Clinical trials: Hypertonia, Muscle
Cerebral Palsy, Spastic
Muscle-tendon Pathology and Metabolic Dysregulation in CP
The main aim of this project is to gain knowledge about the muscle-tendon pathology of moderately to severely affected young people with cerebral palsy and their risk for cardiometabolic diseases and chronic inflammation.
- Trial name
- NCT06330922
- Testing
- Cardiorespiratory fitness training
- Where
- Austria
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Graz
Cerebral Palsy, Spastic
Whole Body Vibration in Children With Cerebral Palsy
Some positive effects of whole body vibration applications in reducing spasticity, improving walking ability, and increasing walking speed have been reported in children with CP, but the evidence is not strong enough.
- Trial name
- CP (NCT05636241)
- Testing
- conventional physiotherapy program, whole body vibration training program
- Where
- Turkey (Türkiye)
- Volunteers
- 13 people
- Sponsor
- Kutahya Health Sciences University
Spasticity, Multiple Sclerosis, Stroke, Trauma
Antispastic Effect of Transcranial Magnetic Stimulation in Patients With Cerebral and Spinal Spasticity
Spasticity - movement disorder, which is part of the syndrome of defeat top motor-neuron, characterized by the rate-dependent increase in muscle tone and increased dry-core reflections from hyperexcitability of stretch receptors…
- Trial name
- ANTMS (NCT01786005)
- Testing
- Transcranial magnetic stimulation
- Where
- Russia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Russian Academy of Medical Sciences
Stroke, Muscle Spasticity
The Effectiveness of Early Botulinum Toxin A Injection for Lower Limbs Spasticity in Subacute Stroke Adults
Botulinum toxin A (BoNT-A) injections are widely used to treat spasticity after stroke. Although this treatment is effective on muscle tone improvement, its effect on gait and ability of daily living on early stage of stroke…
- Trial name
- NCT02505802
- Testing
- BoNT-A injection
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sir Run Run Shaw Hospital
Stroke, Acute, Stroke, Ischemic
Prognosis and Diagnosis of Spasticity in Acute-post Stroke Patients
Spasticity, or greater muscle resistance, is a major disabling condition following stroke. Recovery of lost motor function in patients with stroke may be affected by spasticity, which most commonly develops in elbow and ankle…
- Conditions
- Stroke, Acute, Stroke, Ischemic, Stroke Hemorrhagic, Spasticity as Sequela of Stroke
- Trial name
- NCT05179473
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- McGill University
Multiple Sclerosis
Functional Balance Intervention in Multiple Sclerosis
This project involves two sub-parts: Study 1: Effect of lab-based Functional Balance Intervention (FBI) for physical and cognitive symptoms of Multiple Sclerosis.
- Trial name
- FBIinMS (NCT06341023)
- Testing
- Functional Balance Intervention, Stretching
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Illinois at Chicago
Muscle Spasticity
BOTOX® Economic Spasticity Trial (BEST)
This is a study to investigate if patients who have had a stroke and suffer from spasticity might benefit from being given BOTOX® in addition to the normal Standard Care.
- Trial name
- NCT00549783
- Testing
- Botulinum Toxin Type A 900kD
- Where
- 4 sites in Canada, Germany and 2 more
- Volunteers
- 274 people
- Sponsor
- Allergan
Spinal Cord Injury, Spasticity
Extracorporeal Shock Wave Therapy (ESWT) for the Treatment of Spasticity in Persons With Spinal Cord Injury
Spasticity is the most problematic self-reported secondary medical problem in patients with spinal cord injury. It has the potential to negatively influence quality of life through restricting activities of daily living.
- Trial name
- ESWT (NCT02203994)
- Testing
- Duolith® SD 1 "T-Top" (Storz Medical AG, Switzerland)
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
Spasticity
Botox vs. Baclofen for Upper Limb Spasticity
The purposes of this pilot study are to evaluate the safety and efficacy of Botox® compared to the safety and efficacy of oral baclofen in reducing muscle tone-related disability resulting from neurological damage or a stable…
- Trial name
- NCT00280280
- Testing
- intramuscular Botox versus oral baclofen
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Vanderbilt University
Multiple Sclerosis
Neurophysiological Study of Sativex in Multiple Sclerosis (MS) Spasticity
Aim of this randomized, double-blind, placebo-controlled, cross-over study is to investigate cannabinoid-induced changes in neurophysiological parameters in a group of 40 patients with secondary or primary progressive Multiple…
- Trial name
- NS-MSS (NCT01538225)
- Testing
- Sativex®
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- Almirall, S.A.
Spinal Cord Injuries, Spinal Cord Injury
Neuromodulation to Reduce Muscle Stiffness Following Spinal Cord Injury
People with spinal cord injuries may experience muscle tightness or uncontrollable spasms. This study is being conducted to investigate whether transcutaneous spinal stimulation can improve these symptoms.
- Conditions
- Spinal Cord Injuries, Spinal Cord Injury, Spinal Cord Injury Cervical, Spinal Cord Injury Thoracic
- Trial name
- NCT06274021
- Testing
- Transcutaneous spinal stimulation at 100 Hz, Transcutaneous spinal stimulation at 50 Hz, Transcutaneous spinal stimulation at 50 Hz and single dose of baclofen
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- University of Mississippi Medical Center
Multiple Sclerosis, Muscle Spasticity
Effect of Cervical Mobilization on Balance and Plantar Pressure Distribution in Multiple Sclerosis
MS patients were randomly divided into traditional therapy and traditional therapy + cervical mobilization groups. While muscle strengthening, stretching, balance and coordination exercises were given to the traditional group…
- Conditions
- Multiple Sclerosis, Muscle Spasticity, Pressure Area, Cervical Region Disorder Nos
- Trial name
- NCT04543448
- Testing
- Traditional Rehabilitation for multiple sclerosis, Cervical mobilization for multiple sclerosis
- Where
- Turkey (Türkiye)
- Volunteers
- 12 people
- Sponsor
- Hasan Kalyoncu University
Spastic Cerebral Palsy
INcobotulinumtoxina in ChIldren Upper and Lower Limb sPasticITy (INCIPIT)
Prospective, open-label, non-randomized, single-arm, dose titration, phase II study. The study will consist of three injection cycles. In each, an injection visit is followed by an observation period of 12 to 20 weeks.
- Trial name
- INCIPIT (NCT05340439)
- Testing
- IncobotulinumtoxinA 100 UNT [Xeomin]
- Volunteers
- 30 people
- Sponsor
- Universita di Verona
Stroke, Walking, Difficulty
Agonist and Antagonist Muscle Activations in the Lower Limbs During Walking After Central Nervous System Injury
The retrospective study investigates the part of responsibility of neuromuscular disorders associated with chronic hemiparesis in walking impairment.
- Conditions
- Stroke, Walking, Difficulty, Spasticity/Paresis
- Trial name
- NEUROGAIT (NCT06107556)
- Testing
- Gait analysis
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Henri Mondor University Hospital
Muscle Spasticity, Multiple Sclerosis
Safety of Xeomin for Lower Limb Spasticity in Multiple Sclerosis Patients
The purpose of this study is to determine if Xeomin® will prove effective for significantly improving lower extremity spasticity and will be well tolerated by the majority of MS patients.
- Trial name
- NCT01968902
- Testing
- incabotulinumtoxinA
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Multiple Sclerosis Center of Northeastern New York
Dementia, Paratonia
Short-term Effect of Positioning Cushions and Harmonic Techniques on Paratonia in Persons With Dementia
This study investigated the short-term effect of both harmonic techniques and supporting cushions on muscle tone, range of motion, pain and daily care activities in 22 patients with moderate to severe paratonia.
- Trial name
- NCT03538405
- Testing
- Supporting cushions, Harmonic techniques
- Where
- Belgium
- Volunteers
- 22 people
- Sponsor
- University Ghent
Cerebral Palsy
Short-Burst Interval Treadmill Training Cerebral Palsy
Ambulatory children with cerebral palsy (CP) walk predominately in low intensity stride rates with little variability, thus limiting their walking activity and ability to participate in daily life.
- Trial name
- NCT04026295
- Testing
- Short Burst Interval Treadmill Training (SBLTT), Traditional Locomotor Treadmill Training (TLTT)
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Kristie Bjornson
Deep Pressure, Muscle Activity
Effect of Local Pressure on Muscle Activity and General Relaxation in Persons With Hypertonia Following Stroke
The purpose of this study is to examine the effect of - both constant as intermittent - local application of deep pressure on muscle activity and general relaxation in persons with hypertonia following stroke.
- Conditions
- Deep Pressure, Muscle Activity, General Relaxation, Stroke
- Trial name
- NCT04188769
- Testing
- constant deep pressure applied by an air splint, intermittent deep pressure applied by an air splint, uninflated air splint
- Where
- Belgium
- Sponsor
- University Ghent
Stroke
Morphological Characteristics of the Upper and Lower Extremities Using Ultrasound Examination After Stroke.
Introduction A large number of stroke patients develop spasticity in the upper and lower extremities, which is one of the clinical signs of damage to motor neuron 1, causing abnormal postures and movement patterns due to motor…
- Trial name
- Spasticity (NCT07156760)
- Testing
- Ultrasound diagnostics
- Where
- 2 sites in Chile
- Volunteers
- 80 people
- Sponsor
- Universidad de La Frontera
Stroke, Hemiparesis
"Comparison of Therapist-Led and Robot-Assisted Arm Therapy in Subacute Stroke Rehabilitation"
This study aims to compare the outcomes of upper limb motor therapy conducted by a physiotherapist with robot-assisted therapy using the Luna EMG device in patients in the subacute phase after stroke.
- Conditions
- Stroke, Hemiparesis, Muscle Spasticity, Upper Extremity Dysfunction
- Trial name
- NCT07002463
- Testing
- Luna EMG, Therapist-assisted upper limb training
- Where
- Poland
- Volunteers
- 58 people
- Sponsor
- Wroclaw University of Health and Sport Sciences