Clinical trials: Hypertriglyceridemia
Metabolic Syndrome, Hypertriglyceridemia
Niacin, N-3 Fatty Acids and Insulin Resistance
This research study is being conducted to test the effects of two drugs on blood lipids (cholesterol and triglycerides) and blood sugar (glucose) levels in patients with diabetes or "pre-diabetes" (both of which have a condition…
- Trial name
- NCT00286234
- Testing
- omega-3 acid ethyl esters, extended release niacin, combined treatment
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of South Dakota
Hypertriglyceridemia
Interest of High-speed Centrifugation for Measuring Anti-Xa Activity on Lipemic Plasma
Some hemostasis techniques require spectrophotometric measurements. These are then subject to interference from the sample's lipemia (postprandial, hypertriglyceridemia, etc.), which risks distorting the results; this is…
- Trial name
- LCGV (NCT07200674)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Strasbourg, France
Diabetes Mellitus, Type 2, Hypertriglycemia
Efficacy and Safety of Prescription Omega-3 Fatty Acid Added to Stable Statin Therapy in Patients With Type 2 Diabetes and Hypertriglyceridemia
Assess efficacy and safety of Omacor® 4g with statin treatment for lowering TG levels in subjects with type 2 Diabetes combined with hyperlipidemia
- Trial name
- NCT02305355
- Testing
- Omega-3-acids ethylesters 90 4g, Pravastatin, Simvastatin, Atorvastatin, Rosuvastatin
- Where
- South Korea
- Volunteers
- 68 people
- Sponsor
- Kuhnil Pharmaceutical Co., Ltd.
Inflammation, Hypertriglyceridemia
Impact of Foods on Bile Acids, Metabolites, and Inflammation
Dietary incorporation of pulse crops may be an effective way to lower unhealthy elevations in serum bile acids. These elevations play a direct role in promoting obesity-related diseases estimated to be present in about one third…
- Conditions
- Inflammation, Hypertriglyceridemia, Metabolic Disease, Lipid Metabolism Disorder
- Trial name
- NCT05245357
- Testing
- Lentil, Control
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Montana State University
Dyslipidemias
Evaluate the Safety and Efficacy of Saroglitazar Mg in Patients With Fasting Triglyceride ≥500 mg/dL and ≤1500 mg/dL
To evaluate the safety and efficacy of Saroglitazar Magnesium 1, 2, and 4 mg in patients with fasting triglyceride ≥500 mg/dL and ≤1500 mg/dL.
- Trial name
- NCT03097107
- Testing
- Saroglitazar Magnesium 1 mg, Saroglitazar Magnesium 2 mg, Saroglitazar Magnesium 4 mg
- Where
- 33 sites in United States
- Volunteers
- 124 people
- Sponsor
- Zydus Therapeutics Inc.
Hypertriglyceridemia
Metabolic Effects of Egg Protein and Unsaturated Fat Intakes in Subjects With Hypertriglyceridemia
The goal of this study is to evaluate the effects of replacing some refined starches and added sugars with a combination of egg protein and unsaturated fatty acids on markers of cardiometabolic health in men and women with…
- Trial name
- NCT02924558
- Testing
- Egg protein/unsaturated fatty acid, Control
- Volunteers
- 28 people
- Sponsor
- Midwest Center for Metabolic and Cardiovascular Research
Acute Pancreatitis
Hypertriglyceridemia-associated Acute Pancreatitis: Apheresis Vs. Conservative Treatment
Introduction: Hypertriglyceridemia is one of the etiologies of acute pancreatitis. It may cause severe multi-system disease resulting in high morbidity and mortality.
- Trial name
- NCT04708925
- Testing
- conservative versus plasmapharesis therapy
- Where
- Israel
- Volunteers
- 29 people
- Sponsor
- Meir Medical Center
Peritoneal Dialysis, Hypertriglyceridemia
Effect of Extraneal (Icodextrin)on Triglyceride Levels in PD Patients
This is a Phase IV study evaluating triglyceride levels in peritoneal dialysis patients.
- Trial name
- NCT00397358
- Testing
- Extraneal (7.5% icodextrin) Peritoneal Dialysis Solution
- Where
- 3 sites in United States
- Sponsor
- Vantive Health LLC
Hypertriglyceridemia
Evaluation of Efficacy and Safety of Omacor (Omega-3-acid Ethyl Esters) as Add-on Therapy in Hypertriglyceridemic Subjects Treated With Antara (Fenofibrate) Followed by an 8-week Extension
The purpose of OM5/LOV111859 was to evaluate efficacy and safety of Omacor (omega-3-acid ethyl esters) as add-on therapy to Antara (fenofibrate) and diet for the treatment of patients with very high triglycerides.
- Trial name
- NCT00246636
- Testing
- Antara (fenofibrate) + Lovaza, Antara (fenofibrate)
- Volunteers
- 167 people
- Sponsor
- GlaxoSmithKline
Hypertriglyceridemia
Efficacy and Safety Study of DHA-O in Adults With Hypertriglyceridemia
The purpose of this study is to investigate the efficacy and safety of DHA-O to lower elevated triglyceride levels in healthy adults with hypertriglyceridemia.
- Trial name
- DHA-O (NCT01737099)
- Testing
- DHA-O, Fish oil
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- dsm-firmenich Switzerland AG
Dyslipidemia, Hypercholesterolemia, Hypertriglyceridemia
Safety and Efficacy Study Comparing ABT-143 to Simvastatin in Subjects With Elevated Levels of Low Density Lipoprotein Cholesterol ("Bad Cholesterol") and Triglycerides
The primary purpose of this study is to test the effect and safety of three different doses of ABT-143 compared to simvastatin in subjects with elevated levels of low density lipoprotein cholesterol ("bad cholesterol") and…
- Trial name
- NCT00812955
- Testing
- ABT-143, simvastatin
- Where
- 129 sites in United States
- Volunteers
- 474 people
- Sponsor
- AstraZeneca
Hyperlipidemia
A Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamic Effects of JS401
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetcs and pharmacodynamics of single-dose of JS401 in healthy volunteers with normal or mildly elevated triglycerides.
- Trial name
- NCT06041165
- Testing
- JS401
- Where
- China
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Shanghai Junshi Bioscience Co., Ltd.
Hypertension, Metabolic Syndrome
Regulation of Inflammatory Parameters by Telmisartan in Hypertensive Patients
A number of studies have shown that certain blood-pressure medications such as ACE-inhibitors and angiotensin-II-receptor blockers (ARB) can reduce the incidence of diabetes mellitus type 2.
- Conditions
- Hypertension, Metabolic Syndrome, Hypertriglyceridemia
- Trial name
- METATEL (NCT00560430)
- Testing
- telmisartan
- Where
- 2 sites in Germany
- Volunteers
- 56 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Hypercholesterolemia, Hypertriglyceridemia
Effects of Two Herbal Dietary Supplements on Lipid Metabolism in Moderate Hypercholesterolemia and Hypertriglyceridemia
This study is designed as a pilot study in order to estimate the effect of VAL070-A and VAL070-B products and their variability on LDL cholesterol and lipid metabolism since these data are still unknown for these products and in…
- Trial name
- Lipiback (NCT02989753)
- Testing
- VAL070-A, VAL070-B
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Valbiotis
Elevated Triglycerides, Diabetes
Change of Fructose to Fat in South Asians
The purpose of this study is to determine whether hepatic de novo lipogenesis (DNL) in response to the ingestion of a mixture of glucose and fructose is greater in South Asians compared to controls (Caucasians).
- Conditions
- Elevated Triglycerides, Diabetes, Cardiovascular Disease, Dyslipidemia
- Trial name
- NCT01562782
- Testing
- Fructose + Glucose Beverage
- Where
- 2 sites in United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- The Rogosin Institute
Hypertriglyceridemia, Glucose Intolerance
Impact of Plasma Lipids on β Cell Function and Insulin Sensitivity
The investigators aim to evaluate whether and to what extent glucose tolerance, beta cell function, insulin clearance, and glucose metabolic fluxes change in response to an acute increase in plasma triglycerides during lipid…
- Trial name
- NCT05181514
- Testing
- 20% Intralipid, Normal Saline
- Where
- Italy
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Endocrine System Diseases, Nutritional and Metabolic Diseases
Efficacy and Safety of EzetimiBe/Rosuvastatin in Diabetic Dislipidemia With Hypertriglyceridaemia
To compare and evaluate the effects of LDL-C and Triglyceride (TG) control on the first dose Ezetimibe/Statin (Rosuvastatin 5 mg/Ezetimibe 10 mg) combination therapy compared to the average dose Statin (Rosuvastatin 10 mg)…
- Conditions
- Endocrine System Diseases, Nutritional and Metabolic Diseases, Diabetes Mellitus, Type 2, Dyslipidemias
- Trial name
- REMBRANDT (NCT04700436)
- Testing
- Rosuzet tablet 10/5 mg (Ezetimibe 10 mg/Rosuvastatin 5 mg), Suvast tablet 10 mg (Rosuvastatin 10 mg)
- Where
- 26 sites in South Korea
- Volunteers
- 146 people
- Sponsor
- Seoul National University Hospital
Pancreatitis, Acute, Hypertriglyceridemia
Intravenous Administration of Insulin and Plasma Exchange on Triglyceride Levels in Early Stage of Hypertriglyceridemia-induced Pancreatitis
To investigate an economical and effective way to reduce the level of serum triglyceride in patients with hypertriglyceridemia-induced acute pancreatitis.
- Trial name
- NCT03342807
- Testing
- Insulin, Aphesis
- Volunteers
- 220 people
- Sponsor
- Peking Union Medical College Hospital
HIV, Hyperlipidemia
Changes in Lipids and Safety of Raltegravir in HIV+ Patients With Hyperlipidemia While on Current Standard Therapy
The success of combination antiretroviral therapy heralded a revolution in the treatment of HIV in the mid-1990s. However, severe treatment-associated side effects have been observed including diabetes and increased cholesterol…
- Conditions
- HIV, Hyperlipidemia, Hypertriglyceridemia, HIV Infections
- Trial name
- NCT00887653
- Testing
- raltegravir
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- The Miriam Hospital
Inflammation, Metabolic Disorder
Impact of Aronia Berry Consumption on Inflammation, Metabolites, and the Gut Microbiome
The goal of this project is to elucidate interactions between the gut microbiome, anti-inflammatory/anti-oxidant food metabolomic signatures, and human inflammation phenotypes.
- Conditions
- Inflammation, Metabolic Disorder, Hypertriglyceridemia
- Trial name
- NCT05255718
- Testing
- Aronia juice
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Montana State University