Clinical trials: Hyperthyroidism
Graves Disease
Does Potassium Iodide (SSKI) Reduce Vascularity in Graves' Thyroidectomy?
The purpose of this research is to find out if SSKI (Potassium Iodide) reduces vascularity (the number and concentration of blood vessels) and improves how well patients do after surgery for removal of their whole thyroid gland…
- Trial name
- NCT04080505
- Testing
- SSKI- Potassium Iodide
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Columbia University
Hyperparathyroidism, Secondary
Compare the Efficacy of Cinacalcet vs Traditional Vitamin D for Secondary Hyperparathyroidism (SHPT) Among Subjects Undergoing Hemodialysis
The purpose of this study is to determine the efficacy of treatment with cinacalcet to manage plasma parathyroid levels as to compared traditional vitamin D therapy, whether given orally or intravenously, among hemodialysis…
- Trial name
- NCT01181531
- Testing
- Traditional Vitamin D Therapy, Cinacalcet
- Volunteers
- 312 people
- Sponsor
- Amgen
Thyrotoxicosis
Therapeutic Plasma Exchange in Thyrotoxicosis
Therapeutic plasma exchange (TPE) is indicated in cases where antithyroid medications cannot be used due to the side effects or attain no adequate hormonal suppression response at the highest dosage and in cases of rapid onset of…
- Trial name
- NCT04485975
- Testing
- Therapeutic plasma exchange
- Volunteers
- 27 people
- Sponsor
- Baskent University
Graves' Disease
D-vitamin And Graves' Disease; Morbidity And Relapse Reduction
The purpose of this study is to investigate the effects of vitamin D supplementation on morbidity and risk of relapse in patients with Graves' disease.
- Trial name
- DAGMAR (NCT02384668)
- Testing
- Cholecalciferol
- Where
- 8 sites in Denmark
- Volunteers
- 278 people
- Sponsor
- University of Aarhus
Graves Ophthalmopathy
Comparison of the Effectiveness of Two Glucocorticoid Regimens for Treatment of Graves' Orbitopathy
The goal of this interventional study is to compare the effectiveness of two different glucocorticoid regimens for treatment of active moderate-to-severe Graves' orbitopathy. The main questions it aims to answer are: 1.
- Trial name
- NCT05793359
- Testing
- Methylprednisolone
- Where
- Bulgaria
- Volunteers
- 62 people
- Sponsor
- Medical University of Sofia
Hyperthyroidism, Atrial Fibrillation
Thumb-ECG Ambulant Screening for Atrial Fibrillation in Patients Treated for Hyperthyroidism (TAMBOURINE)
Background: Atrial fibrillation is a common heart rhythm disturbance affecting some 1-2% of the western population. It may cause symptoms such as irregular heartbeats, shortness of breath, and fatigue.
- Trial name
- TAMBOURINE (NCT01945229)
- Where
- 3 sites in Sweden
- Volunteers
- 110 people
- Sponsor
- Karolinska Institutet
Graves Disease
The Relationship Between NK Cell and Graves' Disease
Graves' disease (GD) is one of organ specific autoimmune diseases, the pathogenesis is not elucidated.Natural Killer (Natural Killer, NK) cells is a kind of important immune regulator, several abnormalities of NK cell function…
- Trial name
- NCT04135573
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shandong Provincial Hospital
Hyperthyroidism, Graves Disease
Effect of Hyperthyroidism and Its Treatment in Graves' Disease to Early Marker of Atherosclerosis
During July 2019 to August 2020, a single-blind clinical trial was done to 36 patients with Graves' disease. At the beginning of the study, subjects were accommodated into 2 groups, 17 into PTU groups and 19 into methimazole…
- Conditions
- Hyperthyroidism, Graves Disease, Atherosclerosis of Artery, Pathophysiology
- Trial name
- NCT05118542
- Testing
- Propylthiouracil, Methimazole
- Where
- Indonesia
- Volunteers
- 36 people
- Sponsor
- Universitas Indonesia
Graves Disease
Comparison of Different Doses of 131I in Severe Graves' Hyperthyroidism
The purpose of this study is to determine whether higher doses of radioiodine increase treatment efficacy in severe Graves' disease.
- Trial name
- NCT01039818
- Testing
- Radioiodine
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Hyperthyroidism
Evaluation of Renal Function in Patients With Hyperthyroidism
To evaluate the effect of subclinical and overt Hyperthyroidism in renal function
- Trial name
- NCT06591858
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Complication of Hemodialysis, Hyperthyroidism Treated or Under Control
Early Administration of L-carnitine in Hemodialysis Patients
Hemodialysis is a cause of carnitine deficiency. The deficiency of carnitine induces an anemia by an increase fragility of the red blood cells, a muscular fatigue and a cardiac dysfunction.
- Trial name
- NCT00322322
- Testing
- L-Carnitine
- Where
- 2 sites in France
- Volunteers
- 110 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Thyroid Eye Disease
An Open-label, Rollover Trial to Evaluate the Efficacy and Safety of AMG 732 in Participants With Thyroid Eye Disease
The main objective of this trial is to assess the efficacy of AMG 732 in participants with thyroid eye disease (TED) who are defined as primary nonresponders or relapsed during the safety follow-up in the parent trial…
- Trial name
- HAZEL 401 (NCT07438405)
- Testing
- AMG 732
- Where
- 8 sites in United States, Poland and 2 more
- Volunteers
- 30 people
- Sponsor
- Amgen
Graves Disease, Graves' Disease
Impact of Vitamin D Therapy on Thyroid Function and Antibody Levels in Pediatric Graves' Disease
The goal of this randomized pilot feasibility clinical trial is to determine the feasibility of implementing a protocol for a larger trial to assess the effects of high-dose vitamin D supplementation in pediatric patients (9-17…
- Conditions
- Graves Disease, Graves' Disease, Hyperthyroidism
- Trial name
- NCT07369063
- Testing
- Ergocalciferol 50,000 IU, Methimazole
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwell Health
Thyroid Eye Disease, TED
Triamcinolone Acetonide Injection for Upper Eyelid Retraction in Thyroid Eye Disease
Thyroid eye disease frequently causes upper eyelid retraction, which can lead to ocular surface complications and cosmetic concerns.
- Trial name
- TREAT-OT (NCT07471997)
- Testing
- Triamcinolone Acetonide
- Where
- Mexico
- Volunteers
- 29 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Thyroid Eye Disease, Graves Ophthalmopathy
A Study to Evaluate the Efficacy and Safety of LASN01 in Patients With Thyroid Eye Disease
LASN01 is a novel, fully human antibody directed against the human IL-11 receptor being developed for treatment of patients with thyroid eye disease (TED).
- Conditions
- Thyroid Eye Disease, Graves Ophthalmopathy, Graves Orbitopathy, Thyroid Associated Ophthalmopathy
- Trial name
- NCT06226545
- Testing
- LASN01
- Where
- 15 sites in United States, Spain and 1 more
- Volunteers
- 41 people
- Sponsor
- Lassen Therapeutics Inc.
Thyroid-associated Ophthalmopathy, Dry Eye Syndrome
The Effect of Intravenous Glucocorticoids on the Tearfilm in Eyes With Thyroid-associated Ophthalmopathy
Thyroid-associated ophthalmopathy (TAO), also called Graves' ophthalmopathy or thyroid eye disease, is a common orbital disease in adults.
- Trial name
- NCT01579539
- Testing
- Methylprednisolone, Esomeprazole
- Where
- Austria
- Volunteers
- 18 people
- Sponsor
- Medical University of Vienna
Graves' Ophthalmopathy
The Effect of Early Total Thyroidectomy in the Course of Graves' Orbitopathy
The relationship between the method of the treatment of hyperthyroidism due to Graves' disease and the course of Graves' ophthalmopathy is debated.
- Trial name
- NCT01056419
- Testing
- Total Thyroidectomy, Propylthiouracil
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Ankara University
Thyroid Eye Disease, TED
Multi-modal Medical Images for Extraocular Muscle Fibrosis Assessment
The purpose of this study was to evaluate the elasticity of the extraocular muscles in different stages of thyroid eye disease and to examine the correlation of MRI parameters (native T1 value and ECV) and elasticity for the…
- Trial name
- NCT07056114
- Testing
- The patients with active or inactive TED
- Where
- China
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Tianjin Eye Hospital
Thyroid Neoplasms, Goiter, Nodular
Study of the Efficacy of Local Analgesia as an Adjunct to General Anesthesia in Thyroidectomy and Parathyroidectomy
We aim to study the effect of local anesthetic when used in conjunction with general anesthesia during thyroidectomy or parathyroidectomy.
- Conditions
- Thyroid Neoplasms, Goiter, Nodular, Thyroid Nodule, Graves' Disease
- Trial name
- NCT02205801
- Testing
- Superficial Cervical Plexus Block, Local Wound Infiltration, 0.9% saline
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Chicago
Graves Disease
NEXUS Study: A Study to Test Single and Multiple Doses of MER511 Given to Adults With Graves' Disease
The purpose of this study is to evaluate how well MER511 is tolerated and what side effects may occur in adults who have Graves' disease.
- Trial name
- NCT07305818
- Testing
- MER511 (IV), MER511 (SC), MER511 (SC) for MAD
- Where
- 16 sites in United States, Spain
- Volunteers
- 100 people
- Sponsor
- Merida Biosciences