rennin inhibitor, on renal function and progress of renal disease in hypertensive patients with IgA nephropathy.
- Trial name
- NCT01184599
- Testing
- aliskiren
- Where
- 4 sites in Japan
- Volunteers
- 30 people
- Sponsor
- Kagawa University
Hypertension, Left Ventricular Hypertrophy
Effect of Valsartan on Left Ventricular Myocardial Functions in Hypertensive Patients With Left Ventricular Hypertrophy
The study hypothesis: Valsartan as an angiotensin II receptor blocker treatment has beneficial effects on both midwall mechanics and myocardial functions in hypertensive patients with Left ventricular hypertrophy.
- Trial name
- NCT01425411
- Testing
- valsartan
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Mustafa Kemal University
Hypertension
Comparison of Effects Between Amlodipine and Hydrochlorothiazide in Combination With Losartan on 24-hr Central Blood Pressure in Hypertensive Patients
The purpose of this study is to investigate which combination therapy is more effective for improving the blood pressure (BP) and AM central SBP in hypertensive patients:Angiotensin II receptor blocker (ARB) plus calcium channel…
- Trial name
- NCT02294539
- Testing
- Losartan 50mg/amlodipine 5mg, Losartan 100mg/amlodipine 5mg, Losartan 50mg/Hydrochlorothiazide 12.5mg
- Where
- South Korea
- Volunteers
- 231 people
- Sponsor
- Chong-Jin Kim
Intracranial Hemorrhage, Hypertensive
Minimally-invasive Surgery Versus Craniotomy in Patients With Supratentorial Hypertensive Intracerebral Hemorrhage
The effectiveness of craniotomy in the treatment of intracerebral hemorrhage remains controversial. Two main types of minimally invasive surgery, endoscopic evacuation and stereotactic aspiration, have been attempted for hematoma…
- Trial name
- MISICH (NCT02811614)
- Testing
- Endoscopic Evacuation, Stereotactic Aspiration, Craniotomy
- Where
- China
- Volunteers
- 733 people
- Sponsor
- Chinese PLA General Hospital
Hypertension
Validation of Laser Doppler Vibrometer (LDV) for Measurement of Arterial Stiffness in Hypertensive Patients
The aim is to compare a new technique for assessing local and regional arterial stiffness: the Laser Doppler Vibrometry with the reference techniques, the applanation tonometry and echotracking.
- Trial name
- CARDIS-PWV (NCT03446430)
- Testing
- PWV measurement by LDV
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Hypertension
Effectiveness and Safety of Combination of Amlodipine and Zofenopril in Hypertensive Patients Versus Each Monotherapy
Study to assess the anti-hypertensive efficacy and safety of the extemporaneous combination of Zofenopril 30 mg in combination with Amlodipine 5 mg or AML 10 mg in lowering the sitting diastolic BP after 8 weeks of treatment in…
- Trial name
- Masolino (NCT05279807)
- Testing
- Zofenopril, Amlodipine
- Where
- Hungary
- Volunteers
- 277 people
- Sponsor
- Menarini International Operations Luxembourg SA
Chronic Kidney Disease Stages 3-5, Diabetic Kidney Disease
Role of QRX-3 in Chronic Kidney Disease Patients in Outpatients Clinics
QRX-3, a new drug that stabilized the kidney renal tubular cell and increase the activity of NAD ( nicotinamide adenine dineuclotide )within the kidney cells; leading to decrease oxidative changes intracellularly, repair of renal…
- Conditions
- Chronic Kidney Disease Stages 3-5, Diabetic Kidney Disease, Hypertensive Kidney Disease
- Trial name
- QRX-3 in CKD (NCT06948292)
- Testing
- QRX-3
- Where
- United States
- Volunteers
- 127 people
- Sponsor
- Ebima Clifford Okundaye
Hypertension
Efficacy and Safety of Aliskiren 300 mg Compared to Telmisartan 80 mg After 1 Week of Treatment Withdrawal
This study was specifically designed to provide additional information on the mechanism of action of direct renin inhibition postulating the higher-level RAS cascade inhibition.
- Trial name
- ASSERTIVE (NCT00865020)
- Testing
- Aliskiren, Telmisartan
- Where
- 16 sites in Brazil, Canada and 14 more
- Volunteers
- 822 people
- Sponsor
- Novartis
Essential (Primary) Hypertension, Hypertensive Heart Disease With (Congestive) Heart Failure
Positive Care Effect of the Digital Health Assistant ADELE Blood Pressure for Hypertension Patients
High blood pressure (hypertension) can cause damage to vital organs such as the heart, kidneys, eyes, brain and blood vessels. The risk of developing high blood pressure increases with age.
- Conditions
- Essential (Primary) Hypertension, Hypertensive Heart Disease With (Congestive) Heart Failure, Hypertensive Heart Disease Without (Congestive) Heart Failure, Other Secondary Hypertension
- Trial name
- A0007 (NCT06663280)
- Testing
- Digital health assistant ADELE
- Where
- 2 sites in Germany
- Volunteers
- 108 people
- Sponsor
- Alma Phil Gmbh
Hypertension
Effectiveness of Valsartan/Amlodipine (EXforge®) and Nifedipine treAtment coMparison in Treating Chinese Hypertensive Patients
The purpose of this study was to compare the efficacy and safety of Valsartan/Amlodipine (EXforge®) with nifedipine, as well as vascular function index.
- Trial name
- EXAM (NCT01167153)
- Testing
- Valsartan/Amlodipine, Nifedipine
- Where
- China
- Volunteers
- 564 people
- Sponsor
- Novartis
Hypertension Emergency, End-organ Damage
Post Marketing Study to Evaluate the Two Dose Regimens of Nicardipine Injection in Hypertensive Emergency Patients
To compare the efficacy and safety of two dose adjustment regimens (i.e. weight-based and non-weight-based) for the treatment of Chinese hypertensive emergency patients.
- Trial name
- NCT01872039
- Testing
- Perdipine injection
- Where
- 5 sites in China
- Volunteers
- 163 people
- Sponsor
- Astellas Pharma China, Inc.