Clinical trials: Hypertonic Disorder
Bronchiolitis
Epinephrine, Dexamethasone, and Hypertonic Saline in Bronchiolitis, Randomised Clinical Trial of Efficacy and Safety
In infancy, bronchiolitis is the most common acute infection of the lower respiratory Tract. The current treatment of bronchiolitis is controversial.
- Trial name
- NCT01834820
- Testing
- Epinephrine and Dexamethasone, Hypertonic Saline, Normal Saline
- Where
- Mexico
- Volunteers
- 120 people
- Sponsor
- Hospital General Naval de Alta Especialidad - Escuela Medico Naval
Subarachnoid Hemorrhage, Cerebral Vasospasm
Safety and Feasibility of Hypertonic Saline Solution After Aneurysmal Subarachnoid Hemorrhage:
Subarachnoid hemorrhage (SAH) occurs after rupture of cerebral aneurysms. Treatment of SAH focuses on avoiding medical complications including cerebral vasospasm, which may result in limited circulation to the brain.
- Conditions
- Subarachnoid Hemorrhage, Cerebral Vasospasm, Hyponatremia
- Trial name
- HS3 (NCT02432157)
- Testing
- HTS 3%, Standard fluid management
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Thomas Jefferson University
Moderate to Severe Asthma
Phase I Assessment of Hypertonic Saline in Moderate to Severe Asthmatics
Purpose: To determine if inhaled hypertonic saline (HS) accelerates airway mucociliary clearance (MCC) in well-controlled moderate to severe asthmatics.
- Trial name
- NCT03556683
- Testing
- 3% Hypertonic Saline, 7% Hypertonic Saline, Salbutamol
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of North Carolina, Chapel Hill
Pulmonary Edema
Safety Study of Inhaled Saline in Acute Lung Injury
To determine if an inhaled hypertonic saline solution has any effect on lung function in patients with acute respiratory distress syndrome (ARDS).
- Trial name
- NCT01713595
- Testing
- Hypertonic Saline Aerosol
- Sponsor
- Mayo Clinic
SARS-CoV2 Infection
Washing COVID-19 Away With a Hypertonic Seawater Nasal Irrigation Solution
Nasal irrigations are thought to reduce the amount of virus from the nasal cavity. The aim of the present study is to evaluate the effect of a hypertonic seawater solution containing algal and herbal natural ingredients…
- Trial name
- NCT05729204
- Testing
- Hypertonic seawater solution
- Where
- Greece
- Volunteers
- 56 people
- Sponsor
- Larissa University Hospital
Coronary Artery Disease, Edema
The Efficacy and Safety of Hypertonic Saline in Cardiac Surgery Patients.
The organ dysfunction following cardiopulmonary bypass (CPB) occurs frequently in cardiac surgery patients. Systemic inflammatory response initiated by CPB through releasing of several mediators lead to altered endothelial…
- Trial name
- ESHHS (NCT01675453)
- Testing
- 7.2% NaCl plus 6% hydroxyethyl starch 200/0.5, 0.9% NaCl
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Chronic Obstructive Pulmonary Disease
Nebulized Hypertonic Saline for Inpatient Use in COPD
A comparison of albuterol treatments using hypertonic saline (3%) versus standard saline (0.9%) in patients with admitted patients COPD in regard to Modified Borg Dyspnea scale scores after 4 treatments within 24 hours.
- Trial name
- NCT02266875
- Testing
- hypertonic saline, standard saline
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- OhioHealth
Neuromuscular Diseases
Nebulised Hypertonic Saline in Children and Young People With Neuromuscular Disease and Cerebral Palsy
Pneumonia, respiratory exacerbations, and chronic pulmonary infection are important causes of emergency admissions, hospitalisations and death in children with Neuromuscular disorders and Cerebral Palsy.
- Trial name
- NCT03623698
- Testing
- Nebulised hypertonic saline
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Imperial College London
Brain Injuries, Traumatic
Hypertonic Resuscitation Following Severe Traumatic Brain Injury (TBI)
The purpose of this study is to determine if hypertonic saline with and without dextran can improve neurologic outcomes in victims of severe traumatic brain injury (TBI).
- Trial name
- NCT00316004
- Testing
- 7.5% Hypertonic Saline in 6% Dextran-70 (HSD), 7.5% Hypertonic Saline (HS), 0.9% Normal Saline (NS)
- Where
- 12 sites in United States, Canada
- Volunteers
- 1,331 people
- Sponsor
- University of Washington
Hemorrhoids, Bleeding
Pain and Bleeding Following Hypertonic Saline Sclerotherapy Compared to Brand Ligation for Symptomatic Hemorrhoids
The investigators aim at prospectively comparing procedural pain, adverse events and rebleeding rates of anoscopic rubber band ligation and endoscopic hypertonic saline injection in patients with symptomatic hemorrhoidal disease
- Conditions
- Hemorrhoids, Bleeding, Pain
- Trial name
- NCT02851940
- Testing
- Rubber Band Ligation, Hypertonic Saline Infusion
- Where
- Lebanon
- Sponsor
- American University of Beirut Medical Center
Cystic Fibrosis
Inhaled Xylitol Versus Saline in Stable Subjects With Cystic Fibrosis
Cystic fibrosis (CF) lung disease is characterized by chronic bacterial colonization and recurrent infection of the airways. Lowering the airway surface liquid (ASL) salt concentration has been shown to increase activity of salt…
- Trial name
- NCT01355796
- Testing
- Xylitol, Hypertonic saline
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Joseph Zabner
Bronchiolitis
Nebulized Hypertonic Saline for Bronchiolitis
In randomized controlled trials, the use of nebulized hypertonic saline in acute bronchiolitis has been reported to improve respiratory distress scores, to reduce length of hospital stay and to show a trend towards lower…
- Trial name
- NCT01460524
- Where
- 5 sites in France
- Volunteers
- 2,580 people
- Sponsor
- Hôpital Armand Trousseau
Sodium Lactate, Intracranial Hypertension
Sodium Lactate and Brain Relaxation (LSD)
Resection surgery of brain tumors by craniotomy requires efficient brain relaxation intraoperatively in order to avoid injuries caused by the brain retractors (such as ischemic-reperfusion and cerebral oedema).
- Conditions
- Sodium Lactate, Intracranial Hypertension, Brain Relaxation
- Trial name
- LSD (NCT04488874)
- Testing
- Sodium Lactate, Mannitol 20% Infusion
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Bronchiolitis
Nebulized Hypertonic Saline (3%) Versus Nebulized Adrenaline for Treatment of Bronchiolitis
The primary objective of this study was to compare the effectiveness of nebulized hypertonic saline (3%) and nebulized adrenaline in bronchiolitis.
- Trial name
- NCT03614273
- Testing
- Hypertonic saline, Adrenaline
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Maulana Azad Medical College