Clinical trials: Hypertonic Disorder
Bronchiolitis
Inhaled Hypertonic Saline for Bronchiolitis
Study Design: This randomized, double blind, controlled, multi-centre study will occur in the Emergency Department, hospital-based Urgent Care Centre or paediatric outpatient clinics (collectively "ED") of 3 General Hospitals in…
- Trial name
- 7HSinED (NCT02253576)
- Testing
- inhaled 7% hypertonic saline, inhaled nebulized normal saline
- Where
- 3 sites in Canada
- Sponsor
- Queen's University
Cystic Fibrosis
PEP and O-PEP Device for Nebulization in Cystic Fibrosis
Physiotherapy is an essential element in the comprehensive treatment of patients with cystic fibrosis. In symptomatic individuals, from a respiratory system perspective, it should be performed regularly, as it directly…
- Trial name
- NCT06964074
- Testing
- Nebulization with OPEP device, Nebulization with PEP device, Nebulization with Pari LC Sprint
- Where
- 2 sites in Poland
- Volunteers
- 70 people
- Sponsor
- National Institute for Tuberculosis and Lung Diseases, Poland
Upper Resp Tract Infection, Rhinitis Acute
Evaluation of a Hypertonic Seawater Aerosol Therapy Solution in Adults and Children
The purpose of this study is to evaluate the tolerance, the performance and safety of this device, 22‰ Hypertonic seawater aerosol therapy solution in unidose container, to treat adult and peadiatric patients with of upper…
- Conditions
- Upper Resp Tract Infection, Rhinitis Acute, Rhinopharyngitis, Cold Symptom
- Trial name
- AIR (NCT07267689)
- Testing
- Treatment (22‰ Hypertonic seawater aerosol therapy solution)
- Where
- 4 sites in Poland
- Volunteers
- 110 people
- Sponsor
- Laboratoires Gilbert
Frozen Shoulder
Efficacy of Prolotherapy and Hydrodilatation for Frozen Shoulder
Objective: To determine whether ultrasound-guided Intra-Articular Hypertonic Dextrose and hydrodilatation improves pain and function in patients with frozen shoulder(FS)
- Trial name
- NCT05448794
- Testing
- injection
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Brain Injuries
Feasibility Trial of Traumatic Brain Injured Patients Randomized in the Prehospital Setting to Either Hypertonic Saline and Dextran Versus Normal Saline
This clinical trial will evaluate the ease of conducting a randomized trial on patients with severe head injury who are cared for by paramedics in the out of hospital setting.
- Trial name
- TOPHR HIT (NCT00878631)
- Testing
- hypertonic saline mixed with dextran, Normal Saline
- Where
- 2 sites in Canada
- Volunteers
- 113 people
- Sponsor
- Unity Health Toronto
Acute Viral Bronchiolitis
High Flow Therapy vs Hypertonic Saline in Bronchiolitis
The purpose of this study is to demonstrate that heated, humidified, high-flow nasal cannula (HHHFNC) is superior to hypertonic saline solution (HSS) in the treatment of moderate acute viral bronchiolitis in infants in improving…
- Trial name
- NCT01873144
- Testing
- Epinephrine 1/1000, HSS 3%, HHHFNC
- Where
- 2 sites in Spain
- Volunteers
- 75 people
- Sponsor
- Ministry of Health, Spain
Frozen Shoulder
Hydrodilatation With Hypertonic Dextrose Solution Injection After Intra-articular Steroid Injection for Frozen Shoulder
This study aims to investigate whether intra-articular corticosteroid injection, followed by hypertonic dextrose injection and shoulder joint capsular distension, is more effective than saline injection and shoulder joint…
- Trial name
- NCT06165939
- Testing
- Intra-articular corticosteroid injection, hydrodilation with 15% hypertonic dextrose, hydrodilation with Normal saline
- Volunteers
- 60 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Viral Bronchiolitis
Hypertonic Saline to Reduce Hospital Admissions in Bronchiolitis
Inhaled 3% hypertonic saline (HS) administered every 2-8 hours to infants admitted to hospital with viral bronchiolitis has been shown to improve airway clearance and reduces length of stay.
- Trial name
- NCT00677729
- Testing
- solution contains 1 mg salbutamol plus 3% hypertonic saline, solution contains 1 mg salbutamol plus 0.9% saline
- Where
- 3 sites in Canada
- Volunteers
- 81 people
- Sponsor
- Queen's University
Acute Viral Bronchiolitis
Efficacy of 3% Hypertonic Saline in Acute Viral Bronchiolitis
The purpose of this study is to determine whether nebulized hypertonic saline solution reduces the admission rate 48 hours after initial treatment in the emergency department, when compared to normal saline solution (control).
- Trial name
- GUERANDE (NCT01777347)
- Testing
- 3% Saline, 0.9% Normal Saline
- Where
- 21 sites in France
- Volunteers
- 778 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Arterial Hypertension
Fetuin A as a Predictor of Deterioration of Renal Function in Hypertonic Patients
Commonly used parameters (creatinine, estimated glomerular filtration rate, and urine albumin/creatinine ratio) for prediction of decline of renal function are sensitive for advanced kidney impairment.
- Trial name
- NCT05963126
- Testing
- No intervention.
- Where
- Czechia
- Volunteers
- 200 people
- Sponsor
- University Hospital Ostrava
Increased Intracranial Pressure
Comparison of Two Different Medications Used to Treat Elevated Intracranial Pressure
The overall purpose of this study is to compare the effects of mannitol and hypertonic saline on patients with increased intracranial pressure.
- Trial name
- NCT00359697
- Testing
- Hypertonic Saline, Mannitol
- Volunteers
- 50 people
- Sponsor
- Thomas Jefferson University
Preeclampsia
Hypertonic Saline Use in Preeclampsia
To compare hypertonic saline to Lactated Ringer's solution and assess whether one speeds up the process of getting rid of extra body water faster in women with preeclampsia.
- Trial name
- NCT00181077
- Testing
- 2% buffered hypertonic saline administration
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
Cystic Fibrosis
Impact of Discontinuing Chronic Therapies in People With Cystic Fibrosis on Highly Effective CFTR Modulator Therapy
Despite the increasingly common use of cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapies in treating CF, it is still largely unknown whether or not other chronic therapies can be safely stopped.
- Trial name
- SIMPLIFY (NCT04378153)
- Where
- 80 sites in United States
- Volunteers
- 987 people
- Sponsor
- Nicole Hamblett
Arginine Vasopressin Deficiency, Primary Polydipsia
Copeptin Measurement After Mannitol and Hypertonic Saline for the Diagnosis of Polyuria-polydipsia Syndrome
The aim of this study is to evaluate whether a new test using mannitol infusion can diagnose the cause of polyuria-polydipsia syndrome as accurately as the current standard test (hypertonic saline infusion) and to compare which…
- Trial name
- COMPASS (NCT07569861)
- Testing
- Mannitol, Hypertonic Saline
- Where
- Switzerland
- Volunteers
- 144 people
- Sponsor
- University Hospital, Basel, Switzerland
Nosocomial Infection, Nosocomial Pneumonia
Mechanical Insufflation-exsufflation and Hypertonic Saline in Nosocomial Bacterial Respiratory Tract Infection
Multicenter, randomized open label clinical trial to evaluate IEM and HS as concomitant therapy for respiratory tract infection in patients under artificial ventilation in the ICU.
- Conditions
- Nosocomial Infection, Nosocomial Pneumonia, Tracheobronchitis, Mechanical Ventilation Complication
- Trial name
- ABSENTA (NCT06310941)
- Testing
- Mechanical insufflation-exsufflation, Standard of Care, Hypertonic saline with hyaluronic acid
- Where
- 8 sites in Spain
- Volunteers
- 100 people
- Sponsor
- Hospital San Carlos, Madrid
Nontuberculous Mycobacterial Lung Disease, Bronchiectasis
Hypertonic Saline Inhalation for Nontuberculous Mycobacterial Lung Disease
This multicenter randomized controlled trial evaluates the clinical and microbiological effects of inhaled 3% hypertonic saline in treatment-naïve patients with nontuberculous mycobacterial lung disease (NTM-LD).
- Trial name
- HiNTM (NCT07647575)
- Testing
- Nebulized 3% Hypertonic Saline, Nebulized Normal Saline
- Where
- Taiwan
- Volunteers
- 262 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Corneal Edema
Comparison of 5% Hypertonic Saline Versus 3% Hypertonic Saline in Resolution of Post-operative Corneal Edema.
There is a lack of data to determine the comparative advantages of 5% hypertonic saline and 3% hypertonic saline over the other.
- Trial name
- NCT07605273
- Testing
- 5% Hypertonic Saline, 3% Hypertonic Saline
- Where
- Pakistan
- Volunteers
- 70 people
- Sponsor
- Muhammad Aamir Latif
Allergic Rhinitis
Efficacy of Buffered Hypertonic Saline(BHS)Nasal Irrigation in Allergic Rhinitis (AR) Children
The purpose of this study is to investigate whether buffered hypertonic saline (BHS) is superior to normal saline (NSS) for improving mucociliary function and relief nasal symptoms in children with allergic rhinitis.
- Trial name
- NCT01441778
- Testing
- NSS nasal irrigation salt, BHS nasal irrigation salt
- Where
- Thailand
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Thammasat University
Bronchiolitis
Nebulized 5% Hypertonic Saline for the Treatment of Bronchiolitis
The investigators reasoned that a hypertonic saline concentration higher than 3% could be safe and more efficacious in the treatment of bronchiolitis, alleviating severe symptoms and preventing the need for hospitalization in…
- Trial name
- NCT01016249
- Testing
- Treatment 1. (5% Hypertonic saline + Epinephrine), Treatment 3. (3% Hypertonic saline + Epinephrine), Treatment 2. (Normal saline + Epinephrine)
- Where
- Qatar
- Volunteers
- 187 people
- Sponsor
- Hamad Medical Corporation
Asthma
Sputum Induction by Physiotherapy and Hypertonic Saline Techniques in Asthmatic Children
This study evaluated whether physiotherapy is efficient in sputum induction and in evaluation of pulmonary inflammation in asthmatic children.
- Trial name
- NCT03136042
- Testing
- physiotherapy techniques, hypertonic saline 3%, saline + physiotherapy maneuvers
- Where
- Brazil
- Volunteers
- 33 people
- Sponsor
- University of Sao Paulo